The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils

Journal of Physiology

Volumn 586, Issue 15, 2008, Pages 3639-3644

  Belus, Alexandra ^a,b   Piroddi, Nicoletta ^a,b   Scellini, Beatrice ^a,b   Tesi, Chiara ^a,b   Amati, Giulia D ^c   Girolami, Francesca ^d   Yacoub, Magdi ^a,d   Cecchi, Franco ^a,d   Olivotto, Iacopo ^d   Poggesi, Corrado ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Department of Preclinical and Clinical Pharmacology   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; MUSCLE PROTEIN; MYOSIN HEAVY CHAIN BETA; R403Q PROTEIN; CALCIUM;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSPNEA; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; GENE FUNCTION; GENE MUTATION; HEART CONTRACTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE OUTFLOW TRACT OBSTRUCTION; HEART MUSCLE RELAXATION; HEART MUSCLE TENSION; HUMAN; MALE; MISSENSE MUTATION; MUSCLE FIBRIL; MUSCLE RESECTION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; SARCOMERE LENGTH; BIOMECHANICS; ENERGY TRANSFER; GAIN OF FUNCTION MUTATION; HUMAN CELL; MYH7 GENE; TENSION; YOUNG ADULT;

ADULT; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MUTATION; MYOCARDIAL CONTRACTION; MYOFIBRILS; TISSUE CULTURE TECHNIQUES; VENTRICULAR MYOSINS;

EID: 48549105342     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.155952     Document Type: Article

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