-
1
-
-
0029776766
-
Epothilone A and B-novel 16-membered macrolides with cytotoxic activity: Isolation, crystal structure, and conformation in solution
-
Höfle, G. et al. Epothilone A and B-novel 16-membered macrolides with cytotoxic activity: isolation, crystal structure, and conformation in solution. Angew. Chem. Intern. Ed. Engl. 35, 1567-1569 (1996).
-
(1996)
Angew. Chem. Intern. Ed. Engl.
, vol.35
, pp. 1567-1569
-
-
Höfle, G.1
-
2
-
-
0030018666
-
Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties
-
Gerth, K., Bedorf, N., Höfle, G., Irschik, H. & Reichenbach, H. Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. J. Antibiot. 49, 560-563 (1996).
-
(1996)
J. Antibiot.
, vol.49
, pp. 560-563
-
-
Gerth, K.1
Bedorf, N.2
Höfle, G.3
Irschik, H.4
Reichenbach, H.5
-
3
-
-
0029049468
-
Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
-
Bollag, D. M. et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. 55, 2325-2333 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 2325-2333
-
-
Bollag, D.M.1
-
4
-
-
33947253236
-
Evolutionary diversity of ketoacyl synthases in cellulolytic myxobacterium Sorangium
-
Li, Z. F. et al. Evolutionary diversity of ketoacyl synthases in cellulolytic myxobacterium Sorangium. Syst. Appl. Microbiol. 30, 189-1996 (2007).
-
(2007)
Syst. Appl. Microbiol.
, vol.30
, pp. 189-1996
-
-
Li, Z.F.1
-
5
-
-
34547654448
-
Mutation and a high-throughput screening method for improving the production of Epothilones of Sorangium
-
Gong, G. L. et al. Mutation and a high-throughput screening method for improving the production of Epothilones of Sorangium. J. Ind. Microbiol. Biotechnol. 34, 615-623 (2007).
-
(2007)
J. Ind. Microbiol. Biotechnol.
, vol.34
, pp. 615-623
-
-
Gong, G.L.1
-
6
-
-
70349603841
-
Five new epothilone metabolites from Sorangium cellulosum strain So0157-2
-
Wang, J. et al. Five new epothilone metabolites from Sorangium cellulosum strain So0157-2. J. Antibiot. 62, 483-487 (2009).
-
(2009)
J. Antibiot.
, vol.62
, pp. 483-487
-
-
Wang, J.1
-
7
-
-
0038352074
-
16S-23S ribosomal DNA intergenic spacer regions in cellulolytic myxobacteria and differentiation of closely related strains
-
Nguimbi, E. et al. 16S-23S ribosomal DNA intergenic spacer regions in cellulolytic myxobacteria and differentiation of closely related strains. Syst. Appl. Microbiol. 26, 262-268 (2003).
-
(2003)
Syst. Appl. Microbiol.
, vol.26
, pp. 262-268
-
-
Nguimbi, E.1
-
8
-
-
0034903353
-
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: Isolation, structure elucidation, and SAR studies
-
Hardt, I. H. et al. New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. J. Nat. Prod. 64, 847-856 (2001).
-
(2001)
J. Nat. Prod.
, vol.64
, pp. 847-856
-
-
Hardt, I.H.1
-
9
-
-
14844338576
-
Much anticipated - The bioactive conformation of epothilone and its binding to tubulin
-
Heinz, D. W., Schubert, W. & Höfle, G. Much anticipated-the bioactive conformation of epothilone and its binding to tubulin. Angew. Chem. Int. Ed. 44, 1298-1301 (2005).
-
(2005)
Angew. Chem. Int. Ed.
, vol.44
, pp. 1298-1301
-
-
Heinz, D.W.1
Schubert, W.2
Höfle, G.3
-
10
-
-
33751204460
-
The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide13
-
Sánchez-Pedregal, V. M. et al. The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide13. Angew. Chem. Int. Ed. 45, 7388-7394 (2006).
-
(2006)
Angew. Chem. Int. Ed.
, vol.45
, pp. 7388-7394
-
-
Sánchez-Pedregal, V.M.1
-
11
-
-
66349104251
-
Microbial transformation of epothilone A by Aspergillus niger AS 3.739
-
Wang, Y.-L. et al. Microbial transformation of epothilone A by Aspergillus niger AS 3.739. J. Asian Nat. Prod. Res. 11, 357-364 (2009).
-
(2009)
J. Asian Nat. Prod. Res.
, vol.11
, pp. 357-364
-
-
Wang, Y.-L.1
-
12
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63 (1983).
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
13
-
-
0032213635
-
Derivatization of the C12-C13 functional groups of epothilones A, B and C
-
Sefkow, M., Kiffe, M. & Höfle, G. Derivatization of the C12-C13 functional groups of epothilones A, B and C. Bioorg. Med. Chem. Lett. 8, 3031-3036 (1998).
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 3031-3036
-
-
Sefkow, M.1
Kiffe, M.2
Höfle, G.3
-
14
-
-
0142250006
-
Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations
-
Starks, C. M., Zhou, Y., Liu, F. & Licari, P. J. Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations. J. Nat. Prod. 66, 1313-1317 (2003).
-
(2003)
J. Nat. Prod.
, vol.66
, pp. 1313-1317
-
-
Starks, C.M.1
Zhou, Y.2
Liu, F.3
Licari, P.J.4
-
15
-
-
0036239554
-
Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures
-
Arslanian, R. L. et al. Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures. J. Nat. Prod. 65, 570-572 (2002).
-
(2002)
J. Nat. Prod.
, vol.65
, pp. 570-572
-
-
Arslanian, R.L.1
-
16
-
-
3042748791
-
Recent developments in the maytansinoid antitumor agents
-
Cassady, J. M., Chan, K. K., Floss, H. G. & Leistner, E. Recent developments in the maytansinoid antitumor agents. Chem. Pharm. Bull. 52, 1-26 (2004).
-
(2004)
Chem. Pharm. Bull.
, vol.52
, pp. 1-26
-
-
Cassady, J.M.1
Chan, K.K.2
Floss, H.G.3
Leistner, E.4
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