Statistical optimization and development of gastro retentive system of an antiretroviral drug using a 32 factorial design

Indian Journal of Pharmaceutical Education and Research

Volumn 44, Issue 3, 2010, Pages 236-242

  Dalavi, V V ^a   Patil, J S ^a  

^a BLDE UNIVERSITY   (India)

Author keywords

32 factorial design; Floating system; HPMC; Non fickians diffusion; Zidovudine

Indexed keywords

ANTIRETROVIRUS AGENT; BICARBONATE; CITRIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; TALC; ZIDOVUDINE;

ARTICLE; BULK DENSITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG RELEASE; DRUG RETENTION; DRUG TRANSPORT; FACTORIAL DESIGN; GASTROINTESTINAL TRACT; MATHEMATICAL ANALYSIS; PH; PREDICTION; TABLET COMPRESSION; TABLET FORMULATION; TIME;

EID: 77957348331     PISSN: 00195464     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Arora S, Javed A, Khar RK, et al. Floating Drug Delivery Systems: A Review. AAPS PharmSciTech. 2005; 6 (3) Article 47.E372-390.
2. Kusum V D, Roopa S. P. Antiretrovirals: Need for an Effective Drug Delivery. Indian J. Pharm. Sci. 2006;68 (1): 1-6.
3. Singh Y, Das R.Spectroscopic studies of anti AIDS drug. Indian Drugs 2008;45(1):16-25
4. Kuksal A, et al. Formulation and In Vitro, In Vivo Evaluation of Extended- release Matrix Tablet of Zidovudine. AAPS PharmSciTech. 2006; 7 (1):Article 1, E220-230.
5. Feleke F, Endale A.Oral floating extended release stavudine hydrophilic matrix tablets;formulation design and in vitro investigations.Ethiop pharm J 2007;25:51-62.
6. Punna R R, et al.Design and in vivo evaluation of Zidovudine oral controlled release tablets prepared usinghydroxypropyl methylcellulose.chem. Pharm.Bull. 2008; 56(4):518-524.
7. Baumgartner S, et al. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int.J. Pharm. 2000; 195: 125-135.
8. Narendra C, Srinath MS, Babu G. Optimization of Bilayer Floating Table Containing Metoprolol Tartrate as a Model Drug for Gastric Retention. AAPS PharmSciTech. 2006; 7(2): Article 34. 1-14.
9. Cooper J, Gunn C. Powder flow and compaction.In: Carter SJ, eds. Tutorial Pharmacy. New Delhi, India: CBS Publishers and Distributors; 1986; 211-233.
10. Aulton ME, Wells TI. Pharmaceutics: The Science of Dosage Form Design. London, England:Churchill Livingstone; 1988., p 235-236
11. Gambhire MN, et al. Development and In Vitro Evaluation of an Oral Floating Matrix Tablet Formulation of Diltiazem Hydrochloride.AAPS PharmSciTech. 2007; 8 (3) Article 73,E1-E8.
12. Yang, L, Esharghi J, Fassihi R. A new intra gastric delivery system for the treatment of helicobacter pylori associated gastric ulcers: in vitro evaluation. J Cont. Rel. 1999; 57: 215-222.
13. Shoufeng Li, et al. Statistical Optimization of Gastric Floating System for Oral Controlled Delivery of Calcium.AAPS PharmSciTech 2001; 2 (1) article 1,1-12.
14. Costa P, Lobo J. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001; 13:23-133