-
2
-
-
0035824440
-
A transgenic model of visceral obesity and the metabolic syndrome
-
Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001 294 2166-2170
-
(2001)
Science
, vol.294
, pp. 2166-2170
-
-
Masuzaki, H.1
Paterson, J.2
Shinyama, H.3
Morton, N.M.4
Mullins, J.J.5
Seckl, J.R.6
Flier, J.S.7
-
3
-
-
2342510149
-
Metabolic syndrome without obesity: Hepatic overexpression of 11-hydroxysteroid dehydrogenase type 1 in transgenic mice
-
Paterson JM, Morton NM, Fievet C, Kenyon CJ, Holmes MC, Staels B, Seckl JR, Mullins JJ. Metabolic syndrome without obesity: Hepatic overexpression of 11-hydroxysteroid dehydrogenase type 1 in transgenic mice. Proc Natl Acad Sci U S A 2004 101 7088-7093
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 7088-7093
-
-
Paterson, J.M.1
Morton, N.M.2
Fievet, C.3
Kenyon, C.J.4
Holmes, M.C.5
Staels, B.6
Seckl, J.R.7
Mullins, J.J.8
-
4
-
-
23944493717
-
11b-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
-
Hermanowski-Vosatka A, Balkovec JM, Cheng K, Chen HY, Hernandez M, Koo GC, Le Grand CB, Li Z, Metzger JM, Mundt SS, Noonan H, Nunes CN, Olson SH, Pikounis B, Ren N, Robertson N, Schaeffer JM, Shah K, Springer MS, Strack AM, Strowski M, Wu K, Wu T, Xiao J, Zhang BB, Wright SD, Thieringer R. 11b-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med 2005 202 517-527
-
(2005)
J Exp Med
, vol.202
, pp. 517-527
-
-
Hermanowski-Vosatka, A.1
Balkovec, J.M.2
Cheng, K.3
Chen, H.Y.4
Hernandez, M.5
Koo, G.C.6
Le Grand, C.B.7
Li, Z.8
Metzger, J.M.9
Mundt, S.S.10
Noonan, H.11
Nunes, C.N.12
Olson, S.H.13
Pikounis, B.14
Ren, N.15
Robertson, N.16
Schaeffer, J.M.17
Shah, K.18
Springer, M.S.19
Strack, A.M.20
Strowski, M.21
Wu, K.22
Wu, T.23
Xiao, J.24
Zhang, B.B.25
Wright, S.D.26
Thieringer, R.27
more..
-
5
-
-
0036432995
-
Selective inhibition of 11-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice
-
Alberts P, Engblom L, Edling N, Forsgren M, Klingström G, Larsson C, Rönquist-Nii Y, Ohman B, Abrahmsén L. Selective inhibition of 11-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia 2002 45 1528-1532
-
(2002)
Diabetologia
, vol.45
, pp. 1528-1532
-
-
Alberts, P.1
Engblom, L.2
Edling, N.3
Forsgren, M.4
Klingström, G.5
Larsson, C.6
Rönquist-Nii, Y.7
Ohman, B.8
Abrahmsén, L.9
-
6
-
-
33646516612
-
Inhibition of 11-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice
-
Wang S, Birtles S, de Schoolmeester J, Swales J, Moody G, Hislop D, ODowd J, Smith DM, Turnbull AV, Arch JR. Inhibition of 11-hydroxysteroid dehydrogenase type 1 reduces food intake and weight gain but maintains energy expenditure in diet-induced obese mice. Diabetologia 2006 49 1333-1337
-
(2006)
Diabetologia
, vol.49
, pp. 1333-1337
-
-
Wang, S.1
Birtles, S.2
De Schoolmeester, J.3
Swales, J.4
Moody, G.5
Hislop, D.6
Odowd, J.7
Smith, D.M.8
Turnbull, A.V.9
Arch, J.R.10
-
7
-
-
44449135106
-
Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue
-
Lee M-J, Fried SK, Mundt SS, Wang Y, Sullivan S, Stefanni A, Daugherty BL, Hermanowski-Vosatka A. Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue. Obesity 2008 16 1178-1185
-
(2008)
Obesity
, vol.16
, pp. 1178-1185
-
-
Lee, M.-J.1
Fried, S.K.2
Mundt, S.S.3
Wang, Y.4
Sullivan, S.5
Stefanni, A.6
Daugherty, B.L.7
Hermanowski-Vosatka, A.8
-
8
-
-
33751510948
-
Acute in vivo regulation of 11-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans
-
Wake DJ, Homer NZM, Andrew R, Walker BR. Acute In vivo regulation of 11-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans. J Clin Endocrinol Metab 2006 2006 91 4682-4688
-
(2006)
J Clin Endocrinol Metab 2006
, vol.91
, pp. 4682-4688
-
-
Wake, D.J.1
Homer, N.Z.M.2
Andrew, R.3
Walker, B.R.4
-
9
-
-
14644388141
-
Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone
-
Sandeep TC, Andrew R, Homer NZM, Andrews RC, Smith K, Walker BR. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes 2005 54 872-879
-
(2005)
Diabetes
, vol.54
, pp. 872-879
-
-
Sandeep, T.C.1
Andrew, R.2
Homer, N.Z.M.3
Andrews, R.C.4
Smith, K.5
Walker, B.R.6
-
10
-
-
0036324073
-
Tissue-specific changes in peripheral cortisol metabolism in obese women: Increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity
-
Rask E, Walker BR, Soderberg S, Livingstone DE, Eliasson M, Johnson O, Olsson T. Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 2002 87 3330-3336
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3330-3336
-
-
Rask, E.1
Walker, B.R.2
Soderberg, S.3
Livingstone, D.E.4
Eliasson, M.5
Johnson, O.6
Olsson, T.7
-
11
-
-
0041381335
-
Local and systemic impact of transcriptional up-regulation of 11-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity
-
Wake DJ, Rask E, Livingstone DE, Soderberg S, Olsson T, Walker BR. Local and systemic impact of transcriptional up-regulation of 11-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab 2003 88 3983-3988
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3983-3988
-
-
Wake, D.J.1
Rask, E.2
Livingstone, D.E.3
Soderberg, S.4
Olsson, T.5
Walker, B.R.6
-
12
-
-
4544260173
-
Overexpression of 11{beta}-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: Studies in young adult monozygotic twins
-
Kannisto K, Pietilainen KH, Ehrenborg E, Rissanen A, Kaprio J, Hamsten A, Yki-Järvinen H. Overexpression of 11{beta}-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: Studies in young adult monozygotic twins. J Clin Endocrinol Metab 2004 89 4414-4421
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4414-4421
-
-
Kannisto, K.1
Pietilainen, K.H.2
Ehrenborg, E.3
Rissanen, A.4
Kaprio, J.5
Hamsten, A.6
Yki-Järvinen, H.7
-
13
-
-
33846888049
-
11-Hydroxysteroid dehydrogenase type 1mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients
-
Desbriere R, Vuaroqueaux V, Achard V, Boullu-Ciocca S, Labuhn M, Dutour A, Grino M. 11-Hydroxysteroid dehydrogenase type 1mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity 2006 14 794-798
-
(2006)
Obesity
, vol.14
, pp. 794-798
-
-
Desbriere, R.1
Vuaroqueaux, V.2
Achard, V.3
Boullu-Ciocca, S.4
Labuhn, M.5
Dutour, A.6
Grino, M.7
-
14
-
-
58149330675
-
Impaired Glucose Tolerance and insulin resistance are associated with increased adipose 11-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5a-reductase activity
-
Tomlinson JW, Finney J, Gay C, Hughes BA, Hughes SV, Stewart PM. Impaired Glucose Tolerance and insulin resistance are associated with increased adipose 11-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5a-reductase activity. Diabetes 2008 57 2652-2660
-
(2008)
Diabetes
, vol.57
, pp. 2652-2660
-
-
Tomlinson, J.W.1
Finney, J.2
Gay, C.3
Hughes, B.A.4
Hughes, S.V.5
Stewart, P.M.6
-
15
-
-
0036882136
-
Expression of 11-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity
-
Tomlinson JW, Sinha B, Bujalska I, Hewison M, Stewart PM. Expression of 11-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity. J Clin Endocrinol Metab 2002 87 5630-5635
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 5630-5635
-
-
Tomlinson, J.W.1
Sinha, B.2
Bujalska, I.3
Hewison, M.4
Stewart, P.M.5
-
16
-
-
33846816368
-
Fat cell enlargement is an independent marker of insulin resistance and hyperleptinaemia
-
Lundgren M, Svensson M, Lindmark S, Renström F, Ruge T, Eriksson J. W. Fat cell enlargement is an independent marker of insulin resistance and hyperleptinaemia. Diabetologia 2007 50 625-633
-
(2007)
Diabetologia
, vol.50
, pp. 625-633
-
-
Lundgren, M.1
Svensson, M.2
Lindmark, S.3
Renström, F.4
Ruge, T.5
Eriksson, J.W.6
-
17
-
-
33846228383
-
Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11-hydroxysteroid dehydrogenase type 1 inhibitors
-
Rohde JJ, Pliushchev MA, Sorensen BK, Wodka D, Shuai Q, Wang J, Fung S, Monzon KM, Chiou WJ, Pan L, Deng X, Chovan LE, Ramaiya A, Mullally M, Henry RF, Stolarik DF, Imade HM, Marsh KC, Beno DW, Fey TA, Droz BA, Brune ME, Camp HS, Sham HL, Frevert EU, Jacobson PB, Link JT. Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11-hydroxysteroid dehydrogenase type 1 inhibitors. J Med Chem 2007 50 149-164
-
(2007)
J Med Chem
, vol.50
, pp. 149-164
-
-
Rohde, J.J.1
Pliushchev, M.A.2
Sorensen, B.K.3
Wodka, D.4
Shuai, Q.5
Wang, J.6
Fung, S.7
Monzon, K.M.8
Chiou, W.J.9
Pan, L.10
Deng, X.11
Chovan, L.E.12
Ramaiya, A.13
Mullally, M.14
Henry, R.F.15
Stolarik, D.F.16
Imade, H.M.17
Marsh, K.C.18
Beno, D.W.19
Fey, T.A.20
Droz, B.A.21
Brune, M.E.22
Camp, H.S.23
Sham, H.L.24
Frevert, E.U.25
Jacobson, P.B.26
Link, J.T.27
more..
-
18
-
-
34547799112
-
Altered activity of 11-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes
-
Jang C, Obeyesekere VR, Dilley RJ, Krozowski Z, Inder WJ, Alford FP. Altered activity of 11-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes. J Clin Endocrinol Metab 2007 92 3314-3320
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 3314-3320
-
-
Jang, C.1
Obeyesekere, V.R.2
Dilley, R.J.3
Krozowski, Z.4
Inder, W.J.5
Alford, F.P.6
-
19
-
-
44149086641
-
Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
-
DOI 10.1016/j.bmcl.2008.04.014, PII S0960894X08004058
-
Zhu Y, Olson SH, Graham D, Patel G, Hermanowski-Vosatka A, Mundt S, Shah K, Springer M, Thieringer R, Wright S, Xiao J, Zokian H, Dragovic J, Balkovec JM. Phenylcyclobutyl triazoles as selective inhibitors of 11-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett 2008 18 3412-3416 (Pubitemid 351718311)
-
(2008)
Bioorganic and Medicinal Chemistry Letters
, vol.18
, Issue.11
, pp. 3412-3416
-
-
Zhu, Y.1
Olson, S.H.2
Graham, D.3
Patel, G.4
Hermanowski-Vosatka, A.5
Mundt, S.6
Shah, K.7
Springer, M.8
Thieringer, R.9
Wright, S.10
Xiao, J.11
Zokian, H.12
Dragovic, J.13
Balkovec, J.M.14
-
20
-
-
0037902924
-
Subcutaneous adipose 11-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in pima Indians and Caucasians
-
Lindsay RS, Wake DJ, Nair S, Bunt J, Livingstone DEW, Permana PA, Tataranni PA, Walker BR. Subcutaneous adipose 11-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in pima Indians and Caucasians. J Clin Endocrinol Metab 2003 88 2738-2744
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2738-2744
-
-
Lindsay, R.S.1
Wake, D.J.2
Nair, S.3
Bunt, J.4
Livingstone, D.E.W.5
Permana, P.A.6
Tataranni, P.A.7
Walker, B.R.8
-
21
-
-
33745186881
-
Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women
-
Goedecke JH, Wake DJ, Levitt NS, Lambert EV, Collins MR, Morton NM, Andrew R, Seckl JR, Walker BR. Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women. Clin Endocrinol 2006 65 81-87
-
(2006)
Clin Endocrinol
, vol.65
, pp. 81-87
-
-
Goedecke, J.H.1
Wake, D.J.2
Levitt, N.S.3
Lambert, E.V.4
Collins, M.R.5
Morton, N.M.6
Andrew, R.7
Seckl, J.R.8
Walker, B.R.9
-
22
-
-
0033305631
-
Differentiation of adipose stromal cells: The roles of glucocorticoids and 11-hydroxysteroid dehydrogenase
-
Bujalska IJ, Kumar S, Hewison M, Stewart PM. Differentiation of adipose stromal cells: The roles of glucocorticoids and 11-hydroxysteroid dehydrogenase. Endocrinology 1999 140 3188-3196
-
(1999)
Endocrinology
, vol.140
, pp. 3188-3196
-
-
Bujalska, I.J.1
Kumar, S.2
Hewison, M.3
Stewart, P.M.4
-
23
-
-
33644764205
-
Effect of nutrient ingestion on total-body and splanchnic cortisol production in humans
-
Basu R, Singh R, Basu A, Johnson CM, Rizza RA. Effect of nutrient ingestion on total-body and splanchnic cortisol production in humans. Diabetes 2006 55 667-674
-
(2006)
Diabetes
, vol.55
, pp. 667-674
-
-
Basu, R.1
Singh, R.2
Basu, A.3
Johnson, C.M.4
Rizza, R.A.5
-
24
-
-
0030936556
-
Does central obesity reflect Cushing's disease of the omentum?
-
9060
-
Bujalska IJ, Kumar S, Stewart PM. Does central obesity reflect Cushing's disease of the omentum? Lancet 1997 349 9060 1210-1213
-
(1997)
Lancet
, vol.349
, pp. 1210-1213
-
-
Bujalska, I.J.1
Kumar, S.2
Stewart, P.M.3
-
25
-
-
64849091638
-
Expression of cortisol metabolism-related genes shows circadian rhythmic patterns in human adipose tissue
-
Hernandez-Morante JJ, Gomez-Santos C, Milagro F, Campion J, Martinez JA, Zamora S, Garaulet M. Expression of cortisol metabolism-related genes shows circadian rhythmic patterns in human adipose tissue. Int J Obes 2009 33 473-480
-
(2009)
Int J Obes
, vol.33
, pp. 473-480
-
-
Hernandez-Morante, J.J.1
Gomez-Santos, C.2
Milagro, F.3
Campion, J.4
Martinez, J.A.5
Zamora, S.6
Garaulet, M.7
-
26
-
-
58149138862
-
NGF Gene expression and secretion by canine adipocytes in primary culture: Upregulation by the inflammatory mediators LPS and TNF alpha
-
Ryan VH, German AJ, Wood IS, Hunter L, Morris P, Trayhurn P. NGF Gene expression and secretion by canine adipocytes in primary culture: Upregulation by the inflammatory mediators LPS and TNF alpha. Horm Metab Res 2008 40 861-868
-
(2008)
Horm Metab Res
, vol.40
, pp. 861-868
-
-
Ryan, V.H.1
German, A.J.2
Wood, I.S.3
Hunter, L.4
Morris, P.5
Trayhurn, P.6
-
27
-
-
0036925387
-
Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance
-
Andrews RC, Herlihy O, Livingstone DEW, Andrew R, Walker BR. Abnormal cortisol metabolism and tissue sensitivity to cortisol in patients with glucose intolerance. J Clin Endocrinol Metab 2002 87 5587-5589
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 5587-5589
-
-
Andrews, R.C.1
Herlihy, O.2
Livingstone, D.E.W.3
Andrew, R.4
Walker, B.R.5
-
28
-
-
36448973807
-
Type 2 diabetes and metabolic syndrome are associated with increased expression of 11-hydroxysteroid dehydrogenase 1 in obese subjects
-
Alberti L, Girola A, Gilardini L, Conti A, Cattaldo S, Micheletto G, Invitto C. Type 2 diabetes and metabolic syndrome are associated with increased expression of 11-hydroxysteroid dehydrogenase 1 in obese subjects. Int J Obes 2007 31 1826-1831
-
(2007)
Int J Obes
, vol.31
, pp. 1826-1831
-
-
Alberti, L.1
Girola, A.2
Gilardini, L.3
Conti, A.4
Cattaldo, S.5
Micheletto, G.6
Invitto, C.7
-
29
-
-
34047161483
-
Acute Hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjects
-
Meugnier E, Faraj M, Rome S, Beauregard G, Michaut A, Pelloux V, Chiasson JL, Laville M, Clement K, Vidal H, Rabasa-Lhoret R. Acute Hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjects. Diabetes 2007 56 992-999
-
(2007)
Diabetes
, vol.56
, pp. 992-999
-
-
Meugnier, E.1
Faraj, M.2
Rome, S.3
Beauregard, G.4
Michaut, A.5
Pelloux, V.6
Chiasson, J.L.7
Laville, M.8
Clement, K.9
Vidal, H.10
Rabasa-Lhoret, R.11
-
30
-
-
34848854245
-
11beta-Hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo-pituitary-adrenal axis function
-
Walker EA, Ahmed A, Lavery GG, Tomlinson JW, Kim SY, Cooper MS, Ride JP, Hughes BA, Shackleton CH, McKiernan P, Elias E, Chou JY, Stewart PM. 11beta-Hydroxysteroid dehydrogenase type 1 regulation by intracellular glucose 6-phosphate provides evidence for a novel link between glucose metabolism and hypothalamo-pituitary-adrenal axis function. J Biol Chem 2007 282 27030-27036
-
(2007)
J Biol Chem
, vol.282
, pp. 27030-27036
-
-
Walker, E.A.1
Ahmed, A.2
Lavery, G.G.3
Tomlinson, J.W.4
Kim, S.Y.5
Cooper, M.S.6
Ride, J.P.7
Hughes, B.A.8
Shackleton, C.H.9
McKiernan, P.10
Elias, E.11
Chou, J.Y.12
Stewart, P.M.13
|