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Volumn 26, Issue 4, 2008, Pages 639-648

Dipeptidyl Peptidase-4 as a New Target of Action for Type 2 Diabetes Mellitus: A Systematic Review

Author keywords

Diabetes type 2; Dipeptidyl peptidase 4 inhibitor; DPP 4 inhibitors; Glycohemoglobin A1c; Incretins; Sitagliptin; Vildagliptin

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C; INCRETIN; INSULIN; METFORMIN; MK 04310; PIOGLITAZONE; PLACEBO; PRAMLINTIDE; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 53049091868     PISSN: 07338651     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccl.2008.06.008     Document Type: Review
Times cited : (30)

References (61)
  • 1
    • 0029840022 scopus 로고    scopus 로고
    • The UK prospective diabetes study. UK Prospective Diabetes Study Group
    • Turner R.C., and Holman R.R. The UK prospective diabetes study. UK Prospective Diabetes Study Group. Ann Med 28 5 (1996) 439-444
    • (1996) Ann Med , vol.28 , Issue.5 , pp. 439-444
    • Turner, R.C.1    Holman, R.R.2
  • 2
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler A.E., Janson J., Bonner-Weir S., et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52 1 (2003) 102-110
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3
  • 4
    • 15044352155 scopus 로고    scopus 로고
    • The [pre-] history of the incretin concept
    • Creutzfeldt W. The [pre-] history of the incretin concept. Regul Pept 128 2 (2005) 87-91
    • (2005) Regul Pept , vol.128 , Issue.2 , pp. 87-91
    • Creutzfeldt, W.1
  • 5
    • 0014188893 scopus 로고
    • Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects
    • Perley M.J., and Kipnis D.M. Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 46 12 (1967) 1954-1962
    • (1967) J Clin Invest , vol.46 , Issue.12 , pp. 1954-1962
    • Perley, M.J.1    Kipnis, D.M.2
  • 6
    • 17944365214 scopus 로고    scopus 로고
    • A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans
    • Verdich C., Flint A., Gutzwiller J.P., et al. A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans. J Clin Endocrinol Metab 86 9 (2001) 4382-4389
    • (2001) J Clin Endocrinol Metab , vol.86 , Issue.9 , pp. 4382-4389
    • Verdich, C.1    Flint, A.2    Gutzwiller, J.P.3
  • 7
    • 0030068620 scopus 로고    scopus 로고
    • Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients
    • Willms B., Werner J., Holst J.J., et al. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 81 1 (1996) 327-332
    • (1996) J Clin Endocrinol Metab , vol.81 , Issue.1 , pp. 327-332
    • Willms, B.1    Werner, J.2    Holst, J.J.3
  • 8
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (noninsulin-dependent) diabetes
    • Nauck M., Stockmann F., Ebert R., et al. Reduced incretin effect in type 2 (noninsulin-dependent) diabetes. Diabetologia 29 1 (1986) 46-52
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3
  • 9
    • 0035512742 scopus 로고    scopus 로고
    • Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
    • Meier J.J., Hucking K., Holst J.J., et al. Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes. Diabetes 50 11 (2001) 2497-2504
    • (2001) Diabetes , vol.50 , Issue.11 , pp. 2497-2504
    • Meier, J.J.1    Hucking, K.2    Holst, J.J.3
  • 10
    • 0035041250 scopus 로고    scopus 로고
    • Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    • Lynn F.C., Pamir N., Ng E.H., et al. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 50 5 (2001) 1004-1011
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 1004-1011
    • Lynn, F.C.1    Pamir, N.2    Ng, E.H.3
  • 11
    • 0037268159 scopus 로고    scopus 로고
    • A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells
    • Lynn F.C., Thompson S.A., Pospisilik J.A., et al. A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells. FASEB J 17 1 (2003) 91-93
    • (2003) FASEB J , vol.17 , Issue.1 , pp. 91-93
    • Lynn, F.C.1    Thompson, S.A.2    Pospisilik, J.A.3
  • 12
    • 31844433106 scopus 로고    scopus 로고
    • The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes
    • Zander M., Madsbad S., Deacon C.F., et al. The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes. Diabetologia 49 2 (2006) 369-374
    • (2006) Diabetologia , vol.49 , Issue.2 , pp. 369-374
    • Zander, M.1    Madsbad, S.2    Deacon, C.F.3
  • 13
    • 33749834648 scopus 로고    scopus 로고
    • DPP-4 inhibitors and their potential role in the management of type 2 diabetes
    • Barnett A. DPP-4 inhibitors and their potential role in the management of type 2 diabetes. Int J Clin Pract 60 11 (2006) 1454-1470
    • (2006) Int J Clin Pract , vol.60 , Issue.11 , pp. 1454-1470
    • Barnett, A.1
  • 14
    • 0028823181 scopus 로고
    • CD26 (dipeptidyl peptidase IV/DPP IV) as a novel molecular marker for differentiated thyroid carcinoma
    • Tanaka T., Umeki K., Yamamoto I., et al. CD26 (dipeptidyl peptidase IV/DPP IV) as a novel molecular marker for differentiated thyroid carcinoma. Int J Cancer 64 5 (1995) 326-331
    • (1995) Int J Cancer , vol.64 , Issue.5 , pp. 326-331
    • Tanaka, T.1    Umeki, K.2    Yamamoto, I.3
  • 15
    • 0033760338 scopus 로고    scopus 로고
    • Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer
    • Cordero O.J., Ayude D., Nogueira M., et al. Preoperative serum CD26 levels: diagnostic efficiency and predictive value for colorectal cancer. Br J Cancer 83 9 (2000) 1139-1146
    • (2000) Br J Cancer , vol.83 , Issue.9 , pp. 1139-1146
    • Cordero, O.J.1    Ayude, D.2    Nogueira, M.3
  • 16
    • 0031916924 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig
    • Deacon C.F., Hughes T.E., and Holst J.J. Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig. Diabetes 47 5 (1998) 764-769
    • (1998) Diabetes , vol.47 , Issue.5 , pp. 764-769
    • Deacon, C.F.1    Hughes, T.E.2    Holst, J.J.3
  • 17
    • 39749184723 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes
    • Raz I., Chen Y., Wu M., et al. Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes. Curr Med Res Opin 24 2 (2008) 537-550
    • (2008) Curr Med Res Opin , vol.24 , Issue.2 , pp. 537-550
    • Raz, I.1    Chen, Y.2    Wu, M.3
  • 18
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
    • Mu J., Woods J., Zhou Y.P., et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 55 6 (2006) 1695-1704
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.P.3
  • 19
    • 28844482322 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses
    • Herman G.A., Stevens C., Van Dyck K., et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clin Pharmacol Ther 78 6 (2005) 675-688
    • (2005) Clin Pharmacol Ther , vol.78 , Issue.6 , pp. 675-688
    • Herman, G.A.1    Stevens, C.2    Van Dyck, K.3
  • 20
    • 32844473903 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebo-controlled study in healthy male volunteers
    • Bergman A.J., Stevens C., Zhou Y., et al. Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebo-controlled study in healthy male volunteers. Clin Ther 28 1 (2006) 55-72
    • (2006) Clin Ther , vol.28 , Issue.1 , pp. 55-72
    • Bergman, A.J.1    Stevens, C.2    Zhou, Y.3
  • 21
    • 33749871472 scopus 로고    scopus 로고
    • Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
    • Herman G.A., Bergman A., Stevens C., et al. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab 91 11 (2006) 4612-4619
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.11 , pp. 4612-4619
    • Herman, G.A.1    Bergman, A.2    Stevens, C.3
  • 22
    • 33846443331 scopus 로고    scopus 로고
    • Sitagliptin, a DPP-4 inhibitor: an overview of the pharmacokinetic (PK) profile and the propensity for drug-drug interactions (DDI)
    • [abstract]
    • Herman G., Bergman A., and Wagner J.A. Sitagliptin, a DPP-4 inhibitor: an overview of the pharmacokinetic (PK) profile and the propensity for drug-drug interactions (DDI). [abstract]. Diabetologia 49 Suppl 1 (2006) 481-482
    • (2006) Diabetologia , vol.49 , Issue.SUPPL. 1 , pp. 481-482
    • Herman, G.1    Bergman, A.2    Wagner, J.A.3
  • 23
    • 33745909432 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects
    • Herman G.A., Bergman A., Liu F., et al. Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects. J Clin Pharmacol 46 8 (2006) 876-886
    • (2006) J Clin Pharmacol , vol.46 , Issue.8 , pp. 876-886
    • Herman, G.A.1    Bergman, A.2    Liu, F.3
  • 24
    • 34548820996 scopus 로고    scopus 로고
    • Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers
    • Bergman A., Ebel D., Liu F., et al. Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers. Biopharm Drug Dispos 28 6 (2007) 315-322
    • (2007) Biopharm Drug Dispos , vol.28 , Issue.6 , pp. 315-322
    • Bergman, A.1    Ebel, D.2    Liu, F.3
  • 25
    • 33645037183 scopus 로고    scopus 로고
    • Effect of MK-0431, a dipeptidyl peptidase IV (DPP-4) inhibitor, on glycemic control after 12 weeks in patients with type 2 diabetes
    • Hanefeld M., Herman G., Mickel C., et al. Effect of MK-0431, a dipeptidyl peptidase IV (DPP-4) inhibitor, on glycemic control after 12 weeks in patients with type 2 diabetes. Diabetologia 48 Suppl 1 (2005) 287-288
    • (2005) Diabetologia , vol.48 , Issue.SUPPL. 1 , pp. 287-288
    • Hanefeld, M.1    Herman, G.2    Mickel, C.3
  • 26
    • 33845489598 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
    • Raz I., Hanefeld M., Xu L., et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus. Diabetologia 49 11 (2006) 2564-2571
    • (2006) Diabetologia , vol.49 , Issue.11 , pp. 2564-2571
    • Raz, I.1    Hanefeld, M.2    Xu, L.3
  • 27
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P., Kipnes M.S., Lunceford J.K., et al. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 29 12 (2006) 2632-2637
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3
  • 28
    • 33847024333 scopus 로고    scopus 로고
    • Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes
    • Scott R., Wu M., Sanchez M., et al. Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Int J Clin Pract 61 1 (2007) 171-180
    • (2007) Int J Clin Pract , vol.61 , Issue.1 , pp. 171-180
    • Scott, R.1    Wu, M.2    Sanchez, M.3
  • 29
    • 0035097211 scopus 로고    scopus 로고
    • Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects
    • Mannucci E., Ognibene A., Cremasco F., et al. Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects. Diabetes Care 24 3 (2001) 489-494
    • (2001) Diabetes Care , vol.24 , Issue.3 , pp. 489-494
    • Mannucci, E.1    Ognibene, A.2    Cremasco, F.3
  • 30
    • 34547660561 scopus 로고    scopus 로고
    • Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes
    • Goldstein B.J., Feinglos M.N., Lunceford J.K., et al. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care 30 8 (2007) 1979-1987
    • (2007) Diabetes Care , vol.30 , Issue.8 , pp. 1979-1987
    • Goldstein, B.J.1    Feinglos, M.N.2    Lunceford, J.K.3
  • 31
    • 33750517754 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when coadministered in patients with type 2 diabetes
    • Herman G.A., Bergman A., Yi B., et al. Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when coadministered in patients with type 2 diabetes. Curr Med Res Opin 22 10 (2006) 1939-1947
    • (2006) Curr Med Res Opin , vol.22 , Issue.10 , pp. 1939-1947
    • Herman, G.A.1    Bergman, A.2    Yi, B.3
  • 32
    • 33846796143 scopus 로고    scopus 로고
    • Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes
    • Brazg R., Xu L., Dalla Man C., et al. Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes. Diabetes Obes Metab 9 2 (2007) 186-193
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 186-193
    • Brazg, R.1    Xu, L.2    Dalla Man, C.3
  • 33
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B., Karasik A., Liu J., et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 29 12 (2006) 2638-2643
    • (2006) Diabetes Care , vol.29 , Issue.12 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3
  • 34
    • 34547863123 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin
    • Hermansen K., Kipnes M., Luo E., et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin. Diabetes Obes Metab 9 5 (2007) 733-745
    • (2007) Diabetes Obes Metab , vol.9 , Issue.5 , pp. 733-745
    • Hermansen, K.1    Kipnes, M.2    Luo, E.3
  • 35
    • 33846817233 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, noninferiority trial
    • Nauck M.A., Meininger G., Sheng D., et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, noninferiority trial. Diabetes Obes Metab 9 2 (2007) 194-205
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3
  • 36
    • 33751557143 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
    • Rosenstock J., Brazg R., Andryuk P.J., et al. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 28 10 (2006) 1556-1568
    • (2006) Clin Ther , vol.28 , Issue.10 , pp. 1556-1568
    • Rosenstock, J.1    Brazg, R.2    Andryuk, P.J.3
  • 37
    • 33846404842 scopus 로고    scopus 로고
    • Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects
    • Mistry G.C., Bergman A.J., Luo W.L., et al. Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects. J Clin Pharmacol 47 2 (2007) 159-164
    • (2007) J Clin Pharmacol , vol.47 , Issue.2 , pp. 159-164
    • Mistry, G.C.1    Bergman, A.J.2    Luo, W.L.3
  • 38
    • 0028042205 scopus 로고
    • Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats
    • Barragan J.M., Rodriguez R.E., and Blazquez E. Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats. Am J Physiol 266 3 Pt 1 (1994) E459-E466
    • (1994) Am J Physiol , vol.266 , Issue.3 PART 1
    • Barragan, J.M.1    Rodriguez, R.E.2    Blazquez, E.3
  • 39
    • 0036307872 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    • Yamamoto H., Lee C.E., Marcus J.N., et al. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest 110 1 (2002) 43-52
    • (2002) J Clin Invest , vol.110 , Issue.1 , pp. 43-52
    • Yamamoto, H.1    Lee, C.E.2    Marcus, J.N.3
  • 40
    • 0032976939 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients
    • Toft-Nielsen M.B., Madsbad S., and Holst J.J. Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. Diabetes Care 22 7 (1999) 1137-1143
    • (1999) Diabetes Care , vol.22 , Issue.7 , pp. 1137-1143
    • Toft-Nielsen, M.B.1    Madsbad, S.2    Holst, J.J.3
  • 41
    • 41849099939 scopus 로고    scopus 로고
    • Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild-to-moderate hypertension
    • Mistry G.C., Maes A.L., Lasseter K.C., et al. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild-to-moderate hypertension. J Clin Pharmacol 48 5 (2008) 592-598
    • (2008) J Clin Pharmacol , vol.48 , Issue.5 , pp. 592-598
    • Mistry, G.C.1    Maes, A.L.2    Lasseter, K.C.3
  • 42
    • 27744540889 scopus 로고    scopus 로고
    • Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response
    • Ristic S., Byiers S., Foley J., et al. Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response. Diabetes Obes Metab 7 6 (2005) 692-698
    • (2005) Diabetes Obes Metab , vol.7 , Issue.6 , pp. 692-698
    • Ristic, S.1    Byiers, S.2    Foley, J.3
  • 43
    • 2442482515 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
    • Ahren B., Landin-Olsson M., Jansson P.A., et al. Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes. J Clin Endocrinol Metab 89 5 (2004) 2078-2084
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.5 , pp. 2078-2084
    • Ahren, B.1    Landin-Olsson, M.2    Jansson, P.A.3
  • 44
    • 33745903093 scopus 로고    scopus 로고
    • Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
    • Pratley R.E., Jauffret-Kamel S., Galbreath E., et al. Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes. Horm Metab Res 38 6 (2006) 423-428
    • (2006) Horm Metab Res , vol.38 , Issue.6 , pp. 423-428
    • Pratley, R.E.1    Jauffret-Kamel, S.2    Galbreath, E.3
  • 45
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes
    • Pi-Sunyer F.X., Schweizer A., Mills D., et al. Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes. Diabetes Res Clin Pract 76 1 (2007) 132-138
    • (2007) Diabetes Res Clin Pract , vol.76 , Issue.1 , pp. 132-138
    • Pi-Sunyer, F.X.1    Schweizer, A.2    Mills, D.3
  • 46
    • 33847687205 scopus 로고    scopus 로고
    • Vildagliptin in drug-naive patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study
    • Dejager S., Razac S., Foley J.E., et al. Vildagliptin in drug-naive patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study. Horm Metab Res 39 3 (2007) 218-223
    • (2007) Horm Metab Res , vol.39 , Issue.3 , pp. 218-223
    • Dejager, S.1    Razac, S.2    Foley, J.E.3
  • 47
    • 34147189738 scopus 로고    scopus 로고
    • The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
    • Balas B., Baig M.R., Watson C., et al. The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients. J Clin Endocrinol Metab 92 4 (2007) 1249-1255
    • (2007) J Clin Endocrinol Metab , vol.92 , Issue.4 , pp. 1249-1255
    • Balas, B.1    Baig, M.R.2    Watson, C.3
  • 48
    • 36749024547 scopus 로고    scopus 로고
    • Improved meal-related insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes
    • Ahren B., Pacini G., Tura A., et al. Improved meal-related insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes. Horm Metab Res 39 11 (2007) 826-829
    • (2007) Horm Metab Res , vol.39 , Issue.11 , pp. 826-829
    • Ahren, B.1    Pacini, G.2    Tura, A.3
  • 49
    • 0037667613 scopus 로고    scopus 로고
    • Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes
    • Meier J.J., Gallwitz B., Salmen S., et al. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. J Clin Endocrinol Metab 88 6 (2003) 2719-2725
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.6 , pp. 2719-2725
    • Meier, J.J.1    Gallwitz, B.2    Salmen, S.3
  • 50
    • 34248169217 scopus 로고    scopus 로고
    • Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes
    • Vella A., Bock G., Giesler P.D., et al. Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes. Diabetes 56 5 (2007) 1475-1480
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1475-1480
    • Vella, A.1    Bock, G.2    Giesler, P.D.3
  • 51
    • 38149137991 scopus 로고    scopus 로고
    • Characterization of the influence of vildagliptin on model-assessed cell function in patients with type 2 diabetes and mild hyperglycemia
    • Mari A., Scherbaum W.A., Nilsson P.M., et al. Characterization of the influence of vildagliptin on model-assessed cell function in patients with type 2 diabetes and mild hyperglycemia. J Clin Endocrinol Metab 93 1 (2008) 103-109
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.1 , pp. 103-109
    • Mari, A.1    Scherbaum, W.A.2    Nilsson, P.M.3
  • 52
    • 38149096290 scopus 로고    scopus 로고
    • Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance
    • Rosenstock J., Foley J.E., Rendell M., et al. Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance. Diabetes Care 31 1 (2008) 30-35
    • (2008) Diabetes Care , vol.31 , Issue.1 , pp. 30-35
    • Rosenstock, J.1    Foley, J.E.2    Rendell, M.3
  • 53
    • 37149006184 scopus 로고    scopus 로고
    • Management of type 2 diabetes in treatment-naive elderly patients: benefits and risks of vildagliptin monotherapy
    • Pratley R.E., Rosenstock J., Pi-Sunyer F.X., et al. Management of type 2 diabetes in treatment-naive elderly patients: benefits and risks of vildagliptin monotherapy. Diabetes Care 30 12 (2007) 3017-3022
    • (2007) Diabetes Care , vol.30 , Issue.12 , pp. 3017-3022
    • Pratley, R.E.1    Rosenstock, J.2    Pi-Sunyer, F.X.3
  • 54
    • 34548118796 scopus 로고    scopus 로고
    • Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naive patients with type 2 diabetes
    • Schweizer A., Couturier A., Foley J.E., et al. Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naive patients with type 2 diabetes. Diabet Med 24 9 (2007) 955-961
    • (2007) Diabet Med , vol.24 , Issue.9 , pp. 955-961
    • Schweizer, A.1    Couturier, A.2    Foley, J.E.3
  • 55
    • 33846694046 scopus 로고    scopus 로고
    • Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial
    • Rosenstock J., Baron M.A., Dejager S., et al. Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabetes Care 30 2 (2007) 217-223
    • (2007) Diabetes Care , vol.30 , Issue.2 , pp. 217-223
    • Rosenstock, J.1    Baron, M.A.2    Dejager, S.3
  • 56
    • 9444285818 scopus 로고    scopus 로고
    • Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
    • Ahren B., Gomis R., Standl E., et al. Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes. Diabetes Care 27 12 (2004) 2874-2880
    • (2004) Diabetes Care , vol.27 , Issue.12 , pp. 2874-2880
    • Ahren, B.1    Gomis, R.2    Standl, E.3
  • 57
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E., Camisasca R.P., Collober C., et al. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 30 4 (2007) 890-895
    • (2007) Diabetes Care , vol.30 , Issue.4 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3
  • 58
    • 33846828660 scopus 로고    scopus 로고
    • Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study
    • Garber A.J., Schweizer A., Baron M.A., et al. Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab 9 2 (2007) 166-174
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 166-174
    • Garber, A.J.1    Schweizer, A.2    Baron, M.A.3
  • 59
    • 33846827085 scopus 로고    scopus 로고
    • Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes
    • Rosenstock J., Baron M.A., Camisasca R.P., et al. Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 9 2 (2007) 175-185
    • (2007) Diabetes Obes Metab , vol.9 , Issue.2 , pp. 175-185
    • Rosenstock, J.1    Baron, M.A.2    Camisasca, R.P.3
  • 60
    • 34247874561 scopus 로고    scopus 로고
    • Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
    • Fonseca V., Schweizer A., Albrecht D., et al. Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes. Diabetologia 50 6 (2007) 1148-1155
    • (2007) Diabetologia , vol.50 , Issue.6 , pp. 1148-1155
    • Fonseca, V.1    Schweizer, A.2    Albrecht, D.3
  • 61
    • 38349126264 scopus 로고    scopus 로고
    • Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetes
    • Nonaka K., Kakikawa T., Sato A., et al. Efficacy and safety of sitagliptin monotherapy in Japanese patients with type 2 diabetes. Diabetes Res Clin Pract 79 2 (2008) 291-298
    • (2008) Diabetes Res Clin Pract , vol.79 , Issue.2 , pp. 291-298
    • Nonaka, K.1    Kakikawa, T.2    Sato, A.3


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