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Volumn 16, Issue , 2010, Pages 1880-1892

Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS ACTING ON THE EYE; ALPHA SMOOTH MUSCLE ACTIN; CONNECTIVE TISSUE GROWTH FACTOR; HISTIDINE; MITOMYCIN C; SB 505124; SERINE; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1 INHIBITOR; UNCLASSIFIED DRUG;

EID: 77956968913     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (33)

References (48)
  • 2
    • 0032763469 scopus 로고    scopus 로고
    • Specificity, diversity, and regulation in TGF-β superfamily signaling
    • Piek E, Heldin CH, Ten Dijke P. Specificity, diversity, and regulation in TGF-β superfamily signaling. FASEB J 1999; 13:2105-2124.
    • (1999) FASEB J , vol.13 , pp. 2105-2124
    • Piek, E.1    Heldin, C.H.2    Dijke, T.P.3
  • 3
    • 0028109801 scopus 로고
    • Transforming growth factor β in tissue fibrosis
    • Border WA, Noble NA. Transforming growth factor β in tissue fibrosis. N Engl J Med 1994; 331:1286-1292.
    • (1994) N Engl J Med , vol.331 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 4
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massagué J. TGF-β signal transduction. Annu Rev Biochem 1998; 67:753-791.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massagué, J.1
  • 5
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-β signals
    • Massagué J. How cells read TGF-β signals. Nat Rev Mol Cell Biol 2000; 1:169-178.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 169-178
    • Massagué, J.1
  • 7
    • 0033571072 scopus 로고    scopus 로고
    • Anti-TGF-β treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: A model for human scleroderma
    • McCormick LL, Zhang Y, Tootell E, Gilliam AC. Anti-TGF-β treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma. J Immunol 1999; 163:5693-5699.
    • (1999) J Immunol , vol.163 , pp. 5693-5699
    • McCormick, L.L.1    Zhang, Y.2    Tootell, E.3    Gilliam, A.C.4
  • 8
    • 0028986030 scopus 로고
    • Neutralisation of TGFβ1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring
    • Shah M, Foreman DM, Ferguson MW. Neutralisation of TGFβ1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995; 108:985-1002.
    • (1995) J Cell Sci , vol.108 , pp. 985-1002
    • Shah, M.1    Foreman, D.M.2    Ferguson, M.W.3
  • 9
    • 0033054280 scopus 로고    scopus 로고
    • Expression of vitreous cytokines in proliferative vitreoretinopathy: A prospective study
    • Kon CH, Occleston NL, Aylward GW, Khaw PT. Expression of vitreous cytokines in proliferative vitreoretinopathy: a prospective study. Invest Ophthalmol Vis Sci 1999; 40:705-712.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 705-712
    • Kon, C.H.1    Occleston, N.L.2    Aylward, G.W.3    Khaw, P.T.4
  • 10
    • 0029042745 scopus 로고
    • Cataract induction in lenses cultured with transforming growth factor-β
    • Hales AM, Chamberlain CG, McAvoy JW. Cataract induction in lenses cultured with transforming growth factor-β. Invest Ophthalmol Vis Sci 1995; 36:1709-1713.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 1709-1713
    • Hales, A.M.1    Chamberlain, C.G.2    McAvoy, J.W.3
  • 12
    • 0141833839 scopus 로고    scopus 로고
    • A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization
    • He S, Jin ML, Worpel V, Hinton DR. A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol 2003; 121:1283-1288.
    • (2003) Arch Ophthalmol , vol.121 , pp. 1283-1288
    • He, S.1    Jin, M.L.2    Worpel, V.3    Hinton, D.R.4
  • 13
    • 0036758873 scopus 로고    scopus 로고
    • Expression of transforming growth factor-β receptors in normal rat retina and experimental choroidal neovascularization
    • Yamanaka R, Ogata N, Yamamoto C, Matsushita M, Matsuzaki K, Uyama M, Matsumura M. Expression of transforming growth factor-β receptors in normal rat retina and experimental choroidal neovascularization. Jpn J Ophthalmol 2002; 46:525-532.
    • (2002) Jpn J Ophthalmol , vol.46 , pp. 525-532
    • Yamanaka, R.1    Ogata, N.2    Yamamoto, C.3    Matsushita, M.4    Matsuzaki, K.5    Uyama, M.6    Matsumura, M.7
  • 14
    • 0037324361 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in conjunctival scarring
    • Cordeiro MF. Role of transforming growth factor beta in conjunctival scarring. Clin Sci (Lond) 2003; 104:181-187.
    • (2003) Clin Sci (Lond) , vol.104 , pp. 181-187
    • Cordeiro, M.F.1
  • 15
    • 0036127649 scopus 로고    scopus 로고
    • Beyond Mitomycin: TGF-β and wound healing
    • Cordeiro MF. Beyond Mitomycin: TGF-β and wound healing. Prog Retin Eye Res 2002; 21:75-89.
    • (2002) Prog Retin Eye Res , vol.21 , pp. 75-89
    • Cordeiro, M.F.1
  • 17
    • 0035022414 scopus 로고    scopus 로고
    • Accumulation of latent transforming growth factor-beta binding protein-1 and TGF β1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts
    • Saika S, Yamanaka O, Baba Y, Kawashima Y, Shirai K, Miyamoto T, Okada Y, Ohnishi Y, Ooshima A. Accumulation of latent transforming growth factor-beta binding protein-1 and TGF β1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts. Graefes Arch Clin Exp Ophthalmol 2001; 239:234-241.
    • (2001) Graefes Arch Clin Exp Ophthalmol , vol.239 , pp. 234-241
    • Saika, S.1    Yamanaka, O.2    Baba, Y.3    Kawashima, Y.4    Shirai, K.5    Miyamoto, T.6    Okada, Y.7    Ohnishi, Y.8    Ooshima, A.9
  • 18
    • 0028113970 scopus 로고
    • Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma
    • Migdal C, Gregory W, Hitchings R. Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma. Ophthalmology 1994; 101:1651-1656.
    • (1994) Ophthalmology , vol.101 , pp. 1651-1656
    • Migdal, C.1    Gregory, W.2    Hitchings, R.3
  • 19
    • 0020549636 scopus 로고
    • Histologic characteristics of filtering blebs in glaucomatous eyes
    • Addicks EM, Quigley HA, Green WR, Robin AL. Histologic characteristics of filtering blebs in glaucomatous eyes. Arch Ophthalmol 1983; 101:795-798.
    • (1983) Arch Ophthalmol , vol.101 , pp. 795-798
    • Addicks, E.M.1    Quigley, H.A.2    Green, W.R.3    Robin, A.L.4
  • 21
    • 0032820482 scopus 로고    scopus 로고
    • Transforming growth factor-β1, -β2, and -β3 in vivo: Effects on normal and mitomycin C-modulated conjunctival scarring
    • Cordeiro MF, Reichel MB, Gay JA, D'Esposita F, Alexander RA, Khaw PT. Transforming growth factor-β1, -β2, and -β3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring. Invest Ophthalmol Vis Sci 1999; 40:1975-1982.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1975-1982
    • Cordeiro, M.F.1    Reichel, M.B.2    Gay, J.A.3    D'esposita, F.4    Alexander, R.A.5    Khaw, P.T.6
  • 23
    • 0026475803 scopus 로고
    • Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil
    • Stamper RL, McMenemy MG, Lieberman MF. Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil. Am J Ophthalmol 1992; 114:544-553.
    • (1992) Am J Ophthalmol , vol.114 , pp. 544-553
    • Stamper, R.L.1    McMenemy, M.G.2    Lieberman, M.F.3
  • 24
    • 0032821129 scopus 로고    scopus 로고
    • Human anti-transforming growth factor-β2 antibody: A new glaucoma anti-scarring agent
    • Cordeiro MF, Gay JA, Khaw PT. Human anti-transforming growth factor-β2 antibody: a new glaucoma anti-scarring agent. Invest Ophthalmol Vis Sci 1999; 40:2225-2234.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 2225-2234
    • Cordeiro, M.F.1    Gay, J.A.2    Khaw, P.T.3
  • 25
    • 0041342109 scopus 로고    scopus 로고
    • Evaluation of anti-TGF-β2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
    • Mead AL, Wong TT, Cordeiro MF, Anderson IK, Khaw PT. Evaluation of anti-TGF-β2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci 2003; 44:3394-3401.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3394-3401
    • Mead, A.L.1    Wong, T.T.2    Cordeiro, M.F.3    Anderson, I.K.4    Khaw, P.T.5
  • 27
    • 14544297836 scopus 로고    scopus 로고
    • RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis
    • Nakamura H, Siddiqui SS, Shen X, Malik AB, Pulido JS, Kumar NM, Yue BY. RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. Mol Vis 2004; 10:703-711.
    • (2004) Mol Vis , vol.10 , pp. 703-711
    • Nakamura, H.1    Siddiqui, S.S.2    Shen, X.3    Malik, A.B.4    Pulido, J.S.5    Kumar, N.M.6    Yue, B.Y.7
  • 28
    • 34748861947 scopus 로고    scopus 로고
    • A phase III study of subconjunctival human anti-transforming growth factor β(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy
    • CAT-152 0102 Trabeculectomy Study Group. Khaw P, Grehn F, Holló G, Overton B, Wilson R, Vogel R, Smith Z, PMID: 17908591
    • CAT-152 0102 Trabeculectomy Study Group. Khaw P, Grehn F, Holló G, Overton B, Wilson R, Vogel R, Smith Z. A phase III study of subconjunctival human anti-transforming growth factor β(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology 2007; 114:1822-1830.
    • (2007) Ophthalmology , vol.114 , pp. 1822-1830
  • 30
    • 4544381198 scopus 로고    scopus 로고
    • Biochemical mechanisms of drug action: What does it take for success?
    • Swinney DC. Biochemical mechanisms of drug action: what does it take for success? Nat Rev Drug Discov 2004; 3:801-808.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 801-808
    • Swinney, D.C.1
  • 31
    • 0034788236 scopus 로고    scopus 로고
    • Suppressor and oncogenic roles of transforming growth factor-β and its signaling pathways in tumorigenesis
    • Piek E, Roberts AB. Suppressor and oncogenic roles of transforming growth factor-β and its signaling pathways in tumorigenesis. Adv Cancer Res 2001; 83:1-54.
    • (2001) Adv Cancer Res , vol.83 , pp. 1-54
    • Piek, E.1    Roberts, A.B.2
  • 32
    • 1442299193 scopus 로고    scopus 로고
    • Lateral signaling enhances TGF-β response complexity
    • Byfield SD, Roberts AB. Lateral signaling enhances TGF-β response complexity. Trends Cell Biol 2004; 14:107-111.
    • (2004) Trends Cell Biol , vol.14 , pp. 107-111
    • Byfield, S.D.1    Roberts, A.B.2
  • 33
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi Y, Massagué J. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 2003; 113:685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 37
    • 1342265719 scopus 로고    scopus 로고
    • SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7
    • DaCosta Byfield S, Major C, Laping NJ, Roberts AB. SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2004; 65:744-752.
    • (2004) Mol Pharmacol , vol.65 , pp. 744-752
    • Da Byfield, C.S.1    Major, C.2    Laping, N.J.3    Roberts, A.B.4
  • 40
    • 29644443725 scopus 로고    scopus 로고
    • The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-tomesenchymal transition by transforming growth factor-β
    • Tojo M, Hamashima Y, Hanyu A, Kajimoto T, Saitoh M, Miyazono K, Node M, Imamura T. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-tomesenchymal transition by transforming growth factor-β. Cancer Sci 2005; 96:791-800.
    • (2005) Cancer Sci , vol.96 , pp. 791-800
    • Tojo, M.1    Hamashima, Y.2    Hanyu, A.3    Kajimoto, T.4    Saitoh, M.5    Miyazono, K.6    Node, M.7    Imamura, T.8
  • 41
    • 64049089837 scopus 로고    scopus 로고
    • SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism
    • Xiao YQ, Liu K, Shen JF, Xu GT, Ye W. SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism. Invest Ophthalmol Vis Sci 2009; 50:1698-1706.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1698-1706
    • Xiao, Y.Q.1    Liu, K.2    Shen, J.F.3    Xu, G.T.4    Ye, W.5
  • 42
    • 0019349027 scopus 로고
    • Studies of corneas in vivo and in vitro
    • Yue BY, Baum JL. Studies of corneas in vivo and in vitro. Vision Res 1981; 21:41-43.
    • (1981) Vision Res , vol.21 , pp. 41-43
    • Yue, B.Y.1    Baum, J.L.2
  • 43
    • 0032924313 scopus 로고    scopus 로고
    • Compressional characterization of two dextrose-based directly compressible excipients using an instrumented tablet press
    • Olmo IG, Ghaly ES. Compressional characterization of two dextrose-based directly compressible excipients using an instrumented tablet press. Pharm Dev Technol 1999; 4:221-231.
    • (1999) Pharm Dev Technol , vol.4 , pp. 221-231
    • Olmo, I.G.1    Ghaly, E.S.2
  • 46
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGFbeta signaling inhibitors for cancer therapy
    • Yingling JM, Blanchard KL, Sawyer JS. Development of TGFbeta signaling inhibitors for cancer therapy. Nat Rev Drug Discov 2004; 3:1011-1022.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 47
    • 67651097825 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor β type 1 receptor (ALK5)
    • Li X, Wang L, Long L, Xiao J, Hu Y, Li S. Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor β type 1 receptor (ALK5). Bioorg Med Chem Lett 2009; 19:4868-4872.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 4868-4872
    • Li, X.1    Wang, L.2    Long, L.3    Xiao, J.4    Hu, Y.5    Li, S.6
  • 48
    • 19444371555 scopus 로고    scopus 로고
    • Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-β type I receptor kinase in puromycin-induced nephritis
    • Grygielko ET, Martin WM, Tweed C, Thornton P, Harling J, Brooks DP, Laping NJ. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-β type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther 2005; 313:943-951.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 943-951
    • Grygielko, E.T.1    Martin, W.M.2    Tweed, C.3    Thornton, P.4    Harling, J.5    Brooks, D.P.6    Laping, N.J.7


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