Interaction betweeen PEVK-titin and actin filaments origin of a viscous force component in cardiac myofibrils

Circulation Research

Volumn 89, Issue 10, 2001, Pages 874-881

  Kulke, M ^a   Fujita Becker, S ^a   Rostkova, E ^a   Neagoe, C ^a   Labeit, D ^a   Manstein, D J ^a   Gautel, M ^a   Linke, W A ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Actin binding protein; Connectin; Myocardial viscosity; Myofibril mechanics; Passive tension

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; CALCIUM ION; CONNECTIN; FIBRONECTIN; RECOMBINANT PROTEIN; MUSCLE PROTEIN; PROTEIN KINASE;

ACTIN FILAMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; FLUORESCENCE; HEART CONTRACTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MALE; MUSCLE FIBRIL; MUSCLE FORCE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SARCOMERE; VISCOSITY; ANIMAL; BINDING COMPETITION; BIOASSAY; CHICKEN; GENETICS; HEART MUSCLE; HUMAN; IN VITRO STUDY; MACROMOLECULE; MECHANICAL STRESS; METABOLISM; MICROFILAMENT; PHYSIOLOGY; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; TEMPERATURE;

AMINO ACID MOTIFS; ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL ASSAY; CHICKENS; HUMANS; MACROMOLECULAR SUBSTANCES; MICROFILAMENTS; MUSCLE PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOFIBRILS; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RABBITS; RECOMBINANT PROTEINS; SARCOMERES; STRESS, MECHANICAL; TEMPERATURE; VISCOSITY;

EID: 0035834245     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh2201.099453     Document Type: Article

References (37)

1. Mechanical properties of cardiac muscle
2. The diastolic viscous properties of cat papillary muscle
3. Internal viscoelastic loading in cat papillary muscle
4. An internal viscous element limits unloaded velocity of sarcomere shortening in rat myocardium
5. 2+
6. 2+-dependence of diastolic properties of cardiac sarcomeres: Involvement of titin
7. Cytoskeletal mechanics in pressure-overload cardiac hypertrophy
8. Role of microtubules in the viscoelastic properties of isolated cardiac muscle
9. The role of the cytoskeleton in left ventricular pressure overload hypertrophy and failure
10. Passive and active tension in single cardiac myofibrils
11. Passive tension in cardiac muscle: Contribution of collagen, titin, microtubules, and intermediate filaments
12. The giant protein titin: Emerging roles in physiology and pathophysiology
13. Titins, giant proteins in charge of muscle ultra-structure and elasticity
14. Towards a molecular understanding of the elasticity of titin
15. Assembly of the cardiac I-band region of titin/connectin: Expression of the cardiac-specific regions and their structural relation to the elastic segments
16. Titin elasticity and mechanism of passive force development in rat cardiac myocytes probed by thin-filament extraction
17. Actin-titin interaction in cardiac myofibrils: Probing a physiological role
18. Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: Titin is an adjustable spring
19. I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structure
20. Immunoglobulin-like modules from I-band titin: Extensible components of muscle elasticity
21. Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity
22. Alterations in the determinants of diastolic suction during pacing tachycardia
23. Elastic filaments in situ in cardiac muscle: Deep-etch replica analysis in combination with selective removal of actin and myosin filaments
24. Binding of actin filaments to connectin
25. A survey of the interactions made by titin
26. Calcium-dependent inhibition of in vitro thin-filament motility by native titin
27. Cloned rat cardiac titin class I and class II motifs
28. The effect of genetically expressed cardiac titin fragments on in vitro actin motility
29. A calmodulin-binding sequence in the C-terminus of human cardiac titin kinase
30. Myosin motors with artificial lever arms
31. A simple method for measuring the relative force exerted by myosin on actin filaments in the in vitro motility assay: Evidence that tropomyosin and troponin increase force in single thin filaments
32. Modular motif, structural folds and affinity profiles of the PEVK segment of human fetal skeletal muscle titin
33. Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils
34. Titin develops restoring force in rat cardiac myocytes
35. Direct visualization of extensibility in isolated titin molecules
36. Nature of PEVK-titin elasticity in skeletal muscle
37. Titin and the sarcomere symmetry paradox