Interleukin-2 as a Neuroregulatory Cytokine

NeuroImmune Biology

Volumn 6, Issue C, 2008, Pages 145-165

  Prinz, Marco ^a   Rossum, Denise Van ^a   Hanisch, Uwe Karsten ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77957041316     PISSN: 15677443     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1567-7443(07)10008-9     Document Type: Review

References (142)

1. Waldmann T.A. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol 6 8 (2006) 595-601
2. Ma A., Koka R., and Burkett P. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol 24 (2006) 657-679
3. Budagian V., Bulanova E., Paus R., and Bulfone-Paus S. IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev 17 4 (2006) 259-280
4. Bulfone-Paus S., Bulanova E., Budagian V., and Paus R. The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signaling. Bioessays 28 4 (2006) 362-377
5. Fehervari Z., Yamaguchi T., and Sakaguchi S. The dichotomous role of IL-2: tolerance versus immunity. Trends Immunol 27 3 (2006) 109-111
6. Morgan D.A., Ruscetti F.W., and Gallo R. Selective in vitro growth of T lymphocytes from normal human bone marrows. Science 193 4257 (1976) 1007-1008
7. Devos R., Plaetinck G., Cheroutre H., Simons G., Degrave W., Tavernier J., et al. Molecular cloning of human interleukin 2 cDNA and its expression in E. coli. Nucleic Acids Res 11 13 (1983) 4307-4323
8. Taniguchi T., Matsui H., Fujita T., Takaoka C., Kashima N., Yoshimoto R., et al. Structure and expression of a cloned cDNA for human interleukin-2. Nature 302 5906 (1983) 305-310
9. Gaffen S.L., Goldsmith A., and Greene W.C. Interleukin-2 and the interleukin-2 receptor. In: Thompson A. (Ed). The Cytokine Handbook (1998), Academic Press, SanDiego 73-103
10. Hanisch U.K. Effects of interleukin-2 and interferons on the nervous system. In: Ader R., Felten D.L., and Cohen N. (Eds) (2001), Academic Press, San Diego 585-631
11. Kakiuchi T., Tamura T., Gyotoku Y., and Nariuchi H. IL-2 production by B cells stimulated with a specific antigen. Cell Immunol 138 1 (1991) 207-215
12. Ellery J.M., and Nicholls P.J. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev 13 1 (2002) 27-40
13. Mai Z., Kousoulas K.G., Horohov D.W., and Klei T.R. Cross-species PCR cloning of gerbil (Meriones unguiculatus) interleukin-2 cDNA and its expression in COS-7 cells. Vet Immunol Immunopathol 40 1 (1994) 63-71
14. McKnight A.J., and Classon B.J. Biochemical and immunological properties of rat recombinant interleukin-2 and interleukin-4. Immunology 75 2 (1992) 286-292
15. Theze J. Cytokine receptors: a combinative family of molecules. Eur Cytokine Netw 5 4 (1994) 353-368
16. Bazan J.F. Unraveling the structure of IL-2. Science 257 5068 (1992) 410-413
17. Davies D.R., and Wlodawer A. Cytokines and their receptor complexes. FASEB J 9 1 (1995) 50-56
18. Bamford R.N., Grant A.J., Burton J.D., Peters C., Kurys G., Goldman C.K., et al. The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91 11 (1994) 4940-4944
19. Burton J.D., Bamford R.N., Peters C., Grant A.J., Kurys G., Goldman C.K., et al. A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91 11 (1994) 4935-4939
20. Carson W.E., Giri J.G., Lindemann M.J., Linett M.L., Ahdieh M., Paxton R., et al. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180 4 (1994) 1395-1403
21. Giri J.G., Ahdieh M., Eisenman J., Shanebeck K., Grabstein K., Kumaki S., et al. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13 12 (1994) 2822-2830
22. Grabstein K.H., Eisenman J., Shanebeck K., Rauch C., Srinivasan S., Fung V., et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264 5161 (1994) 965-968
23. Waldmann T.A., Tagaya Y., and Bamford R.N. Interleukin-2, interleukin-15, and their receptors. Int Rev Immunol 16 (1998) 205-226
24. Waldmann T.A., Dubois S., and Tagaya Y. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 14 2 (2001) 105-110
25. Fehniger T.A., Cooper M.A., and Caligiuri M.A. Interleukin-2 and interleukin-15: immunotherapy for cancer. Cytokine Growth Factor Rev 13 2 (2002) 169-183
26. Marks-Konczalik J., Dubois S., Losi J.M., Sabzevari H., Yamada N., Feigenbaum L., et al. IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc Natl Acad Sci USA 97 21 (2000) 11445-11450
27. Bamford R.N., Battiata A.P., Burton J.D., Sharma H., and Waldmann T.A. Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region/IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation. Proc Natl Acad Sci USA 93 7 (1996) 2897-2902
28. Bamford R.N., Battiata A.P., and Waldmann T.A. IL-15: the role of translational regulation in their expression. J Leukoc Biol 59 4 (1996) 476-480
29. Tagaya Y., Bamford R.N., DeFilippis A.P., and Waldmann T.A. IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 4 4 (1996) 329-336
30. Bamford R.N., DeFilippis A.P., Azimi N., Kurys G., and Waldmann T.A. The 5′ untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control. J Immunol 160 9 (1998) 4418-4426
31. Onu A., Pohl T., Krause H., and Bulfone-Paus S. Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms. J Immunol 158 1 (1997) 255-262
32. Tagaya Y., Kurys G., Thies T.A., Losi J.M., Azimi N., Hanover J.A., et al. Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides. Proc Natl Acad Sci USA 94 26 (1997) 14444-14449
33. Theze J., Alzari P.M., and Bertoglio J. Interleukin 2 and its receptors: recent advances and new immunological functions. Immunol Today 17 10 (1996) 481-486
34. Russell S.M., Keegan A.D., Harada N., Nakamura Y., Noguchi M., Leland P., et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science 262 5141 (1993) 1880-1883
35. Noguchi M., Nakamura Y., Russell S.M., Ziegler S.F., Tsang M., Cao X., et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 262 5141 (1993) 1877-1880
36. Anderson D.M., Kumaki S., Ahdieh M., Bertles J., Tometsko M., Loomis A., et al. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J Biol Chem 270 50 (1995) 29862-29869
37. de Jong J.L., Farner N.L., Widmer M.B., Giri J.G., and Sondel P.M. Interaction of IL-15 with the shared IL-2 receptor beta gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complex. J Immunol 156 4 (1996) 1339-1348
38. Giri J.G., Kumaki S., Ahdieh M., Friend D.J., Loomis A., Shanebeck K., et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J 14 15 (1995) 3654-3663
39. Dubois S., Mariner J., Waldmann T.A., and Tagaya Y. IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 17 5 (2002) 537-547
40. Tagaya Y., Burton J.D., Miyamoto Y., and Waldmann T.A. Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells. EMBO J 15 18 (1996) 4928-4939
41. Brennan P., Babbage J.W., Burgering B.M., Groner B., Reif K., and Cantrell D.A. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7 5 (1997) 679-689
42. Gomez J., Garcia A., Borlado L., Bonay P., Martinez A., Silva A., et al. IL-2 signaling controls actin organization through Rho-like protein family, phosphatidylinositol 3-kinase, and protein kinase C-zeta. J Immunol 158 4 (1997) 1516-1522
43. Maslinski W., Remillard B., Tsudo M., and Strom T.B. Interleukin-2 receptor signal transduction: translocation of active serine-threonine kinase Raf-1 from IL-2 receptor into cytosol depends on IL-2-induced tyrosine kinase activation. Transplant Proc 25 1 Pt 1 (1993) 109-110
44. Adunyah S.E., Wheeler B.J., and Cooper R.S. Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15. Biochem Biophys Res Commun 232 3 (1997) 754-758
45. Hatakeyama M., Kawahara A., Mori H., Shibuya H., and Taniguchi T. c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain. Proc Natl Acad Sci USA 89 6 (1992) 2022-2026
46. Ihle J.N. Cytokine receptor signalling. Nature 377 6550 (1995) 591-594
47. Kirken R.A., Malabarba M.G., Xu J., DaSilva L., Erwin R.A., Liu X., et al. Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase. J Biol Chem 272 24 (1997) 15459-15465
48. Johnston J.A., Bacon C.M., Finbloom D.S., Rees R.C., Kaplan D., Shibuya K., et al. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc Natl Acad Sci USA 92 19 (1995) 8705-8709
49. Lai S.Y., Xu W., Gaffen S.L., Liu K.D., Longmore G.D., Greene W.C., et al. The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes. Proc Natl Acad Sci USA 93 1 (1996) 231-235
50. Zhu M.H., Berry J.A., Russell S.M., and Leonard W.J. Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta. J Biol Chem 273 17 (1998) 10719-10725
51. Hanisch U.K., and Quirion R. Interleukin-2 as a neuroregulatory cytokine. Brain Res Brain Res Rev 21 3 (1995) 246-284
52. Araujo D.M., and Lapchak P.A. Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors. Neuroscience 61 4 (1994) 745-754
53. Araujo D.M., Lapchak P.A., Collier B., and Quirion R. Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system. Brain Res 498 2 (1989) 257-266
54. Lapchak P.A., Araujo D.M., Quirion R., and Beaudet A. Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain. Neuroscience 44 1 (1991) 173-184
55. Luber-Narod J., and Rogers J. Immune system associated antigens expressed by cells of the human central nervous system. Neurosci Lett 94 1-2 (1988) 17-1922
56. Arzt E., Stelzer G., Renner U., Lange M., Muller O.A., and Stalla G.K. Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures. J Clin Invest 90 5 (1992) 1944-1951
57. Arzt E., Buric R., Stelzer G., Stalla J., Sauer J., Renner U., et al. Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6. Endocrinology 132 1 (1993) 459-467
58. Hanisch U.K., Lyons S.A., Prinz M., Nolte C., Weber J.R., Kettenmann H., et al. Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity. J Biol Chem 272 46 (1997) 28853-28860
59. Haugen P.K., and Letourneau P.C. Interleukin-2 enhances chick and rat sympathetic, but not sensory, neurite outgrowth. J Neurosci Res 25 4 (1990) 443-452
60. Otero G.C., and Merrill J.E. Cytokine receptors on glial cells. Glia 11 2 (1994) 117-128
61. Otero G.C., and Merrill J.E. Molecular cloning of IL-2R alpha, IL-2R beta, and IL-2R gamma cDNAs from a human oligodendroglioma cell line: presence of IL-2R mRNAs in the human central nervous system. Glia 14 4 (1995) 295-302
62. Petitto J.M., and Huang Z. Molecular cloning of the coding sequence of an interleukin-2 receptor alpha subunit cDNA in murine brain. J Neuroimmunol 59 1-2 (1995) 135-141
63. Saneto R.P., Altman A., Knobler R.L., Johnson H.M., and de Vellis J. Interleukin 2 mediates the inhibition of oligodendrocyte progenitor cell proliferation in vitro. Proc Natl Acad Sci USA 83 23 (1986) 9221-9225
64. Sawada M., Suzumura A., and Marunouchi T. Induction of functional interleukin-2 receptor in mouse microglia. J Neurochem 64 5 (1995) 1973-1979
65. Shimojo M., Imai Y., Nakajima K., Mizushima S., Uemura A., and Kohsaka S. Interleukin-2 enhances the viability of primary cultured rat neocortical neurons. Neurosci Lett 151 2 (1993) 170-173
66. Satoh J., Kurohara K., Yukitake M., and Kuroda Y. Interleukin-15, a T-cell growth factor, is expressed in human neural cell lines and tissues. J Neurol Sci 155 2 (1998) 170-177
67. Petitto J.M., Huang Z., Rinker C.M., and McCarthy D.B. Isolation of IL-2 receptor-beta cDNA clones from AtT-20 pituitary cells: constitutive expression and role in signal transduction. Neuropsychopharmacology 17 2 (1997) 57-66
68. Petitto J.M., Huang Z., Raizada M.K., Rinker C.M., and McCarthy D.B. Molecular cloning of the cDNA coding sequence of IL-2 receptor-gamma (gammac) from human and murine forebrain: expression in the hippocampus in situ and by brain cells in vitro. Brain Res Mol Brain Res 53 1-2 (1998) 152-162
69. Lapchak P.A. A role for interleukin-2 in the regulation of striatal dopaminergic function. Neuroreport 3 2 (1992) 165-168
70. Ashman R.B., Bolitho E.M., and Fulurija A. Cytokine mRNA in brain tissue from mice that show strain-dependent differences in the severity of lesions induced by systemic infection with Candida albicans yeast. J Infect Dis 172 3 (1995) 823-830
71. Eizenberg O., Faber-Elman A., Lotan M., and Schwartz M. Interleukin-2 transcripts in human and rodent brains: possible expression by astrocytes. J Neurochem 64 5 (1995) 1928-1936
72. Lee Y.B., Satoh J., Walker D.G., and Kim S.U. Interleukin-15 gene expression in human astrocytes and microglia in culture. Neuroreport 7 5 (1996) 1062-1066
73. Prinz M., Hanisch U.K., Kettenmann H., and Kirchhoff F. Alternative splicing of mouse IL-15 is due to the use of an internal splice site in exon 5. Brain Res Mol Brain Res 63 1 (1998) 155-162
74. Awatsuji H., Furukawa Y., Nakajima M., Furukawa S., and Hayashi K. Interleukin-2 as a neurotrophic factor for supporting the survival of neurons cultured from various regions of fetal rat brain. J Neurosci Res 35 3 (1993) 305-311
75. Moroni S.C., and Rossi A. Enhanced survival and differentiation in vitro of different neuronal populations by some interleukins. Int J Dev Neurosci 13 1 (1995) 41-49
76. Sarder M., Saito H., and Abe K. Interleukin-2 promotes survival and neurite extension of cultured neurons from fetal rat brain. Brain Res 625 2 (1993) 347-350
77. Yao H., Wang F.Z., Ding A.S., Liu Z.W., and Ling S.G. [Effects of interleukin-1 and interleukin-2 on electrophysiological characteristics of rat hippocampal neurons in culture]. Sheng Li Xue Bao 46 6 (1994) 539-545
78. Mennicken F., and Quirion R. Interleukin-2 increases choline acetyltransferase activity in septal-cell cultures. Synapse 26 2 (1997) 175-183
79. Petitto J.M., McNamara R.K., Gendreau P.L., Huang Z., and Jackson A.J. Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion. J Neurosci Res 56 4 (1999) 441-446
80. Petitto J.M., Huang Z., Lo J., Beck R.D., Rinker C., and Hartemink D.A. Relationship between the development of autoimmunity and sensorimotor gating in MRL-lpr mice with reduced IL-2 production. Neurosci Lett 328 3 (2002) 304-308
81. Beck Jr. R.D., King M.A., Huang Z., and Petitto J.M. Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout. Brain Res 955 2 (2002) 16-23
82. Hanisch U.K., Rowe W., Sharma S., Meaney M.J., and Quirion R. Hypothalamic-pituitary-adrenal activity during chronic central administration of interleukin-2. Endocrinology 135 6 (1994) 2465-2472
83. Hanisch U.K., Rowe W v., Rossum D., Meaney M.J., and Quirion R. Phasic hyperactivity of the HPA axis resulting from chronic central IL-2 administration. Neuroreport 7 18 (1996) 2883-2888
84. Hanisch U.K., Neuhaus J., Quirion R., and Kettenmann H. Neurotoxicity induced by interleukin-2: involvement of infiltrating immune cells. Synapse 24 2 (1996) 104-114
85. Hanisch U.K., Neuhaus J., Rowe W., van Rossum D., Moller T., Kettenmann H., et al. Neurotoxic consequences of central long-term administration of interleukin-2 in rats. Neuroscience 79 3 (1997) 799-818
86. Hanisch U.K. Microglia as a source and target of cytokines. Glia 40 2 (2002) 140-155
87. Nemni R., Iannaccone S., Quattrini A., Smirne S., Sessa M., Lodi M., et al. Effect of chronic treatment with recombinant interleukin-2 on the central nervous system of adult and old mice. Brain Res 591 2 (1992) 248-252
88. Sessa M., Nemni R., Iannaccone S., Quattrini A., Confalonieri V., and Canal N. In vivo modulation of myelin gene expression by human recombinant IL-2. Brain Res Mol Brain Res 12 4 (1992) 331-334
89. Benveniste E.N., and Merrill J.E. Stimulation of oligodendroglial proliferation and maturation by interleukin-2. Nature 321 6070 (1986) 610-613
90. Benveniste E.N., Herman P.K., and Whitaker J.N. Myelin basic protein-specific RNA levels in interleukin-2-stimulated oligodendrocytes. J Neurochem 49 4 (1987) 1274-1279
91. Eitan S., Zisling R., Cohen A., Belkin M., Hirschberg D.L., Lotan M., et al. Identification of an nterleukin 2-like substance as a factor cytotoxic to oligodendrocytes and associated with central nervous system regeneration. Proc Natl Acad Sci USA 89 12 (1992) 5442-5446
92. Eitan S., and Schwartz M. A transglutaminase that converts interleukin-2 into a factor cytotoxic to oligodendrocytes. Science 261 5117 (1993) 106-108
93. Eizenberg O., Kaplitt M.G., Eitan S., Pfaff D.W., Hirschberg D.L., and Schwartz M. Linear dimeric interleukin-2 obtained by the use of a defective herpes simplex viral vector: conformation-activity relationship. Brain Res Mol Brain Res 26 1-2 (1994) 156-162
94. Eitan S., Solomon A., Lavie V., Yoles E., Hirschberg D.L., Belkin M., et al. Recovery of visual response of injured adult rat optic nerves treated with transglutaminase. Science 264 5166 (1994) 1764-1768
95. Sakai N., Kaufman S., and Milstien S. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cells. J Neurochem 65 2 (1995) 895-902
96. Wilkinson P.C., and Liew F.Y. Chemoattraction of human blood T lymphocytes by interleukin-15. J Exp Med 181 3 (1995) 1255-1259
97. Häusler K.G., Prinz M., Nolte C., Weber J.R., Schumann R.R., Kettenmann H., et al. Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide-and pneumococcal cell wall-stimulated mouse microglia and macrophages. Eur J Neurosci 16 11 (2002) 2113-2122
98. Petitto J.M., Huang Z., Lo J., and Streit W.J. IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons. J Neuroimmunol 134 1-2 (2003) 95-103
99. Alonso R., Chaudieu I., Diorio J., Krishnamurthy A., Quirion R., and Boksa P. Interleukin-2 modulates evoked release of [3H]dopamine in rat cultured mesencephalic cells. J Neurochem 61 4 (1993) 1284-1290
100. Anisman H., Kokkinidis L., and Merali Z. Interleukin-2 decreases accumbal dopamine efflux and responding for rewarding lateral hypothalamic stimulation. Brain Res 731 1-2 (1996) 1-11
101. Hanisch U.K., Seto D., and Quirion R. Modulation of hippocampal acetylcholine release: a potent central action of interleukin-2. J Neurosci 13 8 (1993) 3368-3374
102. Pauli S., Linthorst A.C., and Reul J.M. Tumour necrosis factor-alpha and interleukin-2 differentially affect hippocampal serotonergic neurotransmission, behavioural activity, body temperature and hypothalamic-pituitary-adrenocortical axis activity in the rat. Eur J Neurosci 10 3 (1998) 868-878
103. Petitto J.M., McCarthy D.B., Rinker C.M., Huang Z., and Getty T. Modulation of behavioral and neurochemical measures of forebrain dopamine function in mice by species-specific interleukin-2. J Neuroimmunol 73 1-2 (1997) 183-190
104. Seto D., Kar S., and Quirion R. Evidence for direct and indirect mechanisms in the potent modulatory action of interleukin-2 on the release of acetylcholine in rat hippocampal slices. Br J Pharmacol 120 6 (1997) 1151-1157
105. Song C., and Leonard B.E. Interleukin-2-induced changes in behavioural, neurotransmitter, and immunological parameters in the olfactory bulbectomized rat. Neuroimmunomodulation 2 5 (1995) 263-273
106. Zalcman S., Green-Johnson J.M., Murray L., Wan W., Nance D.M., and Greenberg A.H. Interleukin-2-induced enhancement of an antigen-specific IgM plaque-forming cell response is mediated by the sympathetic nervous system. J Pharmacol Exp Ther 271 2 (1994) 977-982
107. Fung M.R., Ju G., and Greene W.C. Co-internalization of the p55 and p70 subunits of the high-affinity human interleukin 2 receptor. Evidence for a stable ternary receptor complex. J Exp Med 168 5 (1988) 1923-1928
108. Legrue S.J., Sheu T.L., and Chernajovsky Y. The role of receptor-ligand endocytosis and degradation in interleukin-2 signaling and T-lymphocyte proliferation. Lymphokine Cytokine Res 10 6 (1991) 431-436
109. Lapchak P.A., and Araujo D.M. Interleukin-2 regulates monoamine and opioid peptide release from the hypothalamus. Neuroreport 4 3 (1993) 303-306
110. Plata-Salaman C.R., and ffrench-Mullen J.M. Interleukin-2 modulates calcium currents in dissociated hippocampal CA1 neurons. Neuroreport 4 5 (1993) 579-581
111. Tancredi V., Zona C., Velotti F., Eusebi F., and Santoni A. Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus. Brain Res 525 1 (1990) 149-151
112. Bianchi M., and Panerai A.E. Interleukin-2 enhances scopolamine-induced amnesia and hyperactivity in the mouse. Neuroreport 4 8 (1993) 1046-1048
113. Beck Jr. R.D., Wasserfall C., Ha G.K., Cushman J.D., Huang Z., Atkinson M.A., et al. Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice. Brain Res 1041 2 (2005) 223-230
114. Saris S.C., Patronas N.J., Rosenberg S.A., Alexander J.T., Frank J., Schwartzentruber D.J., et al. The effect of intravenous interleukin-2 on brain water content. J Neurosurg 71 2 (1989) 169-174
115. De Sarro G., Rotiroti D., Audino M.G., Gratteri S., and Nistico G. Effects of interleukin-2 on various models of experimental epilepsy in DBA/2 mice. Neuroimmunomodulation 1 6 (1994) 361-369
116. De Sarro G.B., and Nistico G. Behavioral and electrocortical power spectrum effects after intracerebral microinfusion of interleukin-2 in rats are antagonized by naloxone. Int J Neurosci 51 3-4 (1990) 209-210
117. Nistico G., and De Sarro G. Is interleukin 2a neuromodulator in the brain?. Trends Neurosci 14 4 (1991) 146-150
118. Nistico G., and De Sarro G. Behavioral and electrocortical spectrum power effects after microinfusion of lymphokines in several areas of the rat brain. Ann NY Acad Sci 621 (1991) 119-134
119. Nistico G. Communications among central nervous system, neuroendocrine and immune systems. Prog Neurobiol 40 (1993) 463-475
120. Petitto J.M., Huang Z., Hartemink D.A., and Beck R. IL-2/15 receptor-beta gene deletion alters neurobehavioral performance. Brain Res 929 2 (2002) 218-225
121. Besedovsky H.O., and del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev 17 1 (1996) 64-102
122. Besedovsky H.O., and del Rey A. Introduction: immune-neuroendocrine network. Front Horm Res 29 (2002) 1-14
123. Karanth S., and McCann S.M. Anterior pituitary hormone control by interleukin 2. Proc Natl Acad Sci USA 88 7 (1991) 2961-2965
124. Smith L.R., Brown S.L., and Blalock J.E. Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor alpha-chain-like molecule on pituitary cells. J Neuroimmunol 21 2-3 (1989) 249-254
125. Cambronero J.C., Rivas F.J., Borrell J., and Guaza C. Interleukin-2 induces corticotropin-releasing hormone release from superfused rat hypothalami: influence of glucocorticoids. Endocrinology 131 2 (1992) 677-683
126. Karanth S., Aguila M.C., and McCann S.M. The influence of interleukin-2 on the release of somatostatin and growth hormone-releasing hormone by mediobasal hypothalamus. Neuroendocrinology 58 2 (1993) 185-190
127. Karanth S., Lyson K., and McCann S.M. Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami. Proc Natl Acad Sci USA 90 8 (1993) 3383-3387
128. Raber J., and Bloom F.E. IL-2 induces vasopressin release from the hypothalamus and the amygdala: role of nitric oxide-mediated signaling. J Neurosci 14 10 (1994) 6187-6195
129. Raber J., Koob G.F., and Bloom F.E. Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response. J Pharmacol Exp Ther 272 2 (1995) 815-824
130. Tominaga T., Fukata J., Naito Y., Usui T., Murakami N., Fukushima M., et al. Prostaglandin-dependent in vitro stimulation of adrenocortical steroidogenesis by interleukins. Endocrinology 128 1 (1991) 526-531
131. Bartholomew S.A., and Hoffman S.A. Effects of peripheral cytokine injections on multiple unit activity in the anterior hypothalamic area of the mouse. Brain Behav Immun 7 4 (1993) 301-316
132. McCann S.M., Lyson K., Karanth S., Gimeno M., Belova N., Kamat A., et al. Role of cytokines in the endocrine system. Ann NY Acad Sci 741 (1994) 50-63
133. McCann S.M., Karanth S., Kamat A., Les D.W., Lyson K., Gimeno M., et al. Induction by cytokines of the pattern of pituitary hormone secretion in infection. Neuroimmunomodulation 1 1 (1994) 2-13
134. Banks W.A., and Kastin A.J. The interleukins-1 alpha, -1 beta, and -2 do not acutely disrupt the murine blood-brain barrier. Int J Immunopharmacol 14 4 (1992) 629-636
135. Waguespack P.J., Banks W.A., and Kastin A.J. Interleukin-2 does not cross the blood-brain barrier by a saturable transport system. Brain Res Bull 34 2 (1994) 103-109
136. Constant S.L., and Bottomly K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 15 (1997) 297-322
137. Petrovsky N., and Harrison L.C. Th1 and Th2: swinging to a hormonal rhythm. Immunol Today 16 12 (1995) 605
138. Ramierz F., Fowell D.J., Puklavec M., Simmonds S., and Mason D. Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J Immunol 156 7 (1996) 2406-2412
139. Denicoff K.D., Durkin T.M., Lotze M.T., Quinlan P.E., Davis C.L., Listwak S.J., et al. The neuroendocrine effects of interleukin-2 treatment. J Clin Endocrinol Metab 69 2 (1989) 402-410
140. Meyers C.A., and Yung W.K. Delayed neurotoxicity of intraventricular interleukin-2: a case report. J Neurooncol 15 3 (1993) 265-267
141. Ravaud A., Negrier S., Cany L., Merrouche Y., Le Guillou M., Blay J.Y., et al. Subcutaneous low-dose recombinant interleukin 2 and alpha-interferon in patients with metastatic renal cell carcinoma. Br J Cancer 69 6 (1994) 1111-1114
142. Vecht C.J., Keohane C., Menon R.S., Punt C.J., and Stoter G. Acute fatal leukoencephalopathy after interleukin-2 therapy. N Engl J Med 323 16 (1990) 1146-1147