메뉴 건너뛰기




Volumn 30, Issue 1, 2010, Pages 139-148

Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in hepatocellular carcinoma

Author keywords

Deleted in liver cancer 1; Hepatocellular carcinoma; Isoforms

Indexed keywords

DELETED IN LIVER CANCER 1 ALPHA; DELETED IN LIVER CANCER 1 BETA; DELETED IN LIVER CANCER 1 GAMMA; MESSENGER RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 73349090904     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.02133.x     Document Type: Article
Times cited : (18)

References (34)
  • 2
    • 48649088986 scopus 로고    scopus 로고
    • Hepatitis B virus-associated multistep hepatocarcinogenesis: a stepwise increase in allelic alterations
    • Lee JM, Wong CM, Ng I.O. Hepatitis B virus-associated multistep hepatocarcinogenesis: a stepwise increase in allelic alterations. Cancer Res 2008; 68: 5988-96.
    • (2008) Cancer Res , vol.68 , pp. 5988-5996
    • Lee, J.M.1    Wong, C.M.2    Ng, I.O.3
  • 3
    • 38849119717 scopus 로고    scopus 로고
    • Molecular pathogenesis of hepatocellular carcinoma
    • Wong CM, Ng I.O. Molecular pathogenesis of hepatocellular carcinoma. Liver Int 2008; 28: 160-74.
    • (2008) Liver Int , vol.28 , pp. 160-174
    • Wong, C.M.1    Ng, I.O.2
  • 4
    • 0032524031 scopus 로고    scopus 로고
    • Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP
    • Yuan BZ, Miller MJ, Keck CL, et al. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Cancer Res 1998; 58: 2196-9.
    • (1998) Cancer Res , vol.58 , pp. 2196-2199
    • Yuan, B.Z.1    Miller, M.J.2    Keck, C.L.3
  • 5
    • 0034548009 scopus 로고    scopus 로고
    • DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1
    • Ng IO, Liang ZD, Cao L, Lee T.K. DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1. Cancer Res 2000; 60: 6581-4.
    • (2000) Cancer Res , vol.60 , pp. 6581-6584
    • Ng, I.O.1    Liang, Z.D.2    Cao, L.3    Lee, T.K.4
  • 6
    • 33847073342 scopus 로고    scopus 로고
    • DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma
    • Kim TY, Lee JW, Kim HP, et al. DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma. Biochem Biophys Res Commun 2007; 355: 72-7.
    • (2007) Biochem Biophys Res Commun , vol.355 , pp. 72-77
    • Kim, T.Y.1    Lee, J.W.2    Kim, H.P.3
  • 7
    • 25444499134 scopus 로고    scopus 로고
    • Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma
    • Wong CM, Yam JW, Ching YP, et al. Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma. Cancer Res 2005; 65: 8861-8.
    • (2005) Cancer Res , vol.65 , pp. 8861-8868
    • Wong, C.M.1    Yam, J.W.2    Ching, Y.P.3
  • 8
    • 48149111026 scopus 로고    scopus 로고
    • DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis
    • Zhou X, Zimonjic DB, Park SW, et al. DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis. Int J Oncol 2008; 32: 1285-91.
    • (2008) Int J Oncol , vol.32 , pp. 1285-1291
    • Zhou, X.1    Zimonjic, D.B.2    Park, S.W.3
  • 9
    • 1442278561 scopus 로고    scopus 로고
    • Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells
    • Zhou X, Thorgeirsson SS, Popescu N.C. Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells. Oncogene 2004; 23: 1308-13.
    • (2004) Oncogene , vol.23 , pp. 1308-1313
    • Zhou, X.1    Thorgeirsson, S.S.2    Popescu, N.C.3
  • 10
    • 44849097747 scopus 로고    scopus 로고
    • DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma
    • Xue W, Krasnitz A, Lucito R, et al. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev 2008; 22: 1439-44.
    • (2008) Genes Dev , vol.22 , pp. 1439-1444
    • Xue, W.1    Krasnitz, A.2    Lucito, R.3
  • 11
    • 33748861305 scopus 로고    scopus 로고
    • High frequent promoter hypermethylation of DLC-1 gene in multiple myeloma
    • Song YF, Xu R, Zhang XH, et al. High frequent promoter hypermethylation of DLC-1 gene in multiple myeloma. J Clin Pathol 2006; 59: 947-51.
    • (2006) J Clin Pathol , vol.59 , pp. 947-951
    • Song, Y.F.1    Xu, R.2    Zhang, X.H.3
  • 12
    • 33645058409 scopus 로고    scopus 로고
    • Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications
    • Guan M, Zhou X, Soulitzis N, Spandidos DA, Popescu N.C. Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications. Clin Cancer Res 2006; 12: 1412-9.
    • (2006) Clin Cancer Res , vol.12 , pp. 1412-1419
    • Guan, M.1    Zhou, X.2    Soulitzis, N.3    Spandidos, D.A.4    Popescu, N.C.5
  • 13
    • 0037438985 scopus 로고    scopus 로고
    • Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers
    • Yuan BZ, Durkin ME, Popescu N.C. Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers. Cancer Genet Cytogenet 2003; 140: 113-7.
    • (2003) Cancer Genet Cytogenet , vol.140 , pp. 113-117
    • Yuan, B.Z.1    Durkin, M.E.2    Popescu, N.C.3
  • 14
    • 0038001053 scopus 로고    scopus 로고
    • Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells
    • Kim TY, Jong HS, Song SH, et al. Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. Oncogene 2003; 22: 3943-51.
    • (2003) Oncogene , vol.22 , pp. 3943-3951
    • Kim, T.Y.1    Jong, H.S.2    Song, S.H.3
  • 15
    • 33846941189 scopus 로고    scopus 로고
    • The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation
    • Seng TJ, Low JS, Li H, et al. The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Oncogene 2007; 26: 934-44.
    • (2007) Oncogene , vol.26 , pp. 934-944
    • Seng, T.J.1    Low, J.2    Li, H.3
  • 16
    • 0344844475 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma
    • Wong CM, Lee JM, Ching YP, Jin DY, Ng I.O. Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma. Cancer Res 2003; 63: 7646-51.
    • (2003) Cancer Res , vol.63 , pp. 7646-7651
    • Wong, C.M.1    Lee, J.2    Ching, Y.P.3    Jin, DY.4    Ng, I.O.5
  • 17
    • 33947426013 scopus 로고    scopus 로고
    • Aberrant methylation of the 8p22 tumor suppressor gene DLC1 in renal cell carcinoma
    • Zhang Q, Ying J, Zhang K, et al. Aberrant methylation of the 8p22 tumor suppressor gene DLC1 in renal cell carcinoma. Cancer Lett 2007; 249: 220-6.
    • (2007) Cancer Lett , vol.249 , pp. 220-226
    • Zhang, Q.1    Ying, J.2    Zhang, K.3
  • 18
    • 0037855764 scopus 로고    scopus 로고
    • Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma
    • Ching YP,Wong CM, Chan SF, et al. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. J Biol Chem 2003; 278: 10824-30.
    • (2003) J Biol Chem , vol.278 , pp. 10824-10830
    • Ching, Y.P.1    Wong, C.M.2    Chan, S.F.3
  • 19
    • 36048999562 scopus 로고    scopus 로고
    • STARTGAP3/ DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology
    • Kawai K, Kiyota M, Seike J, Deki Y, Yagisawa H. STARTGAP3/ DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology. Biochem Biophys Res Commun 2007; 364: 783-9.
    • (2007) Biochem Biophys Res Commun , vol.364 , pp. 783-789
    • Kawai, K.1    Kiyota, M.2    Seike, J.3    Deki, Y.4    Yagisawa, H.5
  • 20
    • 33748994597 scopus 로고    scopus 로고
    • Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression
    • Yam JW, Ko FC, Chan CY, Jin DY, Ng I.O. Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression. Cancer Res 2006; 66: 8367-72.
    • (2006) Cancer Res , vol.66 , pp. 8367-8372
    • Yam, J.W.1    Ko, F.C.2    Chan, C.Y.3    Jin, D.Y.4    Ng, I.O.5
  • 21
    • 34547451763 scopus 로고    scopus 로고
    • Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities
    • Qian X, Li G, Asmussen HK, et al. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci USA 2007; 104: 9012-7.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 9012-9017
    • Qian, X.1    Li, G.2    Asmussen, H.K.3
  • 22
    • 33846010146 scopus 로고    scopus 로고
    • The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1
    • Liao YC, Si L, deVere White RW, Lo S.H. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J Cell Biol 2007; 176: 43-9.
    • (2007) J Cell Biol , vol.176 , pp. 43-49
    • Liao, Y.C.1    Si, L.2    deVere White, R.W.3    Lo, S.H.4
  • 23
    • 0034739882 scopus 로고    scopus 로고
    • Prediction of the coding sequences of unidentified human genes. X.I.X. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
    • Nagase T, Kikuno R, Hattori A, et al. Prediction of the coding sequences of unidentified human genes. X.I.X. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res 2000; 7: 347-55.
    • (2000) DNA Res , vol.7 , pp. 347-355
    • Nagase, T.1    Kikuno, R.2    Hattori, A.3
  • 24
    • 35648981592 scopus 로고    scopus 로고
    • DLC-1: a Rho GTPaseactivating protein and tumour suppressor
    • Durkin ME, Yuan BZ, Zhou X, et al. DLC-1: a Rho GTPaseactivating protein and tumour suppressor. J Cell Mol Med 2007; 11: 1185-207.
    • (2007) J Cell Mol Med , vol.11 , pp. 1185-1207
    • Durkin, M.E.1    Yuan, B.Z.2    Zhou, X.3
  • 25
    • 0018718742 scopus 로고
    • Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line
    • Aden DP, Fogel A, Plotkin S, Damjanov I, Knowles B.B. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 1979; 282: 615-6.
    • (1979) Nature , vol.282 , pp. 615-616
    • Aden, D.P.1    Fogel, A.2    Plotkin, S.3    Damjanov, I.4    Knowles, B.B.5
  • 26
    • 0002591270 scopus 로고
    • Establishment and some biological characteristics of human hepatocellular cell line Bel7402
    • Cheng RM, Zhu DH, Ye XZ, Shen B.W. Establishment and some biological characteristics of human hepatocellular cell line Bel7402. Acta Biol Exp Sin 1978; 11: 37-45.
    • (1978) Acta Biol Exp Sin , vol.11 , pp. 37-45
    • Cheng, R.M.1    Zhu, D.2    Ye, X.Z.3    Shen, B.W.4
  • 27
    • 0002605932 scopus 로고
    • The establishment and primary biological characteristics of human hepatoma SMMC-7721 cell line
    • Tong R, Zhou R, Lu F, Tao W. The establishment and primary biological characteristics of human hepatoma SMMC-7721 cell line. J 2nd Milit Med Univ 1980; 1: 5-9.
    • (1980) J 2nd Milit Med Univ , vol.1 , pp. 5-9
    • Tong, R.1    Zhou, R.2    Lu, F.3    Tao, W.4
  • 28
    • 54249145175 scopus 로고    scopus 로고
    • Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function
    • Liao YC, Shih YP, Lo S.H. Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function. Cancer Res 2008; 68: 7718-22.
    • (2008) Cancer Res , vol.68 , pp. 7718-7722
    • Liao, Y.C.1    Shih, Y.P.2    Lo, S.H.3
  • 29
    • 65949099133 scopus 로고    scopus 로고
    • Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for tensin2 PTB domain interaction and is required for tumor-suppressive function
    • Chan LK, Ko FC, Ng IO, Yam J.W. Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for tensin2 PTB domain interaction and is required for tumor-suppressive function. PLoS One 2009; 4: e5572.
    • (2009) PLoS One , vol.4
    • Chan, L.K.1    Ko, F.C.2    Ng, I.O.3    Yam, J.W.4
  • 30
    • 58549090099 scopus 로고    scopus 로고
    • Cardioprotective effects of pitavastatin on cardiac performance and remodeling in failing rat hearts
    • Kobayashi N, Takeshima H, Fukushima H, et al. Cardioprotective effects of pitavastatin on cardiac performance and remodeling in failing rat hearts. Am J Hypertens 2009; 22: 176-82.
    • (2009) Am J Hypertens , vol.22 , pp. 176-182
    • Kobayashi, N.1    Takeshima, H.2    Fukushima, H.3
  • 31
    • 57749113537 scopus 로고    scopus 로고
    • Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration
    • Kim TY, Healy KD, Der CJ, et al. Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration. J Biol Chem 2008; 283: 32762-70.
    • (2008) J Biol Chem , vol.283 , pp. 32762-32770
    • Kim, T.Y.1    Healy, K.D.2    Der, C.J.3
  • 32
    • 0037061766 scopus 로고    scopus 로고
    • Genetic mechanisms of hepatocarcinogenesis
    • Feitelson MA, Sun B, Satiroglu Tufan NL, et al. Genetic mechanisms of hepatocarcinogenesis. Oncogene 2002; 21: 2593-604.
    • (2002) Oncogene , vol.21 , pp. 2593-2604
    • Feitelson, M.A.1    Sun, B.2    Satiroglu Tufan, N.L.3
  • 33
    • 13844257513 scopus 로고    scopus 로고
    • DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development
    • Durkin ME, Avner MR, Huh CG, et al. DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development. FEBS Lett 2005; 579: 1191-6.
    • (2005) FEBS Lett , vol.579 , pp. 1191-1196
    • Durkin, M.E.1    Avner, M.R.2    Huh, C.G.3
  • 34
    • 50649114599 scopus 로고    scopus 로고
    • Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma
    • Wong CC, Wong CM, Ko FC, et al. Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma. PLoS ONE 2008; 3: e2779.
    • (2008) PLoS ONE , vol.3
    • Wong, C.C.1    Wong, C.M.2    Ko, F.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.