X-ray structure and mutational analysis of the atrazine chlorohydrolase TrzN

Journal of Biological Chemistry

Volumn 285, Issue 40, 2010, Pages 30606-30614

  Seffernick, Jennifer L ^a   Reynolds, Erik ^a   Fedorov, Alexander A ^b   Fedorov, Elena ^b   Almo, Steven C ^b   Sadowsky, Michael J ^a   Wackett, Lawrence P ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ATOMS; CARBON DIOXIDE; CARBONIC ANHYDRASE; CHLORINE; ENZYMES; OXYGEN; PHOSPHATASES; PROTONS; REACTION KINETICS; ZINC;

ACTIVE SITE; AMETRYN; AMIDOHYDROLASE SUPERFAMILY; ASPARTATES; ATRAZINES; BACTERIAL METABOLISM; COORDINATED WATER; HOMODIMERS; HYDROLASES; ISOSTERIC; KINETIC DETERMINATION; MUTATIONAL ANALYSIS; NATIVE ENZYMES; NUCLEOPHILIC DISPLACEMENT; OXYGEN ATOM; S-TRIAZINES; SIDE CHAINS; WILD TYPES; X-RAY STRUCTURE; ZINC ATOMS;

HERBICIDES;

AMETRYN; ASPARTIC ACID; ATRAZINE; ATRAZINE CHLOROHYDROLASE 2; CARBON DIOXIDE; CARBONATE DEHYDRATASE; GLUTAMIC ACID; HYDROLASE; SERINE; THREONINE; UNCLASSIFIED DRUG; ATRATONE; BACTERIAL PROTEIN; TRIAZINE DERIVATIVE; TRZN PROTEIN, NOCARDIOIDES SP. C190; ZINC;

AMINO ACID SUBSTITUTION; ARTICLE; BIOREMEDIATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE MUTATION; MUTANT; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; WILD TYPE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; KINETICS; MISSENSE MUTATION; PH; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS);

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; HYDROGEN-ION CONCENTRATION; HYDROLASES; KINETICS; MUTATION, MISSENSE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRIAZINES; ZINC;

EID: 77957256812     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.138677     Document Type: Article

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