The application of probiotic fermented milks in cancer and intestinal inflammation

Proceedings of the Nutrition Society

Volumn 69, Issue 3, 2010, Pages 421-428

  De Moreno De Leblanc, Alejandra ^a   Perdigón, Gabriela ^a,b  

^a CENTRO DE REFERENCIA PARA LACTOBACILOS CERELA CONICET   (Argentina)

^b UNIVERSIDAD NACIONAL DE TUCUMÁN   (Argentina)

Author keywords

Cancer; Fermented milk; Intestinal inflammation; Probiotic

Indexed keywords

BETA GLUCURONIDASE; CYTOKINE; DIMETHYLHYDRAZINE; GAMMA INTERFERON; IMMUNOGLOBULIN A; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 6; KEFIR; NITROREDUCTASE; PROBIOTIC AGENT; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; YOGHURT;

APOPTOSIS; BACTERIAL STRAIN; BACTERIAL STRAIN R389; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CANCER MODEL; CANCER THERAPY; CARCINOGENESIS; COLON CANCER; CONFERENCE PAPER; CYTOKINE PRODUCTION; DEFENSE MECHANISM; DISEASE MODEL; DOWN REGULATION; ENTERITIS; FERMENTED PRODUCT; HELPER CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; INFLAMMATION; INTESTINE FLORA; LACTIC ACID BACTERIUM; LACTOBACILLUS HELVETICUS; LAMINA PROPRIA; MAMMARY GLAND; METABOLIC BALANCE; MILK; NONHUMAN; SECRETORY CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BIOLOGICAL PRODUCTS; BREAST NEOPLASMS; COLON; COLONIC NEOPLASMS; CULTURED MILK PRODUCTS; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-10; INTERLEUKIN-6; INTESTINAL MUCOSA; LACTOBACILLUS; MICE; NEOPLASMS; PROBIOTICS;

LACTOBACILLUS HELVETICUS; MURINAE; MUS;

EID: 77957369073     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S002966511000159X     Document Type: Conference Paper

References (40)

1. Codex Alimentarius (2003) Codex standard for fermented milks. CODEX STAN 243-2003. http://www.codexalimentarius.net/web/standard-list.do.
2. Perdigon G, Fuller R & Raya R (2001) Lactic acid bacteria and their effect on the immune system. Curr Issues Intest Microbiol 2, 27-42.
3. Kato I (2000) Antitumor activity of lactic acid bacteria. In Probiotics 3: Immunomodulation by the Gut Microflora and Probiotics, pp. 115-138 [R Fuller & G Perdigon, editors]. London: Kluwer Academic Publishers.
4. de Moreno de Leblanc A & Perdigon G (2004) Yogurt feeding inhibits promotion and progression of experimental colorectal cancer. Med Sci Monit 10, BR96-BR104.
5. Matar C, Valdez JC, Medina M et al. (2001) Immunomodulating effects of milks fermented by Lactobacillus helveticus and its non-proteolytic variant. J Dairy Res 68, 601-609.
6. Kato I, Yokokura T & Mutai M (1984) Augmentation of mouse natural killer cell activity by Lactobacillus casei and its surface antigens. Microbiol Immunol 28, 209-217.
7. Hayashi K & Ohwaki M (1989) Antitumoor activity of Lactobacillus casei (LC 9018) in mice: T cell subset depletion. Biotherapy 3, 1568-1574.
8. de Moreno de LeBlanc A & Perdigon G (2005) Reduction of beta-glucuronidase and nitroreductase activity by yoghurt in a murine colon cancer model. Biocell 29, 15-24. (Pubitemid 40695350)
9. de Moreno de LeBlanc A, Valdez J & Perdigón G (2004) Inflammatory immune response. Eur J Inflamm 2, 21-31.
10. Bogdan C, Rollinghoff M & Diefenbach A (2000) The role of nitric oxide in innate immunity. Immunol Rev 173, 17-26.
11. Patton EA, La Flamme AC, Pedras-Vasoncelos JA et al. (2002) Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasis. Infect Immun 70, 177-184.
12. Perdigon G, de Moreno de LeBlanc A, Valdez J et al. (2002) Role of yoghurt in the prevention of colon cancer. Eur J Clin Nutr 56, Suppl. 3, S65-S68.
13. Langholz E, Munkholm P, Davidsen M et al. (1992) Colorectal cancer risk and mortality in patients with ulcerative colitis. Gastroenterology 103, 1444-1451.
14. Gillen CD, Walmsley RS, Prior P et al. (1994) Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut 35, 1590-1592.
15. Linskens RK, Huijsdens XW, Savelkoul PH et al. (2001) The bacterial flora in inflammatory bowel disease: current insights in pathogenesis and the influence of antibiotics and probiotics. Scand J Gastroenterol Suppl 36, 29-40.
16. de Moreno de LeBlanc A, Chaves S & Perdigón G (2009) Effect of yoghurt on the cytokine profile using a murine model of intestinal inflammation. Eur J Inflamm 7, 97-109.
17. Rath HC, Wilson KH & Sartor RB (1999) Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli. Infect Immun 67, 2969-2974.
18. Verdu EF, Bercik P, Cukrowska B et al. (2000) Oral administration of antigens from intestinal flora anaerobic bacteria reduces the severity of experimental acute colitis in BALB/c mice. Clin Exp Immunol 120, 46-50.
19. Chandran P, Satthaporn S, Robins A et al. (2003) Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (I). Surgeon 1, 63-75. (Pubitemid 36575697)
20. Videla S, Vilaseca J, Guarner F et al. (1994) Role of intestinal microflora in chronic inflammation and ulceration of the rat colon. Gut 35, 1090-1097.
21. Favier C, Neut C, Mizon C et al. (1997) Fecal beta-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease. Dig Dis Sci 42, 817-822.
22. Malin M, Suomalainen H, Saxelin M et al. (1996) Promotion of IgA immune response in patients with Crohn's disease by oral bacteriotherapy with Lactobacillus GG. Ann Nutr Metab 40, 137-145.
23. de Moreno de LeBlanc A, Matar C & Perdigon G (2007) The application of probiotics in cancer. Br J Nutr 98, Suppl. 1, S105-S110.
24. Fuss IJ, Neurath M, Boirivant M et al. (1996) Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157, 1261-1270.
25. Dong C (2006) Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 6, 329-333.
26. Zhang Z, Zheng M, Bindas J et al. (2006) Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm Bowel Dis 12, 382-388.
27. Berg DJ, Davidson N, Kuhn R et al. (1996) Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4 (+) TH1-like responses. J Clin Invest 98, 1010-1020.
28. Singh B, Read S, Asseman C et al. (2001) Control of intestinal inflammation by regulatory T cells. Immunol Rev 182, 190-200.
29. Brandtzaeg P, Farstad IN & Haraldsen G (1999) Regional specialization in the mucosal immune system: primed cells do not always home along the same track. Immunol Today 20, 267-277.
30. Brandtzaeg P & Pabst R (2004) Let's go mucosal: communication on slippery ground. Trends Immunol 25, 570-577.
31. de Moreno de LeBlanc A, Maldonado Galdeano C, Chaves S et al. (2005) Oral administration of Lactobacillus casei CRL 431 increases immunity in bronchus and mammary glands. Eur J Inflamm 3, 23-28.
32. LeBlanc JG, Matar C, Valdez JC et al. (2002) Immunomodulating effects of peptidic fractions issued from milk fermented with Lactobacillus helveticus. J Dairy Sci 85, 2733-2742.
33. Vinderola CG, Duarte J, Thangavel D et al. (2005) Immunomodulating capacity of kefir. J Dairy Res 72, 195-202.
34. Furukawa N, Matsuoka A, Takahashi T et al. (1990) Effects of orally administered yogurt and kefir on tumor growth in mice. J Jpn Soc Nutr Food Sci 43, 450-453.
35. Murofushi M, Mizuguchi J, Aibara K et al. (1986) Immunopotentiative effect of polysaccharide from kefir grain, KGF-C, administered orally in mice. Immunopharmacology 12, 29-35.
36. de Moreno de LeBlanc A, Matar C, Farnworth E et al. (2006) Study of cytokines involved in the prevention of a murine experimental breast cancer by kefir. Cytokine 34, 1-8.
37. Reome JB, Hylind JC, Dutton RW et al. (2004) Type 1 and type 2 tumor infiltrating effector cell subpopulations in progressive breast cancer. Clin Immunol 111, 69-81.
38. Zhang G, Li W, Holle L et al. (2002) A novel design of targeted endocrine and cytokine therapy for breast cancer. Clin Cancer Res 8, 1196-1205.
39. Reed MJ & Purohit A (1997) Breast cancer and the role of cytokines in regulating estrogen synthesis: an emerging hypothesis. Endocr Rev 18, 701-715.
40. de Moreno de LeBlanc A, Matar C, LeBlanc N et al. (2005) Effects of milk fermented by Lactobacillus helveticus R389 on a murine breast cancer model. Breast Cancer Res 7, 477-486.