Expression of mutant protein p53 and Hsp70 and Hsp90 chaperones in cockles Cerastoderma edule affected by neoplasia

Diseases of Aquatic Organisms

Volumn 90, Issue 3, 2010, Pages 215-222

  Diaz S ^a   Cao, A ^a   Villalba, A ^a   Carballal, M J ^a  

^a CENTRO DE INVESTIGACIÓNS MARIÑAS   (Spain)

Author keywords

Cerastoderma edule; Disseminated neoplasia; Hsp70; Hsp90; P53

Indexed keywords

BIVALVE; CANCER; CARCINOGEN; MARINE ECOSYSTEM; MICROSCOPY; MORTALITY; PROTEIN;

BIVALVIA; CERASTODERMA EDULE; CRASSOSTREA GIGAS; CRASSOSTREA RHIZOPHORAE; MOLLUSCA; MYA; MYA ARENARIA; MYTILUS; MYTILUS EDULIS; MYTILUS TROSSULUS; OSTREIDAE; SPISULA; SPISULA SOLIDISSIMA; VERTEBRATA;

HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PROTEIN P53;

ANIMAL; ARTICLE; COCKLE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CARDIIDAE; GENE EXPRESSION REGULATION, NEOPLASTIC; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77957342036     PISSN: 01775103     EISSN: 16161580     Source Type: Journal    
DOI: 10.3354/dao02231     Document Type: Article

References (61)

1. Auffret M, Poder M (1986) Sarcomatous lesion in the cockle Cerastoderma edule: II. Electron microscopical study. Aquaculture 58:9-15
2. Barber BJ (2004) Neoplastic diseases of commercially important marine bivalves. Aquat Living Resour 17:449-466
3. Barker CM, Calvert RJ, Walker CW, Reinisch CL (1997) Detection of mutant p53 in clam leukemia cells. Exp Cell Res 232:240-245
4. Beere HM, Wolf BB, Cain K, Mosser DD and others (2000) Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2:469-475
5. Böttger S, Jerszyk E, Low B, Walker C (2008) Genotoxic stress-induced expression of p53 and apoptosis in leukemic clam hemocytes with cytoplasmically sequestered p53. Cancer Res 68:777-782 (Pubitemid 351206754)
6. Boutet I, Tanguy A, Rosseau S, Auffret M, Morana D (2003a) Molecular identification and expression of heat shock cognate 70 (hsc70) and heat shock protein 70 (hsp70) gene in the Pacific oyster Crassostrea gigas. Cell Stress Chaperones 8:76-85 (Pubitemid 36444093)
7. Boutet I, Tanguy A, Auffret M, Mujdzic N, Morana D (2003b) Expression of Hsp70 in experimentally metal-exposed European flat oysters Ostrea edulis. J Shellfish Res 22: 763-766 (Pubitemid 39039967)
8. Bradford MM (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal Biochem 72:248-254
9. Butler RA, Kelley ML, Olberding KE, Gardner GR, Van Beneden RJ (2004) Aryl hydrocarbon receptor (AhR)-independent effects of 2,3, 7,8- tetrachlorodibenzo-p-dioxin (TCDD) on softshell clam (Mya arenaria) reproductive tissue. Comp Biochem Physiol 138:375-381
10. Cao A, Ramos JI, Barcia R (2004) Implication of PKA and PKC in the activation of the haemocytes of Mytilus galloprovincialis Lmk. by LPS and IL-2. Mol Immunol 41:45-52 (Pubitemid 38609395)
11. Carballal MJ, Iglesias D, Santamarina J, Ferro-Soto B, Villalba A (2001) Parasites and pathologic conditions of the cockle Cerastoderma edule populations of the coast of Galicia (NW Spain). J Invertebr Pathol 78:87-97 (Pubitemid 33092176)
12. Ciocan CM, Rotchell JM (2005) Conservation of cancer genes in the marine invertebrate Mytilus edulis. Environ Sci Technol 39:3029-3033
13. Ciocan CM, Moore JD, Rotchell JM (2006) The role of ras gene in the development of haemic neoplasia in Mytilus trossulus. Mar Environ Res 62:S147-S150
14. Ciocca DR, Calderwood SK (2005) Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10:86-103
15. Collins CM, Mulcahy MF (2003) Cell-free transmission of a haemic neoplasm in the cockle Cerastoderma edule. Dis Aquat Org 54:61-67
16. Cooper KR, Brown RS, Chang PW (1982) Accuary of blood cytological screening techniques for the diagnosis of a possible hematopoietic neoplasm in the bivalve mollusc, Mya arenaria. J Invertebr Pathol 39:149-157
17. Cox RL, Stephens RE, Reinisch CL (2003) p63/73 homologues in surf clam: Novel singling motifs and implications for control of expression. Gene 320:49-58
18. Dobbelstein M, Roth J (1998) The large T antigen of Simian virus 40 binds and inactivates p53 but not p73. J Gen Virol 79:3079-3083 (Pubitemid 29002346)
19. Farley CA, Plutschak DL, Scott RF (1991) Epizootiology and distribution of transmisible sarcoma Maryland soft shell clams, Mya arenaria, 1984-1988. Environ Health Perspect 90:35-41
20. Gabai VL, Yaglom JA, Volloch V, Meriin AB and others (2000) Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol 20:6826-6836
21. Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 54:4855-4878 (Pubitemid 24289415)
22. Helmbrecht K, Zeise E, Rensing L (2000) Chaperones in cell cycle regulation and mitogenic signal transduction: A review. Cell Prolif 33:341-365
23. Holbrook LAC, Butler RA, Cashon RE, Van Beneden RJ (2009) Soft-shell clam (Mya arenaria) p53: A structural and functional comparison to human p53. Gene 433:81-87
24. House ML, Kim CH, Reno PW (1998) Soft shell clams Mya arenaria with disseminated neoplasia demonstrate reverse transcriptase activity. Dis Aquat Org 34:187-192
25. Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M (1998) Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 17:6124-6134 (Pubitemid 28497786)
26. Jolly C, Morimoto RI (2000) Role of the heat shock response and molecular chaperones in oncogenesis and cell death. Natl Cancer Inst 92:1564-1572
27. Kelley ML, Van Beneden RJ (2000) Identification of an E3 ubiquitin-protein ligase in the softshell clam (Mya arenaria). Mar Environ Res 50:289-293
28. Kelley ML, Winge P, Heaney JD, Stephens RE and others (2001) Expression of homologues for p53 and p73 in the softshell clam (Mya arenaria), a naturally occurring model for human cancer. Oncogene 20:748-758 (Pubitemid 32179343)
29. Leavitt DF, McDowell Capuzo J, Smolowitz RM, Miosky DL, Lancaster BA (1990) Hematopoietic neoplasia in Mya arenaria: Prevalence and indices of physiological condition. Mar Biol 105:313-321
30. Li CY, Lee JS, Ko YG, Kim JL, Seo JS (2000) Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J Biol Chem 275:25665-25671
31. Medina DJ, Paquette GE, Sadasiv EC, Chang PW (1993) Isolation of infectious particles having reverse transcriptase activity and producing hematopoietic neoplasia in Mya arenaria. J Shellfish Res 12:112-113
32. Moll UM, Riou G, Levine AJ (1992) Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion. Proc Natl Acad Sci USA 89:7262-7266
33. Moll UM, LaQuaglia M, Benard J, Riou G (1995) Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 92:4407-4411
34. Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B (2000) The chaperone function of Hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol 16:1126-1137
35. Muttray AF, Cox RL, St-Jean S, van Poppelen P, Reinisch CL, Baldwin SA (2005) Identification and phylogenetic comparison of p53 in two distinct mussel species (Mytilus). Comp Biochem Physiol C 140:237-250 (Pubitemid 40720043)
36. Muttray AF, Cox RL, Reinisch CL, Baldwin SA (2007) Identification of deltaN isoform and polyadenylation site choice variants in molluscan p63/p73-like homologues. Mar Biotechnol 9:217-230
37. Nikolaev AY, Li M, Puskas N, Quin J, Gu W (2003) Parc: A cytoplasmic anchor for p53. Cell 112:29-40 (Pubitemid 36106416)
38. Nylandsted J, Rohde M, Brand K, Bastholm L, Elling F, Jaattela M (2000) Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc Natl Acad Sci USA 97:7871-7876 (Pubitemid 30460740)
39. Olberding KE, Kelley ML, Butler RA, Van Beneden RJ (2004) A HECT E3 ubiquitin-protein ligase with sequence similarity to E6AP does not target p53 for degradation in the softshell clam (Mya arenaria). Mutat Res 552:61-71
40. Oprandy JJ, Chang PW (1983) 5-bromodeoxyuridine induction of hematopoietic neoplasia and retrovirus activation in the soft-shell clam, Mya arenaria. J Invertebr Pathol 42:196-206
41. Oprandy JJ, Chang PW, Pronovost AD, Cooper KR, Brown RS, Yates VJ (1981) Isolation of a viral agent causing hematopoietic neoplasia in the soft-shell clam, Mya arenaria. J Invertebr Pathol 38:45-51
42. Peters EC (1988) Recent investigations on the disseminated sarcomas of marine bivalve molluscs. Am Fish Soc Spec Publ 18:74-92
43. Pockley AG (2003) Heat shock proteins as regulators of the immune response. Lancet 362:469-476 (Pubitemid 36999714)
44. Poder M, Auffret M (1986) Sarcomatus lesion in the cockle Cerastoderma edule L. Morphology and population survey in Brittany, France. Aquaculture 58:1-8
45. Robert J (2003) Evolution of heat shock protein and immunity. Dev Comp Immunol 27:449-464 (Pubitemid 36411906)
46. Romalde JL, Vilariño ML, Beaz R, Rodríguez JM, Díaz S, Villalba A, Carballal MJ (2007) Evidence of retroviral etiology for disseminated neoplasia in cockles (Cerastoderma edule). J Invertebr Pathol 94:95-101 (Pubitemid 46157247)
47. Royds JA, Iacopetta B (2006) p53 and disease: When the guardian angel fails. Cell Death Differ 13:1017-1026 (Pubitemid 43753492)
48. Sanders BM (1993) Stress proteins in aquatic organisms: An environmental perspective. Crit Rev Toxicol 23:49-75 (Pubitemid 23094394)
49. Skowyra D, Georgopoulos C, ZyliczM(1990) The Escherichia coli dnaK gene product, the hsp70 homologue, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis- dependent manner. Cell 62:939-944 (Pubitemid 20269140)
50. Snyder MJ, Girvertz E, Mulder EP (2001) Induction of marine mollusc stress proteins by chemical or physical stress. Arch Environ Contam Toxicol 41:22-29
51. Song J, Takeda M, Morimoto RI (2001) Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat Cell Biol 3:276-282 (Pubitemid 32201323)
52. St-Jean SD, Stephens RE, Courtenay SC, Reinisch CL (2005) Detecting p53 family proteins in haemocytic leukemia cells of Mytilus edulis from Pictou Harbour, Nova Scotia, Canada. Can J Fish Aquat Sci 62:2055-2066
53. Stephens RE, Walker CW, Reinisch CL (2001) Multiple protein differences distinguish clam leukemia cells from normal hemocytes: Evidence for the involvement of p53 homologues. Comp Biochem Physiol 129:329-338
54. Sunila I (1994) Viral transmission and tumor promotion of sarcoma in the softshell, Mya arenaria. In: Rosenfield A, Kern FG, Keller BJ (eds) Invertebrate neoplasia: Initation and promotion mechanisms. US Department of Commerce, Woods Hole, MA, p 3-5
55. Twomey E, Mulcahy MF (1984) A proliferative disorder of possible haemic origin in the common cockle, Cerastoderma edule. J Invertebr Pathol 44:109-111
56. Twomey E, Mulcahy MF (1988) Transmission of a sarcoma in the cockle Cerastoderma edule (Bivalvia; Mollusca) using cell transplants. Dev Comp Immunol 12:195-200 (Pubitemid 18075894)
57. Villalba A, Carballal MJ, López C (2001) Disseminated neoplasia and large foci indicating heavy haemocytic infiltration in cockles Cerastoderma edule from Galicia (NW Spain). Dis Aquat Org 46:213-216 (Pubitemid 33001754)
58. Walker C, Böttger S, Low B (2006) Mortalin-based cytoplasmic sequestration of p53 in a nonmammalian cancer model. Am J Pathol 168:1526-1530
59. Wickner S, Maurizi MR, Gottesman S (1999) Posttranslational quality control: Folding, refolding and degrading proteins. Science 286:1888-1893 (Pubitemid 129515889)
60. Yevich PP, Barszcz CA (1976) Gonadal and hematopoietic neoplasm in Mya arenaria. Mar Fish Rev 38:42-43
61. Zylicz M, King FW, Wawrzynow A (2001) Hsp70 interactions with the p53 tumour suppressor protein. EMBO J 20: 4634-4638 (Pubitemid 32848616)