Malignant but not naïve hepatocytes of human and rodent origin are killed by TNF after metabolic depletion of ATP by fructose

Journal of Hepatology

Volumn 53, Issue 5, 2010, Pages 896-902

  Speicher, Tobias ^a   Foehrenbacher, Annika ^a   Pochic, Isabelle ^a   Weiland, Timo ^a   Wendel, Albrecht ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Hepatocellular carcinoma; Hexokinase II; Selective targeting; TNF; Warburg theory

Indexed keywords

ADENOSINE TRIPHOSPHATE; FRUCTOKINASE; FRUCTOSE; FRUCTOSE BISPHOSPHATE ALDOLASE; HEXOKINASE; HEXOKINASE 2; HYPOXIA INDUCIBLE FACTOR 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; FRUCTOSE METABOLISM; HUMAN; HUMAN CELL; IMMUNOTHERAPY; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CELLS, CULTURED; CYTOPROTECTION; FRUCTOKINASES; FRUCTOSE; FRUCTOSE-BISPHOSPHATE ALDOLASE; HEPATOCYTES; HEXOKINASE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; MICE; RATS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77957363088     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.05.024     Document Type: Article

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