Smad7 inhibits transforming growth factor-β family type I receptors through two distinct modes of interaction

Journal of Biological Chemistry

Volumn 285, Issue 40, 2010, Pages 30804-30813

  Kamiya, Yuto ^a   Miyazono, Kohei ^a   Miyazawa, Keiji ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SIGNALING;

ADDITIONAL MODE; FINGER-LIKE STRUCTURE; INHIBITORY EFFECT; NEGATIVE REGULATORS; PHYSICAL INTERACTIONS; RECEPTOR-LIKE KINASE; TRANSFORMING GROWTH FACTORS;

PEPTIDES;

ACTIVIN RECEPTOR LIKE KINASE 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 1B; PROTEIN SERINE THREONINE KINASE; SMAD6 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; SMAD6 PROTEIN, HUMAN; SMAD7 PROTEIN, HUMAN; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETICS; HEPG2 CELL LINE; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HEP G2 CELLS; HUMANS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD6 PROTEIN; SMAD7 PROTEIN;

EID: 77957267462     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.166140     Document Type: Article

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