PEGylated PEI-based biodegradable polymers as non-viral gene vectors

Acta Biomaterialia

Volumn 6, Issue 11, 2010, Pages 4285-4295

  Huang, Fu Wei ^a   Wang, Hui Yuan ^a   Li, Cao ^a   Wang, Hua Fen ^a   Sun, Yun Xia ^a   Feng, Jun ^a   Zhang, Xian Zheng ^a   Zhuo, Ren Xi ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Biodegradable cationic polymer; Cytotoxicity; Gene transfection; Gene vector; PSI g PEI g PEG

Indexed keywords

BIODEGRADABLE POLYMERS; CYTOTOXICITY; ETHYLENE GLYCOL; GENE TRANSFER; GENES; LANTHANUM COMPOUNDS; MOLECULAR BIOLOGY; PARTICLE SIZE; POLYOLS; VECTORS;

BIODEGRADABLE CATIONIC POLYMER; CATIONIC POLYMERS; GENE TRANSFECTION; GENE VECTORS; HELA CELL; NONVIRAL; PEGYLATED; PEGYLATION; PSI-G-PEI-G-PEG; VIRAL GENES;

POLYETHYLENE GLYCOLS;

MACROGOL; METHOXY POLY(ETHYLENE GLYCOL); PLASMID DNA; POLY(SUCCINIMIDE) G POLYETHYLENIMINE G POLY(ETHYLENE GLYCOL); POLYETHYLENEIMINE; POLYMER; POLYSUCCINIMIDE; POLYSUCCINIMIDE G POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ADHESION; ARTICLE; BINDING KINETICS; BIODEGRADABILITY; CELL VIABILITY; COMPLEX FORMATION; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; EMBRYO; FEMALE; GENE THERAPY; GENE VECTOR; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO GENE TRANSFER; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; SYNTHESIS; ZETA POTENTIAL;

EID: 77956905327     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.06.016     Document Type: Article

References (26)

1. R.A. Morgan, M.E. Dudley, J.R. Wunderlich, M.S. Hughes, J.C. Yang, and R.M. Sherry Cancer regression in patients after transfer of genetically engineered lymphocytes Science 314 2006 126
2. R. Wolkowicz, and G.P. Nolan Gene therapy progress and prospects: novel gene therapy approaches for AIDS Gene Ther 12 2005 467
3. A.C. Hunter Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity Adv Drug Deliv Rev 58 2006 1523
4. J. Li, C. Yang, H.Z. Li, X. Wang, S.H. Goh, and J.L. Ding Cationic supramolecules composed of multiple oligoethylenimine-grafted cyclodextrins threaded on a polymer chain for efficient gene delivery Adv Mater 18 2006 2969
5. T. Schmitz, I. Bravo-Osuna, C. Vauthier, G. Ponchel, B. Loretz, and A. Bernkop-Schnurch Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system Biomaterials 28 2007 524
6. J.H. Yu, J.S. Quan, J. Huang, C.Y. Wang, B. Sun, and J.W. Nah α,β-Poly(l-aspartate-graft-PEI): a pseudo-branched PEI as a gene carrier with low toxicity and high transfection efficiency Acta Biomater 5 2009 2485
7. C. Moreir, H. Oliveira, L.R. Pires, S. Simoes, M. Barbosa, and A.P. Pego Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone Acta Biomater 5 2009 2995
8. S.I. Weiss, N. Sieverling, M. Niclasen, C. Maucksch, A.F. Thunemann, and H. Mohwald Uronic acids functionalized polyethyleneimine (PEI)- polyethyleneglycol (PEG)-graft-copolymers as novel synthetic gene carriers Biomaterials 27 2006 2302
9. Y.X. Sun, X. Zeng, Q.F. Meng, X.Z. Zhang, S.X. Cheng, and R.X. Zhuo The influence of RGD addition on the gene transfer characteristics of disulfide-containing polyethyleneimine/DNA complexes Biomaterials 29 2008 4356
10. H. Chen, Y.Y. Li, X. Zeng, Y.X. Sun, X.Z. Zhang, and R.X. Zhuo Protamine sulfate/poly(l-aspartic acid) (PS/PASP) polyionic complexes (PICs) self-assembled via electrostatic attractions for co-delivery of drug and gene Biomaterials 30 2009 1246
11. Z.Y. Zhong, J. Feijen, M.C. Lok, W.E. Hennink, L.V. Christensen, and J.W. Yockman Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: synthesis, characterization, and in vitro gene transfer properties Biomacromolecules 6 2005 3440
12. M.P. Xiong, M.L. Forrest, G. Ton, A. Zhao, N.M. Davies, and G.S. Kwon Poly(aspartate-g-PEI800), a polyethylenimine analogue of low toxicity and high transfection efficiency for gene delivery Biomaterials 28 2007 4889
13. M. Thomas, Q. Ge, J.J. Lu, J. Chen, and A.M. Klibanov Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo Pharm Res 22 2005 373
14. F.W. Huang, J. Feng, J. Nie, S.X. Cheng, X.Z. Zhang, and R.X. Zhuo Convenient preparation of biodegradable PEI-containing polymers as non-viral vectors for gene transfection Macromol Biosci 9 2009 1176
15. G.P. Tang, J.M. Zeng, S.J. Gao, Y.X. Ma, L. Shi, and Y. Li Polyethylene glycol modified polyethylenimine for improved CNS gene transfer: effects of PEGylation extent Biomaterials 24 2003 2351
16. Y.T. Wen, S.R. Pan, X. Luo, X. Zhang, W. Zhang, and M. Feng A biodegradable low molecular weight polyethylenimine derivative as low toxicity and efficient gene vector Bioconjug Chem 20 2009 322
17. A. Kichler, M. Chillon, C. Leborgne, O. Danos, and B. Frisch Intranasal gene delivery with a polyethylenimine-PEG conjugate J Control Release 81 2002 379
18. H. Petersen, P.M. Fechner, A.L. Martin, K. Kunath, S. Stolnik, and C.J. Roberts Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer clock structure on DNA complexation and biological activities as gene delivery system Bioconjug Chem 13 2002 845
19. D. Klink, Q.C. Yu, M.C. Glick, and T. Scanlin Lactosylated poly-l-lysine targets a potential lactose receptor in cystic fibrosis and non-cystic fibrosis airway epithelial cells Mol Ther 7 2003 73
20. X. Zhang, S.R. Pan, H.M. Hu, G.F. Wu, M. Feng, and W. Zhang Poly(ethylene glycol)-block-polyethylenimine copolymers as carriers for gene delivery: effects of PEG molecular weight and PEGylation degree J Biomed Mater Res Part A 84 2008 795
21. H. Petersen, P.M. Fechner, D. Fischer, and T. Kissel Synthesis, characterization, and biocompatibility of polyethylenimine-graft-poly(ethylene glycol) block copolymers Macromolecules 35 2002 6867
22. H. Petersen, P.M. Fechner, A.L. Martin, K. Kunath, S. Stolnik, and C.J. Roberts Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance DNA condensation of low molecular weight polyethylenimines Biomacromolecules 3 2002 926
23. R. Kircheis, L. Wightman, and E. Wagner Design and gene delivery activity of modified polyethylenimines Adv Drug Deliv Rev 53 2001 341
24. T.I. Kim, J.U. Baek, J.K. Yoon, J.S. Choi, K. Kim, and J.S. Park Synthesis and characterization of a novel arginine-grafted dendritic block copolymer for gene delivery and study of its cellular uptake pathway leading to transfection Bioconjug Chem 18 2007 309
25. M.R. Park, K.O. Han, I.K. Han, M.H. Cho, J.W. Nah, and Y.J. Choi Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers J Control Release 105 2005 367
26. D.M. Xu, S.D. Yao, Y.B. Liu, K.L. Sheng, J. Hong, and P.J. Gong Size-dependent properties of M-PEIs nanogels for gene delivery in cancer cells Int J Pharm 338 2007 291