A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats

Toxicology Mechanisms and Methods

Volumn 20, Issue 8, 2010, Pages 445-451

  Kassa, Jiri ^a   Karasova, Jana Zdarova ^a   Tesarova, Sandra ^b   Kuca, Kamil ^c   Musilek, Kamil ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b 7th Field Hospital of the Czech Army   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Antidotal treatment; Funtional observational battery; Nerve agents; Oximes

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ATROPINE; BIS(PYRIDINIUM OXIME) DERIVATIVE; K 203; OBIDOXIME; SOMAN; TRIMEDOXIME; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; GAS POISONING; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ATROPINE; BEHAVIOR, ANIMAL; CHEMICAL WARFARE AGENTS; DRUG THERAPY, COMBINATION; MALE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; OXIMES; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR; SOMAN;

RATTUS;

EID: 77956842288     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2010.497975     Document Type: Article

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