Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties

Toxicology Letters

Volumn 196, Issue 2, 2010, Pages 67-73

  Hein, Nichole D ^a   Stuckey, Jeanne A ^b   Rainier, Shirley R ^a   Fink, John K ^a,c   Richardson, Rudy J ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c Education   (United States)

Author keywords

Hereditary spastic paraplegia (HSP); Motor neuron disease (MND); Neuropathy target esterase (NTE); Organophosphorus compound induced delayed neuropathy (OPIDN)

Indexed keywords

ARGININE; CHLORPYRIFOS; CHLORPYRIFOS OXON; DYFLOS; HISTIDINE; METHIONINE; MIPAFOX; MUTANT PROTEIN; NEUROTOXIC ESTERASE; NUCLEOPHILE; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE; VALERIC ACID PHENYL ESTER; VALINE; CARBOXYLESTERASE; DRUG DERIVATIVE; ENZYME INHIBITOR; O,O DIETHYL O 3,5,6 TRICHLORO 2 PYRIDYL PHOSPHATE; O,O-DIETHYL O-3,5,6-TRICHLORO-2-PYRIDYL PHOSPHATE; RECOMBINANT PROTEIN;

AGING; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME REACTIVATION; ENZYME SUBSTRATE; GENE CONSTRUCT; GENE MUTATION; HUMAN; HYDROLYSIS; MOTOR NEURON DISEASE; PRIORITY JOURNAL; PROTEIN DOMAIN; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HEREDITARY MOTOR SENSORY NEUROPATHY; KINETICS; METABOLISM; MUTATION; SITE DIRECTED MUTAGENESIS;

CARBOXYLIC ESTER HYDROLASES; CATALYTIC DOMAIN; CHLORPYRIFOS; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; ISOFLUROPHATE; KINETICS; MOTOR NEURON DISEASE; MUTAGENESIS, SITE-DIRECTED; MUTATION; RECOMBINANT PROTEINS; SPASTIC PARAPLEGIA, HEREDITARY; SUBSTRATE SPECIFICITY; VALERATES;

EID: 77952746543     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.03.1120     Document Type: Article

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