Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing

Journal of Proteome Research

Volumn 9, Issue 10, 2010, Pages 5065-5075

  Gupta, Nitin ^a,d   Bark, Steven J ^a   Lu, Weiya D ^a   Taupenot, Laurent ^b   OConnor, Daniel T ^b   Pevzner, Pavel ^c   Hook, Vivian ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

cell cell communication; mass spectrometry; neuroendocrine; neuropeptides; neuropeptidomics; peptides; prohormones; proteolysis; secretory vesicles

Indexed keywords

CHROMOGRANIN; HORMONE PRECURSOR; MEMBRANE PROTEIN; NEUROPEPTIDE; PROENKEPHALIN; PRONEUROPEPTIDE Y; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; CELL COMMUNICATION; CHROMAFFIN SYSTEM; HUMAN; HUMAN CELL; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; PEPTIDOMICS; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SECRETORY VESICLE;

ADRENAL GLAND NEOPLASMS; ADRENAL MEDULLA; AMINO ACID SEQUENCE; CELL COMMUNICATION; CHROMAFFIN GRANULES; CHROMATOGRAPHY, LIQUID; ENKEPHALINS; HUMANS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; PEPTIDES; PHEOCHROMOCYTOMA; PROTEIN PRECURSORS; PROTEOMICS; SECRETOGRANIN II; SECRETORY VESICLES;

EID: 77957364518     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100358b     Document Type: Article

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