Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor Xa

Journal of Biological Chemistry

Volumn 280, Issue 29, 2005, Pages 27393-27401

  Bukys, Michael A ^a   Blum, Melissa A ^a   Kim, Paul Y ^b   Brufatto, Nicole ^b   Nesheim, Michael E ^b   Kalafatis, Michael ^a,c  

^a CLEVELAND STATE UNIVERSITY   (United States)

^b QUEEN S UNIVERSITY   (Canada)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CATALYST ACTIVITY; CONCENTRATION (PROCESS); PHOSPHOLIPIDS; POSITIVE IONS;

CLEAVAGES; MUTANTS; PROTHROMBIN; PROTHROMBINASE;

ENZYMES;

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; PROTHROMBIN; RECOMBINANT BLOOD CLOTTING FACTOR 5; THROMBIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BLOOD CLOTTING; ENZYME ACTIVITY; HUMAN; KINETICS; MUTAGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; THERMODYNAMICS;

BINDING SITES; CATALYSIS; FACTOR VA; FACTOR XA; HUMANS; KINETICS; MUTATION, MISSENSE; PROTHROMBIN; THROMBOPLASTIN;

EID: 22844452221     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M503435200     Document Type: Article

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