A panel of cancer-testis genes exhibiting broad-spectrum expression in haematological malignancies

Cancer Immunity

Volumn 10, Issue , 2010, Pages 1-12

  Liggins, Amanda P ^a   Lim, Seah H ^b   Soilleux, Elizabeth J ^c   Pulford, Karen ^a   Banham, Alison H ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b TEXAS ONCOLOGY   (United States)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

CT antigens; Haematological cancer; Human; Immunohistochemistry; RT PCR; Western blotting

Indexed keywords

CANCER TESTIS ANTIGEN; MELANOMA ANTIGEN 1; MESSENGER RNA; NY ESO 1 ANTIGEN; PAS DOMAIN CONTAINING 1 PROTEIN; PREFERENTIALLY EXPRESSED ANTIGEN OF MELANOMA PROTEIN; PROTEIN CAGE; PROTEIN CSAGE; PROTEIN CTAGE1; PROTEIN HAGE; PROTEIN PLU 1; SPERM PROTEIN 17; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE LOCATION; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; MALE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T CELL LYMPHOMA; WESTERN BLOTTING; X CHROMOSOME;

EID: 77957158585     PISSN: None     EISSN: 14249634     Source Type: Journal    
DOI: None     Document Type: Article

References (82)

1. Ng AK. Diffuse large B-cell lymphoma. Semin Radiat Oncol 2007; 17: 169-175. (PMID: 17591563)
2. Weigert O, Unterhalt M, Hiddemann W, Dreyling M. Current man-agement of mantle cell lymphoma. Drugs 2007; 67: 1689-1702. (PMID: 17683170)
3. Richardson PG, Mitsiades C, Schlossman R, Munshi N, Anderson K. New drugs for myeloma. Oncologist 2007; 12: 664-689. (PMID: 17602058)
4. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD. The World Health Organiza-tion classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November, 1997. Ann Oncol 1999; 10: 1419-1432. (PMID: 10643532)
5. Horning SJ, Rosenberg SA. The natural history of initially untreated low-grade non-Hodgkin's lymphomas. N Engl J Med 1984; 311: 1471-1475. (PMID: 6548796)
6. Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan WC, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp PM, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, Staudt LM. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med 2004; 351: 2159-2169. (PMID: 15548776)
7. Veelken H, Osterroth F. Vaccination strategies in the treatment of lymphomas. Oncology 2002; 62: 187-200. (PMID: 12065865)
8. Ruffini PA, Neelapu SS, Kwak LW, Biragyn A. Idiotypic vaccination for B-cell malignancies as a model for therapeutic cancer vaccines: from prototype protein to second generation vaccines. Haematolog-ica 2002; 87: 989-1001. (PMID: 12217812)
9. Bogen B, Ruffini PA, Corthay A, Fredriksen AB, Frøyland M, Lun-din K, Røsjø E, Thompson K, Massaia M. Idiotype-specific immu-notherapy in multiple myeloma: suggestions for future directions of research. Haematologica 2006; 91: 941-948. (PMID: 16818282)
10. Scanlan MJ, Gure AO, Jungbluth AA, Old LJ, Chen YT. Cancer/tes-tis antigens: an expanding family of targets for cancer immunother-apy. Immunol Rev 2002; 188: 22-32. (PMID: 12445278)
11. Scanlan MJ, Simpson AJ, Old LJ. The cancer/testis genes: review, standardization, and commentary. Cancer Immun 2004; 4: 1. URL: http://www.cancerimmunity.org/v4p1/031220.htm
12. Simpson AJ, Caballero OL, Jungbluth A, Chen YT, Old LJ. Cancer/ testis antigens, gametogenesis and cancer. Nat Rev Cancer 2005; 5: 615-625. (PMID: 16034368)
13. Hofmann O, Caballero OL, Stevenson BJ, Chen YT, Cohen T, Chua R, Maher CA, Panji S, Schaefer U, Kruger A, Lehvaslaiho M, Carn-inci P, Hayashizaki Y, Jongeneel CV, Simpson AJ, Old LJ, Hide W. Genome-wide analysis of cancer/testis gene expression. Proc Natl Acad Sci U S A 2008; 105: 20422-20427. (PMID: 19088187)
14. Juretic A, Spagnoli GC, Schultz-Thater E, Sarcevic B. Cancer/testis tumour-associated antigens: immunohistochemical detection with monoclonal antibodies. Lancet Oncol 2003; 4: 104-109. (PMID: 12573352)
15. Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, Wells JW, Banham AH, Mufti GJ. Humoral detection of leukaemia-asso-ciated antigens in presentation acute myeloid leukaemia. Biochem Biophys Res Commun 2005; 335: 1293-1304. (PMID: 16112646)
16. Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH. A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein. Br J Cancer 2004; 91: 141-149. (PMID: 15162151)
17. Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH. Sero-logic detection of diffuse large B-cell lymphoma-associated anti-gens. Int J Cancer 2004; 110: 563-569. (PMID: 15122589)
18. Ait-Tahar K, Liggins AP, Collins GP, Campbell A, Barnardo M, Lawrie C, Moir D, Hatton C, Banham AH, Pulford K. Cytolytic T-cell response to the PASD1 cancer testis antigen in patients with dif-fuse large B-cell lymphoma. Br J Haematol 2009; 146: 396-407. (PMID: 19552722)
19. Cooper CD, Liggins AP, Ait-Tahar K, Roncador G, Banham AH, Pulford K. PASD1, a DLBCL-associated cancer testis antigen and candidate for lymphoma immunotherapy. Leukemia 2006; 20: 2172-2174. (PMID: 17024112)
20. Sahota SS, Goonewardena CM, Cooper CD, Liggins AP, Ait-Tahar K, Zojer N, Stevenson FK, Banham AH, Pulford K. PASD1 is a potential multiple myeloma-associated antigen. Blood 2006; 108: 3953-3955. (PMID: 17114574)
21. Huang S, Preuss KD, Xie X, Regitz E, Pfreundschuh M. Analysis of the antibody repertoire of lymphoma patients. Cancer Immunol Immunother 2002; 51: 655-662. (PMID: 12439611)
22. Xie X, Wacker HH, Huang S, Regitz E, Preuss KD, Romeike B, Par-waresch R, Tiemann M, Pfreundschuh M. Differential expression of cancer testis genes in histological subtypes of non-Hodgkin's lym-phomas. Clin Cancer Res 2003; 9: 167-173. (PMID: 12538465)
23. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J Jr, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Levy R, Wilson W, Grever MR, Byrd JC, Botstein D, Brown PO, Staudt LM. Distinct types of diffuse large B-cell lymphoma identi-fied by gene expression profiling. Nature 2000; 403: 503-511. (PMID: 10676951)
24. Brown PJ, Ashe SL, Leich E, Burek C, Barrans S, Fenton JA, Jack AS, Pulford K, Rosenwald A, Banham AH. Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL. Blood 2008; 111: 2816-2824. (PMID: 18077790)
25. Straughn JM Jr, Shaw DR, Guerrero A, Bhoola SM, Racelis A, Wang Z, Chiriva-Internati M, Grizzle WE, Alvarez RD, Lim SH, Strong TV. Expression of sperm protein 17 (Sp17) in ovarian cancer. Int J Cancer 2004; 108: 805-811. (PMID: 14712480)
26. Häffner AC, Tassis A, Zepter K, Storz M, Tureci O, Burg G, Nestle FO. Expression of cancer/testis antigens in cutaneous T cell lym-phomas. Int J Cancer 2002; 97: 668-670. (PMID: 11807795)
27. Dhodapkar MV, Osman K, Teruya-Feldstein J, Filippa D, Hedvat CV, Iversen K, Kolb D, Geller MD, Hassoun H, Kewalramani T, Comenzo RL, Coplan K, Chen YT, Jungbluth AA. Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7, and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease. Cancer Immun 2003; 3: 9. URL: http://www.cancerimmunity.org/v3p9/030709.htm
28. Jungbluth AA, Ely S, DiLiberto M, Niesvizky R, Williamson B, Fro-sina D, Chen YT, Bhardwaj N, Chen-Kiang S, Old LJ, Cho HJ. The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are com-monly expressed in multiple myeloma and correlate with plasma-cell proliferation. Blood 2005; 106: 167-174. (PMID: 15761016)
29. Taylor BJ, Reiman T, Pittman JA, Keats JJ, de Bruijn DR, Mant MJ, Belch AR, Pilarski LM. SSX cancer testis antigens are expressed in most multiple myeloma patients: co-expression of SSX1, 2, 4, and 5 correlates with adverse prognosis and high frequencies of SSX-posi-tive PCs. J Immunother 2005; 28: 564-575. (PMID: 16224274)
30. Atanackovic D, Arfsten J, Cao Y, Gnjatic S, Schnieders F, Bartels K, Schilling G, Faltz C, Wolschke C, Dierlamm J, Ritter G, Eiermann T, Hossfeld DK, Zander AR, Jungbluth AA, Old LJ, Bokemeyer C, Kröger N. Cancer-testis antigens are commonly expressed in multi-ple myeloma and induce systemic immunity following allogeneic stem cell transplantation. Blood 2007; 109: 1103-1112. (PMID: 17023585)
31. Condomines M, Hose D, Raynaud P, Hundemer M, De Vos J, Bau-dard M, Moehler T, Pantesco V, Moos M, Schved JF, Rossi JF, Rème T, Goldschmidt H, Klein B. Cancer/testis genes in multiplemyeloma: expression patterns and prognosis value determined by microarray analysis. J Immunol 2007; 178: 3307-3315. (PMID: 17312182)
32. Luetkens T, Schafhausen P, Uhlich F, Stasche T, Akbulak R, Bartels BM, Hildebrandt Y, Gontarewicz A, Kobold S, Meyer S, Gordic M, Bartels K, Lajmi N, Cao Y, Kröger N, Bokemeyer C, Brümmendorf TH, Atanackovic D. Expression, epigenetic regulation, and humoral immunogenicity of cancer-testis antigens in chronic myeloid leuke-mia. Leuk Res 2010; in press. (PMID: 20409582)
33. van Baren N, Chambost H, Ferrant A, Michaux L, Ikeda H, Millard I, Olive D, Boon T, Coulie PG. PRAME, a gene encoding an antigen recognized on a human melanoma by cytolytic T cells, is expressed in acute leukaemia cells. Br J Haematol 1998; 102: 1376-1379. (PMID: 9753074)
34. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neopla-sia 2004; 6: 1-6. (PMID: 15068665)
35. Mathieu MG, Linley AJ, Reeder SP, Badoual C, Tartour E, Rees RC, McArdle SE. HAGE, a cancer/testis antigen expressed at the protein level in a variety of cancers. Cancer Immun 2010; 10: 2. URL: http:// www.cancerimmunity.org/v10p2/091211.htm
36. Chen YT, Güre AO, Tsang S, Stockert E, Jager E, Knuth A, Old LJ. Identification of multiple cancer/testis antigens by allogeneic anti-body screening of a melanoma cell line library. Proc Natl Acad Sci U S A 1998; 95: 6919-6923. (PMID: 9618514)
37. Old LJ. Cancer/Testis (CT) antigens-a new link between gametoge-nesis and cancer. Cancer Immun 2001; 1: 1. URL: http://www.can-cerimmunity.org/v1p1/010304.htm
38. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Müller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, Falini B, Banham AH, Rosenwald A, Staudt LM, Connors JM, Armitage JO, Chan WC. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immu-nohistochemistry using a tissue microarray. Blood 2004; 103: 275-282. (PMID: 14504078)
39. Brasseur F, Rimoldi D, Liénard D, Lethe B, Carrel S, Arienti F, Suter L, Vanwijck R, Bourlond A, Humblet Y, Vacca A, Conese M, Lahaye T, Degiovanni G, Deraemaecker R, Beauduin M, Sastre X, Salamon E, Dréno B, Jäger E, Knuth A, Chevreau C, Suciu S, Lachapelle JM, Pouillart P, Parmiani G, Lejeune F, Cerottini JC, Boon T, Marchand M. Expression of MAGE genes in primary and metastatic cutaneous melanoma. Int J Cancer 1995; 63: 375-380. (PMID: 7591235)
40. Kurashige T, Noguchi Y, Saika T, Ono T, Nagata Y, Jungbluth A, Ritter G, Chen YT, Stockert E, Tsushima T, Kumon H, Old LJ, Nakayama E. Ny-ESO-1 expression and immunogenicity associated with transitional cell carcinoma: correlation with tumor grade. Can-cer Res 2001; 61: 4671-4674. (PMID: 11406534)
41. Kawano R, Karube K, Kikuchi M, Takeshita M, Tamura K, Uike N, Eto T, Ohshima K, Suzumiya J. Oncogene associated cDNA microarray analysis shows PRAME gene expression is a marker for response to anthracycline containing chemotherapy in patients with diffuse large B-cell lymphoma. J Clin Exp Hematopathol 2009; 49: 1-7.
42. Lim SH, Wang Z, Chiriva-Internati M, Xue Y. Sperm protein 17 is a novel cancer-testis antigen in multiple myeloma. Blood 2001; 97: 1508-1510. (PMID: 11222401)
43. Chiriva-Internati M, Wang Z, Salati E, Bumm K, Barlogie B, Lim SH. Sperm protein 17 (Sp17) is a suitable target for immunotherapy of multiple myeloma. Blood 2002; 100: 961-965. (PMID: 12130509)
44. Chiriva-Internati M, Wang Z, Salati E, Timmins P, Lim SH. Tumor vaccine for ovarian carcinoma targeting sperm protein 17. Cancer 2002; 94: 2447-2453. (PMID: 12015770)
45. Old LJ. Cancer vaccines: an overview. Cancer Immun 2008; 8 Suppl. 1: 1. URL: http://www.cancerimmunity.org/v8suppl1p1/ 080104.htm
46. Jäger E, Gnjatic S, Nagata Y, Stockert E, Jäger D, Karbach J, Neu-mann A, Rieckenberg J, Chen YT, Ritter G, Hoffman E, Arand M, Old LJ, Knuth A. Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers. Proc Natl Acad Sci U S A 2000; 97: 12198-12203. (PMID: 11027314)
47. Jäger E, Stockert E, Zidianakis Z, Chen YT, Karbach J, Jäger D, Arand M, Ritter G, Old LJ, Knuth A. Humoral immune responses of cancer patients against Cancer-Testis antigen NY-ESO-1: correla-tion with clinical events. Int J Cancer 1999; 84: 506-510. (PMID: 10502728)
48. Sadanaga N, Nagashima H, Mashino K, Tahara K, Yamaguchi H, Ohta M, Fujie T, Tanaka F, Inoue H, Takesako K, Akiyoshi T, Mori M. Dendritic cell vaccination with MAGE peptide is a novel thera-peutic approach for gastrointestinal carcinomas. Clin Cancer Res 2001; 7: 2277-2284. (PMID: 11489802)
49. Marchand M, van Baren N, Weynants P, Brichard V, Dréno B, Tess-ier MH, Rankin E, Parmiani G, Arienti F, Humblet Y, Bourlond A, Vanwijck R, Liénard D, Beauduin M, Dietrich PY, Russo V, Kerger J, Masucci G, Jäger E, De Greve J, Atzpodien J, Brasseur F, Coulie PG, van der Bruggen P, Boon T. Tumor regressions observed in patients with metastatic melanoma treated with an antigenic pep-tide encoded by gene MAGE-3 and presented by HLA-A1. Int J Cancer 1999; 80: 219-230. (PMID: 9935203)
50. Dadabayev AR, Wang Z, Zhang Y, Zhang J, Robinson WR, Lim SH. Cancer immunotherapy targeting Sp17: when should the laboratory findings be translated to the clinics? Am J Hematol 2005; 80: 6-11. (PMID: 16138340)
51. Curioni-Fontecedro A, Knights AJ, Tinguely M, Nuber N, Schneider C, Thomson CW, von Boehmer L, Bossart W, Pahlich S, Gehring H, Moch H, Renner C, Knuth A, Zippelius A. MAGE-C1/ CT7 is the dominant cancer-testis antigen targeted by humoral immune responses in patients with multiple myeloma. Leukemia 2008; 22: 1646-1648. (PMID: 18323799)
52. Wang Z, Zhang Y, Mandal A, Zhang J, Giles FJ, Herr JC, Lim SH. The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies. Clin Cancer Res 2004; 10: 6544-6550. (PMID: 15475442)
53. Wang Z, Zhang Y, Liu H, Salati E, Chiriva-Internati M, Lim SH. Gene expression and immunologic consequence of SPAN-Xb inmyeloma and other hematologic malignancies. Blood 2003; 101: 955-960. (PMID: 12393489)
54. Adams SP, Sahota SS, Mijovic A, Czepulkowski B, Padua RA, Mufti GJ, Guinn BA. Frequent expression of HAGE in presentation chronic myeloid leukaemias. Leukemia 2002; 16: 2238-2242. (PMID: 12399967)
55. Lendvai N, Gnjatic S, Ritter E, Mangone M, Austin W, Reyner K, Jayabalan D, Niesvizky R, Jagannath S, Bhardwaj N, Chen-Kiang S, Old LJ, Cho HJ. Cellular immune responses against CT7 (MAGE-C1) and humoral responses against other cancer-testis antigens in multiple myeloma patients. Cancer Immun 2010; 10: 4. URL: http:// www.cancerimmunity.org/v10p4/091213.htm
56. Goodyear OC, Pratt G, McLarnon A, Cook M, Piper K, Moss P. Differential pattern of CD4+ and CD8+ T-cell immunity to MAGE-A1/A2/A3 in patients with monoclonal gammopathy of undeter-mined significance (MGUS) and multiple myeloma. Blood 2008; 112: 3362-3372. (PMID: 18658027)
57. Quintarelli C, Dotti G, De Angelis B, Hoyos V, Mims M, Luciano L, Heslop HE, Rooney CM, Pane F, Savoldo B. Cytotoxic T lympho-cytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia. Blood 2008; 112: 1876-1885. (PMID: 18591381)
58. Frank C, Hundemer M, Ho AD, Goldschmidt H, Witzens-Harig M. Cellular immune responses against the cancer-testis antigen SPAN-XB in healthy donors and patients with multiple myeloma. Leuk Lymphoma 2008; 49: 779-785. (PMID: 18398747)
59. van Rhee F, Szmania SM, Zhan F, Gupta SK, Pomtree M, Lin P, Batchu RB, Moreno A, Spagnoli G, Shaughnessy J, Tricot G. NY-ESO-1 is highly expressed in poor-prognosis multiple myeloma and induces spontaneous humoral and cellular immune responses. Blood 2005; 105: 3939-3944. (PMID: 15671442)
60. Goodyear O, Piper K, Khan N, Starczynski J, Mahendra P, Pratt G, Moss P. CD8+ T cells specific for cancer germline gene antigens are found in many patients with multiple myeloma, and their frequency correlates with disease burden. Blood 2005; 106: 4217-4224. (PMID: 16144804)
61. Jungbluth AA, Chen YT, Stockert E, Busam KJ, Kolb D, Iversen K, Coplan K, Williamson B, Altorki N, Old LJ. Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues. Int J Cancer 2001; 92: 856-860. (PMID: 11351307)
62. Jungbluth AA, Stockert E, Chen YT, Kolb D, Iversen K, Coplan K, Williamson B, Altorki N, Busam KJ, Old LJ. Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours. Br J Cancer 2000; 83: 493-497. (PMID: 10945497)
63. Pulford K, Banham AH, Lyne L, Jones M, Ippolito GC, Liu H, Tucker PW, Roncador G, Lucas E, Ashe S, Stockwin L, Walewska R, Karran L, Gascoyne RD, Mason DY, Dyer MJ. The BCL11AXL transcription factor: its distribution in normal and malignant tis-sues and use as a marker for plasmacytoid dendritic cells. Leukemia 2006; 20: 1439-1441. (PMID: 16710303)
64. Sambrook J, Russell DW. Molecular Cloning: A Laboratory Approach. 3rd ed. New York (NY): Cold Spring Harbor Laboratory Press; 2001.
65. van Baren N, Brasseur F, Godelaine D, Hames G, Ferrant A, Leh-mann F, André M, Ravoet C, Doyen C, Spagnoli GC, Bakkus M, Thielemans K, Boon T. Genes encoding tumor-specific antigens are expressed in human myeloma cells. Blood 1999; 94: 1156-1164. (PMID: 10438702)
66. Yuasa T, Okamoto K, Kawakami T, Mishina M, Ogawa O, Okada Y. Expression patterns of cancer testis antigens in testicular germ cell tumors and adjacent testicular tissue. J Urol 2001; 165: 1790-1794. (PMID: 11342977)
67. Güre AO, Wei IJ, Old LJ, Chen YT. The SSX gene family: character-ization of 9 complete genes. Int J Cancer 2002; 101: 448-453. (PMID: 12216073)
68. Chen YT, Scanlan MJ, Sahin U, Türeci O, Gure AO, Tsang S, Will-iamson B, Stockert E, Pfreundschuh M, Old LJ. A testicular antigen aberrantly expressed in human cancers detected by autologous anti-body screening. Proc Natl Acad Sci U S A 1997; 94: 1914-1918. (PMID: 9050879)
69. Scanlan MJ, Altorki NK, Gure AO, Williamson B, Jungbluth A, Chen YT, Old LJ. Expression of cancer-testis antigens in lung can-cer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9. Cancer Lett 2000; 150: 155-164. (PMID: 10704737)
70. Güre AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT. CT10: a new cancer-testis (CT) antigen homolo-gous to CT7 and the MAGE family, identified by representational-difference analysis. Int J Cancer 2000; 85: 726-732. (PMID: 10699956)
71. Liu XF, Helman LJ, Yeung C, Bera TK, Lee B, Pastan I. XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. Cancer Res 2000; 60: 4752-4755. (PMID: 10987281)
72. Martelange V, De Smet C, De Plaen E, Lurquin C, Boon T. Identifi-cation on a human sarcoma of two new genes with tumor-specific expression. Cancer Res 2000; 60: 3848-3855. (PMID: 10919659)
73. Scanlan MJ, Gordon CM, Williamson B, Lee SY, Chen YT, Stockert E, Jungbluth A, Ritter G, Jäger D, Jäger E, Knuth A, Old LJ. Identifi-cation of cancer/testis genes by database mining and mRNA expres-sion analysis. Int J Cancer 2002; 98: 485-492. (PMID: 11920606)
74. Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D. Serological detection of cutaneous T-cell lymphoma-associated antigens. Proc Natl Acad Sci U S A 2001; 98: 629-634. (PMID: 11149944)
75. Lin C, Mak S, Meitner PA, Wolf JM, Bluman EM, Block JA, Terek RM. Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma. Gene 2002; 285: 269-278. (PMID: 12039054)
76. Cho B, Lim Y, Lee DY, Park SY, Lee H, Kim WH, Yang H, Bang YJ, Jeoung DI. Identification and characterization of a novel cancer/tes-tis antigen gene CAGE. Biochem Biophys Res Commun 2002; 292: 715-726. (PMID: 11922625)
77. Sahin U, Koslowski M, Türeci O, Eberle T, Zwick C, Romeike B, Moringlane JR, Schwechheimer K, Feiden W, Pfreundschuh M. Expression of cancer testis genes in human brain tumors. Clin Can-cer Res 2000; 6: 3916-3922. (PMID: 11051238)
78. Barrett A, Madsen B, Copier J, Lu PJ, Cooper L, Scibetta AG, Burch-ell J, Taylor-Papadimitriou J. PLU-1 nuclear protein, which is upreg-ulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen? Int J Cancer 2002; 101: 581-588. (PMID: 12237901)
79. Roth RB, Hevezi P, Lee J, Willhite D, Lechner SM, Foster AC, Zlot-nik A. Gene expression analyses reveal molecular relationships among 20 regions of the human CNS. Neurogenetics 2006; 7: 67-80. (PMID: 16572319)
80. Ge X, Yamamoto S, Tsutsumi S, Midorikawa Y, Ihara S, Wang SM, Aburatani H. Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005; 86: 127-141. (PMID: 15950434)
81. Shyamsundar R, Kim YH, Higgins JP, Montgomery K, Jorden M, Sethuraman A, van de Rijn M, Botstein D, Brown PO, Pollack JR. A DNA microarray survey of gene expression in normal human tis-sues. Genome Biol 2005; 6: R22. (PMID: 15774023)
82. Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J, Dil-lon W, Lee KF, Clark KE, Haverty P, Weng Z, Mutter GL, Frosch MP, Macdonald ME, Milford EL, Crum CP, Bueno R, Pratt RE, Mahadevappa M, Warrington JA, Stephanopoulos G, Stephanopou-los G, Gullans SR. A compendium of gene expression in normal human tissues. Physiol Genomics 2001; 7: 97-104. (PMID: 11773596)