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Volumn 3, Issue 9, 2010, Pages 3005-3020

Oral hypoglycemic drugs: Pathophysiological basis of their mechanism of action

Author keywords

Hypoglycemic drugs; Incretin mimetics; Sulfonylureas; Thiazolidinediones

Indexed keywords

ACARBOSE; ACETOHEXAMIDE; ALPHA GLUCOSIDASE INHIBITOR; BIGUANIDE DERIVATIVE; CHLORPROPAMIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; GLIPIZIDE; GLITAZONE DERIVATIVE; INCRETIN; LIRAGLUTIDE; MEGLITINIDE; METFORMIN; MIGLITOL; NATEGLINIDE; ORAL ANTIDIABETIC AGENT; PIOGLITAZONE; REPAGLINIDE; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA DERIVATIVE; TOLAZAMIDE; TOLBUTAMIDE; UNINDEXED DRUG; VILDAGLIPTIN;

EID: 77957314296     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph3093005     Document Type: Review
Times cited : (122)

References (62)
  • 2
    • 0029099086 scopus 로고
    • Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus
    • The Multicenter Metformin Study Group
    • DeFronzo, R.A.; Goodman, A.M. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. N. Engl. J. Med. 1995, 333, 541-549.
    • (1995) N. Engl. J. Med , vol.333 , pp. 541-549
    • Defronzo, R.A.1    Goodman, A.M.2
  • 3
    • 0032929173 scopus 로고    scopus 로고
    • Efficacy of metformin in the treatment of NIDDM: A metanalysis
    • Johansen, K. Efficacy of metformin in the treatment of NIDDM: a metanalysis. Diabetes Care 1999, 22, 33-37.
    • (1999) Diabetes Care , vol.22 , pp. 33-37
    • Johansen, K.1
  • 4
    • 0029132285 scopus 로고
    • Worldwide experience of metformin as an effective glucose lowering agent: A metanalysis
    • Campbell, I.W.; Howlett, H.C.S. Worldwide experience of metformin as an effective glucose lowering agent: a metanalysis. Diabetes Metab. Rev. 1995, 11, 57-62.
    • (1995) Diabetes Metab. Rev , vol.11 , pp. 57-62
    • Campbell, I.W.1    Howlett, H.C.S.2
  • 5
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
    • Currie, C.J.; Poole, C.D.; Gale, E.A. The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009, 52, 1766-1777.
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.3
  • 6
    • 34548658535 scopus 로고    scopus 로고
    • Metformin, heart failure, and lactic acidosis: Is metformin absolutely contraindicated?
    • Tahrani, A.A.; Varughese, G.I.; Scarpello, J.H.; Hanna, F.W. Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated? Br. Med. J. 2007, 335, 508-512.
    • (2007) Br. Med. J , vol.335 , pp. 508-512
    • Tahrani, A.A.1    Varughese, G.I.2    Scarpello, J.H.3    Hanna, F.W.4
  • 7
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen, M.R.; Doran, E.; Halestrap, A.P. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J. 2000, 348, 607-614.
    • (2000) Biochem. J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 8
    • 44649110211 scopus 로고    scopus 로고
    • Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment
    • Bruijstens, L.A.; van Luin, M.; Buscher-Jungerhans, P.M.M; Bosch, F.H. Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment. Netherlands J. Med. 2008, 66, 185-190.
    • (2008) Netherlands J. Med , vol.66 , pp. 185-190
    • Bruijstens, L.A.1    van Luin, M.2    Buscher-Jungerhans, P.M.M.3    Bosch, F.H.4
  • 9
    • 24044478791 scopus 로고    scopus 로고
    • Metformin contraindications should be contraindicated
    • McCormack, J.; Johns, K.; Tildesley, H. Metformin contraindications should be contraindicated. Ca. Med. Ass. J. 2005, 173, 502-504.
    • (2005) Ca. Med. Ass. J , vol.173 , pp. 502-504
    • McCormack, J.1    Johns, K.2    Tildesley, H.3
  • 11
    • 0031396662 scopus 로고    scopus 로고
    • Pharmacological regulation of blood glucose levels in non-insulindependent diabetes mellitus
    • Bressler, R.; Johnson, D.G. Pharmacological regulation of blood glucose levels in non-insulindependent diabetes mellitus. Arch. Intern. Med. 1997, 157, 836-848.
    • (1997) Arch. Intern. Med , vol.157 , pp. 836-848
    • Bressler, R.1    Johnson, D.G.2
  • 12
    • 0030974812 scopus 로고    scopus 로고
    • Prospective randomized study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus
    • The DIGAMI Study Group
    • Malmberg, K.; The DIGAMI Study Group. Prospective randomized study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. Br. Med. J. 1997, 314, 1512-1515.
    • (1997) Br. Med. J , vol.314 , pp. 1512-1515
    • Malmberg, K.1
  • 14
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • United Kingdom Prospective Diabetes Study (UKPDS) Group, (Published erratum appears in Lancet 1999, 354, 602)
    • United Kingdom Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352, 837-853, (Published erratum appears in Lancet 1999, 354, 602).
    • (1998) Lancet , vol.837-853 , pp. 352
  • 16
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • DeFronzo, R.A. Pharmacologic therapy for type 2 diabetes mellitus. Ann. Intern. Med. 1999, 131, 281-303.
    • (1999) Ann. Intern. Med , vol.131 , pp. 281-303
    • Defronzo, R.A.1
  • 17
    • 70449360911 scopus 로고    scopus 로고
    • Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from ADVANCE trial
    • ADVANCE Collaborative Group; Cass, A.; Glasziou, P.; Harrap, S.; Lisheng, L.; Mancia, G.; Pillai, A.; Poulter, N.; Perkovic, V.; Travert, F
    • Zoungas, S.; de Galan, B.E.; Ninomiya, T.; Grobbee, D.; Hamet, P.; Heller, S.; MacMahon, S.; Marre, M.; Neal, B.; Patel, A.; Woodward, M.; Chalmers, J, ADVANCE Collaborative Group; Cass, A.; Glasziou, P.; Harrap, S.; Lisheng, L.; Mancia, G.; Pillai, A.; Poulter, N.; Perkovic, V.; Travert, F. Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from ADVANCE trial. Diabetes Care 2009, 32, 2068-2074.
    • (2009) Diabetes Care , vol.32 , pp. 2068-2074
    • Zoungas, S.1    de Galan, B.E.2    Ninomiya, T.3    Grobbee, D.4    Hamet, P.5    Heller, S.6    MacMahon, S.7    Marre, M.8    Neal, B.9    Patel, A.10    Woodward, M.11    Chalmers, J.12
  • 19
    • 0031892659 scopus 로고    scopus 로고
    • Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes
    • Fuhlendorff, J.; Rorsman, P.; Kofod, H.; Brand, C.L,; Rolin, B.; MacKay, P.; Shymko, R.; Carr, R.D. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes 1998, 47, 345-351.
    • (1998) Diabetes , vol.47 , pp. 345-351
    • Fuhlendorff, J.1    Rorsman, P.2    Kofod, H.3    Brand, C.L.4    Rolin, B.5    Mackay, P.6    Shymko, R.7    Carr, R.D.8
  • 21
    • 0037579664 scopus 로고    scopus 로고
    • Multinational Repaglinide Renal Study Group. Safety and efficacy of repaglinide in type 2 diabetic patients with and without impaired renal function
    • Hasslacher, C. Multinational Repaglinide Renal Study Group. Safety and efficacy of repaglinide in type 2 diabetic patients with and without impaired renal function. Diabetes Care 2003, 26, 886-891.
    • (2003) Diabetes Care , vol.26 , pp. 886-891
    • Hasslacher, C.1
  • 22
    • 19244365650 scopus 로고    scopus 로고
    • Drug Therapy: Thiazolidinediones
    • Yki-Jarvinen, H. Drug Therapy: Thiazolidinediones. N. Engl. J. Med. 2004, 351, 1106-1118.
    • (2004) N. Engl. J. Med , vol.351 , pp. 1106-1118
    • Yki-Jarvinen, H.1
  • 24
    • 33846964860 scopus 로고    scopus 로고
    • Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes
    • Kolak, M.; Yki-Jarvinen, H.; Kannisto, K. Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 2007, 92, 720-724.
    • (2007) J. Clin. Endocrinol. Metab , vol.92 , pp. 720-724
    • Kolak, M.1    Yki-Jarvinen, H.2    Kannisto, K.3
  • 25
    • 0030977450 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
    • Vidal-Puig, A.J.; Considine, R.V.; Jimenez-Linan, M.; Werman, A.; Pories, W.J.; Caro, J.F.; Flier, J.S. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J. Clin. Invest. 1997, 99, 2416-2422.
    • (1997) J. Clin. Invest , vol.99 , pp. 2416-2422
    • Vidal-Puig, A.J.1    Considine, R.V.2    Jimenez-Linan, M.3    Werman, A.4    Pories, W.J.5    Caro, J.F.6    Flier, J.S.7
  • 26
    • 0004473133 scopus 로고    scopus 로고
    • PPARgamma Gene Expression is Elevated In Skeletal Muscle of Obese and Type II Diabetic Subjects
    • Park, K.S.; Ciaraldi, T.P.; Abrams-Carter, L.; Mudaliar, S.; Nikoulina, S.E.; Henry, R.R. PPARgamma Gene Expression is Elevated In Skeletal Muscle of Obese and Type II Diabetic Subjects. Diabetes 1997, 46, 1230-1234.
    • (1997) Diabetes , vol.46 , pp. 1230-1234
    • Park, K.S.1    Ciaraldi, T.P.2    Mudaliar, S.3    Nikoulina, S.E.4    Henry, R.R.5
  • 27
    • 33847006604 scopus 로고    scopus 로고
    • Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism
    • Sharma, A.M.; Staels, B. Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism. J. Clin. Endocrinol. Metab. 2007, 92, 386-395.
    • (2007) J. Clin. Endocrinol. Metab , vol.92 , pp. 386-395
    • Sharma, A.M.1    Staels, B.2
  • 28
    • 28144451163 scopus 로고    scopus 로고
    • Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus
    • Nissen, S.E.; Wolski, K.; Topol, E.J. Effect of muraglitazar on death and major adverse cardiovascular events in patients with type 2 diabetes mellitus. JAMA 2005, 294, 2581-2586.
    • (2005) JAMA , vol.294 , pp. 2581-2586
    • Nissen, S.E.1    Wolski, K.2    Topol, E.J.3
  • 29
    • 67649839953 scopus 로고    scopus 로고
    • Effect of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): A phase II, randomised, dose-ranging study
    • Henry, R.R.; Lincoff, A.M.; Mudaliar, S.; Rabbia, M.; Chognot, C.; Herz, M.; Effect of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study. Lancet 2009, 374, 126-135.
    • (2009) Lancet , vol.374 , pp. 126-135
    • Henry, R.R.1    Lincoff, A.M.2    Mudaliar, S.3    Rabbia, M.4    Chognot, C.5    Herz, M.6
  • 30
    • 33847403059 scopus 로고    scopus 로고
    • A randomized trial of the effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetes
    • Stocker, D.J.; Taylor, A.J.; Langley, R.W.; Jezior, M.R.; Vigersky, R.A. A randomized trial of the effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetes. Am. Heart J. 2007, 153, 445.e1-6.
    • (2007) Am. Heart J , vol.153 , Issue.445
    • Stocker, D.J.1    Taylor, A.J.2    Langley, R.W.3    Jezior, M.R.4    Vigersky, R.A.5
  • 31
    • 33845400193 scopus 로고    scopus 로고
    • Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: A randomized trial
    • Mazzone, T.; Meyer, P.M.; Feinstein, S.B.; Davidson, M.H.; Kondos, G.T.; D'Agostino, R.B.; Sr, Perez, A.; Provost, J.C.; Haffner, S.M.;Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial. JAMA 2006, 296, 2572-2581.
    • (2006) JAMA , vol.296 , pp. 2572-2581
    • Mazzone, T.1    Meyer, P.M.2    Feinstein, S.B.3    Davidson, M.H.4    Kondos, G.T.5    D'Agostino, R.B.6    Provost, J.C.7    Haffner, S.M.8
  • 32
    • 33846961821 scopus 로고    scopus 로고
    • Differential effects of oral hypoglycemic agents on glucose control and cardiovascular risk
    • Uwaifo, G.I.; Ratner, R.E. Differential effects of oral hypoglycemic agents on glucose control and cardiovascular risk. Am. J. Cardiol. 2007, 99, 51B-67B.
    • (2007) Am. J. Cardiol , vol.99
    • Uwaifo, G.I.1    Ratner, R.E.2
  • 34
    • 34250212715 scopus 로고    scopus 로고
    • Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
    • Nissen, S.E.; Wolski, K. Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes. N. Engl. J. Med. 2007, 356, 2457-2471.
    • (2007) N. Engl. J. Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 35
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials
    • Lincoff, A.M.; Wolski, K.; Nicholls, S.J.; Nissen, S.E. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA 2007, 298, 1180-1188.
    • (2007) JAMA , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 36
    • 34548303246 scopus 로고    scopus 로고
    • The Rosiglitazone Story - Lessons from an FDA Advisory Committee Meeting
    • Rosen, C.J. The Rosiglitazone Story - Lessons from an FDA Advisory Committee Meeting. N. Engl. J. Med. 2007, 357, 844-846.
    • (2007) N. Engl. J. Med , vol.357 , pp. 844-846
    • Rosen, C.J.1
  • 37
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with rosiglitazone: A meta-analysis
    • Singh, S. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA 2007, 298, 1189-1195.
    • (2007) JAMA , vol.298 , pp. 1189-1195
    • Singh, S.1
  • 38
    • 34548330055 scopus 로고    scopus 로고
    • Rosiglitazone for type 2 diabetes mellitus
    • Art. No.: CD006063; doi: 10.1002/14651858.CD006063.pub2
    • Richter, B.; Bandeira-Echtler, E.; Bergerhoff, K.; Clar, C.; Ebrahim, S.H. Rosiglitazone for type 2 diabetes mellitus. Cochrane Database Syst. Rev. 2007, 3. Art. No.: CD006063; doi: 10.1002/14651858.CD006063.pub2.
    • (2007) Cochrane Database Syst. Rev , pp. 3
    • Richter, B.1
  • 39
    • 35848930559 scopus 로고    scopus 로고
    • Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death
    • Diamond, G.A.; Bax, L.; Kaul, S. Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular death. Ann. Intern. Med. 2007, 147, 578-581.
    • (2007) Ann. Intern. Med , vol.147 , pp. 578-581
    • Diamond, G.A.1    Bax, L.2    Kaul, S.3
  • 41
    • 67149146438 scopus 로고    scopus 로고
    • RECORD Study Team;Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): A multicentre, randomised, open-label trial
    • Home, P.D.; Pocock, S.J.; Beck-Nielsen, H.; Curtis, P.S.; Gomis, R.; Hanefeld, M.; Jones, N.P.; Komajda, M.; McMurray, J.J. RECORD Study Team;Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 2009, 373, 2125-2135.
    • (2009) Lancet , vol.373 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3    Curtis, P.S.4    Gomis, R.5    Hanefeld, M.6    Jones, N.P.7    Komajda, M.8    McMurray, J.J.9
  • 43
    • 23844472901 scopus 로고    scopus 로고
    • Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption
    • Guan, Y.; Hao, C.; Cha, D.R. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat. Med. 2005, 11, 861-866.
    • (2005) Nat. Med , vol.11 , pp. 861-866
    • Guan, Y.1    Hao, C.2    Cha, D.R.3
  • 45
    • 0027947449 scopus 로고
    • The efficacy of acarbose in the treatment of patients with non-insulindependent diabetes mellitus. A multicenter controlled clinical trial
    • Chiasson, J.L.; Josse, R.G.; Hunt, J.A.; Palmason, C.; Rodger, N.W.; Ross, S.A.; Ryan, E.A.; Tan, M.H.; Wolever, T.M. The efficacy of acarbose in the treatment of patients with non-insulindependent diabetes mellitus. A multicenter controlled clinical trial. Ann. Intern. Med. 1994, 121, 928-935.
    • (1994) Ann. Intern. Med , vol.121 , pp. 928-935
    • Chiasson, J.L.1    Josse, R.G.2    Hunt, J.A.3    Palmason, C.4    Rodger, N.W.5    Ross, S.A.6    Ryan, E.A.7    Tan, M.H.8    Wolever, T.M.9
  • 46
    • 63849220179 scopus 로고    scopus 로고
    • Incretin-Based Therapies in Type 2 Diabetes Mellitus
    • Chee, W.; Egan, C.; Egan, J.M. Incretin-Based Therapies in Type 2 Diabetes Mellitus. Curr. Protein Pept. Sci. 2009, 10, 46-55.
    • (2009) Curr. Protein Pept. Sci , vol.10 , pp. 46-55
    • Chee, W.1    Egan, C.2    Egan, J.M.3
  • 47
    • 0032982267 scopus 로고    scopus 로고
    • Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion
    • Rocca, A.S.; Brubaker, P.L. Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion. Endocrinology 1999, 140, 1687-1694.
    • (1999) Endocrinology , vol.140 , pp. 1687-1694
    • Rocca, A.S.1    Brubaker, P.L.2
  • 48
    • 22744442874 scopus 로고    scopus 로고
    • Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors
    • Demuth, H.U.; McIntosh, C.H.; Pederson, R.A. Type 2 diabetes--therapy with dipeptidyl peptidase IV inhibitors. Biochim. Biophys. Acta 2005, 1751, 33-34.
    • (2005) Biochim. Biophys. Acta , vol.1751 , pp. 33-34
    • Demuth, H.U.1    McIntosh, C.H.2    Pederson, R.A.3
  • 49
    • 0036323269 scopus 로고    scopus 로고
    • Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells
    • Abraham, E.J.; Leech, C.A.; Lin, J.C.; Zulewski, H.; Habener, J.F. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology 2002, 143, 3152-3161.
    • (2002) Endocrinology , vol.143 , pp. 3152-3161
    • Abraham, E.J.1    Leech, C.A.2    Lin, J.C.3    Zulewski, H.4    Habener, J.F.5
  • 50
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker, D.J. The biology of incretin hormones. Cell. Metab. 2006, 3, 153-65.
    • (2006) Cell. Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 52
    • 68949159829 scopus 로고    scopus 로고
    • Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors Pharmacol
    • Verspohl, E.J. Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors Pharmacol. Ther. 2009, 124, 113-138.
    • (2009) Ther , vol.124 , pp. 113-138
    • Verspohl, E.J.1
  • 53
    • 7444228521 scopus 로고    scopus 로고
    • Exenatide-113 Clinical Study Group; Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylureatreated patients with type 2 diabetes
    • Buse, J.B.; Henry, R.R.; Han, J.; Kim, D.D.; Fineman, M.S.; Baron, A.D. Exenatide-113 Clinical Study Group; Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylureatreated patients with type 2 diabetes. Diabetes Care 2004, 27, 2628-2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 54
    • 53249142132 scopus 로고    scopus 로고
    • DURATION-1 Study Group; Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • Drucker, D.J.; Buse, J.B.; Taylor, K.; Kendall, D.M.; Trautmann, M.; Zhuang, D.; Porter, L. DURATION-1 Study Group; Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008, 372, 1240-1250.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3    Kendall, D.M.4    Trautmann, M.5    Zhuang, D.6    Porter, L.7
  • 55
    • 26944477362 scopus 로고    scopus 로고
    • GWAA Study Group; Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: A randomized trial
    • Heine, R.J.; Van Gaal, L.F.; Johns, D.; Mihm, M.J.; Widel, M.H.; Brodows, R.G. GWAA Study Group; Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial. Ann. Intern. Med. 2005, 143, 559-569.
    • (2005) Ann. Intern. Med , vol.143 , pp. 559-569
    • Heine, R.J.1    van Gaal, L.F.2    Johns, D.3    Mihm, M.J.4    Widel, M.H.5    Brodows, R.G.6
  • 56
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin treated patients with type 2 diabetes
    • De Fronzo, R.A.; Ratner, R.E.; Han, J.; Kim, D.D.; Fineman, M.S.; Baron, A.D. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin treated patients with type 2 diabetes. Diabetes Care 2005, 28, 1092-1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • de Fronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 57
    • 77957312776 scopus 로고    scopus 로고
    • FDC reports
    • FDC reports. The Pink Sheet. 2008, 70, 9.
    • (2008) The Pink Sheet , vol.70 , pp. 9
  • 58
    • 0036066641 scopus 로고    scopus 로고
    • Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reducesfasting and postprandial glycemia in type 2 diabetes
    • Juhl, C.B.; Hollingdal, M.; Sturis, J.; Jakobsen, G.; Agersø, H.; Veldhuis, J.; Pørksen, N.; Schmitz, O. Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reducesfasting and postprandial glycemia in type 2 diabetes. Diabetes 2002, 51, 424-429.
    • (2002) Diabetes , vol.51 , pp. 424-429
    • Juhl, C.B.1    Hollingdal, M.2    Sturis, J.3    Jakobsen, G.4    Agersø, H.5    Veldhuis, J.6    Pørksen, N.7    Schmitz, O.8
  • 59
    • 34249891874 scopus 로고    scopus 로고
    • Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
    • Kim, D.; MacConell, L.; Zhuang, D.; Kothare, P.A.; Trautmann, M.; Fineman, M.; Taylor, K. Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. Diabetes Care 2007, 30, 1487-1493.
    • (2007) Diabetes Care , vol.30 , pp. 1487-1493
    • Kim, D.1    Macconell, L.2    Zhuang, D.3    Kothare, P.A.4    Trautmann, M.5    Fineman, M.6    Taylor, K.7
  • 61
    • 33749993064 scopus 로고    scopus 로고
    • Multiple dose administration ofMK-0431 (sitagliptin), an inhibitor of dipeptidyl peptidase-IV, does not meaningfully alter the plasma pharmacokinetics or pharmacodynamics of single doses of warfarin
    • Wright, D.; Maes, A.L.; Yi, B.; Liu, Q.; Johnson-Levonas, A.O.; Wagner, J.A. Multiple dose administration ofMK-0431 (sitagliptin), an inhibitor of dipeptidyl peptidase-IV, does not meaningfully alter the plasma pharmacokinetics or pharmacodynamics of single doses of warfarin. Clin. Pharmacol. Ther. 2006, 79, 76-76.
    • (2006) Clin. Pharmacol. Ther , vol.79 , pp. 76-76
    • Wright, D.1    Maes, A.L.2    Yi, B.3    Liu, Q.4    Johnson-Levonas, A.O.5    Wagner, J.A.6
  • 62
    • 53049091868 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 as a new target of action for type 2 diabetes mellitus: A systematic review
    • Wani, J.H.; John-Kalarickal, J.; Fonseca, V.A. Dipeptidyl peptidase-4 as a new target of action for type 2 diabetes mellitus: a systematic review. Cardiol. Clin. 2008, 26, 639-648.
    • (2008) Cardiol. Clin , vol.26 , pp. 639-648
    • Wani, J.H.1    John-Kalarickal, J.2    Fonseca, V.A.3


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