메뉴 건너뛰기




Volumn 42, Issue 11, 2010, Pages 1784-1787

Signalling through FOXP3 as an X-linked tumor suppressor

Author keywords

Breast cancer; Epithelial cell; FOXP3; Prostate cancer; X linked tumor suppressor gene

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; MYC PROTEIN; PROTEIN P21; S PHASE KINASE ASSOCIATED PROTEIN 2; TRANSCRIPTION FACTOR FOXP3; TUMOR SUPPRESSOR PROTEIN;

EID: 77957260371     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.07.015     Document Type: Short Survey
Times cited : (25)

References (31)
  • 1
    • 47149085982 scopus 로고    scopus 로고
    • P21 and p27: roles in carcinogenesis and drug resistance
    • Abukhdeir A.M., Park B.H. P21 and p27: roles in carcinogenesis and drug resistance. Expert Rev Mol Med 2008, 10:e19.
    • (2008) Expert Rev Mol Med , vol.10
    • Abukhdeir, A.M.1    Park, B.H.2
  • 2
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
    • Bettelli E., Dastrange M., Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci USA 2005, 102:5138-5143.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3
  • 3
    • 26844476814 scopus 로고    scopus 로고
    • The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis
    • Chang X., Gao J.X., Jiang Q., Wen J., Seifers N., Su L., et al. The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med 2005, 202:1141-1151.
    • (2005) J Exp Med , vol.202 , pp. 1141-1151
    • Chang, X.1    Gao, J.X.2    Jiang, Q.3    Wen, J.4    Seifers, N.5    Su, L.6
  • 4
    • 45949099261 scopus 로고    scopus 로고
    • Cutting edge: broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells
    • Chen G.Y., Chen C., Wang L., Chang X., Zheng P., Liu Y. Cutting edge: broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells. J Immunol 2008, 180:5163-5166.
    • (2008) J Immunol , vol.180 , pp. 5163-5166
    • Chen, G.Y.1    Chen, C.2    Wang, L.3    Chang, X.4    Zheng, P.5    Liu, Y.6
  • 5
    • 42349092708 scopus 로고    scopus 로고
    • The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells
    • Ebert L.M., Tan B.S., Browning J., Svobodova S., Russell S.E., Kirkpatrick N., et al. The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells. Cancer Res 2008, 68:3001-3009.
    • (2008) Cancer Res , vol.68 , pp. 3001-3009
    • Ebert, L.M.1    Tan, B.S.2    Browning, J.3    Svobodova, S.4    Russell, S.E.5    Kirkpatrick, N.6
  • 6
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
    • Fontenot J.D., Rudensky A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005, 6:331-337.
    • (2005) Nat Immunol , vol.6 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 7
    • 34548590227 scopus 로고    scopus 로고
    • Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    • Hinz S., Pagerols-Raluy L., Oberg H.H., Ammerpohl O., Grussel S., Sipos B., et al. Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res 2007, 67:8344-8350.
    • (2007) Cancer Res , vol.67 , pp. 8344-8350
    • Hinz, S.1    Pagerols-Raluy, L.2    Oberg, H.H.3    Ammerpohl, O.4    Grussel, S.5    Sipos, B.6
  • 8
    • 62549154975 scopus 로고    scopus 로고
    • Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis
    • Holmes D., Jiang Q., Zhang L., Su L. Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis. Immunol Res 2008, 41:248-266.
    • (2008) Immunol Res , vol.41 , pp. 248-266
    • Holmes, D.1    Jiang, Q.2    Zhang, L.3    Su, L.4
  • 9
  • 11
    • 70449717294 scopus 로고    scopus 로고
    • Epigenetic mechanisms of regulation of Foxp3 expression
    • Lal G., Bromberg J.S. Epigenetic mechanisms of regulation of Foxp3 expression. Blood 2009, 114:3727-3735.
    • (2009) Blood , vol.114 , pp. 3727-3735
    • Lal, G.1    Bromberg, J.S.2
  • 12
    • 43549112146 scopus 로고    scopus 로고
    • FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1
    • Lee S.M., Gao B., Fang D. FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1. Blood 2008, 111:3599-3606.
    • (2008) Blood , vol.111 , pp. 3599-3606
    • Lee, S.M.1    Gao, B.2    Fang, D.3
  • 13
    • 34248379172 scopus 로고    scopus 로고
    • FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
    • Li B., Samanta A., Song X., Iacono K.T., Bembas K., Tao R., et al. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci USA 2007, 104:4571-4576.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4571-4576
    • Li, B.1    Samanta, A.2    Song, X.3    Iacono, K.T.4    Bembas, K.5    Tao, R.6
  • 14
    • 65549142268 scopus 로고    scopus 로고
    • FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus
    • Liu R., Wang L., Chen G., Katoh H., Chen C., Liu Y., et al. FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus. Cancer Res 2009, 69:2252-2259.
    • (2009) Cancer Res , vol.69 , pp. 2252-2259
    • Liu, R.1    Wang, L.2    Chen, G.3    Katoh, H.4    Chen, C.5    Liu, Y.6
  • 15
    • 67651002347 scopus 로고    scopus 로고
    • Activating transcription factor 2 and c-Jun-mediated induction of FoxP3 for experimental therapy of mammary tumor in the mouse
    • Liu Y., Wang Y., Li W., Zheng P., Liu Y. Activating transcription factor 2 and c-Jun-mediated induction of FoxP3 for experimental therapy of mammary tumor in the mouse. Cancer Res 2009, 69:5954-5960.
    • (2009) Cancer Res , vol.69 , pp. 5954-5960
    • Liu, Y.1    Wang, Y.2    Li, W.3    Zheng, P.4    Liu, Y.5
  • 16
    • 77953288029 scopus 로고    scopus 로고
    • X-linked tumor suppressors: perplexing inheritance, a unique therapeutic opportunity
    • Liu Y., Wang L., Zheng P. X-linked tumor suppressors: perplexing inheritance, a unique therapeutic opportunity. Trends Genet 2010, 26:260-265.
    • (2010) Trends Genet , vol.26 , pp. 260-265
    • Liu, Y.1    Wang, L.2    Zheng, P.3
  • 17
    • 33747762947 scopus 로고    scopus 로고
    • Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor
    • Lopes J.E., Torgerson T.R., Schubert L.A., Anover S.D., Ocheltree E.L., Ochs H.D., et al. Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor. J Immunol 2006, 177:3133-3142.
    • (2006) J Immunol , vol.177 , pp. 3133-3142
    • Lopes, J.E.1    Torgerson, T.R.2    Schubert, L.A.3    Anover, S.D.4    Ocheltree, E.L.5    Ochs, H.D.6
  • 19
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: cell-cycle control and cancer
    • Nakayama K.I., Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 2006, 6:369-381.
    • (2006) Nat Rev Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 20
    • 34247215187 scopus 로고    scopus 로고
    • Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    • Ono M., Yaguchi H., Ohkura N., Kitabayashi I., Nagamura Y., Nomura T., et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 2007, 446:685-689.
    • (2007) Nature , vol.446 , pp. 685-689
    • Ono, M.1    Yaguchi, H.2    Ohkura, N.3    Kitabayashi, I.4    Nagamura, Y.5    Nomura, T.6
  • 21
    • 69549120242 scopus 로고    scopus 로고
    • Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells
    • Pan F., Yu H., Dang E.V., Barbi J., Pan X., Grosso J.F., et al. Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science 2009, 325:1142-1146.
    • (2009) Science , vol.325 , pp. 1142-1146
    • Pan, F.1    Yu, H.2    Dang, E.V.3    Barbi, J.4    Pan, X.5    Grosso, J.F.6
  • 22
    • 0036781812 scopus 로고    scopus 로고
    • C-MYC: more than just a matter of life and death
    • Pelengaris S., Khan M., Evan G. c-MYC: more than just a matter of life and death. Nat Rev Cancer 2002, 2:764-776.
    • (2002) Nat Rev Cancer , vol.2 , pp. 764-776
    • Pelengaris, S.1    Khan, M.2    Evan, G.3
  • 23
    • 71749094333 scopus 로고    scopus 로고
    • Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome
    • Ruan Q., Kameswaran V., Tone Y., Li L., Liou H.C., Greene M.I., et al. Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity 2009, 31:932-940.
    • (2009) Immunity , vol.31 , pp. 932-940
    • Ruan, Q.1    Kameswaran, V.2    Tone, Y.3    Li, L.4    Liou, H.C.5    Greene, M.I.6
  • 24
    • 73349085919 scopus 로고    scopus 로고
    • Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
    • Spector N.L., Blackwell K.L. Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 2009, 27:5838-5847.
    • (2009) J Clin Oncol , vol.27 , pp. 5838-5847
    • Spector, N.L.1    Blackwell, K.L.2
  • 26
    • 70349466655 scopus 로고    scopus 로고
    • Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate
    • Wang L., Liu R., Li W., Chen C., Katoh H., Chen G.Y., et al. Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell 2009, 16:336-346.
    • (2009) Cancer Cell , vol.16 , pp. 336-346
    • Wang, L.1    Liu, R.2    Li, W.3    Chen, C.4    Katoh, H.5    Chen, G.Y.6
  • 27
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu Y., Borde M., Heissmeyer V., Feuerer M., Lapan A.D., Stroud J.C., et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 2006, 126:375-387.
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3    Feuerer, M.4    Lapan, A.D.5    Stroud, J.C.6
  • 28
    • 72049096373 scopus 로고    scopus 로고
    • Up-regulation of Foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer
    • Zhang H.Y., Sun H. Up-regulation of Foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer. Cancer Lett 2010, 287:91-97.
    • (2010) Cancer Lett , vol.287 , pp. 91-97
    • Zhang, H.Y.1    Sun, H.2
  • 29
    • 33847220736 scopus 로고    scopus 로고
    • Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells
    • Zheng Y., Josefowicz S.Z., Kas A., Chu T.T., Gavin M.A., Rudensky A.Y. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature 2007, 445:936-940.
    • (2007) Nature , vol.445 , pp. 936-940
    • Zheng, Y.1    Josefowicz, S.Z.2    Kas, A.3    Chu, T.T.4    Gavin, M.A.5    Rudensky, A.Y.6
  • 30
    • 36849053106 scopus 로고    scopus 로고
    • FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2
    • Zuo T., Liu R., Zhang H., Chang X., Liu Y., Wang L., et al. FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J Clin Invest 2007, 117:3765-3773.
    • (2007) J Clin Invest , vol.117 , pp. 3765-3773
    • Zuo, T.1    Liu, R.2    Zhang, H.3    Chang, X.4    Liu, Y.5    Wang, L.6
  • 31
    • 34250863911 scopus 로고    scopus 로고
    • FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
    • Zuo T., Wang L., Morrison C., Chang X., Zhang H., Li W., et al. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 2007, 129:1275-1286.
    • (2007) Cell , vol.129 , pp. 1275-1286
    • Zuo, T.1    Wang, L.2    Morrison, C.3    Chang, X.4    Zhang, H.5    Li, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.