Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase

Biochemistry

Volumn 47, Issue 30, 2008, Pages 7963-7974

  Hirbawi, Jamila ^a   Bukys, Michael A ^a   Barhoover, Melissa A ^a,c   Erdogan, Evrim ^a,d   Kalafatis, Michael ^a,b  

^a CLEVELAND STATE UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^d ARUP LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ORGANIC ACIDS;

ACID REGION; COOH TERMINAL; HEAVY CHAIN (VH); PROTHROMBINASE;

HEALTH;

AMINO ACID; ASPARTYLTYROSYLASPARTYLGLUTAMINE; ASPARTYLTYROSYLASPARTYLTYROSINE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; CARBOXYLIC ACID; HIRUDIN; MEIZOTHROMBIN; PENTAPEPTIDE; RECOMBINANT FACTOR V;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; GEL ELECTROPHORESIS; HEAVY CHAIN; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; COS CELLS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME PRECURSORS; ESCHERICHIA COLI; FACTOR V; FACTOR VA; HIRUDINS; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; OLIGOPEPTIDES; POLYMERASE CHAIN REACTION; PROTHROMBIN; RECOMBINANT PROTEINS; THROMBIN; THROMBOPLASTIN;

EID: 48249130435     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800593k     Document Type: Article

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