Alteration of substrate specificity by a naturally-occurring aldolase B mutation (Ala337→Val) in fructose intolerance

Biochemical Journal

Volumn 340, Issue 1, 1999, Pages 321-327

  Rellos, Peter ^a   Ali, Manir ^a,d   Vidailhet, Michel ^b   Sygusch, Jurgen ^c   Cox, Timothy M ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY HOSPITAL OF NANCY   (France)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Catalytic defect; Enzyme mutant; Human gene

Indexed keywords

FRUCTOSE 1 PHOSPHATE; FRUCTOSE 1,6 BISPHOSPHATE; FRUCTOSE BISPHOSPHATE ALDOLASE; RECOMBINANT ENZYME;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CASE REPORT; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME SPECIFICITY; ENZYME STABILITY; ESCHERICHIA COLI; GENE MUTATION; HEREDITARY FRUCTOSE INTOLERANCE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; MICHAELIS CONSTANT; NEWBORN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN EXPRESSION;

AMINO ACID SUBSTITUTION; BINDING SITES; CATALYSIS; CHILD, PRESCHOOL; CIRCULAR DICHROISM; DNA MUTATIONAL ANALYSIS; ESCHERICHIA COLI; FRUCTOSE INTOLERANCE; FRUCTOSE-BISPHOSPHATE ALDOLASE; FRUCTOSEDIPHOSPHATES; FRUCTOSEPHOSPHATES; GENOTYPE; HUMANS; INFANT, NEWBORN; KINETICS; MUTATION, MISSENSE; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TRIOSES;

ESCHERICHIA COLI;

EID: 0033562970     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3400321     Document Type: Article

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