Female X-chromosome mosaicism for gp91phox expression diversifies leukocyte responses during endotoxemia

Critical Care Medicine

Volumn 38, Issue 10, 2010, Pages 2003-2010

  Chandra, Rachna ^a   Federici, Stephanie ^a   Haskó, György ^a   Deitch, Edwin A ^a   Spolarics, Zoltán ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

gender; gp91phox; inflammation; lipopolysaccharide; polymorphonuclear; X chromosome inactivation

Indexed keywords

ALISAMYCIN; BIOLOGICAL MARKER; CD11B ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; GENOMIC DNA; GLYCOPROTEIN GP 91; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; CCL2 PROTEIN, MOUSE; CYBB PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL SUBPOPULATION; CHROMOSOME MARKER; CONTROLLED STUDY; ENDOTOXEMIA; ESCHERICHIA COLI; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENOTYPE; HETEROZYGOTE; IMMUNE RESPONSE; INFLAMMATION; KNOCKOUT MOUSE; LEUKOCYTE ACTIVATION; MOSAICISM; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SPLEEN CELL; T LYMPHOCYTE; X CHROMOSOME; ANIMAL; BLOOD; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INBRED MOUSE STRAIN; LYMPHOCYTE ACTIVATION; SEX CHROMOSOME ABERRATION; X CHROMOSOMAL INHERITANCE;

ANIMALS; CHEMOKINE CCL2; ENDOTOXEMIA; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENES, X-LINKED; GENOTYPE; INTERLEUKIN-10; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED STRAINS; MOSAICISM; NADPH OXIDASE; SEX CHROMOSOME ABERRATIONS; X CHROMOSOME;

EID: 77957235520     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181eb9ed6     Document Type: Article

References (32)

1. Liu PY, Death AK, Handelsman DJ: Andro-gens and cardiovascular disease. Endocr Rev 2003; 24:313-340
2. Chen CC, Parker CR Jr: Adrenal androgens and the immune system. Semin Reprod Med 2004; 22:369-377
3. Angele MK, Schwacha MG, Ayala A, et al: Effect of gender and sex hormones on immune responses following shock. Shock 2000; 14:81-90
4. Kovacs EJ, Messingham KA, Gregory MS: Estrogen regulation of immune responses after injury. Mol Cell Endocrinol 2002; 193: 129-135
5. Choudhry MA, Bland KI, Chaudry IH: Gender and susceptibility to sepsis following trauma. Endocr Metab Immune Disord Drug Targets 2006; 6:127-135
6. George RL, McGwin G Jr, Windham ST, et al: Age-related gender differential in outcome after blunt or penetrating trauma. Shock 2003; 19:28-32
7. Gannon CJ, Pasquale M, Tracy JK, et al: Male gender is associated with increased risk for postinjury pneumonia. Shock 2004; 21: 410-414
8. De Maio A, Torres MB, Reeves RH: Genetic determinants influencing the response to injury, inflammation, and sepsis. Shock 2005; 23:11-17
9. Spolarics Z: The X-files of inflammation: Cellular mosaicism of X-linked polymorphic genes and the female advantage in the host response to injury and infection. Shock 2007; 27:597-604
10. Torres MB, Trentzsch H, Stewart D, et al: Protection from lethal endotoxic shock after testosterone depletion is linked to chromosome X. Shock 2005; 24:318-323
11. Migeon BR: The role of X inactivation and cellular mosaicism in women's health and sex-specific diseases. JAMA 2006; 295: 1428-1433
12. Migeon BR: Why females are mosaics, X-chromosome inactivation, and sex differences in disease. Gend Med 2007; 4:97-105
13. Heard E, Disteche CM: Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes Dev 2006; 20: 1848-1867
14. Goto T, Monk M: Regulation of X-chromo-some inactivation in development in mice and humans. Microbiol Mol Biol Rev 1998; 62:362-378
15. Latham KE. X chromosome imprinting and inactivation in preimplantation mammalian embryos. Trends Genet 2005; 21:120-127
16. Pollock JD, Williams DA, Gifford MA, et al: Mouse model of X-linked chronic granulo-matous disease, an inherited defect in phagocyte superoxide production. Nat Genet 1995; 9:202-209
17. Chandra R, Villanueva E, Feketova E, et al: Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: The effect of G6PD deficiency. J Leukoc Biol 2008; 83:1541-1550
18. Abkowitz JL, Golinelli D, Harrison DE, et al: In vivo kinetics of murine hemopoietic stem cells. Blood 2000; 96:3399-3405
19. Abkowitz JL, Catlin SN, Guttorp P: Evidence that hematopoiesis may be a stochastic process in vivo. Nat Med 1996; 2:190-197
20. Piccoli C, D'Aprile A, Ripoli M, et al: Bone-marrow derived hematopoietic stem/progenitor cells express multiple isoforms of NADPH oxidase and produce constitutively reactive oxygen species. Biochem Biophys Res Commun 2007; 353:965-972
21. Piccoli C, Ria R, Scrima R, et al: Characterization of mitochondrial and extra-mito-chondrial oxygen consuming reactions in human hematopoietic stem cells Novel evidence of the occurrence of NAD(P)H oxidase activity. J Biol Chem 2005; 280:26467-26476
22. Guo RF, Ward PA: Role of oxidants in lung injury during sepsis. Antioxid Redox Signal 2007; 9:1991-2002
23. Spolarics Z: Endotoxemia, pentose cycle, and the oxidant/antioxidant balance in the hepatic sinusoid. J Leukoc Biol 1998; 63: 534-541
24. Gao XP, Standiford TJ, Rahman A, et al: Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: Studies in p47phox-/-and gp91phox-/-mice. J Immunol 2002; 168:3974-3982
25. Zhang WJ, Wei H, Frei B: Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo. Free Radic Biol Med 2009; 46:791-798
26. Sanmun D, Witasp E, Jitkaew S, et al: Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: Implications for chronic granulomatous disease. Am J Physiol Cell Physiol 2009; 297:C621-C631
27. Frasch SC, Berry KZ, Fernandez-Boyanapalli R, et al: NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A. J Biol Chem 2008; 283: 33736-33749
28. Remick DG, Ward PA: Evaluation of endo-toxin models for the study of sepsis. Shock 2005; 24(Suppl 1):7-11
29. Deitch EA, Ananthakrishnan P, Cohen DB, et al: Neutrophil activation is modulated by sex hormones after trauma-hemorrhagic shock and burn injuries. Am J Physiol Heart Circ Physiol 2006; 291:H1456-H1465
30. Yang S, Choudhry MA, Hsieh YC, et al: Es-trus cycle: Influence on cardiac function following trauma-hemorrhage. Am J Physiol Heart Circ Physiol 2006; 291:H2807-H2815
31. Schaffner SF: The X chromosome in population genetics. Nat Rev Genet 2004; 5:43-51
32. Clayton DG: Sex chromosomes and genetic association studies. Genome Med 2009; 1:110