메뉴 건너뛰기




Volumn 30, Issue 5, 2010, Pages 681-692

IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (TH17) cells in the periphery

Author keywords

anti retroviral therapy; cytokines; HIV 1; Human; interleukin 17; interleukin 2; T cells; T regs

Indexed keywords

ANTIRETROVIRUS AGENT; CD28 ANTIGEN; CD3 ANTIGEN; CYTOMEGALOVIRUS ANTIGEN PP65; GAG PROTEIN; INTERLEUKIN 17; INTERLEUKIN 2; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

EID: 77957571862     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-010-9432-3     Document Type: Article
Times cited : (9)

References (62)
  • 1
    • 34250005444 scopus 로고    scopus 로고
    • H17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    • DOI 10.1038/nm1585, PII NM1585
    • A Amadi-Obi CR Yu X Liu RM Mahdi GL Clarke RB Nussenblatt, et al. 2007 TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 Nat Med 13 711 718 10.1038/nm1585 17496900 1:CAS:528:DC%2BD2sXmtFeks7c%3D (Pubitemid 46889754)
    • (2007) Nature Medicine , vol.13 , Issue.6 , pp. 711-718
    • Amadi-Obi, A.1    Yu, C.-R.2    Liu, X.3    Mahdi, R.M.4    Clarke, G.L.5    Nussenblatt, R.B.6    Gery, I.7    Lee, Y.S.8    Egwuagu, C.E.9
  • 2
    • 34548651152 scopus 로고    scopus 로고
    • Cutting edge: Opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression
    • 17641006 1:CAS:528:DC%2BD2sXnvVyntr0%3D
    • I Kryczek S Wei L Vatan J Escara-Wilke W Szeliga ET Keller, et al. 2007 Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression J Immunol 179 1423 1426 17641006 1:CAS:528:DC%2BD2sXnvVyntr0%3D
    • (2007) J Immunol , vol.179 , pp. 1423-1426
    • Kryczek, I.1    Wei, S.2    Vatan, L.3    Escara-Wilke, J.4    Szeliga, W.5    Keller, E.T.6
  • 3
    • 34249806717 scopus 로고    scopus 로고
    • Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment
    • 17513719 1:CAS:528:DC%2BD2sXlsVOnt7s%3D
    • I Kryczek S Wei L Zou S Altuwaijri W Szeliga J Kolls, et al. 2007 Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment J Immunol 178 6730 6733 17513719 1:CAS:528: DC%2BD2sXlsVOnt7s%3D
    • (2007) J Immunol , vol.178 , pp. 6730-6733
    • Kryczek, I.1    Wei, S.2    Zou, L.3    Altuwaijri, S.4    Szeliga, W.5    Kolls, J.6
  • 4
    • 43249093908 scopus 로고    scopus 로고
    • Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection
    • DOI 10.1097/QAD.0b013e3282ff884e, PII 0000203020080511000011
    • LC Ndhlovu JM Chapman AR Jha JE Snyder-Cappione M Pagan FE Leal, et al. 2008 Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection Aids 22 990 992 10.1097/QAD. 0b013e3282ff884e 18453860 1:CAS:528:DC%2BD1cXltl2ju7k%3D (Pubitemid 351652251)
    • (2008) AIDS , vol.22 , Issue.8 , pp. 990-992
    • Ndhlovu, L.C.1    Chapman, J.M.2    Jha, A.R.3    Snyder-Cappione, J.E.4    Pagan, M.5    Leal, F.E.6    Boland, B.S.7    Norris, P.J.8    Rosenberg, M.G.9    Nixon, D.F.10
  • 5
    • 45749136793 scopus 로고    scopus 로고
    • + T cells are detectable in early human immunodeficiency virus type 1 infection
    • DOI 10.1128/JVI.02550-07
    • FY Yue A Merchant CM Kovacs M Loutfy D Persad MA Ostrowski 2008 Virus-specific interleukin-17-producing CD4+ T cells are detectable in early human immunodeficiency virus type 1 infection J Virol 82 6767 6771 10.1128/JVI.02550-07 18434403 1:CAS:528:DC%2BD1cXnslyqtLo%3D (Pubitemid 351875153)
    • (2008) Journal of Virology , vol.82 , Issue.13 , pp. 6767-6771
    • Feng, Y.Y.1    Merchant, A.2    Kovacs, C.M.3    Loutfy, M.4    Persad, D.5    Ostrowski, M.A.6
  • 7
    • 46949086111 scopus 로고    scopus 로고
    • A rush to judgment on Th17
    • DOI 10.1084/jem.20072066
    • L Steinman 2008 A rush to judgment on Th17 J Exp Med 205 1517 1522 10.1084/jem.20072066 18591407 1:CAS:528:DC%2BD1cXosVKktrg%3D (Pubitemid 351962013)
    • (2008) Journal of Experimental Medicine , vol.205 , Issue.7 , pp. 1517-1522
    • Steinman, L.1
  • 8
    • 61449115882 scopus 로고    scopus 로고
    • Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection
    • 10.1371/journal.ppat.1000295 19214220 1:CAS:528:DC%2BD1MXisFyntL8%3D
    • D Favre S Lederer B Kanwar ZM Ma S Proll Z Kasakow, et al. 2009 Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection PLoS Pathog 5 e1000295 10.1371/journal.ppat.1000295 19214220 1:CAS:528:DC%2BD1MXisFyntL8%3D
    • (2009) PLoS Pathog , vol.5 , pp. 1000295
    • Favre, D.1    Lederer, S.2    Kanwar, B.3    Ma, Z.M.4    Proll, S.5    Kasakow, Z.6
  • 9
    • 77649250683 scopus 로고    scopus 로고
    • HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells
    • Prendergast A, Prado JG, Kang YH, Chen F, Riddell LA, Luzzi G, et al. HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells. Aids. 24:491-502.
    • Aids , vol.24 , pp. 491-502
    • Prendergast, A.1    Prado, J.G.2    Kang, Y.H.3    Chen, F.4    Riddell, L.A.5    Luzzi, G.6
  • 10
    • 77749295656 scopus 로고    scopus 로고
    • Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection
    • El Hed A, Khaitan A, Kozhaya L, Manel N, Daskalakis D, Borkowsky W, et al. Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection. J Infect Dis. 201:843-54.
    • J Infect Dis. , vol.201 , pp. 843-854
    • El Hed, A.1    Khaitan, A.2    Kozhaya, L.3    Manel, N.4    Daskalakis, D.5    Borkowsky, W.6
  • 11
    • 54449084622 scopus 로고    scopus 로고
    • Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses
    • 10.1038/mi.2008.35 19079215 1:CAS:528:DC%2BD1cXht1CmsL%2FK
    • M Macal S Sankaran TW Chun E Reay J Flamm TJ Prindiville, et al. 2008 Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses Mucosal Immunol 1 475 488 10.1038/mi.2008.35 19079215 1:CAS:528:DC%2BD1cXht1CmsL%2FK
    • (2008) Mucosal Immunol , vol.1 , pp. 475-488
    • MacAl, M.1    Sankaran, S.2    Chun, T.W.3    Reay, E.4    Flamm, J.5    Prindiville, T.J.6
  • 12
    • 69249153068 scopus 로고    scopus 로고
    • Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection
    • 10.1038/mi.2009.90 19571800 1:CAS:528:DC%2BD1MXpvFygs74%3D
    • M Kader X Wang M Piatak J Lifson M Roederer R Veazey, et al. 2009 Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection Mucosal Immunol 2 439 449 10.1038/mi.2009.90 19571800 1:CAS:528:DC%2BD1MXpvFygs74%3D
    • (2009) Mucosal Immunol , vol.2 , pp. 439-449
    • Kader, M.1    Wang, X.2    Piatak, M.3    Lifson, J.4    Roederer, M.5    Veazey, R.6
  • 14
    • 39449127389 scopus 로고    scopus 로고
    • Th17 cells and mucosal host defense
    • DOI 10.1016/j.smim.2007.10.009, PII S104453230700084X
    • SJ Aujla PJ Dubin JK Kolls 2007 Th17 cells and mucosal host defense Semin Immunol 19 377 382 10.1016/j.smim.2007.10.009 18054248 1:CAS:528: DC%2BD1cXisVSrsLk%3D (Pubitemid 351274047)
    • (2007) Seminars in Immunology , vol.19 , Issue.6 , pp. 377-382
    • Aujla, S.J.1    Dubin, P.J.2    Kolls, J.K.3
  • 18
    • 0037131199 scopus 로고    scopus 로고
    • Interleukin-2 accelerates CD4 cell reconstitution in HIV-infected patients with severe immunosuppression despite highly active antiretroviral therapy: The ILSTIM study - ANRS 082
    • DOI 10.1097/00002030-200210180-00007
    • C Katlama G Carcelain C Duvivier C Chouquet R Tubiana M De Sa, et al. 2002 Interleukin-2 accelerates CD4 cell reconstitution in HIV-infected patients with severe immunosuppression despite highly active antiretroviral therapy: the ILSTIM study-ANRS 082 Aids 16 2027 2034 10.1097/00002030-200210180-00007 12370501 1:CAS:528:DC%2BD38Xns1CmtrY%3D (Pubitemid 35205266)
    • (2002) AIDS , vol.16 , Issue.15 , pp. 2027-2034
    • Katlama, C.1    Carcelain, G.2    Duvivier, C.3    Chouquet, C.4    Tubiana, R.5    De Sa, M.6    Zagury, L.7    Calvez, V.8    Autran, B.9    Costagliola, D.10
  • 21
    • 0035282639 scopus 로고    scopus 로고
    • Rapid effect of interleukin-2 therapy in human immunodeficiency virus-infected patients whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment
    • DOI 10.1086/318824
    • D David L Nait-Ighil B Dupont J Maral B Gachot J Theze 2001 Rapid effect of interleukin-2 therapy in human immunodeficiency virus-infected patients whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment J Infect Dis 183 730 735 10.1086/318824 11181149 1:CAS:528: DC%2BD3MXhvFeksL0%3D (Pubitemid 32171747)
    • (2001) Journal of Infectious Diseases , vol.183 , Issue.5 , pp. 730-735
    • David, D.1    Nait-Ighil, L.2    Dupont, B.3    Maral, J.4    Gachot, B.5    Theze, J.6
  • 22
    • 16944364282 scopus 로고    scopus 로고
    • Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected persons
    • 10.1086/513971 9086130 1:CAS:528:DyaK2sXisFGqsrw%3D
    • RT Davey Jr DG Chaitt SC Piscitelli M Wells JA Kovacs RE Walker, et al. 1997 Subcutaneous administration of interleukin-2 in human immunodeficiency virus type 1-infected persons J Infect Dis 175 781 789 10.1086/513971 9086130 1:CAS:528:DyaK2sXisFGqsrw%3D
    • (1997) J Infect Dis , vol.175 , pp. 781-789
    • Davey Jr., R.T.1    Chaitt, D.G.2    Piscitelli, S.C.3    Wells, M.4    Kovacs, J.A.5    Walker, R.E.6
  • 23
    • 0031439413 scopus 로고    scopus 로고
    • Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects
    • 10.1172/JCI119819 9389737
    • P De Paoli S Zanussi C Simonelli MT Bortolin M D'Andrea C Crepaldi, et al. 1997 Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV+ subjects J Clin Invest 100 2737 2743 10.1172/JCI119819 9389737
    • (1997) J Clin Invest , vol.100 , pp. 2737-2743
    • De Paoli, P.1    Zanussi, S.2    Simonelli, C.3    Bortolin, M.T.4    D'Andrea, M.5    Crepaldi, C.6
  • 25
    • 7844229880 scopus 로고    scopus 로고
    • Randomized, controlled phase II trial of subcutaneous interleukin-2 in combination with highly active antiretroviral therapy (HAART) in HIV patients
    • 10.1097/00002030-199817000-00003 9863864 1:CAS:528:DyaK1MXlt1Gq
    • UR Hengge M Goos S Esser V Exner H Dotterer H Wiehler, et al. 1998 Randomized, controlled phase II trial of subcutaneous interleukin-2 in combination with highly active antiretroviral therapy (HAART) in HIV patients Aids 12 F225 F234 10.1097/00002030-199817000-00003 9863864 1:CAS:528: DyaK1MXlt1Gq
    • (1998) Aids , vol.12
    • Hengge, U.R.1    Goos, M.2    Esser, S.3    Exner, V.4    Dotterer, H.5    Wiehler, H.6
  • 27
    • 0028912032 scopus 로고
    • Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study
    • 10.1056/NEJM199503023320904 7646637 1:STN:280:DyaK2M7ktVSlsQ%3D%3D
    • JA Kovacs M Baseler RJ Dewar S Vogel RT Davey Jr J Falloon, et al. 1995 Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study N Engl J Med 332 567 575 10.1056/NEJM199503023320904 7646637 1:STN:280: DyaK2M7ktVSlsQ%3D%3D
    • (1995) N Engl J Med , vol.332 , pp. 567-575
    • Kovacs, J.A.1    Baseler, M.2    Dewar, R.J.3    Vogel, S.4    Davey Jr., R.T.5    Falloon, J.6
  • 28
    • 0033907083 scopus 로고    scopus 로고
    • Subcutaneous interleukin-2 in combination with anti-retroviral therapy for treatment of HIV-1-infected subjects
    • 10.1080/003655400750045259 10826900 1:STN:280:DC%2BD3cvktVKnuw%3D%3D
    • CS Larsen L Ostergard BK Moller MR Buhl 2000 Subcutaneous interleukin-2 in combination with anti-retroviral therapy for treatment of HIV-1-infected subjects Scand J Infect Dis 32 153 160 10.1080/003655400750045259 10826900 1:STN:280:DC%2BD3cvktVKnuw%3D%3D
    • (2000) Scand J Infect Dis , vol.32 , pp. 153-160
    • Larsen, C.S.1    Ostergard, L.2    Moller, B.K.3    Buhl, M.R.4
  • 31
    • 10744227590 scopus 로고    scopus 로고
    • + Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens
    • DOI 10.1128/JVI.78.5.2454-2459.2004
    • EM Aandahl J Michaelsson WJ Moretto FM Hecht DF Nixon 2004 Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens J Virol 78 2454 2459 10.1128/JVI.78.5.2454- 2459.2004 14963140 1:CAS:528:DC%2BD2cXhs1SltLw%3D (Pubitemid 38228938)
    • (2004) Journal of Virology , vol.78 , Issue.5 , pp. 2454-2459
    • Aandahl, E.M.1    Michaelsson, J.2    Moretto, W.J.3    Hecht, F.M.4    Nixon, D.F.5
  • 32
    • 3543098686 scopus 로고    scopus 로고
    • + HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status
    • DOI 10.1084/jem.20032069
    • AL Kinter M Hennessey A Bell S Kern Y Lin M Daucher, et al. 2004 CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status J Exp Med 200 331 343 10.1084/jem.20032069 15280419 1:CAS:528: DC%2BD2cXmsVCkur8%3D (Pubitemid 39031252)
    • (2004) Journal of Experimental Medicine , vol.200 , Issue.3 , pp. 331-343
    • Kinter, A.L.1    Hennessey, M.2    Bell, A.3    Kern, S.4    Lin, Y.5    Daucher, M.6    Planta, M.7    McGlaughlin, M.8    Jackson, R.9    Ziegler, S.F.10    Fauci, A.S.11
  • 33
    • 15444363618 scopus 로고    scopus 로고
    • Depletion of regulatory T cells in HIV infection is associated with immune activation
    • 15778406 1:CAS:528:DC%2BD2MXisVChtL8%3D
    • MP Eggena B Barugahare N Jones M Okello S Mutalya C Kityo, et al. 2005 Depletion of regulatory T cells in HIV infection is associated with immune activation J Immunol 174 4407 4414 15778406 1:CAS:528:DC%2BD2MXisVChtL8%3D
    • (2005) J Immunol , vol.174 , pp. 4407-4414
    • Eggena, M.P.1    Barugahare, B.2    Jones, N.3    Okello, M.4    Mutalya, S.5    Kityo, C.6
  • 34
    • 38949128315 scopus 로고    scopus 로고
    • FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection
    • DOI 10.1189/jlb.0507281
    • LC Ndhlovu CP Loo G Spotts DF Nixon FM Hecht 2008 FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection J Leukoc Biol 83 254 262 10.1189/jlb.0507281 17982112 1:CAS:528:DC%2BD1cXhvFaqt7k%3D (Pubitemid 351225605)
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.2 , pp. 254-262
    • Ndhlovu, L.C.1    Loo, C.P.2    Spotts, G.3    Nixon, D.F.4    Hecht, F.M.5
  • 35
    • 17444407451 scopus 로고    scopus 로고
    • The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients
    • 15749840 1:CAS:528:DC%2BD2MXitVeiurk%3D
    • J Andersson A Boasso J Nilsson R Zhang NJ Shire S Lindback, et al. 2005 The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients J Immunol 174 3143 3147 15749840 1:CAS:528:DC%2BD2MXitVeiurk%3D
    • (2005) J Immunol , vol.174 , pp. 3143-3147
    • Andersson, J.1    Boasso, A.2    Nilsson, J.3    Zhang, R.4    Shire, N.J.5    Lindback, S.6
  • 36
    • 13544254620 scopus 로고    scopus 로고
    • Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251
    • 15699118 1:CAS:528:DC%2BD2MXhtV2rsrk%3D
    • J Nacsa Y Edghill-Smith WP Tsai D Venzon E Tryniszewska A Hryniewicz, et al. 2005 Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251 J Immunol 174 1913 1921 15699118 1:CAS:528:DC%2BD2MXhtV2rsrk%3D
    • (2005) J Immunol , vol.174 , pp. 1913-1921
    • Nacsa, J.1    Edghill-Smith, Y.2    Tsai, W.P.3    Venzon, D.4    Tryniszewska, E.5    Hryniewicz, A.6
  • 38
    • 0004781509 scopus 로고    scopus 로고
    • Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial
    • 10.1001/jama.284.2.183 10889591 1:CAS:528:DC%2BD3cXlsFSht74%3D
    • RT Davey Jr RL Murphy FM Graziano SL Boswell AT Pavia M Cancio, et al. 2000 Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: a randomized controlled trial Jama 284 183 189 10.1001/jama.284.2.183 10889591 1:CAS:528:DC%2BD3cXlsFSht74%3D
    • (2000) Jama , vol.284 , pp. 183-189
    • Davey Jr., R.T.1    Murphy, R.L.2    Graziano, F.M.3    Boswell, S.L.4    Pavia, A.T.5    Cancio, M.6
  • 40
    • 70350441282 scopus 로고    scopus 로고
    • Interleukin-2 therapy in patients with HIV infection
    • 10.1056/NEJMoa0903175 19828532 1:CAS:528:DC%2BD1MXht1OktLbM
    • D Abrams Y Levy MH Losso A Babiker G Collins DA Cooper, et al. 2009 Interleukin-2 therapy in patients with HIV infection N Engl J Med 361 1548 1559 10.1056/NEJMoa0903175 19828532 1:CAS:528:DC%2BD1MXht1OktLbM
    • (2009) N Engl J Med , vol.361 , pp. 1548-1559
    • Abrams, D.1    Levy, Y.2    Losso, M.H.3    Babiker, A.4    Collins, G.5    Cooper, D.A.6
  • 41
    • 74849114986 scopus 로고    scopus 로고
    • Interleukin-2 therapy in patients with HIV infection
    • author reply 271
    • Sellier P, Lafuente-Lafuente C, Bergmann JF. Interleukin-2 therapy in patients with HIV infection. N Engl J Med. 362:270-1; author reply 271.
    • N Engl J Med. , vol.362 , pp. 270-271
    • Sellier, P.1    Lafuente-Lafuente, C.2    Bergmann, J.F.3
  • 42
    • 74849085147 scopus 로고    scopus 로고
    • Effects of immunoadjuvant therapy with IL-2 in HIV-positive HAART-naive patients in advanced stage of disease: A characterization of the divere immunological responses to IL-2
    • Madrid
    • Tincati C, Meroni L, Bellistri G, et al. Effects of immunoadjuvant therapy with IL-2 in HIV-positive HAART-naive patients in advanced stage of disease: a characterization of the divere immunological responses to IL-2. 11th European AIDS Conference/European AIDS Clinical Society. Madrid, 2007.
    • (2007) 11th European AIDS Conference/European AIDS Clinical Society
    • Tincati, C.1    Meroni, L.2    Bellistri, G.3
  • 43
    • 58849148911 scopus 로고    scopus 로고
    • Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: A randomized controlled trial
    • 10.1097/QAD.0b013e32831cc114 19098490 1:CAS:528:DC%2BD1cXhsFWku7%2FO
    • BO Porter KB Anthony J Shen B Hahn CE Keh F Maldarelli, et al. 2009 Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: a randomized controlled trial Aids 23 203 212 10.1097/QAD.0b013e32831cc114 19098490 1:CAS:528:DC%2BD1cXhsFWku7%2FO
    • (2009) Aids , vol.23 , pp. 203-212
    • Porter, B.O.1    Anthony, K.B.2    Shen, J.3    Hahn, B.4    Keh, C.E.5    Maldarelli, F.6
  • 44
    • 33746690674 scopus 로고    scopus 로고
    • Decreased CD127 expression on T cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy
    • DOI 10.1097/01.qai.0000223027.47456.d0, PII 0012633420060815000003
    • SW Read J Higgins JA Metcalf RA Stevens A Rupert MC Nason, et al. 2006 Decreased CD127 expression on T Cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy J Acquir Immune Defic Syndr 42 537 544 10.1097/01.qai.0000223027.47456.d0 16837861 1:CAS:528:DC%2BD28Xnt1Oqurc%3D (Pubitemid 44162421)
    • (2006) Journal of Acquired Immune Deficiency Syndromes , vol.42 , Issue.5 , pp. 537-544
    • Read, S.W.1    Higgins, J.2    Metcalf, J.A.3    Stevens, R.A.4    Rupert, A.5    Nason, M.C.6    Lane, H.C.7    Sereti, I.8
  • 46
    • 0032859377 scopus 로고    scopus 로고
    • Induction of HIV-1-specific T cell responses by administration of cytokines in late-stage patients receiving highly active anti-retroviral therapy
    • DOI 10.1046/j.1365-2249.1999.01012.x
    • N Imami GA Hardy MR Nelson S Morris-Jones R Al-Shahi C Antonopoulos, et al. 1999 Induction of HIV-1-specific T cell responses by administration of cytokines in late-stage patients receiving highly active anti-retroviral therapy Clin Exp Immunol 118 78 86 10.1046/j.1365-2249.1999.01012.x 10540163 1:CAS:528:DyaK1MXnt1Crtbc%3D (Pubitemid 29479787)
    • (1999) Clinical and Experimental Immunology , vol.118 , Issue.1 , pp. 78-86
    • Imami, N.1    Hardy, G.A.D.2    Nelson, M.R.3    Morris-Jones, S.4    Al-Shahi, R.5    Antonopoulos, C.6    Gazzard, B.7    Gotch, F.M.8
  • 47
    • 33746845212 scopus 로고    scopus 로고
    • Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
    • DOI 10.1002/jmv.20675
    • J Yu H Chen H Horton A Bansal JM McElrath R Reichman, et al. 2006 Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection J Med Virol 78 1147 1157 10.1002/jmv.20675 16847956 1:CAS:528:DC%2BD28XptVajtro%3D (Pubitemid 44182230)
    • (2006) Journal of Medical Virology , vol.78 , Issue.9 , pp. 1147-1157
    • Yu, J.1    Chen, H.2    Horton, H.3    Bansal, A.4    McElrath, J.M.5    Reichman, R.6    Goepfert, P.7    Jin, X.8
  • 49
    • 0042626615 scopus 로고    scopus 로고
    • Performance characteristics of a new less sensitive HIV-1 enzyme immunoassay for use in estimating HIV seroincidence
    • DOI 10.1097/00126334-200308150-00012
    • D Kothe RH Byers SP Caudill GA Satten RS Janssen WH Hannon, et al. 2003 Performance characteristics of a new less sensitive HIV-1 enzyme immunoassay for use in estimating HIV seroincidence J Acquir Immune Defic Syndr 33 625 634 10.1097/00126334-200308150-00012 12902808 1:CAS:528:DC%2BD3sXlvF2qtbk%3D (Pubitemid 36975851)
    • (2003) Journal of Acquired Immune Deficiency Syndromes , vol.33 , Issue.5 , pp. 625-634
    • Kothe, D.1    Byers, R.H.2    Caudill, S.P.3    Satten, G.A.4    Janssen, R.S.5    Hannon, W.H.6    Mei, J.V.7
  • 53
    • 44049100797 scopus 로고    scopus 로고
    • Th17 cells: A new fate for differentiating helper T cells
    • 10.1007/s12026-007-8014-9 18172584 1:CAS:528:DC%2BD1cXhtFSrurvL
    • Z Chen JJ O'Shea 2008 Th17 cells: a new fate for differentiating helper T cells Immunol Res 41 87 102 10.1007/s12026-007-8014-9 18172584 1:CAS:528:DC%2BD1cXhtFSrurvL
    • (2008) Immunol Res , vol.41 , pp. 87-102
    • Chen, Z.1    O'Shea, J.J.2
  • 55
    • 33748588423 scopus 로고    scopus 로고
    • + T Helper Cells
    • DOI 10.1016/j.cell.2006.07.035, PII S0092867406011056
    • II Ivanov BS McKenzie L Zhou CE Tadokoro A Lepelley JJ Lafaille, et al. 2006 The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 1121 1133 10.1016/j.cell.2006. 07.035 16990136 1:CAS:528:DC%2BD28XhtVCnsrrE (Pubitemid 44380299)
    • (2006) Cell , vol.126 , Issue.6 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6    Cua, D.J.7    Littman, D.R.8
  • 56
    • 34848821989 scopus 로고    scopus 로고
    • Distinct regulation of interleukin-17 in human T helper lymphocytes
    • DOI 10.1002/art.22866
    • Z Chen CM Tato L Muul A Laurence JJ O'Shea 2007 Distinct regulation of interleukin-17 in human T helper lymphocytes Arthritis Rheum 56 2936 2946 10.1002/art.22866 17763419 1:CAS:528:DC%2BD2sXht1GgtbzE (Pubitemid 47502740)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.9 , pp. 2936-2946
    • Chen, Z.1    Tato, C.M.2    Muul, L.3    Laurence, A.4    O'Shea, J.J.5
  • 57
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • DOI 10.1038/nri1032
    • JA Bluestone AK Abbas 2003 Natural versus adaptive regulatory T cells Nat Rev Immunol 3 253 257 10.1038/nri1032 12658273 1:CAS:528:DC%2BD3sXitleqtLg%3D (Pubitemid 37323210)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 58
    • 70349736116 scopus 로고    scopus 로고
    • Cross-regulation of signaling pathways by interferon-gamma: Implications for immune responses and autoimmune diseases
    • 10.1016/j.immuni.2009.09.002 19833085 1:CAS:528:DC%2BD1MXhsVChtL3L
    • X Hu LB Ivashkiv 2009 Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases Immunity 31 539 550 10.1016/j.immuni.2009.09.002 19833085 1:CAS:528: DC%2BD1MXhsVChtL3L
    • (2009) Immunity , vol.31 , pp. 539-550
    • Hu, X.1    Ivashkiv, L.B.2
  • 59
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • 10.1038/ni.1731 19412181 1:CAS:528:DC%2BD1MXltlSrsbY%3D
    • MA Koch G Tucker-Heard NR Perdue JR Killebrew KB Urdahl DJ Campbell 2009 The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation Nat Immunol 10 595 602 10.1038/ni.1731 19412181 1:CAS:528:DC%2BD1MXltlSrsbY%3D
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 61
    • 33746215298 scopus 로고    scopus 로고
    • Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection
    • 16849446 1:CAS:528:DC%2BD28XmvFCmt7k%3D
    • A Cruz SA Khader E Torrado A Fraga JE Pearl J Pedrosa, et al. 2006 Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection J Immunol 177 1416 1420 16849446 1:CAS:528:DC%2BD28XmvFCmt7k%3D
    • (2006) J Immunol , vol.177 , pp. 1416-1420
    • Cruz, A.1    Khader, S.A.2    Torrado, E.3    Fraga, A.4    Pearl, J.E.5    Pedrosa, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.