Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts

Investigative Ophthalmology and Visual Science

Volumn 39, Issue 2, 1998, Pages 449-454

  Crowston, Jonathan G ^a,d   Akbar, Arne N ^b   Constable, Peter H ^a   Occleston, Nicholas L ^a,c   Daniels, Julie T ^a   Khaw, Peng T ^a  

^a MOORFIELDS EYE HOSPITAL   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

^c Institute of Ophthalmology ^*

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; FLUOROURACIL; LACTATE DEHYDROGENASE; MITOMYCIN C;

APOPTOSIS; CONJUNCTIVA; CONTROLLED STUDY; FETAL CALF SERUM; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVIEW;

ANTIMETABOLITES; APOPTOSIS; CELL COUNT; CELLS, CULTURED; CONNECTIVE TISSUE; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; FLUOROURACIL; HUMANS; L-LACTATE DEHYDROGENASE; MITOMYCIN;

EID: 0031916861     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (10)

1. Desmouliere A, Redard M, Darby I, Gabbiani G. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol. 1995;146:56-66.
2. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239-257.
3. Khaw PT, Ward S, Porter A, Grierson I, Hitchings RA, Rice NS. The long-term effects of 5-fluorouracil and sodium butyrate on human Tenon's fibroblasts. Invest Ophthalmol Vis Sci. 1992;33:2043-2052.
4. Occleston NL, Alexander RA, Mazure A, Larkin G, Khaw PT. Effects of single exposures to antiproliferative agents on ocular fibroblast-mediated collagen contraction. Invest Ophthalmol Vis Sci. 1994; 35:3681-3690.
5. Jampel HD. Effect of brief exposure to mitomycin C on viability and proliferation of cultured human Tenon's capsule fibroblasts. Ophthalmology. 1992;99:1471-1476.
6. Smith S, D'Amore PA, Dreyer EB. Comparative toxicity of mitomycin C and 5-fluorouracil in vitro. Am J Ophthalmol. 1994;118:332-337.
7. Shields MB, Scroggs MW, Sloop CM, Simmons RB. Clinical and histopathologic observations concerning hypotony after trabeculectomy with adjunctive mitomycin C. Am J Ophthalmol. 1993; 116:673-683.
8. Harrington EA, Bennett MR, Fanidi A, Evan GI. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 1994;13:3286-3295.
9. Khaw PT, Occleston NL, Schultz G, Grierson I, Sherwood MB, Larkin G. Activation and suppression of fibroblast function. Eye. 1994;8(Pt 2):188-195.
10. Grand RJ, Milner AE, Mustoe T, et al. A novel protein expressed in mammalian cells undergoing apoptosis. Exp Cell Res. 1995;218: 439-451.