Glutamate exocrine dynamics augmented by plasma glutamine and the distribution of amino acid transporters of the rat pancreas

Journal of Physiology and Pharmacology

Volumn 61, Issue 3, 2010, Pages 265-271

  Fukushima, D ^a   Doi, H ^a   Fukushima, K ^a,b   Katsura, K ^a   Ogawa, N ^a   Sekiguchi, S ^a   Fujimori, K ^a   Sato, A ^a   Satomi, S ^a   Ishida, K ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Amino acid; Exocrine; Glutamate; Glutamine; Pancreas; Pancreatic juice; Transporter

Indexed keywords

4F2 HEAVY CHAIN PROTEIN; ALANYLGLUTAMINE; AMINO ACID TRANSPORTER; B0 POSITIVE TYPE AMINO ACID TRANSPORTER 1; CYSTEINYLGLUTAMIC ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMIC ACID; L TYPE AMINO ACID TRANSPORTER; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; DIPEPTIDE; GLUTAMATE TRANSPORTER; GLUTAMINE; XCT PROTEIN, RAT;

ACINAR CELL; AMINO ACID COMPOSITION; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR DYNAMICS; NONHUMAN; PANCREAS DUCT; PANCREAS ISLET CELL; PANCREAS JUICE; PANCREAS SECRETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; ANIMAL; BLOOD; METABOLISM; PANCREAS; PANCREAS ISLET; SPRAGUE DAWLEY RAT;

AMINO ACID TRANSPORT SYSTEM X-AG; AMINO ACID TRANSPORT SYSTEM Y+; AMINO ACID TRANSPORT SYSTEMS; AMINO ACID TRANSPORT SYSTEMS, ACIDIC; ANIMALS; DIPEPTIDES; GLUTAMIC ACID; GLUTAMINE; ISLETS OF LANGERHANS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; MALE; PANCREAS; PANCREATIC JUICE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77957074583     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Deloar HM, Fujiwara T, Nakamura T, et al. Estimation of internal absorbed dose of L-[methyl-11C]methionine using whole-body positron emission tomography. Eur J Nucl Med 1998; 25: 629-633.
2. Hustinx R, Lemaire C, Jerusalem G, et al. Whole-body tumor imaging using PET and 2-18F-fluoro-L-tyrosine: preliminary evaluation and comparison with 18F-FDG. J Nucl Med 2003; 44: 533-539.
3. Sutinen E, Jyrkkio S, Varpula M, et al. Nodal staging of lymphoma with whole-body PET: comparison of [11C] methionine and FDG. J Nucl Med 2000; 41: 1980-1988.
4. Van Venrooij WJ, Poort C, Kramer MF, Jansen MT. Relationship between extracellular amino acids and protein synthesis in vitro in the rat pancreas. Eur J Biochem 1972; 30: 427-433.
5. Webster PD, Black O, Mainz DL, Singh M. Pancreatic acinar cell metabolism and function. Gastroenterology 1977; 73: 1434-1449.
6. Fukushima K, Doi H, Satomi S. Free amino acids are secreted into pancreatic juice in the rat. JJSMN 2006; 40: 13-26.
7. Yumikari K, Nakamura A. Seikagakujikkenkouza. Vol. 11. Tokyo, Tokyokagakudoujin Inc., 1977, pp. 1080-1087.
8. Behar KL, Rothman DL. In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyric acid-glutamine cycling in rodent and human cortex: the central role of glutamine. J Nutr 2001; 131(Suppl 9): 2498S-504S; discussion 523S-524S.
9. Curi TC, De Melo MP, De Azevedo RB, Zorn TM, Curi R. Glutamine utilization by rat neutrophils: presence of phosphate-dependent glutaminase. Am J Physiol 1997; 273: C1124-C1129.
10. Gstraunthaler G, Holcomb T, Feifel E, Liu W, Spitaler N, Curthoys NP. Differential expression and acid-base regulation of glutaminase mRNAs in gluconeogenic LLC-PK(1)-FBPase(+) cells. Am J Physiol Renal Physiol 2000; 278: F227-F237.
11. Newsholme P, Procopio J, Lima MM, Pithon-Curi TC, Curi R. Glutamine and glutamate - their central role in cell metabolism and function. Cell Biochem Funct 2003; 21: 1-9.
12. Reeds PJ, Burrin DG, Stoll B, Jahoor F. Intestinal glutamate metabolism. J Nutr 2000; 130(Suppl 4S): 978S-982S.
13. Watford M, Chellaraj V, Ismat A, Brown P, Raman P. Hepatic glutamine metabolism. Nutrition 2002; 18: 301-303.
14. Garlick PJ. The role of leucine in the regulation of protein metabolism. J Nutr 2005; 135(Suppl 6):1553S-1556S.
15. Li C, Buettger C, Kwagh J, et al. A signaling role of glutamine in insulin secretion. J Biol Chem 2004; 279: 13393-13401.
16. Newsholme P, Brennan L, Rubi B, Maechler P. New insights into amino acid metabolism, beta-cell function and diabetes. Clin Sci 2005; 108: 185-194.
17. Zawalich WS, Yamazaki H, Zawalich KC, Cline G. Comparative effects of amino acids and glucose on insulin secretion from isolated rat or mouse islets. J Endocrinol 2004; 183: 309-319.
18. Funakoshi A, Miyasaka K, Kitani K, et al. Comperative effects of mammalian pancreastatins on the pancreatic exocrine secretion. Jpn J Physiol 1989; 39: 901-905.
19. Arii K, Kai T, Kokuba Y. Degradation kinetics of L-alanyl-L-glutamine and its derivatives in aqueous solution. Eur J Pharm Sci 1999; 7: 107-112.
20. Furst P, Albers S, Stehle P. Availability of glutamine supplied intravenously as alanylglutamine. Metabolism 1989; 38(8 Suppl 1): 67-72.
21. Beyreuther K, Biesalski HK, Fernstrom JD, et al. Consensusmeeting: monosodium glutamate - an update. Eur J Clin Nutr 2007; 61: 304-313.
22. Furst P, Pogan K, Stehle P. Glutamine dipeptides in clinical nutrition. Nutrition 1997; 13: 731-737.
23. Kapica M, Puzio I, Kato I, Kuwahara A, Zabielski A. Role of feed-regulating peptides on pancreatic exocrine secretion J Physiol Pharmacol 2008, 59(Suppl 2): 145-159.
24. Christensen HN. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev 1990; 70: 43-77.
25. Kanai Y. Family of neutral and acidic amino acid transporters: molecular biology, physiology and medical implications. Curr Opin Cell Biol 1997; 9: 565-572.
26. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 1998; 273: 23629-23632.
27. Chairoungdua A, Segawa H, Kim JY, et al. Identification of an amino acid transporter associated with the cystinuriarelated type II membrane glycoprotein. J Biol Chem 1999; 274: 28845-28848.
28. Kanai Y, Endou H. Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Curr Drug Metab 2001; 4: 339-354.
29. Hisano S. Vesicular glutamate transporters in the brain. Anat Sci Int 2003; 78: 191-204.
30. Sato H, Tamba M, Ishii T, Bannai S. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J Biol Chem 1999; 274: 11455-11458.
31. Kanai Y, Hediger MA. The glutamate and neutral amino acid transporter family: physiological and pharmacological implications. Eur J Pharmacol 2003; 479: 237-247.
32. Howell JA, Matthews AD, Swanson KC, Harmon DL, Mattheus JC. Molecular identification of high-affinity glutamate transporters in sheep and cattle forestomach, intestine, liver, kidney, and pancreas. J Anim Sci 2001; 79: 1329-1336.
33. von Schonfeld J, Goebell H, Muller MK. The islet-acinar axis of the pancreas. Int J Pancreatol 1994; 16: 131-140.
34. Williams JA, Goldfine ID. The insulin-pancreatic acinar axis. Diabetes 1985; 34: 980-986.
35. Furuta A, Noda M, Suzuki SO, et al. Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy. Am J Pathol 2003; 163: 779-787.
36. Sewell WA, Young JA. Secretion of electrolytes by the pancreas of the anaestetized rat. J Physiol 1975; 252: 379-396.
37. Bonner-Weir S, Toschi E, Inada A, et al. The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes 2004; 5(Suppl 2): 16-22.
38. Rosenberg L. Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model. Microsc Res Tech 1998; 43: 337-346.
39. Izzat NN, Overturf M, Weisbrodt NW, Loose DD. Bile acid transport in hypercholesterolemic resistant rabbits. J Physiol Pharmacol 2009; 60: 79-84.
40. Perriello G, Jorde R, Nurjhan N. Estimation of glucosealanine-lactate-glutamine cycles in postabsorptive humans: role of skeletal muscle. Am J Physiol 1995; 269: E443-E450.