Trichothecene-induced cytotoxicity on human cell lines

Mycotoxin Research

Volumn 25, Issue 2, 2009, Pages 77-84

  Nielsen, Carina ^a   Casteel, Maximilian ^a   Didier, Andrea ^a   Dietrich, Richard ^a   Märtlbauer, Erwin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Human cell lines; HUVEC; Mycotoxin; Trichothecene

Indexed keywords

HT 2 TOXIN; NIVALENOL; SATRATOXIN G; SATRATOXIN H; T 2 TOXIN; TRICHOTHECENE; UNCLASSIFIED DRUG; VOMITOXIN;

ARTICLE; CELL ASSAY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; UMBILICAL VEIN;

EID: 67651089713     PISSN: 01787888     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12550-009-0011-5     Document Type: Article

References (41)

1. D Abramson RM Clear E Usleber R Gessler TW Nowicki E Märtlbauer 1998 Fusarium species and 8-keto-trichothecene mycotoxins in Manitoba barley Cereal Chem 75 137 141 10.1094/CCHEM.1998.75.1.137 (Pubitemid 28131999)
2. JW Bennett M Klich 2003 Mycotoxins Clin Microbiol Rev 16 497 516 10.1128/CMR.16.3.497-516.2003
3. GS Bondy JJ Pestka 2000 Immunomodulation by fungal toxins J Toxicol Environ Health B 3 109 143 10.1080/109374000281113 (Pubitemid 30245577)
4. C Bouaziz O Sharaf El Dein E El Golli S Abid-Essefi C Brenner C Lemaire H Bacha 2008 Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells Toxicology 254 19 28 10.1016/j.tox.2008.08. 020
5. TL Brasel JM Martin CG Carriker SC Wilson DC Straus 2005 Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins in the indoor environment Appl Environ Microbiol 71 7376 7388 10.1128/AEM.71.11.7376- 7388.2005
6. TW Calvert KE Aidoo AG Candlish AR Fuat 2005 Comparison of in vitro cytotoxicity of Fusarium mycotoxins, deoxynivalenol, T-2 toxin and zearalenone on selected human epithelial cell lines Mycopathologia 159 413 419 10.1007/s11046-005-0254-4
7. Y Cetin LB Bullerman 2005 Cytotoxicity of Fusarium mycotoxins to mammalian cell cultures as determined by the MTT bioassay Food Chem Toxicol 43 755 764 10.1016/j.fct.2005.01.016
8. JH Chen JL Cao YL Chu ZL Wang ZT Yang HL Wang 2008 T-2 toxin-induced apoptosis involving Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 signaling pathways in human chondrocytes J Zhejiang Univ Sci B 9 455 463 10.1631/jzus.B0820013
9. WA Croft BB Jarvis CS Yatawara 1986 Airborne outbreak of trichothecene toxicosis Atmos Environ 20 549 552 10.1016/0004-6981(86) 90096-X (Pubitemid 16131532)
10. V Curtui E Usleber R Dietrich J Lepschy E Märtlbauer 1998 A survey on the occurrence of mycotoxins in wheat and maize from western Romania Mycopathologia 143 97 103 10.1023/A:1006987205986
11. V Curtui A Brockmeyer R Dietrich O Kappenstein H Klaffke J Lepschy E Märtlbauer E Schneider C Seidler G Thielert E Usleber R Weber J Wolff 2005 Deoxynivalenol in food Mycotoxin Res 21 83 88 10.1007/BF02954424
12. Gareis M (2006) Diagnostischer Zellkulturtest (MTT-Test) für den Nachweis von zytotoxischen Kontaminanten und Rückständen. J Verbraucherschutz Lebensmittelsicherheit 1:354-363 (Pubitemid 44924768)
13. C Gottschalk J Bauer K Meyer 2006 Determination of macrocyclic trichothecenes in mouldy indoor materials by LC-MS/MS Mycotoxin Res 22 189 192 10.1007/BF02959275
14. JS Gray JJ Pestka 2007 Transcriptional regulation of deoxynivalenol- induced IL-8 expression in human monocytes Toxicol Sci 99 502 511 10.1093/toxsci/kfm182
15. JF Grove 1993 Macrocyclic trichothecenes Nat Prod Rep 10 429 448 10.1039/np9931000429 (Pubitemid 23959264)
16. AC Gutleb E Morrison AJ Murk 2002 Cytotoxicity assays for mycotoxins produced by Fusarium strains: a review Environ Toxicol Pharmacol 11 309 320 10.1016/S1382-6689(02) 00020-0 (Pubitemid 34694011)
17. M Hanelt M Gareis B Kollarczik 1994 Cytotoxicity of mycotoxins evaluated by the MTT-cell culture assay Mycopathologia 128 167 174 10.1007/BF01138479
18. Z Islam CC Hegg HK Bae JJ Pestka 2008 Satratoxin G-induced apoptosis in PC-12 neuronal cells is mediated by PKR and caspase independent Toxicol Sci 105 142 152 10.1093/toxsci/kfn110
19. L Ivanova S Uhlig 2008 A bioassay for the simultaneous measurement of metabolic activity, membrane integrity, and lysosomal activity in cell cultures Anal Biochem 379 16 19 10.1016/j.ab.2008.04.035
20. E Johanning R Biagini D Hull P Morey B Jarvis P Landsbergis 1996 Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment Int Arch Occup Environ Health 68 207 218 (Pubitemid 26152432)
21. E Johanning M Gareis S Yang E-L Hintikka M Nikulin B Jarvis R Dietrich 1998 Toxicity screening of materials from buildings with fungal indoor air quality problems (Stachybotrys chartarum) Mycotoxin Res 14 60 73 10.1007/BF02945095
22. E Johanning P Landsbergis M Gareis CS Yang E Olmsted 1999 Clinical experience and results of a Sentinel Health Investigation related to indoor fungal exposure Environ Health Perspect 107 Suppl 3 489 494 10.2307/3434632 (Pubitemid 29346998)
23. M Königs G Schwerdt M Gekle H-U Humpf 2008 Effects of the mycotoxin deoxynivalenol on human primary hepatocytes Mol Nutr Food Res 52 830 839 10.1002/mnfr.200700439
24. M Königs D Mulac G Schwerdt M Gekle H-U Humpf 2009 Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture Toxicology 258 106 115 10.1016/j.tox.2009.01.012
25. S Mayer V Curtui E Usleber M Gareis 2007 Airborne mycotoxins in dust from grain elevators Mycotoxin Res 23 94 100 10.1007/BF02946033
26. S Mayer S Engelhart A Kolk H Blome 2008 The significance of mycotoxins in the framework of assessing workplace related risks Mycotoxin Res 24 151 164 10.1007/BF03032342
27. CS [tmp] McLaughlin MH Vaughan IM Campbell CM Wei ME Stafford BS Hansen 1977
28. FA Meky LJ Hardie SW Evans CP Wild 2001 Deoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine production Food Chem Toxicol 39 827 836 10.1016/S0278-6915(01) 00029-1 (Pubitemid 32575250)
29. T Nasri RR Bosch S Voorde J Fink-Gremmels 2006 Differential induction of apoptosis by type A and B trichothecenes in Jurkat T-lymphocytes Toxicol In Vitro 20 832 840 10.1016/j.tiv.2006.01.003
30. Nielsen C, Lippke H, Didier A, Dietrich R, Märtlbauer E (2009) Potential of deoxynivalenol to induce transcription factors in human hepatoma cells. Mol Nutr Food Res 53:479-491
31. JJ Pestka 2008 Mechanisms of deoxynivalenol-induced gene expression and apoptosis Food Addit Contam 25 1128 1140
32. JJ Pestka I Yike DG Dearborn MDW Ward JR Harkema 2008 Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: New insights into a public health enigma Toxicol Sci 104 4 26 10.1093/toxsci/kfm284
33. G Reubel M Gareis WM Amselgruber 1987 Cytotoxicity evaluation of mycotoxins by an MTT-bioassay Mycotoxin Res 3 85 96
34. GH Reubel M Gareis WM Amselgruber 1989 Effects of the Fusarium mycotoxins zearalenone and deoxynivalenol on the mitochondrial methylthiazol tetrazolium-cleavage activity of monolayer cells Toxicol In Vitro 3 311 316 10.1016/0887-2333(89) 90038-6 (Pubitemid 20019735)
35. S Schoettler M Bascope O Sterner T Anke 2006 Isolation and characterization of two verrucarins from Myrothecium roridum Z Naturforsch 61 C 309 314 (Pubitemid 44073418)
36. SCOOP (2003) (Scientific Cooperation) Collection of occurrence data of fusarium toxins in food and assessment of dietary intake by the population of EU member states. SCOOP Task 3.2.10 Final Report. Available: http://europa.eu.int/ comm/food/fs/scoop/task3210.pdf. (Scientific Cooperation)
37. WG Sorenson DG Frazer BB Jarvis J Simpson VA Robinson 1987 Trichothecene mycotoxins in aerosolized conidia of Stachybotrys atra Appl Environ Microbiol 53 1370 1375 (Pubitemid 17112874)
38. A Thuvander C Wikman I Gadhasson 1999 In vitro exposure of human lymphocytes to trichothecenes: individual variation in sensitivity and effects of combined exposure on lymphocyte function Food Chem Toxicol 37 639 648 10.1016/S0278-6915(99) 00038-1 (Pubitemid 29438564)
39. PC Turner JA Rothwell KLM White Y Gong JE Cade CP Wild 2008 Urinary deoxynivalenol is correlated with cereal intake in individuals from the United Kingdom Environ Health Perspect 116 21 25
40. CM Wei CS [tmp] McLaughlin 1974 Structure-function relationship in 12, 13-epoxytrichothecenes - novel inhibitors of protein-synthesis Biochem Biophys Res Commun 57 838 844 10.1016/0006-291X(74) 90622-6
41. J Widestrand T Lundh H Pettersson JE Lindberg 1999 Cytotoxicity of four trichothecenes evaluated by three colorimetric bioassays Mycopathologia 147 149 155 10.1023/A:1007127919901