Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia

International Journal of Hyperthermia

Volumn 18, Issue 2, 2002, Pages 153-164

  Wachsberger, P R ^a   Burd, R ^a   Wahl, M L ^b   Leeper, D B ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Apoptosis; Betulinic acid; Hyperthermia; Low pH

Indexed keywords

BETULIC ACID;

ACIDIFICATION; ACIDOSIS; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SENSITIZATION; HUMAN; HUMAN CELL; HYPERTHERMIC THERAPY; MELANOMA CELL; NICK END LABELING; PH; PH MEASUREMENT; TISSUE GROWTH; TUMOR GROWTH;

APOPTOSIS; CASPASES; CELL SURVIVAL; ENZYME ACTIVATION; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERTHERMIA, INDUCED; MELANOMA; POLY(ADP-RIBOSE) POLYMERASES; TRITERPENES; TUMOR CELLS, CULTURED;

EID: 0036126037     PISSN: 02656736     EISSN: None     Source Type: Journal    
DOI: 10.1080/02656730110091333     Document Type: Article

References (32)

1. Can screening for melanoma and skin cancer save lives?
2. Thermoradiotherapy in the management of superficial malignant tumors
3. Current status of knowledge and critical issues in tumor oxygenation. Results from 25 years research in tumor pathophysiology
4. Microenvironmental changes in irradiated tumors
5. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
6. Mammalian cells adapted to growth at pH 6.7 have elevated HSP27 levels and are resistant to cisplatin
7. Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma
8. Effects of betulinic acid alone and in combination with irradiation in human melanoma cells
9. The chemoresistance of human malignant melanoma: An update
10. Effects of 42°C hyperthermia on intracellular pH in ovarian carcinoma cells during acute or chronic exposure to low extracellular pH
11. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
12. Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors
13. Betulinic acid induces apoptosis in human neuroblastoma cell lines
14. p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma
15. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
16. Enhanced cytotoxicity of some triterpenes toward leukemia L1210 cells cultured in low pH media: Possibility of a new mode of cell killing
17. Form-determining function of the genes required for the assembly of the head of bacteriophage T4
18. Altered proton extrusion in cells adapted to growth at low extracellular pH
19. X-ray and ultraviolet sensitivity of synchronized Chinese hamster cells at various stages of the cell cycle
20. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
21. Tumor oxygenation and acidification are increased in melanoma after exposure to meta-iodo-benzylguanidine: Implications for radio- and hyperthermic sensitization
22. Camptothecin analogues with enhanced antitumor activity at acidic pH
23. Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: Reversal by respiratory inhibitors
24. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
25. Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
26. Response of tumours to hyperglycaemia: Characterization, significance and role in hyperthermia
27. Effect of hyperglycemia on the thermal response of murine normal and tumor tissues
28. Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
29. Upregulation of heat shock proteins and induction of cytoskeletal stability in human melanoma cells adapted to growth at low pH
30. Mammalian cells adapted to growth at pH 6.7 have elevated HSP27 levels and are resistant to cisplatin
31. Mitochondrion as a novel target of anticancer chemotherapy
32. Effect of acidic environment and p53 on apoptosis induction by hyperthermia