Activation of phenylalanine hydroxylase induces positive cooperativity toward the natural cofactor

Journal of Biological Chemistry

Volumn 285, Issue 40, 2010, Pages 30686-30697

  Gersting, Søren W ^a   Staudigl, Michael ^a   Truger, Marietta S ^a   Messing, Dunja D ^a   Danecka, Marta K ^a   Sommerhoff, Christian P ^b   Kemter, Kristina F ^a   Muntau, Ania C ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ASSAYS; CHEMICAL ACTIVATION; DRUG THERAPY; ENZYMES;

ACTIVATED ENZYMES; ACTIVITY ASSAYS; ALLOSTERY; COFACTORS; COMPREHENSIVE ANALYSIS; COOPERATIVITY; ENZYME FUNCTIONS; ERYTHRO; KINETIC ANALYSIS; L-PHENYLALANINE; METABOLIC STATE; MOLECULAR BASIS; PHENYLALANINE HYDROXYLASE; PRODUCT SEPARATION; PROTEIN MISFOLDING; RESIDUAL ENZYMES; STANDARD METHOD; STEADY-STATE KINETICS; STRUCTURAL IMPACT; TARGET PROTEINS; TETRAHYDROBIOPTERIN; WILD TYPES;

ENZYME ACTIVITY;

PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; SAPROPTERIN; BIOPTERIN; COENZYME;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME KINETICS; PRIORITY JOURNAL; WILD TYPE; ALLOSTERISM; ANALOGS AND DERIVATIVES; CHEMISTRY; COENZYME; ENZYMOLOGY; FLUORESCENCE; GENETICS; HUMAN; KINETICS; METABOLISM; MISSENSE MUTATION; PHENYLKETONURIAS; THERAPEUTIC USE;

ALLOSTERIC REGULATION; BIOPTERIN; COENZYMES; ENZYME ACTIVATION; FLUORESCENCE; HUMANS; KINETICS; MUTATION, MISSENSE; PHENYLALANINE; PHENYLALANINE HYDROXYLASE; PHENYLKETONURIAS;

EID: 77957265261     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.124016     Document Type: Article

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