Impact of DUSP1 on the apoptotic potential of deoxynivalenol in the epithelial cell line HepG2

Toxicology Letters

Volumn 199, Issue 1, 2010, Pages 43-50

  Casteel, Maximilian ^a   Nielsen, Carina ^a   Kothlow, Sonja ^a   Dietrich, Richard ^a   Märtlbauer, Erwin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apoptosis; Deoxynivalenol; Dual specificity protein phosphatase 1; Mitogen activated protein kinases

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; STRESS ACTIVATED PROTEIN KINASE 1; VOMITOXIN; DUSP1 PROTEIN, HUMAN; MAPK1 PROTEIN, HUMAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; STRESS ACTIVATED PROTEIN KINASE; TRICHOTHECENE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL LINE; CELL STRAIN HEPG2; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIUM CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; DRUG EFFECTS; GENE EXPRESSION; GENE SILENCING; GENETICS; HEPG2 CELL LINE; HUMAN; LIVER CELL; METABOLISM; PATHOLOGY; TOXICITY;

APOPTOSIS; DUAL SPECIFICITY PHOSPHATASE 1; ENZYME ACTIVATION; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HEP G2 CELLS; HEPATOCYTES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA, MESSENGER; TRICHOTHECENES;

EID: 77957166472     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.08.004     Document Type: Article

References (29)

1. Bhalla U.S., Ram P.T., Iyengar R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 2002, 297:1018-1023.
2. Brondello J.M., Brunet A., Pouysségur J., McKenzie F.R. The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade. J. Biol. Chem. 1997, 272:1368-1376.
3. Brondello J.M., Pouysségur J., McKenzie F.R. Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 1999, 286:2514-2517.
4. Camps M., Nichols A., Arkinstall S. Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J. 2000, 14:6-16.
5. Chang L., Karin M. Mammalian MAP kinase signalling cascades. Nature 2001, 410:37-40.
6. Chen P., Li J., Barnes J., Kokkonen G.C., Lee J.C., Liu Y. Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J. Immunol. 2002, 169:6408-6416.
7. Chen Y.R., Tan T.H. The c-Jun N-terminal kinase pathway and apoptotic signaling (review). Int. J. Oncol. 2000, 16:651-662.
8. Concannon C.G., Gorman A.M., Samali A. On the role of Hsp27 in regulating apoptosis. Apoptosis 2003, 8:61-70.
9. Ehrlich K.C., Daigle K.W. Protein synthesis inhibition by 8-oxo-12,13-epoxythrichothecenes. Biochim. Biophys. Acta 1987, 923(2):206-213.
10. Hazel C.M., Patel S. Influence of processing on trichothecene levels. Toxicol. Lett. 2004, 153:51-59.
11. Kinser S., Jia Q., Li M., Laughter A., Cornwell P., Corton J.C., Pestka J. Gene expression profiling in spleens of deoxynivalenol-exposed mice: immediate early genes as primary targets. J. Toxicol. Environ. Health A 2004, 67:1423-1441.
12. Liu Y., Shepherd E.G., Nelin L.D. MAPK phosphatases-regulating the immune response. Nat. Rev. Immunol. 2007, 7:202-212.
13. Moon Y., Pestka J.J. Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases. Toxicol. Sci. 2002, 69:373-382.
14. Nelin L.D., Wang X., Zhao Q., Chicoine L.G., Young T.L., Hatch D.M., English B.K., Liu Y. MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge. Am. J. Physiol. Cell. Physiol. 2007, 293:C632-640.
15. Nielsen C., Lippke H., Didier A., Dietrich R., Märtlbauer E. Potential of deoxynivalenol to induce transcription factors in human hepatoma cells. Mol. Nutr. Food Res. 2009, 53:479-491.
16. Nielsen C., Casteel M., Didier A., Dietrich R., Märtlbauer E. Trichothecene-induced cytotoxicity on human cell lines. Mycotoxicol. Res. 2009, 25:77-84.
17. Pestka J.J. Mechanisms of deoxynivalenol induced gene expression and apoptosis. Food. Addit. Contam. Part A 2008, 1-13.
18. Rotter B.A., Prelusky D.B., Pestka J.J. Toxicology of deoxynivalenol (vomitoxin). J. Toxicol. Environ. Health 1996, 48:1-34.
19. Sánchez-Perez I., Murguía J.R., Perona R. Cisplatin induces a persistent activation of JNK that is related to cell death. Oncogene 1998, 16:533-540.
20. SCOOP (Scientific Cooperation) Report of experts participating in Task 3.2.10: collection of occurrence data of Fusarium toxins in food and assessment of dietary intake by the population of EU Member States 2003, http://europa.eu.int/comm/food/fs/scoop/task3210.pdf.
21. Sergent T., Parys M., Garsou S., Pussemier L., Schneider Y.J., Larondelle Y. Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations. Toxicol. Lett. 2006, 164:167-176.
22. Shifrin V.I., Anderson P. Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J. Biol. Chem. 1999, 274:13985-13992.
23. Slack D.N., Seternes O.M., Gabrielsen M., Keyse S.M. Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. J. Biol. Chem. 2001, 276:16491-16500.
24. Sugiyama K., Muroi M., Tanamoto K., Nishijima M., Sugita-Konishi Y. Deoxynivalenol and nivalenol inhibit lipopolysaccharide-induced nitric oxide production by mouse macrophage cells. Toxicol. Lett. 2010, 192:150-154.
25. Wang X., Liu Y. Regulation of innate immune response by MAP kinase phosphatase-1. Cell. Signal. 2007, 19:1372-1382.
26. Yang G.H., Jarvis B.B., Chung Y.J., Pestka J.J. Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation. Toxicol. Appl. Pharmacol. 2000, 164:149-160.
27. Yang H., Chung D.H., Kim Y.B., Choi Y.H., Moon Y. Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cells. Toxicology 2008, 243:145-154.
28. Yang H., Park S.H., Choi H.J., Moon Y. Epithelial cell survival by activating transcription factor 3 (ATF3) in response to chemical ribosome-inactivating stress. Biochem. Pharmacol. 2009, 77:1105-1115.
29. Zhou H.R., Islam Z., Pestka J.J. Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol. Toxicol. Sci. 2005, 87:113-122.