Contribution of amino acid region 659-663 of factor Va heavy chain to the activity of factor Xa within prothrombinase

Biochemistry

Volumn 49, Issue 39, 2010, Pages 8520-8534

  Hirbawi, Jamila ^a,b   Vaughn, John L ^a   Bukys, Michael A ^a   Vos, Hans L ^c   Kalafatis, Michael ^a,b,d,e  

^a CLEVELAND STATE UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d TAUSSIG CANCER INSTITUTE   (United States)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID REGION; ACIDIC AMINO ACIDS; ACTIVATION PROCESS; COFACTOR ACTIVITY; COFACTORS; COOH-TERMINAL; DIVALENT METAL ION; FACTOR XA; GEL ELECTROPHORESIS ANALYSIS; HEAVY AND LIGHT CHAINS; HEAVY CHAIN; KINETIC ANALYSIS; MAMMALIAN CELLS; PROTHROMBIN ACTIVATION; PROTHROMBINASE; RECOMBINANT MOLECULES; SITE DIRECTED MUTAGENESIS; TWO STAGE; WILD TYPES;

AMINO ACIDS; ELECTROPHORESIS; GELS; GLYCOPROTEINS; MAMMALS; METAL IONS; ORGANIC ACIDS;

MOLECULES;

ALANINE; AMINO ACID; ARGININE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; LYSINE; MEIZOTHROMBIN; PROTHROMBIN;

ARTICLE; CONTROLLED STUDY; ENZYME KINETICS; GEL ELECTROPHORESIS; GENE ACTIVATION; GENE DELETION; HEAVY CHAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ENZYME PRECURSORS; FACTOR V; FACTOR VA; FACTOR XA; GENE EXPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; POINT MUTATION; PROTHROMBIN; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; THROMBIN; THROMBOPLASTIN;

MAMMALIA;

EID: 77957269197     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101097t     Document Type: Article

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