Protodynamic intracellular acidification by cis-urocanic acid promotes apoptosis of melanoma cells in vitro and in vivo

Journal of Investigative Dermatology

Volumn 130, Issue 10, 2010, Pages 2431-2439

  Laihia, Jarmo K ^a   Kallio, Janne P ^b,c   Taimen, Pekka ^b,d   Kujari, Harry ^b   Kähäri, Veli Matti ^b,c   Leino, Lasse ^a  

^a BioCis Pharma Ltd   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

UROCANIC ACID; ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL PH; CELL PROLIFERATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MELANOMA CELL; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOMA CELL; SCID MOUSE; STROMA CELL; TUMOR XENOGRAFT; ANIMAL; CELL DIVISION; CYTOSOL; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; FEMALE; FIBROSARCOMA; HELA CELL LINE; MELANOMA; METABOLISM; PATHOLOGY; PH; PHYSIOLOGY; SKIN NEOPLASMS; TRANSFORMED CELL LINE; UTERINE CERVICAL NEOPLASMS;

ACIDS; ANIMALS; APOPTOSIS; CELL DIVISION; CELL LINE, TRANSFORMED; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROSARCOMA; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; IN VITRO TECHNIQUES; MELANOMA; MICE; MICE, SCID; SKIN NEOPLASMS; UROCANIC ACID; UTERINE CERVICAL NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77956877953     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.151     Document Type: Article

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