Protection from lethal endotoxic shock after testosterone depletion is linked to chromosome X

Shock

Volumn 24, Issue 4, 2005, Pages 318-323

  Torres, Manuel B ^a   Trentzsch, Heiko ^a   Stewart, Dylan ^a   Mooney, Maria Lourdes ^a   Fuentes, Joseph M ^a   Saad, Daniel F ^a   Reeves, Roger H ^a   De Maio, Antonio ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Orthopaedic Surgery   (United States)

Author keywords

Cytokines; Genetics; Injury; Sepsis; Sex steroids

Indexed keywords

ANDROSTANOLONE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; SEX HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; CASTRATION; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; INFECTION SENSITIVITY; INFLAMMATION; MALE; MOUSE; NONHUMAN; SEPTIC SHOCK; SURVIVAL; TESTOSTERONE BLOOD LEVEL; X CHROMOSOME;

ANIMALS; CHROMOSOME MAPPING; ESTROGENS; INTERLEUKIN-10; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; SHOCK, SEPTIC; TESTOSTERONE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING; X CHROMOSOME;

EID: 26244465481     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000177639.22863.99     Document Type: Article

References (47)

1. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 348:138-150, 2003.
2. Angus DC, Wax RS: Epidemiology of sepsis: an update. Crit Care Med 29:S109-S116, 2001.
3. Livingston DH, Mosenthal AC, Deitch EA: Sepsis and multiple organ dysfunction syndrome: a clinical-mechanistic overview. New Horiz 3:257-266, 1995.
4. De Maio A, Torres MB, Reeves RH: Genetic determinants influencing the response to injury, inflammation, and sepsis. Shock 23:11-17, 2005.
5. De Maio A, Mooney ML, Matesic LE, Paidas CN, Reeves RH: Genetic component in the inflammatory response induced by bacterial lipopolysaccharide. Shock 10:319-323, 1998.
6. Stewart D, Fulton WB, Wilson C, Monitto CL, Paidas CN, Reeves RH, De Maio A: Genetic contribution to the septic response in a mouse model. Shock 18:342-347, 2002.
7. Torres MB, De Maio A: An exaggerated inflammatory response after CLP correlates with a negative outcome. J Surg Res 125:88-93, 2005.
8. Radojicic C, Andric B, Simovic M, Dujic A, Marinkovic D: Genetic basis of resistance to trauma in inbred strains of mice. J Trauma 30:211-213, 1990.
9. Deitch EA, Ma L, Ma J-W, Berg RD: Lethal burn-induced bacterial translocation: role of genetic resistance. J Trauma 29:1480-1487, 1989.
10. Schwacha MG, Holland LT, Chaudry IH, Messina JL: Genetic variability in the immune-inflammatory response after major burn injury. Shock 23:123-128, 2005.
11. O'Malley J, Matesic LE, Zink C, Strandberg JD, Mooney ML, De Maio A, Reeves RH: Comparison of acute endotoxin-induced lesions in A/J and C57BL/6J mice. J Hered 89:525-530, 1998.
12. Matesic LE, Niemitz EL, De Maio A, Reeves RH: Quantitative trait loci modulate neutrophil infiltration in the liver during LPS-induced inflammation. FASEB J 14:2247-2254, 2000.
13. Poltorak A, He X, Smirnova I, Liu M-Y, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088, 1998.
14. Qureshi ST, Lariviere L, Sebastiani G, Clermont S, Skamene E, Gros P, Malo D: A high-resolution map in the chromosomal region surrounding the Lps locus. Genomics 31:283-294, 1996.
15. Barrow RE, Herndon DN: Thermal burns, gender, and survival. Lancet 2:1076-1077, 1988.
16. Knudson MM, Lieberman J, Morris JA Jr, Cushing BM, Stubbs HA: Mortality factors in geriatric blunt trauma patients. Arch Surg 129:448-453, 1994.
17. Oberholzer A, Keel M, Zellweger R, Steckholzer U, Trentz O, Ertel W: Incidence of septic complications and multiple organ failure in severely injured patients is sex specific. J Trauma 48:932-937, 2000.
18. Schroder J, Kahlke V, Staubach KH, Zabel P, Stuber F: Gender differences in human sepsis. Arch Surg 133:1200-1205, 1998.
19. Bauerle R, Rucker A, Schmandra TC, Holzer K, Encke A, Hanisch E: Markov cohort simulation study reveals evidence for sex-based risk difference in intensive care unit patients. Am J Surg 179:207-211, 2000.
20. Schroder J, Kahlke V, Book M, Stuber F: Gender differences in sepsis: genetically determined? Shock 14:307-310, 2000.
21. Aube H, Milan C, Blettery B: Risk factors for septic shock in the early management of bacteremia. Am J Med 93:283-288, 1992.
22. Wichmann MW, Inthorn D, Andress HJ, Schildberg FW: Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome. Intensive Care Med 26:167-172, 2000.
23. George RL, McGwin G Jr, Metzger J, Chaudry IH, Rue LW III: The association between gender and mortality among trauma patients as modified by age. J Trauma 54:464-471, 2003.
24. Offner PJ, Moore EE, Biffl WL: Male gender is a risk factor for major infections after surgery. Arch Surg 134:935-938, 1999.
25. Napolitano LM, Greco ME, Rodriguez A, Kufera JA, West RS, Scalea TM: Gender differences in adverse outcomes after blunt trauma. J Trauma 50:274-280, 2001.
26. Borgdorff MW, Nagelkerke NJ, Dye C, Nunn P: Gender and tuberculosis: a comparison of prevalence surveys with notification data to explore sex differences in case detection. Int J Tuberc Lung Dis 4:123-132, 2000.
27. McGowan JE Jr, Barnes MW, Finland M: Bacteremia at Boston City Hospital: occurrence and mortality during 12 selected years (1935-1972), with special reference to hospital-acquired cases. J Infect Dis 132:316-335, 1975.
28. McLauchlan GJ, Anderson ID, Grant IS, Fearon KC: Outcome of patients with abdominal sepsis treated in an intensive care unit. Br J Surg 82:524-529, 1995.
29. Evans L: Female compared with male fatality risk from similar physical impacts. J Trauma 50:281-288, 2001.
30. Eachempati SR, Hydo L, Barie PS: Gender-based differences in outcome in patients with sepsis. Arch Surg 134:1342-1347, 1999.
31. Guidet B, Barakett V, Vassal T, Petit JC, Offenstadt G: Endotoxemia and bacteremia in patients with sepsis syndrome in the intensive care unit. Chest 106:1194-1201, 1994.
32. Riche F, Panis Y, Laisne MJ, Briard C, Cholley B, Bernard-Poenaru O, Graulet AM, Gueris J, Valleur P: High tumor necrosis factor serum level is associated with increased survival in patients with abdominal septic shock: a prospective study in 59 patients. Surgery 120:801-807, 1996.
33. Morrison WE, Arbelaez JJ, Fackler JC, De Maio A, Paidas CN: Gender and age effects on outcome after pediatric traumatic brain injury. Pediatr Crit Care Med 5:145-151, 2004.
34. Trentzsch H, Stewart D, De Maio A: Genetic background conditions the effect of sex steroids on the inflammatory response during endotoxic shock. Crit Care Med 31:232-236, 2003.
35. Angele MK, Knoferl MW, Schwacha MG, Ayala A, Cioffi WG, Bland KI, Chaudry IH: Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage. Am J Physiol 277:C35-C42, 1999.
36. Gregory MS, Faunce DE, Duffner LA, Kovacs EL: Gender difference in cell-mediated immunity after thermal injury is mediated, in part, by elevated levels of interleukin-6. J Leukocyte Biol 67:319-326, 2000.
37. Zuckerman SH, Ahmari SE, Bryan-Poole N, Evans GF, Short L, Glasebrook AL: Estriol: a potent regulator of TNF and IL-6 expression in a murine model of endotoxemia. Inflammation 20:581-597, 1996.
38. Zellweger R, Wichmann MW, Ayala A, Stein S, DeMaso CM, Chaudry IH: Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males. Crit Care Med 25:106-110, 1997.
39. Klein SL: The effects of hormones on sex differences in infection: from genes to behavior. Neurosci Biobehav Rev 24:627-638, 2000.
40. Angele MK, Wichmann MW, Ayala A, Cioffi WG, Chaudry IH: Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis. Arch Surg 132:1207-1214, 1997.
41. Ayala A, Perrin MM, Ertel W, Chaudry IH: Differential effects of hemorrhage on Kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release. Cytokine 4:66-75, 1992.
42. Wichmann MW, Angele MK, Ayala A, Cioffi WG, Chaudry IH: Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. Shock 8:242-248, 1997.
43. Remmers DE, Wang P, Cioffi WG, Bland KI, Chaudry IH: Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males. Am J Physiol 273:H2919-H2925, 1997.
44. Laubach VE, Foley PL, Shockey KS, Tribble CG, Kron IL: Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice. Am J Physiol 275:H2211-H2218, 1998.
45. Hubacek JA, Stuber F, Frohlich D, Book M, Wetegrove S, Ritter M, Rothe G, Schmitz G: Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. Crit Care Med 29:557-561, 2001.
46. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH: Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation. Cytokine 8:853-863, 1996.
47. Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH: Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage. Am J Physiol 274:C1530-C1536, 1998.