Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention

AAPS PharmSciTech

Volumn 7, Issue 2, 2006, Pages

  Narendra, C ^a,c   Srinath, M S ^b   Babu, Ganesh ^b  

^a KRUPANIDHI COLLEGE OF PHARMACY   (India)

^b Government College of Pharmacy   (India)

^c Visveswarapura Institute of Pharmaceutical Sciences   (India)

Author keywords

Bilayered tablet; Factorial design; GFDDS; HPMC; Metoprolol tartrate

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; METOPROLOL TARTRATE; POLYMER; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOMATERIAL; DRUG DERIVATIVE; METHYLCELLULOSE; METOPROLOL;

ARTICLE; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG RETENTION; FACTORIAL ANALYSIS; FEASIBILITY STUDY; GASTRIC FLOATING DRUG DELIVERY SYSTEM; IN VITRO STUDY; MATHEMATICAL MODEL; PREDICTION; QUANTITATIVE ANALYSIS; REGRESSION ANALYSIS; TABLET; TIME; VISCOSITY; ABSORPTION; ARTIFICIAL MEMBRANE; BIOAVAILABILITY; CHEMISTRY; COMBINATORIAL CHEMISTRY; DIFFUSION; DRUG DESIGN; MATERIALS TESTING; METHODOLOGY; SOLUBILITY; STOMACH; STOMACH JUICE;

ABSORPTION; ADRENERGIC BETA-ANTAGONISTS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; COATED MATERIALS, BIOCOMPATIBLE; COMBINATORIAL CHEMISTRY TECHNIQUES; DIFFUSION; DRUG DESIGN; GASTROINTESTINAL CONTENTS; MATERIALS TESTING; MEMBRANES, ARTIFICIAL; METHYLCELLULOSE; METOPROLOL; SOLUBILITY; STOMACH; TABLETS; VISCOSITY;

EID: 33645834504     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070234     Document Type: Article

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