Organophosphates induce distal axonal damage, but not brain oedema, by inactivating neuropathy target esterase

Toxicology and Applied Pharmacology

Volumn 245, Issue 1, 2010, Pages 108-115

  Read, David J ^a   Li, Yong ^a   Chao, Moses V ^b   Cavanagh, John B ^c   Glynn, Paul ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Conditional knock out; Molecular target identification; Neurotoxicity; Serine hydrolase

Indexed keywords

4 BROMOPHENYLACETYLUREA; BENZYLSULFONYL FLUORIDE; CRE RECOMBINASE; ETHYLOCTYLPHOSPHONOFLUORIDATE; NESTIN; NEUROTOXIC ESTERASE; ORGANOPHOSPHATE; ORGANOPHOSPHORUS COMPOUND; PHENYLDIPENTYLPHOSPHINATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; CHICKEN; CONTROLLED STUDY; ENZYME INACTIVATION; GENE DELETION; HINDLIMB; MALE; MOUSE; MOUSE STRAIN; NERVOUS TISSUE; NEUROTOXICITY; NONHUMAN; PERIPHERAL NERVE INJURY; PROTEIN TARGETING; SENSORY NERVE CELL; WILD TYPE;

ANIMALS; AXONS; BRAIN EDEMA; BRAIN INJURIES; CARBOXYLIC ESTER HYDROLASES; HINDLIMB; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PHOSPHORIC ACID ESTERS; UREA;

GALLUS GALLUS; MUS;

EID: 77952549592     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.02.010     Document Type: Article

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