Mortalin-based cytoplasmic sequestration of p53 in a nonmammalian cancer model

American Journal of Pathology

Volumn 168, Issue 5, 2006, Pages 1526-1530

  Walker, Charles ^a   Böttger, Stefanie ^a   Low, Ben ^a  

^a UNIVERSITY OF NEW HAMPSHIRE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYL 2 [[3 ETHYL 5 (3 METHYLBENZOTHIAZOLIN 2 YLIDENE) 4 OXOTHIAZOLIDIN 2 YLIDENE]METHYL]PYRIDINIUM CHLORIDE; CATION; HEAT SHOCK PROTEIN 70; MORTALIN; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD CELL; CELL MOTION; CLAM; COLORECTAL CARCINOMA; CONTROLLED STUDY; GENE INACTIVATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; GLIOBLASTOMA; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; LIVER CELL CARCINOMA; MOLECULAR MECHANICS; MOLECULAR MODEL; MYA; NEUROBLASTOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RETINOBLASTOMA;

EID: 33646496005     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2006.050603     Document Type: Article

References (12)

1. Nikolaev AY, Li M, Puskas N, Qin J, Gu W: Parc: a cytoplasmic anchor for p53. Cell 2003, 112:29-40
2. Dundas SR, Lawrie LC, Rooney PH, Murray GI: Mortalin is overexpressed by colorectal adenocarcinomas and correlates with poor survival. J Pathol 2005, 205:74-81
3. Wadhwa R, Taira K, Kaul SC: Mortalin: a potential candidate for biotechnology and biomedicine. Histol Histopathol 2002, 17:1173-1177
4. Walker HA, Lorda E, Saila SB: A comparison of the incidence of five pathological conditions in soft-shell clams, Mya arenaria, from environments with various pollution histories. Mar Environ Res 1981, 5:109-123
5. Reinisch CL, Charles AM, Stone AM: Epizootic neoplasia in soft shell clams collected from New Bedford Harbor. Hazard Waste 1984, 1:73-81
6. Laevitt DF, Capuzzo JM, Smolowitz RM, Miosky DL, Lancaster BA, Reinisch CL: Hematopoietic neoplasia in Mya arenaria: prevalence and indices of physiological condition. Mar Biol 1990, 105:313-323
7. Sible J, Marsh AG, Walker CW: Effect of extrinsic polyamines on post-spawning testes of the sea star (Asterias vulgaris) (Echinodermata): implications for seasonal regulation of spermatogenesis. Invertebrate Reprod Dev 1992, 19:257-265
8. Wadhwa R, Sugihara T, Yoshida A, Nomura H, Reddel RR, Simpson R, Maruta H, Kaul SC: Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res 2000, 60:6818-6821
9. Giannakakou P, Nakano M, Nicolaou KC, O'Brate A, Yu J, Blagosklonny MV, Greber UF, Fojo T: Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics. Proc Natl Acad Sci USA 2002, 99:10855-10860
10. Kelley ML, Winge P, Heaney JD, Stephens RE, Farell JH, Van Beneden RJ, Reinisch CL, Lesser MP, Walker CW: Expression of homologues for p53 and p73 in the softshell clam (Mya arenaria), a naturally-occurring model for human cancer. Oncogene 2001, 20:748-758
11. Ostermeyer AG, Runko E, Winkfield B, Ahn B, Moll UM: Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide. Proc Natl Acad Sci USA 1996, 93:15190-15194
12. Moll UM, LaQuaglia M, Benard J, Riou G: Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 1995, 92:4407-4411