Fetotoxicity and reproductive effects of monocrotaline in pregnant rats

Journal of Ethnopharmacology

Volumn 69, Issue 2, 2000, Pages 181-188

  Medeiros, Rosane Maria T ^a   Górniak, Silvana L ^b   Guerra, José Luis ^b  

^a FEDERAL UNIVERSITY OF CAMPINA GRANDE   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Crotalaria spectabilis; Fetotoxicity; Monocorotaline; Teratogenic effects

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; LACTATE DEHYDROGENASE; MONOCROTALINE; UREA;

ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG TOXICITY; FEMALE; FETOTOXICITY; FETUS; FLUID INTAKE; FOOD INTAKE; INTERSTITIAL PNEUMONIA; LIVER INJURY; LIVER WEIGHT; NONHUMAN; PREGNANCY; RAT; WEIGHT GAIN;

ANIMALS; CREATININE; DRINKING; EATING; FEMALE; FETUS; LIVER; MATERNAL-FETAL EXCHANGE; MONOCROTALINE; ORGAN SIZE; PREGNANCY; PREGNANCY, ANIMAL; RATS; RATS, WISTAR; TERATOGENS; UREA;

EID: 0034141923     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(99)00149-X     Document Type: Article

References (14)

1. Allen J.R., Carstens B.S. Clinical signs and pathologic changes in Crotalaria spectabilis-intoxicated rats. American Journal Veterinary Research. 31:1970;1059-1070.
2. Cheeke P.R. Natural toxicants in feeds, forages and poisonous plants. 1998;479 Interstate Publishers, Danville.
3. Cooper, R.A., 1996. Pyrrolizidine Alkaloids: Chemical Basis of Toxicity. PhD thesis, University of Arizona, 157.
4. D'Ercole A.J., Underwood L.E. Growth factors in fetal growth and development. Nony M.J., Resko J.A. Fetal Endocrinology. 1981;155-182 Academic Press, New York.
5. Goodman D.R., James R.C., Harbison R.D. Placental toxicology. Food Chemistry and Toxicology. 20:1982;123-128.
6. Harbone J.B. Phytochemical methods-a guide to modern techniques of plant analysis. 2:1984;287 Chapman and Hall, London.
7. Hooper P.T. Pyrrolizidine alkaloid poisoning with particular reference to differences in animal and plant species. Keeler R.F., Van Kampen K.R., James L.F. Effects of Poisonous Plants on Livestock. 1978;161-170 Academic Press, New York.
8. Mattocks, A.R., 1986. Toxicology of pyrrolizidine alkaloids in animal. In: Mattocks, A.R., (Ed.) Chemistry and Toxicology of Pyrrolizidine Alkaloids. Academic Press, New York, pp. 191-219.
9. Sriraman P.K., Gopal Naidu N.R., Rama R.A.O.P. Effects of monocrotaline, a pyrrolizidine alkaloid on the progeny of rats. Indian Journal of Animal Science. 58:1988;1292-1295.
10. Staples R.E., Schenell V.L. Refinements in rapid clearinh technic in the KOH-alizarin red S method for fetal bone. Stain Tecnology. 39:1964;61-63.
11. Sundaresson, A.E., 1942. An experimental study on placental permeability to cirrhogenic poisons. The Journal of Pathology and Bacteriology LIV, 289-299.
12. Willians M.C., Molyneux R.J. Occurrence, concentration and toxicity of pyrrolizidine alkaloids in Crotalaria seeds. Weed Science. 35:1987;476-481.
13. Wilson J.C. Methods for administering agents and detecting malformations in experimental animals. Wilson J.C., Warkany J. Teratology: Principles and Techniques. 1965;University of Chicago Press, Chicago.
14. World Health Organization., 1967. Principles for the testing of drugs for teratogenicity, World Health Organization Technical Report Series, Geneva, p. 364.