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Volumn 107, Issue 33, 2010, Pages 14615-14620

Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny

Author keywords

Cis regulation; Gene regulatory network; Neural development; Phylogenomics; Transcription factor

Indexed keywords

CIS ACTING ELEMENT; TRANS ACTING FACTOR; DROSOPHILA PROTEIN; GREEN FLUORESCENT PROTEIN; LOLA PROTEIN, DROSOPHILA; TRANSCRIPTION FACTOR;

EID: 77957034280     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002876107     Document Type: Article
Times cited : (22)

References (58)
  • 1
    • 0036532201 scopus 로고    scopus 로고
    • Deciphering gene expression regulatory networks
    • Wyrick J, Young R (2002) Deciphering gene expression regulatory networks. Curr Opin Genet Dev 12:130-136.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 130-136
    • Wyrick, J.1    Young, R.2
  • 2
    • 60149091656 scopus 로고    scopus 로고
    • ChIP-seq accurately predicts tissue-specific activity of enhancers
    • Visel A, et al. (2009) ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457:854-858.
    • (2009) Nature , vol.457 , pp. 854-858
    • Visel, A.1
  • 3
    • 15744362285 scopus 로고    scopus 로고
    • Computational methods for transcriptional regulation
    • Siggia E (2005) Computational methods for transcriptional regulation. Curr Opin Genet Dev 15:214-221.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 214-221
    • Siggia, E.1
  • 4
    • 60749129337 scopus 로고    scopus 로고
    • Integrating sequence, evolution and functional genomics in regulatory genomics
    • Vingron M, et al. (2009) Integrating sequence, evolution and functional genomics in regulatory genomics. Genome Biol 10:202.
    • (2009) Genome Biol , vol.10 , pp. 202
    • Vingron, M.1
  • 5
    • 0037154273 scopus 로고    scopus 로고
    • Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome
    • Berman B, et al. (2002) Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome. Proc Natl Acad Sci USA 99:757-762.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 757-762
    • Berman, B.1
  • 6
    • 0036067977 scopus 로고    scopus 로고
    • Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model
    • Halfon M, Grad Y, Church G, Michelson A (2002) Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. Genome Res 12:1019-1028.
    • (2002) Genome Res , vol.12 , pp. 1019-1028
    • Halfon, M.1    Grad, Y.2    Church, G.3    Michelson, A.4
  • 7
    • 0037162497 scopus 로고    scopus 로고
    • SCORE: A computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data
    • Rebeiz M, Reeves N, Posakony J (2002) SCORE: A computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Proc Natl Acad Sci USA 99:9888-9893.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9888-9893
    • Rebeiz, M.1    Reeves, N.2    Posakony, J.3
  • 8
    • 19344375742 scopus 로고    scopus 로고
    • Transcriptional control in the segmentation gene network of Drosophila
    • Schroeder M, et al. (2004) Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol 2:e271.
    • (2004) PLoS Biol , vol.2
    • Schroeder, M.1
  • 9
    • 33750218960 scopus 로고    scopus 로고
    • PhyloGibbs: A Gibbs sampling motif finder that incorporates phylogeny
    • Siddharthan R, Siggia E, van Nimwegen E (2005) PhyloGibbs: A Gibbs sampling motif finder that incorporates phylogeny. PLoS Comput Biol 1:e67.
    • (2005) PLoS Comput Biol , vol.1
    • Siddharthan, R.1    Siggia, E.2    Van Nimwegen, E.3
  • 10
    • 30344439849 scopus 로고    scopus 로고
    • Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity
    • Hallikas O, et al. (2006) Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. Cell 124:47-59.
    • (2006) Cell , vol.124 , pp. 47-59
    • Hallikas, O.1
  • 11
    • 33751360783 scopus 로고    scopus 로고
    • Identifying cis-regulatory modules by combining comparative and compositional analysis of DNA
    • Pierstorff N, Bergman C, Wiehe T (2006) Identifying cis-regulatory modules by combining comparative and compositional analysis of DNA. Bioinformatics 22:2858-2864.
    • (2006) Bioinformatics , vol.22 , pp. 2858-2864
    • Pierstorff, N.1    Bergman, C.2    Wiehe, T.3
  • 12
    • 0032032780 scopus 로고    scopus 로고
    • Specificity, free energy and information content in protein-DNA interactions
    • DOI 10.1016/S0968-0004(98)01187-6
    • Stormo G, Fields D (1998) Specificity, free energy and information content in protein-DNA interactions. Trends Biochem Sci 23:109-113. (Pubitemid 28175261)
    • (1998) Trends in Biochemical Sciences , vol.23 , Issue.3 , pp. 109-113
    • Stormo, G.D.1    Fields, D.S.2
  • 13
    • 2942517992 scopus 로고    scopus 로고
    • Statistical extraction of Drosophila cis-regulatory modules using exhaustive assessment of local word frequency
    • Nazina A, Papatsenko D (2003) Statistical extraction of Drosophila cis-regulatory modules using exhaustive assessment of local word frequency. BMC Bioinformatics 4:65.
    • (2003) BMC Bioinformatics , vol.4 , pp. 65
    • Nazina, A.1    Papatsenko, D.2
  • 14
    • 25444528967 scopus 로고    scopus 로고
    • Some statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the Drosophila genome: The fluffy-tail test
    • Abnizova I, te Boekhorst R, Walter K, Gilks W (2005) Some statistical properties of regulatory DNA sequences, and their use in predicting regulatory regions in the Drosophila genome: The fluffy-tail test. BMC Bioinformatics 6:109.
    • (2005) BMC Bioinformatics , vol.6 , pp. 109
    • Abnizova, I.1    Te Boekhorst, R.2    Walter, K.3    Gilks, W.4
  • 15
    • 27744473016 scopus 로고    scopus 로고
    • Using hexamers to predict cis-regulatory motifs in Drosophila
    • Chan B, Kibler D (2005) Using hexamers to predict cis-regulatory motifs in Drosophila. BMC Bioinformatics 6:262.
    • (2005) BMC Bioinformatics , vol.6 , pp. 262
    • Chan, B.1    Kibler, D.2
  • 16
    • 70249151095 scopus 로고    scopus 로고
    • Identifying cis-regulatory sequences by word profile similarity
    • Leung G, Eisen M, Provart N (2009) Identifying cis-regulatory sequences by word profile similarity. PLoS ONE 4:e6901.
    • (2009) PLoS ONE , vol.4
    • Leung, G.1    Eisen, M.2    Provart, N.3
  • 17
    • 70349996336 scopus 로고    scopus 로고
    • Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse
    • Kantorovitz M, et al. (2009) Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse. Dev Cell 17:568-579.
    • (2009) Dev Cell , vol.17 , pp. 568-579
    • Kantorovitz, M.1
  • 18
    • 15244358503 scopus 로고    scopus 로고
    • Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
    • Xie X, et al. (2005) Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals. Nature 434:338-345.
    • (2005) Nature , vol.434 , pp. 338-345
    • Xie, X.1
  • 19
    • 33744507263 scopus 로고    scopus 로고
    • The discovery, positioning and verification of a set of transcription-associated motifs in vertebrates
    • Ettwiller L, et al. (2005) The discovery, positioning and verification of a set of transcription-associated motifs in vertebrates. Genome Biol 6:R104.
    • (2005) Genome Biol , vol.6
    • Ettwiller, L.1
  • 21
    • 0034628901 scopus 로고    scopus 로고
    • Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae
    • Hughes J, Estep P, Tavazoie S, Church G (2000) Computational identification of cis-regulatory elements associated with groups of functionally related genes in Saccharomyces cerevisiae. J Mol Biol 296:1205-1214.
    • (2000) J Mol Biol , vol.296 , pp. 1205-1214
    • Hughes, J.1    Estep, P.2    Tavazoie, S.3    Church, G.4
  • 22
    • 0344906814 scopus 로고    scopus 로고
    • Combining phylogenetic data with co-regulated genes to identify regulatory motifs
    • Wang T, Stormo G (2003) Combining phylogenetic data with co-regulated genes to identify regulatory motifs. Bioinformatics 19:2369-2380.
    • (2003) Bioinformatics , vol.19 , pp. 2369-2380
    • Wang, T.1    Stormo, G.2
  • 23
    • 8844270153 scopus 로고    scopus 로고
    • Prediction of similarly acting cis-regulatory modules by subsequence profiling and comparative genomics in Drosophila melanogaster and D. pseudoobscura
    • Grad Y, Roth F, Halfon M, Church G (2004) Prediction of similarly acting cis-regulatory modules by subsequence profiling and comparative genomics in Drosophila melanogaster and D. pseudoobscura. Bioinformatics 20:2738-2750.
    • (2004) Bioinformatics , vol.20 , pp. 2738-2750
    • Grad, Y.1    Roth, F.2    Halfon, M.3    Church, G.4
  • 24
    • 33847727867 scopus 로고    scopus 로고
    • Identification of muscle-specific regulatory modules in Caenorhabditis elegans
    • Zhao G, Schriefer L, Stormo G (2007) Identification of muscle-specific regulatory modules in Caenorhabditis elegans. Genome Res 17:348-357.
    • (2007) Genome Res , vol.17 , pp. 348-357
    • Zhao, G.1    Schriefer, L.2    Stormo, G.3
  • 25
    • 34547540506 scopus 로고    scopus 로고
    • Discovering transcriptional regulatory regions in Drosophila by a nonalignment method for phylogenetic footprinting
    • Sosinsky A, Honig B, Mann R, Califano A (2007) Discovering transcriptional regulatory regions in Drosophila by a nonalignment method for phylogenetic footprinting. Proc Natl Acad Sci USA 104:6305-6310.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6305-6310
    • Sosinsky, A.1    Honig, B.2    Mann, R.3    Califano, A.4
  • 26
    • 1042264827 scopus 로고    scopus 로고
    • A probabilistic method to detect regulatory modules
    • Sinha S, van Nimwegen E, Siggia E (2003) A probabilistic method to detect regulatory modules. Bioinformatics 19 suppl 1:i292-301.
    • (2003) Bioinformatics , vol.19 , Issue.SUPPL. 1
    • Sinha, S.1    Van Nimwegen, E.2    Siggia, E.3
  • 27
    • 22144491990 scopus 로고    scopus 로고
    • MONKEY: Identifying conserved transcription-factor binding sites in multiple alignments using a binding site-specific evolutionary model
    • Moses A, Chiang D, Pollard D, Iyer V, Eisen M (2004) MONKEY: Identifying conserved transcription-factor binding sites in multiple alignments using a binding site-specific evolutionary model. Genome Biol 5:R98.
    • (2004) Genome Biol , vol.5
    • Moses, A.1    Chiang, D.2    Pollard, D.3    Iyer, V.4    Eisen, M.5
  • 28
    • 0037226131 scopus 로고    scopus 로고
    • Automated de novo identification of repeat sequence families in sequenced genomes
    • Bao Z, Eddy S (2002) Automated de novo identification of repeat sequence families in sequenced genomes. Genome Res 12:1269-1276.
    • (2002) Genome Res , vol.12 , pp. 1269-1276
    • Bao, Z.1    Eddy, S.2
  • 29
    • 0025761636 scopus 로고
    • Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc
    • Cubas P, De Celis J, Campuzano S, Modolell J (1991) Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Gene Dev 5:996-1008.
    • (1991) Gene Dev , vol.5 , pp. 996-1008
    • Cubas, P.1    De Celis, J.2    Campuzano, S.3    Modolell, J.4
  • 30
    • 24344459151 scopus 로고    scopus 로고
    • Lateral inhibition in proneural clusters: Cis-regulatory logic and default repression by suppressor of Hairless
    • Castro B, Barolo S, Bailey A, Posakony J (2005) Lateral inhibition in proneural clusters: Cis-regulatory logic and default repression by suppressor of Hairless. Development 132:3333-3344.
    • (2005) Development , vol.132 , pp. 3333-3344
    • Castro, B.1    Barolo, S.2    Bailey, A.3    Posakony, J.4
  • 31
    • 0028131542 scopus 로고
    • Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling
    • Singson A, Leviten M, Bang A, Hua X, Posakony J (1994) Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling. Gene Dev 8:2058-2071.
    • (1994) Gene Dev , vol.8 , pp. 2058-2071
    • Singson, A.1    Leviten, M.2    Bang, A.3    Hua, X.4    Posakony, J.5
  • 32
    • 0032128198 scopus 로고    scopus 로고
    • Proneural gene self-stimulation in neural precursors: An essential mechanism for sense organ development that is regulated by Notch signaling
    • Culí J, Modolell J (1998) Proneural gene self-stimulation in neural precursors: An essential mechanism for sense organ development that is regulated by Notch signaling. Gene Dev 12:2036-2047.
    • (1998) Gene Dev , vol.12 , pp. 2036-2047
    • Culí, J.1    Modolell, J.2
  • 33
    • 0036631456 scopus 로고    scopus 로고
    • Proneural genes and the specification of neural cell types
    • Bertrand N, Castro DS, Guillemot F (2002) Proneural genes and the specification of neural cell types. Nat Rev Neurosci 3:517-530.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 517-530
    • Bertrand, N.1    Castro, D.S.2    Guillemot, F.3
  • 34
    • 52249111368 scopus 로고    scopus 로고
    • Sponge genes provide new insight into the evolutionary origin of the neurogenic circuit
    • Richards GS, et al. (2008) Sponge genes provide new insight into the evolutionary origin of the neurogenic circuit. Curr Biol 18:1156-1161.
    • (2008) Curr Biol , vol.18 , pp. 1156-1161
    • Richards, G.S.1
  • 35
    • 0348014688 scopus 로고    scopus 로고
    • Senseless acts as a binary switch during sensory organ precursor selection
    • Jafar-Nejad H, et al. (2003) Senseless acts as a binary switch during sensory organ precursor selection. Gene Dev 17:2966-2978.
    • (2003) Gene Dev , vol.17 , pp. 2966-2978
    • Jafar-Nejad, H.1
  • 36
    • 26644431823 scopus 로고    scopus 로고
    • Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling
    • Wildonger J, Mann R (2005) Evidence that nervy, the Drosophila homolog of ETO/MTG8, promotes mechanosensory organ development by enhancing Notch signaling. Dev Biol 286:507-520.
    • (2005) Dev Biol , vol.286 , pp. 507-520
    • Wildonger, J.1    Mann, R.2
  • 37
    • 2942567746 scopus 로고    scopus 로고
    • Phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development
    • Pi H, Huang S, Tang C, Sun Y, Chien C (2004) phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development. Proc Natl Acad Sci USA 101:8378-8383.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8378-8383
    • Pi, H.1    Huang, S.2    Tang, C.3    Sun, Y.4    Chien, C.5
  • 38
    • 14644445199 scopus 로고    scopus 로고
    • Genetic programs activated by proneural proteins in the developing Drosophila PNS
    • Reeves N, Posakony J (2005) Genetic programs activated by proneural proteins in the developing Drosophila PNS. Dev Cell 8:413-425.
    • (2005) Dev Cell , vol.8 , pp. 413-425
    • Reeves, N.1    Posakony, J.2
  • 39
    • 84887212475 scopus 로고    scopus 로고
    • Van Gogh and Frizzled act redundantly in the Drosophila sensory organ precursor cell to orient its asymmetric division
    • Gomes JE, Corado M, Schweisguth F (2009) Van Gogh and Frizzled act redundantly in the Drosophila sensory organ precursor cell to orient its asymmetric division. PLoS ONE 4:e4485.
    • (2009) PLoS ONE , vol.4
    • Gomes, J.E.1    Corado, M.2    Schweisguth, F.3
  • 41
    • 43149106745 scopus 로고    scopus 로고
    • NF-κB/Rel-mediated regulation of the neural fate in Drosophila
    • Ayyar S, et al. (2007) NF-κB/Rel-mediated regulation of the neural fate in Drosophila. PLoS ONE 2:e1178.
    • (2007) PLoS ONE , vol.2
    • Ayyar, S.1
  • 42
    • 0025766486 scopus 로고
    • Transcriptional activation by heterodimers of the achaetescute and daughterless gene products of Drosophila
    • Cabrera C, Alonso M (1991) Transcriptional activation by heterodimers of the achaetescute and daughterless gene products of Drosophila. EMBO J 10:2965-2973.
    • (1991) EMBO J , vol.10 , pp. 2965-2973
    • Cabrera, C.1    Alonso, M.2
  • 43
    • 0025778902 scopus 로고
    • The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes
    • Van Doren M, Ellis H, Posakony J (1991) The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes. Development 113:245-255.
    • (1991) Development , vol.113 , pp. 245-255
    • Van Doren, M.1    Ellis, H.2    Posakony, J.3
  • 44
    • 6344248555 scopus 로고    scopus 로고
    • The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites
    • Powell L, zur Lage P, Prentice D, Senthinathan B, Jarman A (2004) The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites. Mol Cell Biol 24:9517-9526.
    • (2004) Mol Cell Biol , vol.24 , pp. 9517-9526
    • Powell, L.1    Zur Lage, P.2    Prentice, D.3    Senthinathan, B.4    Jarman, A.5
  • 45
    • 73249134379 scopus 로고    scopus 로고
    • Experimental determination of the evolvability of a transcription factor
    • Maerkl S, Quake S (2009) Experimental determination of the evolvability of a transcription factor. Proc Natl Acad Sci USA 106:18650-18655.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 18650-18655
    • Maerkl, S.1    Quake, S.2
  • 46
    • 48249118063 scopus 로고    scopus 로고
    • JASPAR, the open access database of transcription factor-binding profiles: New content and tools in the 2008 update
    • Bryne J, et al. (2007) JASPAR, the open access database of transcription factor-binding profiles: New content and tools in the 2008 update. Nucleic Acids Res.
    • (2007) Nucleic Acids Res
    • Bryne, J.1
  • 47
    • 0033198359 scopus 로고    scopus 로고
    • Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators
    • Nellesen D, Lai E, Posakony J (1999) Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev Biol 213:33-53.
    • (1999) Dev Biol , vol.213 , pp. 33-53
    • Nellesen, D.1    Lai, E.2    Posakony, J.3
  • 48
    • 0028973381 scopus 로고
    • The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling
    • Lecourtois M, Schweisguth F (1995) The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Gene Dev 9:2598-2608.
    • (1995) Gene Dev , vol.9 , pp. 2598-2608
    • Lecourtois, M.1    Schweisguth, F.2
  • 49
    • 0028973380 scopus 로고
    • Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity
    • Bailey A, Posakony J (1995) Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Gene Dev 9:2609-2622.
    • (1995) Gene Dev , vol.9 , pp. 2609-2622
    • Bailey, A.1    Posakony, J.2
  • 50
    • 58149199579 scopus 로고    scopus 로고
    • FlyBase: Enhancing Drosophila gene ontology annotations
    • Tweedie S, et al. (2009) FlyBase: Enhancing Drosophila gene ontology annotations. Nucleic Acids Res 37:D555-D559.
    • (2009) Nucleic Acids Res , vol.37
    • Tweedie, S.1
  • 51
    • 0033045351 scopus 로고    scopus 로고
    • Cis-regulatory elements of the mitotic regulator, string/Cdc25
    • Lehman D, et al. (1999) Cis-regulatory elements of the mitotic regulator, string/Cdc25. Development 126:1793-1803.
    • (1999) Development , vol.126 , pp. 1793-1803
    • Lehman, D.1
  • 52
    • 0028178116 scopus 로고
    • Lola encodes a putative transcription factor required for axon growth and guidance in Drosophila
    • Giniger E, Tietje K, Jan L, Jan Y (1994) lola encodes a putative transcription factor required for axon growth and guidance in Drosophila. Development 120:1385-1398.
    • (1994) Development , vol.120 , pp. 1385-1398
    • Giniger, E.1    Tietje, K.2    Jan, L.3    Jan, Y.4
  • 53
    • 0041358544 scopus 로고    scopus 로고
    • Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila
    • Goeke S, et al. (2003) Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila. Nat Neurosci 6:917-924.
    • (2003) Nat Neurosci , vol.6 , pp. 917-924
    • Goeke, S.1
  • 54
    • 31444452060 scopus 로고    scopus 로고
    • Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing
    • Ferres-Marco D, et al. (2006) Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature 439:430-436.
    • (2006) Nature , vol.439 , pp. 430-436
    • Ferres-Marco, D.1
  • 55
    • 37349015557 scopus 로고    scopus 로고
    • Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye
    • Zheng L, Carthew R (2008) Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye. Mech Develop 125:18-29.
    • (2008) Mech Develop , vol.125 , pp. 18-29
    • Zheng, L.1    Carthew, R.2
  • 56
    • 0025971830 scopus 로고
    • The choice of cell fate in the epidermis of Drosophila
    • Heitzler P, Simpson P (1991) The choice of cell fate in the epidermis of Drosophila. Cell 64:1083-1092.
    • (1991) Cell , vol.64 , pp. 1083-1092
    • Heitzler, P.1    Simpson, P.2
  • 57
    • 70449132583 scopus 로고    scopus 로고
    • Combinatorial binding predicts spatio-temporal cis-regulatory activity
    • Zinzen R, Girardot C, Gagneur J, Braun M, Furlong E (2009) Combinatorial binding predicts spatio-temporal cis-regulatory activity. Nature 462:65-70.
    • (2009) Nature , vol.462 , pp. 65-70
    • Zinzen, R.1    Girardot, C.2    Gagneur, J.3    Braun, M.4    Furlong, E.5
  • 58
    • 2642574503 scopus 로고    scopus 로고
    • R Development Core Team (R Foundation for Statistical Computing, Vienna), ISBN3-900051-07-0
    • R Development Core Team (2009) R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, Vienna), ISBN3-900051-07-0.
    • (2009) A Language and Environment for Statistical Computing


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