Motor neuron disease due to neuropathy target esterase mutation: Enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis

Toxicology Letters

Volumn 199, Issue 1, 2010, Pages 1-5

  Hein, Nichole D ^a   Rainier, Shirley R ^a   Richardson, Rudy J ^a,b   Fink, John K ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

Fibroblast; Motor neuron disease (MND); Mutation; Neuropathy target esterase (NTE); Organophosphorus compound induced delayed neurotoxicity (OPIDN)

Indexed keywords

MIPAFOX; NEUROTOXIC ESTERASE; CARBOXYLESTERASE;

ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; GENE INSERTION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO SELECTION; MOTOR NEURON DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN TARGETING; CELL CULTURE; ENZYMOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; HETEROZYGOTE; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY;

CARBOXYLIC ESTER HYDROLASES; CELLS, CULTURED; DNA MUTATIONAL ANALYSIS; FIBROBLASTS; GENOTYPE; HETEROZYGOTE; HUMANS; MOTOR NEURON DISEASE; MUTAGENESIS, INSERTIONAL;

EID: 77957138756     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.06.020     Document Type: Article

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