Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation

Oncogene

Volumn 25, Issue 52, 2006, Pages 6936-6947

  Candeias, M M ^a   Powell, D J ^a   Roubalova, E ^b   Apcher, S ^a   Bourougaa, K ^a   Vojtesek, B ^b   Bruzzoni Giovanelli, H ^a   Fahraeus R ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

Author keywords

Alternative translation initiation; p53; p53 47; Stress response

Indexed keywords

CYTOTOXIC AGENT; MESSENGER RNA; PROTEIN P47; PROTEIN P53;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ARTICLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; PROTEIN VARIANT; RNA SYNTHESIS; SECOND MESSENGER; TRANSACTIVATION; TRANSCRIPTION INITIATION SITE; TRANSLATION INITIATION; TRANSLATION REGULATION;

5' UNTRANSLATED REGIONS; BLOTTING, NORTHERN; CELL LINE, TUMOR; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33750600407     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209996     Document Type: Article

References (41)

1. Bourdon JC, Fernandes K, Murray-Zmijewski F, Liu G, Diot A, Xirodimas DP et al. (2005). p53 isoforms can regulate p53 transcriptional activity. Genes Dev 19: 2122-2137.
2. Coldwell MJ, Mitchell SA, Stoneley M, MacFarlane M, Willis AE. (2000). Initiation of Apaf-1 translation by internal ribosome entry. Oncogene 19: 899-905.
3. Courtois S, Verhaegh G, North S, Luciani MG, Lassus P, Hibner U et al. (2002). DeltaN-p53, a natural isoform of p53 lackingthe first transactivation domain, counteracts growth suppression by wild-type p53. Oncogene 21: 6722-6728.
4. Creancier L, Mercier P, Prats AC, Morello D. (2001). c-myc Internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice. Mol Cell Biol 21: 1833-1840.
5. de Rozieres S, Maya R, Oren M, Lozano G. (2000). The loss of mdm2 induces p53-mediated apoptosis. Oncogene 19: 1691-1697.
6. Fernandez J, Yaman I, Sarnow P, Snider MD, Hatzoglou M. (2002). Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha. J Biol Chem 277: 19198-19205.
7. Fu L, Ma W, Benchimol S. (1999). A translation repressor element resides in the 3′ untranslated region of human p53 mRNA. Oncogene 18: 6419-6424.
8. Fu L, Minden MD, Benchimol S. (1996). Translational regulation of human p53 gene expression. EMBO J 15: 4392-4401.
9. Geballe AP, Morris DR. (1994). Initiation codons within 5′-leaders of mRNAs as regulators of translation. Trends Biochem Sci 19: 159-164.
10. Ghosh A, Stewart D, Matlashewski G. (2004). Regulation of human p53 activity and cell localization by alternative splicing. Mol Cell Biol 24: 7987-7997.
11. Gray NK, Wickens M. (1998). Control of translation initiation in animals. Annu Rev Cell Dev Biol 14: 399-458.
12. Hansen S, Lane DP, Midgley CA. (1998). The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability. J Mol Biol 275: 575-588.
13. Harding HP, Zhang Y, Ron D. (1999). Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274.
14. Harris SL, Levine AJ. (2005). The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908.
15. Haupt Y, Maya R, Kazaz A, Oren M. (1997). Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299.
16. Hellen CU, Sarnow P. (2001). Internal ribosome entry sites in eukaryotic mRNA molecules. Genes Dev 15: 1593-1612.
17. Herbreteau CH, Weill L, Decimo D, Prevot D, Darlix JL, Sargueil B et al. (2005). HIV-2 genomic RNA contains a novel type of IRES located downstream of its initiation codon. Nat Struct Mol Biol 12: 1001-1007.
18. Holcik M, Lefebvre C, Yeh C, Chow T, Korneluk RG. (1999). A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection. Nat Cell Biol 1: 190-192.
19. Holcik M, Sonenberg N. (2005). Translational control in stress and apoptosis. Nat Rev Mol Cell Biol 6: 318-327.
20. Honda R, Tanaka H, Yasuda H. (1997). Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420: 25-27.
21. Jackson RJ. (2000). A comparative view of initiation site selection mechanisms. In: Sonenberg N, Hershey JWB, Mathews MB (eds). Translational Control of Gene Expression. Cold Spring Harbour Press, NY, pp 127-184.
22. Johannes G, Sarnow P. (1998). Cap-independent polysomal association of natural mRNAs encodingc-myc, BiP, and eIF4G conferred by internal ribosome entry sites. Rna 4: 1500-1513.
23. Kubbutat MH, Jones SN, Vousden KH. (1997). Regulation of p53 stability by Mdm2. Nature 387: 299-303.
24. Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ et al. (1996). Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274: 948-953.
25. Lang KJ, Kappel A, Goodall GJ. (2002). Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation duringnormoxia and hypoxia. Mol Biol Cell 13: 1792-1801.
26. Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T et al. (2004). Modulation of mammalian life span by the short isoform of p53. Genes Dev 18: 306-319.
27. Mokdad-Gargouri R, Belhadj K, Gargouri A. (2001). Translational control of human p53 expression in yeast mediated by 5′-UTR-ORF structural interaction. Nucleic Acids Res 29: 1222-1227.
28. Mosner J, Mummenbrauer T, Bauer C, Sczakiel G, Grosse F, Deppert W. (1995). Negative feedback regulation of wild-type p53 biosynthesis. EMBO J 14: 4442-4449.
29. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. (1991). A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139: 271-279.
30. Pelletier J, Sonenberg N. (1988). Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334: 320-325.
31. Pyronnet S, Pradayrol L, Sonenberg N. (2000). A cell cycle-dependent internal ribosome entry site. Mol Cell 5: 607-616.
32. Rohaly G, Chemnitz J, Dehde S, Nunez AM, Heukeshoven J, Deppert W et al. (2005). A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint. Cell 122: 21-32.
33. Schneider R. (2001). New ways of initiating translation in eukaryotes. Mol Cell Biol 21: 8238-8246.
34. Spriggs KA, Bushell M, Mitchell SA, Willis AE. (2005). Internal ribosome entry segment-mediated translation during apoptosis: the role of IRES-trans-actingfactors. Cell Death Differ 12: 585-591.
35. Stoneley M, Willis AE. (2004). Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression. Oncogene 23: 3200-3207.
36. Takagi M, Absalon MJ, McLure KG, Kastan MB. (2005). Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123: 49-63.
37. Venot C, Maratrat M, Sierra V, Conseiller E, Debussche L. (1999). Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains. Oncogene 18: 2405-2410.
38. Warnakulasuriyarachchi D, Cerquozzi S, Cheung HH, Holcik M. (2004). Translational induction of the inhibitor of apoptosis protein HIAP2 duringendoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element. J Biol Chem 279: 17148-17157.
39. Wazer DE, Chu Q, Liu XL, Gao Q, Safaii H, Band V. (1994). Loss of p53 protein during radiation transformation of primary human mammary epithelial cells. Mol Cell Biol 14: 2468-2478.
40. Yin Y, Stephen CW, Luciani MG, Fahraeus R. (2002). p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products. Nat Cell Biol 4: 462-467.
41. Zhu J, Zhou W, Jiang J, Chen X. (1998). Identification of a novel p53 functional domain that is necessary for mediating apoptosis. J Biol Chem 273: 13030-13036.