Potential applications of breath isoprene as a biomarker in modern medicine: A concise overview

Wiener Klinische Wochenschrift

Volumn 117, Issue 5-6, 2005, Pages 180-186

  Salerno Kennedy, Rossana ^a   Cashman, Kevin D ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Breath analysis; Cholesterol metabolism; Isoprene; Mevalonate

Indexed keywords

ANTILIPEMIC AGENT; BIOLOGICAL MARKER; CHOLESTEROL; ISOPRENE; LIPID; MEVALONIC ACID; VOLATILE ORGANIC COMPOUND;

AIR SAMPLING; BIOSYNTHESIS; BREATH ANALYSIS; CANCER SCREENING; CHOLESTEROL SYNTHESIS; DIAGNOSTIC TEST; DIETARY INTAKE; DRUG EFFICACY; EXPIRED AIR; HUMAN; LIFESTYLE; LIPID METABOLISM; MASS SCREENING; MEASUREMENT; METABOLIC DISORDER; PARAMETER; PATHOPHYSIOLOGY; PATIENT MONITORING; REVIEW; STANDARDIZATION; TECHNIQUE;

BIOLOGICAL MARKERS; BREATH TESTS; BUTADIENES; CHOLESTEROL; CLINICAL TRIALS; HEMITERPENES; HUMANS; HYPERCHOLESTEROLEMIA; NEOPLASMS; PENTANES; STATISTICS;

EID: 18444383957     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00508-005-0336-9     Document Type: Review

References (66)

1. Phillips M, Greenberg J, Awad J (1994) Metabolic and environmental origins of volatile organic compounds in breath. J Clin Pathol 47: 1052-1053
2. Miekisch W, Schubert JK, Noeldge-Schomburg GF (2004) Diagnostic potential of breath analysis - focus on volatile organic compounds. Clin Chim Acta 347: 25-39
3. Romagnuolo J, Schiller D, Bailey RJ (2002) Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation. Am J Gastroenterol 97: 1113-1126
4. Meryn S (1994) Diagnosis of Helicobacter pylori infection. Wien Klin Wochenschr 106: 559-562
5. Lembcke B (1997) Breath tests in intestinal diseases and functional gastrointestinal diagnosis. Schweiz Rundsch Med Prax 86: 1060-1067
6. Hammer HF, Petritsch W, Pristautz H, Krejs GJ (1996) Assessment of the influence of hydrogen nonexcretion on the usefulness of the hydrogen breath test and lactose tolerance test. Wien Klin Wochenschr 108: 137-141
7. Armuzzi A, Candelli M, Zocco MA, Andreoli A, De Lorenzo A, Nista EC, Miele L, Cremonini F, Cazzato IA, Grieco A, Gasbarrini G, Gasbarrini A (2002) Breath testing for human liver function assessment. Aliment Pharmacol Ther 16: 1977-1996
8. Di Campli C, Angeleini G, Armuzzi A, Nardo B, Zocco MA, Candelli M, Santoliquido A, Cavallari A, Bernardi M, Gasbarrini A (2003) Quantitative evaluation of liver function by the methionine and aminopyrine breath tests in the early stages of liver transplantation. Europ J Gastroenterol Hepatol 15: 727-732
9. Dupont LJ, Demedts MG, Verleden GM (2003) Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. Chest 123: 751-756
10. Taalman R (1996) Isoprene: background and issues. Toxicology 113: 242-246
11. Cailleux A, Cogney M, Allain P (1992) Blood isoprene concentrations in humans and in some animal species. Bioch Med Metab Biol 47: 157-160
12. Gelmont D, Stein RA, Mead JF (1981) Isoprene the main hydrocarbon in human breath. Biochem Biophys Res Commun 99: 1456-1460
13. Nelson N, Lagesson V, Nostrabadi AR, Ludvigson J, Tagesson C (1998) Exhaled isoprene and acetone in newborn infants and in children with diabetes mellitus. Peadiatr Res 44: 363-367
14. Taucher J, Hansel A, Jordan A, Fall R, Futrell JH, Lindinger W (1997) Detection of isoprene in expired air from human subjects using proton-transfer-reaction mass spectrometry. Rapid Commun Mass Spectrom 11: 1230-1234
15. Diskin AM, Spaněl P, Smith D (2003) Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days. Physiol Meas 24: 107-119
16. Mendis S, Sobotka PA, Euler DE (1994) Pentane and isoprene in expired air from humans: gas-chromatographic analysis of single breath. Clin Chem 40: 1485-1488
17. Karl T, Prazeller P, Mayr D, Jordan A, Rieder J, Fall R, Lindinger W (2001) Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling. J Appl Physiol 91: 762-770
18. Euler DE, Dave SJ, Guo H (1996) Effect of cigarette smoking on pentane excretion in alveolar breath. Clin Chem 42: 303-308
19. Cailleux A, Allain P (1989) Isoprene and sleep. Life Sci 44: 1877-1880
20. Stone BG, Besse TJ, Duane WC, Evans CD, DeMaster EG (1993) Effect of regulating cholesterol biosynthesis on breath isoprene excretion in men. Lipids 28: 705-708
21. Miekisch W, Schubert JK, Vagts DA, Geiger K (2001) Analysis of volatile disease markers in blood. Clin Chem 47: 1053-1060
22. Cailleux A, Moreau X, Delhumeau A, Allain P (1993) Decrease of isoprene concentrations in blood during general anesthesia. Biochem Med Metab Biol 49: 321-325
23. Mohler ER, Reaven P, Stegner JE, Fineberg NS, Hathaway DR (1996) Gas chromatographic method using photoionization detection for the determination of breathpentane. J Chromatogr B Biomed Appl 685: 201-209
24. Grote C, Pawliszyn J (1997) Solid-phase microextraction for the analysis of human breath. Anal Chem 69: 587-596
25. Spaněl P, Rolfe P, Rajan B, Smith D (1996) The selected ion flow tube (SIFT) - a novel technique for biological monitoring. Ann Occup Hyg 40: 615-626
26. Jordan A, Hansel A, Holzinger R, Lindinger W (1995) Acetonitrile and benzene in the breath of smokers and nonsmokers investigated by proton transfer reaction mass spectrometry. Int J Mass Spectrom Ion Processes 148: L1-L3
27. Taucher J, Lagg A, Hansel A, Vogel W, Lindinger W (1995) Methanol in human breath. Alcohol Clin Exp Res 19: 1147-1150
28. Taucher J, Hansel A, Jordan A, Lindinger W (1996) Analysis of compounds in human breath after ingestion of garlic using proton-transfer-reaction mass spectrometry. J Agric Food Chem 44: 3778-3782
29. Hyspler R, Crhova S, Gasparic J, Zadak Z, Cizkova M, Balasova V (2000) Determination of isoprene in human expired breath using solid-phase microextraction and gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl 739: 183-190
30. Spaněl P, Smith D (1995) Reactions of hydrated hydronium ions and hydrated hydroxide ions with some hydrocarbons and oxygen-bearing organic molecules. J Phys Chem 99: 15551-15556
31. + ions with some organic molecules: the potential for trace gas analysis of air. J Chem Phys 104: 1893-1899
32. Smith D, Spaněl P (1996) Review. The novel SIFT approach to trace gas analysis of air and breath. Rapid Commun Mass Spectrom 10: 1183
33. + precursor ions for the detection and quantification of diverse trace gases in the presence of air and breath by selected ion flow tube mass-spectrometry. Int J Mass Spectrome 209: 81-97
34. Spaněl P, Davies S, Smith D (1999) Quantification of breath isoprene using the selected ion flow tube mass spectrometric analytical method. Rapid Commun Mass Spectrom 13: 1733-1738
35. Deneris ES, Stein RA, Mead JF (1984) In vitro biosynthesis of isoprene from mevalonate utilizing a rat liver cytosolic fraction. Biochem Biophys Res Commun 123: 691-696
36. Deneris ES, Stein RA, Mead JF (1985) Acid-catalyzed formation of isoprene from a mevalonate-derived product using a rat liver cytosolic fraction. J Biol Chem 260: 1382-1385
37. Stein RA, Mead JF (1988) Small hydrocarbons formed by the peroxidation of squalene. Chem Phys Lipids 46: 117-120
38. Jones PJH, Schoeller DA (1990) Evidence for diurnal periodicity in human cholesterol synthesis. J Lipid Res 31: 667-673
39. DeMaster EG, Nagasawa HT (1978) Isoprene, an endogenous constituent of human alveolar air with a diurnal pattern of excretion. Life Sci 22: 91-97
40. Zadak Z, Hyspier R, Crhova S, Gasparic J, Cizkova M, Balasova V (1999) Isoprene in expired air as a marker of cholesterol synthesis for the statin therapy monitoring. Atherosclerosis 144: 206
41. Lin DS, Connor WE (1980) The long term effects of dietary cholesterol upon the plasma lipids, lipoproteins, cholesterol absorption, and the sterol balance in man: the demonstration of feedback inhibition of cholesterol biosynthesis and increased bile acid excretion. J Lipid Res 21: 1042-1052
42. Quintao E, Grundy SM, Ahrens EH Jr (1971) Effects of dietary cholesterol on the regulation of total body cholesterol in man. J Lipid Res 12: 233-247
43. Smith D, Spaněl P, Davies S (1999) Trace gases in breath of healthy volunteers when fasting and after a protein-calorie meal: a preliminary study. J Appl Physiol 87: 1584-1588
44. Hyspler R, Crhova S, Zadak Z, Gasparic J (1999) Breath isoprene as a measure of the depression in cholesterol synthesis in intensive care patients. Klin Biochem Metab 7: 131-134
45. Rao KN (1995) The significance of the cholesterol biosynthetic pathway in cell growth and carcinogenesis. Anticancer Res 15: 309-314
46. Siperstein MD (1984) Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth. J Lipid Res 25: 1462-1468
47. Goldstein JL, Brown MS (1990) Regulation of the mevalonate pathway. Nature 343: 425-430
48. Kaneko I, Hazama-Shimada Y, Endo A (1978) Inhibitory effects on lipid metabolism in cultured cells of ML-236B, a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase. Eur J Biochem 87: 313-321
49. Cuthbert JA, Lipsky PE (1990) Inhibition by 6-fluoromevalonate demonstrates that mevalonate or one of the mevalonate phosphates is necessary for lymphocyte proliferation. J Biol Chem 265: 18568-18575
50. Habenicht AJ, Glomset JA, Ross R (1980) Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor. J Biol Chem 255: 5134-5140
51. Chan KK, Oza AM, Siu LL (2003) The statins as anticancer agents. Clin Cancer Res 9: 10-19
52. Jakobisiak M, Golab J (2003) Potential antitumor effects of statins. Int J Oncol 23: 1055-1056
53. Rieder J, Lirk P, Ebenbichler C, Gruber G, Prazeller P, Lindinger W, Amann A (2001) Analysis of volatile organic compounds: possible applications in metabolic disorders and cancer screening. Wien Klin Wochenschr 113: 181-185
54. Scholpp J, Schubert JK, Miekisch W, Geiger K (2002) Breath markers and soluble lipid peroxidation markers in critically ill patients. Clin Chem Lab Med 40: 587-594
55. Kohlmuller D, Kochen W (1993) Is n-pentane really an index of lipid peroxidation in humans and animals? A methodological reevaluation. Anal Biochem 210: 268-276
56. McGrath LT, Patrick R, Silke B (2001) Breath isoprene in patients with heart failure. Eur J Heart Fail 3: 423-427
57. Mendis S, Sobotka PA, Leja FL, Euler DE (1995) Breath pentane and plasma lipid peroxides in ischemic heart disease. Free Radic Biol Med 19: 679-684
58. Pelli MA, Trovarelli G, Capodicasa E, De Medio GE, Bassotti G (1999) Breath alkanes determination in ulcerative colitis and Crohn's disease. Dis Colon Rectum 42: 71-76
59. Schubert JK, Miekisch W, Geiger K, Noldge-Schomburg GF (2004) Breath analysis in critically ill patients: potential and limitations. Expert Rev Mol Diagn 4: 619-629
60. Studer SM, Orens JB, Rosas I, Krishnan JA, Cope KA, Yang S, Conte JV, Becker PB, Risby TH (2001) Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection. J Heart Lung Transplant 20: 1158-1166
61. Sehnert SS, Jiang L, Burdick JF, Risby TH (2002) Breath biomarkers for detection of human liver diseases: preliminary study. Biomarkers 7: 174-187
62. Capodicasa E, Trovarelli G, De Medio GE, Pelli MA, Lippi G, Verdura C, Timio M (1999) Volatile alkanes and increased concentrations of isoprene in exhaled air during hemodialysis. Nephron 82: 331-337
63. Trovarelli G, Brunori F, De Medio GE, Timio M, Lippi G, Pelli MA, Capodicasa E (2001) Onset, time course, and persistence of increased haemodialysis-induced breath isoprene emission. Nephron 88: 44-47
64. Davies S, Spaněl P, Smith D (2001) A new 'online' method to measure increased exhaled isoprene in end-stage renal failure. Nephrol Dial Transplant 16: 836-839
65. Lirk P, Bodrogi F, Raifer H, Greiner K, Ulmer H, Rieder J (2003) Elective haemodialysis increases exhaled isoprene. Nephrol Dial Transplant 18: 937-941
66. Capodicasa E, Trovarelli G, Brunori F, Vecchi L, Carobi C, De M, Pelli MA, Buoncristiani U (2002) Lack of isoprene overproduction during peritoneal dialysis. Perit Dial Int 22: 48-52