메뉴 건너뛰기




Volumn 20, Issue 3, 2010, Pages 453-458

Pharmacological activity of monocrotalina isolated from plants of the genus Crotalaria;Atividade farmacológica da monocrotalina isolada de plantas do gênero Crotalaria

Author keywords

Crotalaria; Dehydromonocrotaline; Hepatotoxity; Monocrotaline

Indexed keywords

CROTALIA RETUSA EXTRACT; MONOCROTALINE; MONOCROTALINE PYRROLE; UNCLASSIFIED DRUG;

EID: 77957579919     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0102-695x2010000300025     Document Type: Article
Times cited : (8)

References (58)
  • 1
    • 0027493514 scopus 로고
    • Intoxication due to Crotalaria retusa and C. spectabilis in chickens and geese
    • Alfonso HA, Sanchez LM, Figueredo MA, Gómez BC 1993. Intoxication due to Crotalaria retusa and C. spectabilis in chickens and geese. Vet Hum Toxicol 35: 539-544.
    • (1993) Vet Hum Toxicol , vol.35 , pp. 539-544
    • Alfonso, H.A.1    Sanchez, L.M.2    Figueredo, M.A.3    Gómez, B.C.4
  • 2
    • 0032921958 scopus 로고    scopus 로고
    • Hepatotoxicity associated with pyrrolizidine alkaloid (Crotalaria spp) ingestion in a horse on Easter Island
    • Arzt J, Mount M 1999. Hepatotoxicity associated with pyrrolizidine alkaloid (Crotalaria spp) ingestion in a horse on Easter Island. Vet Hum Toxicol 41: 96-99.
    • (1999) Vet Hum Toxicol , vol.41 , pp. 96-99
    • Arzt, J.1    Mount, M.2
  • 3
    • 16844384166 scopus 로고
    • The pyrrolizidine alkaloids from Indian Crotalarias
    • Atal CK, Sawhney RS 1973. The pyrrolizidine alkaloids from Indian Crotalarias. Indian J Pharm 35: 1-12.
    • (1973) Indian J Pharm , vol.35 , pp. 1-12
    • Atal, C.K.1    Sawhney, R.S.2
  • 6
    • 0021689127 scopus 로고
    • Effects of Crotalaria saltiana on Nubian Goats
    • Barri MES, Adam SEI 1984. Effects of Crotalaria saltiana on Nubian Goats. Vet Hum Toxicol 26: 476-480.
    • (1984) Vet Hum Toxicol , vol.26 , pp. 476-480
    • Barri, M.E.S.1    Adam, S.E.I.2
  • 7
    • 0019842001 scopus 로고
    • The toxicity of Crotalaria saltiana to calves
    • Barri MES, Adam SEI 1981. The toxicity of Crotalaria saltiana to calves. J Comp Pathol 91: 621-627.
    • (1981) J Comp Pathol , vol.91 , pp. 621-627
    • Barri, M.E.S.1    Adam, S.E.I.2
  • 8
    • 0032864104 scopus 로고    scopus 로고
    • Dietary X-carotene protects lung and liver parenchyma of rats treated with monocrotaline
    • Baybutt RC, Molteni A 1999. Dietary X-carotene protects lung and liver parenchyma of rats treated with monocrotaline. Toxicology 137: 69-80.
    • (1999) Toxicology , vol.137 , pp. 69-80
    • Baybutt, R.C.1    Molteni, A.2
  • 9
    • 0037076906 scopus 로고    scopus 로고
    • Dietary fish oil protects against lung and liver inflammation and fibrosis in monocrotaline treated rats
    • Baybutt RC, Rosales C, Brady H, Molteni A 2002. Dietary fish oil protects against lung and liver inflammation and fibrosis in monocrotaline treated rats. Toxicology 175: 1-13.
    • (2002) Toxicology , vol.175 , pp. 1-13
    • Baybutt, R.C.1    Rosales, C.2    Brady, H.3    Molteni, A.4
  • 10
    • 0002317075 scopus 로고
    • The histological evidence of liver damage from pyrrolizidine alkaloids: Megalocytosis of the liver cells and inclusion globules
    • Bull LB 1955. The histological evidence of liver damage from pyrrolizidine alkaloids: megalocytosis of the liver cells and inclusion globules. Aust Vet J 18: 33-40.
    • (1955) Aust Vet J , vol.18 , pp. 33-40
    • Bull, L.B.1
  • 11
    • 0014754696 scopus 로고
    • Lesions in the liver and lungs of rats given pyrrole derivatives of pyrrolizidine alkaloids
    • Butler WH, Mattocks AR, Barnes JM 1970. Lesions in the liver and lungs of rats given pyrrole derivatives of pyrrolizidine alkaloids. J Pathol 100: 169-175.
    • (1970) J Pathol , vol.100 , pp. 169-175
    • Butler, W.H.1    Mattocks, A.R.2    Barnes, J.M.3
  • 12
  • 13
    • 0014819718 scopus 로고
    • Arterial degeneration and glomerular hyalinization in the kidney of monocrotaline-intoxicated rats
    • Carstens LA, Allen JR 1970. Arterial degeneration and glomerular hyalinization in the kidney of monocrotaline-intoxicated rats. Am J Pathol 60: 75-90.
    • (1970) Am J Pathol , vol.60 , pp. 75-90
    • Carstens, L.A.1    Allen, J.R.2
  • 14
    • 0003825628 scopus 로고    scopus 로고
    • Natural toxicants in feeds, forages and poisonous plants
    • Cheecke PR 1998. Natural toxicants in feeds, forages and poisonous plants. Danville: Interstate Publishers.
    • (1998) Danville: Interstate Publishers
    • Cheecke, P.R.1
  • 15
    • 0015948208 scopus 로고
    • Influence of dietary protein and sulfur amino acid levels on the toxicity of Senecio jacobaea (Tansy Ragwort) to rats
    • Cheeke PR, Garman GR 1974. Influence of dietary protein and sulfur amino acid levels on the toxicity of Senecio jacobaea (Tansy Ragwort) to rats. Nutr Rep Int 9: 197-202.
    • (1974) Nutr Rep Int , vol.9 , pp. 197-202
    • Cheeke, P.R.1    Garman, G.R.2
  • 16
    • 0024078378 scopus 로고
    • Natural toxicants in feeds and poisonous plants. Westport: AVI Publishing Company. Cheeke PR 1988. Toxicity and metabolism of pyrrolizidine alkaloids
    • Cheeke PR, Shull LR 1985. Natural toxicants in feeds and poisonous plants. Westport: AVI Publishing Company. Cheeke PR 1988. Toxicity and metabolism of pyrrolizidine alkaloids. J Anim Sci 66: 2343-2350
    • (1985) J Anim Sci , vol.66 , pp. 2343-2350
    • Cheeke, P.R.1    Shull, L.R.2
  • 17
    • 0036158951 scopus 로고    scopus 로고
    • Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure
    • Copple BL, Banes A, Ganey PE, Roth RA 2002. Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure. Toxicol Sci 65: 309-318.
    • (2002) Toxicol Sci , vol.65 , pp. 309-318
    • Copple, B.L.1    Banes, A.2    Ganey, P.E.3    Roth, R.A.4
  • 18
    • 0030226332 scopus 로고    scopus 로고
    • A screening test for subclinical liver disease in horses affected by pyrrolizidine alkaloid toxicosis
    • Curran JM, Sutherland RJ, Peet RL 1996. A screening test for subclinical liver disease in horses affected by pyrrolizidine alkaloid toxicosis. Aust Vet J 74: 236-240.
    • (1996) Aust Vet J , vol.74 , pp. 236-240
    • Curran, J.M.1    Sutherland, R.J.2    Peet, R.L.3
  • 19
    • 0347040596 scopus 로고
    • Patologia de la intoxicacion experimental aguda por Crotalaria retusa y C. spectabilis em pollos
    • Figueredo MLA, Rodríguez J, Alfonso HA 1987. Patologia de la intoxicacion experimental aguda por Crotalaria retusa y C. spectabilis em pollos. Rev Cubana Cienc Vet 18: 63-71.
    • (1987) Rev Cubana Cienc Vet , vol.18 , pp. 63-71
    • Figueredo, M.L.A.1    Rodríguez, J.2    Alfonso, H.A.3
  • 20
    • 77957600717 scopus 로고    scopus 로고
    • Aspectos fitogeográficos das espécies de Crotalaria L. (Leguminosae-Faboideae) na Região Sul do Brasil
    • Flores AS, Miotto STS 2005. Aspectos fitogeográficos das espécies de Crotalaria L. (Leguminosae-Faboideae) na Região Sul do Brasil. Acta Bot Bras 19: 245-249.
    • (2005) Acta Bot Bras , vol.19 , pp. 245-249
    • Flores, A.S.1    Miotto, S.T.S.2
  • 21
    • 11844259351 scopus 로고
    • Studies on Crotalaria crispata, a newly recognised cause of Kimberley horse disease
    • Gardiner MR, Royce R, Bokor A 1965. Studies on Crotalaria crispata, a newly recognised cause of Kimberley horse disease. J Comp Pathol 89: 43-53.
    • (1965) J Comp Pathol , vol.89 , pp. 43-53
    • Gardiner, M.R.1    Royce, R.2    Bokor, A.3
  • 22
    • 11844253122 scopus 로고
    • An outbreak of cirrosis of the liver in horses
    • Gibbons WJ, Durr EH, Cox SA 1953. An outbreak of cirrosis of the liver in horses. N Am Vet 34: 556-558.
    • (1953) N Am Vet , vol.34 , pp. 556-558
    • Gibbons, W.J.1    Durr, E.H.2    Cox, S.A.3
  • 23
    • 0014056244 scopus 로고
    • Renal and pulmonary alterations induced in rats by a single injection of monocrotaline
    • Hayashi Y, Lalich JJ 1967. Renal and pulmonary alterations induced in rats by a single injection of monocrotaline. P Soc Exp Biol Med 124: 392-396.
    • (1967) P Soc Exp Biol Med , vol.124 , pp. 392-396
    • Hayashi, Y.1    Lalich, J.J.2
  • 24
    • 77957556037 scopus 로고
    • Leguminosas papilionaceas: Crotalaria e Lupinus
    • Hoehne, F.C. (ed.), São Paulo: Graphicars
    • Hoehne FC 1939. Leguminosas papilionaceas: Crotalaria e Lupinus. In: Hoehne, F.C. (ed.). Plantas e substâncias vegetais tóxicas e medicinais. São Paulo: Graphicars,. p. 137-196.
    • (1939) Plantas E Substâncias Vegetais Tóxicas E Medicinais , pp. 137-196
    • Hoehne, F.C.1
  • 26
    • 0025090591 scopus 로고
    • Activation and pulmonary toxicity of pirrolizidine alkaloids
    • Huxtable RJ 1990. Activation and pulmonary toxicity of pirrolizidine alkaloids. Pharmacol Therapeut 47: 371-389.
    • (1990) Pharmacol Therapeut , vol.47 , pp. 371-389
    • Huxtable, R.J.1
  • 29
    • 0035903966 scopus 로고    scopus 로고
    • DNA cross-linking by a phototriggered pyrrolic progenitor developed from monocrotaline
    • Kosogof C, Tepe JJ, Williams, RM 2001. DNA cross-linking by a phototriggered pyrrolic progenitor developed from monocrotaline. Tetrahedron Lett 42: 6641-6643.
    • (2001) Tetrahedron Lett , vol.42 , pp. 6641-6643
    • Kosogof, C.1    Tepe, J.J.2    Williams, R.M.3
  • 30
    • 0008956767 scopus 로고
    • Toxicology of pyrrolizidine alkaloids in animal
    • Mattocks A R., New York: Academic Press
    • Mattocks AR 1986. Toxicology of pyrrolizidine alkaloids in animal. In: Mattocks A R. Chemistry and toxicology of pyrrolizidine alkaloids. New York: Academic Press, p. 191-219.
    • (1986) Chemistry and Toxicology of Pyrrolizidine Alkaloids , pp. 191-219
    • Mattocks, A.R.1
  • 31
    • 0016611931 scopus 로고
    • Crotalaria spectabilis toxicity in swine: Characterization of the renal glomerular lesion
    • Mcgrath JPM, Duncan JR, Munnell JF 1975. Crotalaria spectabilis toxicity in swine: characterization of the renal glomerular lesion. J Comp Pathol 85: 185-194.
    • (1975) J Comp Pathol , vol.85 , pp. 185-194
    • McGrath, J.P.M.1    Duncan, J.R.2    Munnell, J.F.3
  • 32
    • 0014891493 scopus 로고
    • The toxic actions of pyrrolizidine (Senecio) alkaloids
    • Mclean EK 1970. The toxic actions of pyrrolizidine (Senecio) alkaloids. Pharm Vet 22: 429-483.
    • (1970) Pharm Vet , vol.22 , pp. 429-483
    • McLean, E.K.1
  • 33
    • 0034141923 scopus 로고    scopus 로고
    • Fetotoxicity and reproductive effects of monocrotaline in pregnant rats
    • Medeiros RMT, Górniak SL, Guerra JL 2000. Fetotoxicity and reproductive effects of monocrotaline in pregnant rats. J Ethnopharmacol 69: 181-188.
    • (2000) J Ethnopharmacol , vol.69 , pp. 181-188
    • Medeiros, R.M.T.1    Górniak, S.L.2    Guerra, J.L.3
  • 35
    • 0016166028 scopus 로고
    • Influence of light, riboflavin, and carotene on the response of rats to the acute toxicity of aflatoxin and monocrotaline
    • Newberne PM, Chan WCM, Rogers AE 1974. Influence of light, riboflavin, and carotene on the response of rats to the acute toxicity of aflatoxin and monocrotaline. Toxicol Appl Pharm 28: 200-208.
    • (1974) Toxicol Appl Pharm , vol.28 , pp. 200-208
    • Newberne, P.M.1    Chan, W.C.M.2    Rogers, A.E.3
  • 36
    • 0017237012 scopus 로고
    • The bioenergetics of brown adipose tissue mitochondria
    • Nicholls DG 1976. The bioenergetics of brown adipose tissue mitochondria. FEBS Lett. 61: 103-110.
    • (1976) FEBS Lett , vol.61 , pp. 103-110
    • Nicholls, D.G.1
  • 38
    • 11844299550 scopus 로고    scopus 로고
    • Intoxication by Crotalaria retusa in ruminants and eqüidae in the state of Paraíba, northeastern Brazil
    • Acamovich T., Stewart C.S. & Pennycott T.W. (ed.), CAB International, Glasgow, UK
    • Nobre VMT, Riet-Correa F, Dantas AFM, Tabosa IM, Medeiros RMT, Barbosa Filho JM 2004a. Intoxication by Crotalaria retusa in ruminants and eqüidae in the state of Paraíba, northeastern Brazil. In: Acamovich T., Stewart C.S. & Pennycott T.W. (ed.). Plant Poisoning and related Toxins. CAB International, Glasgow, UK, p. 275-278.
    • (2004) Plant Poisoning and Related Toxins , pp. 275-278
    • Nobre, V.M.T.1    Riet-Correa, F.2    Dantas, A.F.M.3    Tabosa, I.M.4    Medeiros, R.M.T.5    Barbosa, F.J.M.6
  • 41
    • 0018462178 scopus 로고
    • Toxicity of Crotalaria goreensis for chickens
    • Norton JH, O'rourke PK 1979. Toxicity of Crotalaria goreensis for chickens. Aust Vet J 55: 173-174.
    • (1979) Aust Vet J , vol.55 , pp. 173-174
    • Norton, J.H.1    O'Rourke, P.K.2
  • 42
    • 85004280712 scopus 로고
    • Cytogenetic studies in mexican populations of species of Crotalaria (Leguminosae - Papilionoideae)
    • Palomino G, Vázquez R, 1991. Cytogenetic studies in mexican populations of species of Crotalaria (Leguminosae - Papilionoideae). Cytologia 56: 343-351.
    • (1991) Cytologia , vol.56 , pp. 343-351
    • Palomino, G.1    Vázquez, R.2
  • 44
    • 0021276897 scopus 로고
    • Characterization of hepatic DNA damage induced in rats by the pyrrolizidine alkaloid monocrotaline
    • Petry TW, Bowden G T, Huxtable RJ, Sipes IG 1984. Characterization of hepatic DNA damage induced in rats by the pyrrolizidine alkaloid monocrotaline. Cancer Res 44: 1505-1509.
    • (1984) Cancer Res , vol.44 , pp. 1505-1509
    • Petry, T.W.1    Bowden, G.T.2    Huxtable, R.J.3    Sipes, I.G.4
  • 46
    • 0027304182 scopus 로고
    • Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
    • Ribeiro LR, Silva AR, Bautista AR, Costa SL, Sales LA, Rios AC, Salvadori DM 1993. Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells. Mutat Res 300: 253-258.
    • (1993) Mutat Res , vol.300 , pp. 253-258
    • Ribeiro, L.R.1    Silva, A.R.2    Bautista, A.R.3    Costa, S.L.4    Sales, L.A.5    Rios, A.C.6    Salvadori, D.M.7
  • 47
    • 84981973649 scopus 로고
    • Field and experimental investigation of walk about disease of horses (Kimberley horse disease) in Northern Australia: Crotalaria poisoning in horses
    • Rose AL, Gardner C A, McConnell JD, Bull LB 1957a. Field and experimental investigation of walk about disease of horses (Kimberley horse disease) in Northern Australia: Crotalaria poisoning in horses. Aust Vet J 33: 25-33.
    • (1957) Aust Vet J , vol.33 , pp. 25-33
    • Rose, A.L.1    Gardner, C.A.2    McConnell, J.D.3    Bull, L.B.4
  • 48
    • 0343127259 scopus 로고
    • Field and experimental investigation of walk about disease of horses (Kimberley horse disease) in Northern Australia: Crotalaria poisoning in horses
    • Rose AL, Gardner CA, McConnell JD, Bull LB 1957b. Field and experimental investigation of walk about disease of horses (Kimberley horse disease) in Northern Australia: Crotalaria poisoning in horses. Aust Vet J 34: 49-62.
    • (1957) Aust Vet J , vol.34 , pp. 49-62
    • Rose, A.L.1    Gardner, C.A.2    McConnell, J.D.3    Bull, L.B.4
  • 49
    • 0025203256 scopus 로고
    • Monocrotaline-induced angiogenesis
    • Schraufnagel DE 1990. Monocrotaline-induced angiogenesis. Am J Pathol 137: 1083-1090.
    • (1990) Am J Pathol , vol.137 , pp. 1083-1090
    • Schraufnagel, D.E.1
  • 50
    • 0033531730 scopus 로고    scopus 로고
    • DNA cross-linking by a phototriggered dehydromonocrotaline progenitor
    • Tepe JJ, Williams RM 1999. DNA cross-linking by a phototriggered dehydromonocrotaline progenitor. J Am Chem Soc 121: 2951-2955.
    • (1999) J Am Chem Soc , vol.121 , pp. 2951-2955
    • Tepe, J.J.1    Williams, R.M.2
  • 51
    • 0030296590 scopus 로고    scopus 로고
    • Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA
    • Thomas HC, Lamé MW, Wilson DW, Segall HJ 1996. Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA. Toxicol Appl Pharm 141: 319-329.
    • (1996) Toxicol Appl Pharm , vol.141 , pp. 319-329
    • Thomas, H.C.1    Lamé, M.W.2    Wilson, D.W.3    Segall, H.J.4
  • 54
    • 77957593622 scopus 로고    scopus 로고
    • Plantas experimentalmente tóxicas para bovinos, porém incerto se de interesse pecuário
    • Tokarnia CH, Döbereiner J, Peixoto PV (ed.), 2. ed. Rio de Janeiro: Helianthus
    • Tokarnia CH, Döbereiner J, Peixoto PV 2000. Plantas experimentalmente tóxicas para bovinos, porém incerto se de interesse pecuário. In: Tokarnia CH, Döbereiner J, Peixoto PV (ed.) Plantas tóxicas do Brasil. 2. ed. Rio de Janeiro: Helianthus, p.240-242.
    • (2000) Plantas Tóxicas Do Brasil , pp. 240-242
    • Tokarnia, C.H.1    Döbereiner, J.2    Peixoto, P.V.3
  • 56
    • 0008891162 scopus 로고
    • Occurrence, concentration and toxicity of pyrrolizidine alkaloids in Crotalaria seeds
    • Williams MC, Molyneux RJ 1987. Occurrence, concentration and toxicity of pyrrolizidine alkaloids in Crotalaria seeds. Weed Sci 35: 476-481.
    • (1987) Weed Sci , vol.35 , pp. 476-481
    • Williams, M.C.1    Molyneux, R.J.2
  • 57
    • 0025515490 scopus 로고
    • Pirrolizidine alkaloid poisoning in yaks. First report and confirmation by identification of sulphurbound pyrrolic metabolites of the alkaloids in preserved liver tissue
    • Winter H, Seawright AA, Mattocks AR, Jukes R, Tshewang AR, Gurung BJ 1990. Pirrolizidine alkaloid poisoning in yaks. First report and confirmation by identification of sulphurbound pyrrolic metabolites of the alkaloids in preserved liver tissue. Aust Vet J 67: 411-412.
    • (1990) Aust Vet J , vol.67 , pp. 411-412
    • Winter, H.1    Seawright, A.A.2    Mattocks, A.R.3    Jukes, R.4    Tshewang, A.R.5    Gurung, B.J.6
  • 58
    • 0030041887 scopus 로고    scopus 로고
    • Effects of taurine and guanidioethane sulfnate on toxicity of the pyrrolizidine alkaloid monocrotaline
    • Yan CC, Huxtable RJ 1996. Effects of taurine and guanidioethane sulfnate on toxicity of the pyrrolizidine alkaloid monocrotaline. Biochem Pharmacol 51: 321-329.
    • (1996) Biochem Pharmacol , vol.51 , pp. 321-329
    • Yan, C.C.1    Huxtable, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.