메뉴 건너뛰기




Volumn 41, Issue 5, 2010, Pages 315-323

Expression of Sonic Hedgehog Signaling Components in Hepatocellular Carcinoma and Cyclopamine-induced Apoptosis Through Bcl-2 Downregulation In Vitro

Author keywords

Apoptosis; Bcl 2; Hepatocellular carcinoma; Sonic hedgehog signaling

Indexed keywords

CASPASE 3; CASPASE 9; CYCLOPAMINE; MESSENGER RNA; PROTEIN BCL 2; PROTEIN PATCHED; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

EID: 77956827224     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2010.06.003     Document Type: Article
Times cited : (48)

References (40)
  • 1
  • 3
    • 33847069207 scopus 로고    scopus 로고
    • Genomics and signaling pathways in hepatocellular carcinoma
    • Villanueva A., Newell P., Chiang D.Y., et al. Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis 2007, 27:55-76.
    • (2007) Semin Liver Dis , vol.27 , pp. 55-76
    • Villanueva, A.1    Newell, P.2    Chiang, D.Y.3
  • 4
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the Hedgehog pathway in cancer
    • Rubin L.L., de Sauvage F.J. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006, 5:1026-1033.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 1026-1033
    • Rubin, L.L.1    de Sauvage, F.J.2
  • 5
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nüsslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287:795-801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nüsslein-Volhard, C.1    Wieschaus, E.2
  • 6
    • 34250622479 scopus 로고    scopus 로고
    • Hedgehog signaling: a biophysical or biomechanical modulator in embryonic development?
    • Nagase T., Nagase M., Machida M., et al. Hedgehog signaling: a biophysical or biomechanical modulator in embryonic development?. Ann NY Acad Sci 2007, 1101:412-438.
    • (2007) Ann NY Acad Sci , vol.1101 , pp. 412-438
    • Nagase, T.1    Nagase, M.2    Machida, M.3
  • 7
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened
    • Denef N., Neubüser D., Perez L., et al. Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened. Cell 2000, 18:521-531.
    • (2000) Cell , vol.18 , pp. 521-531
    • Denef, N.1    Neubüser, D.2    Perez, L.3
  • 8
    • 0345059765 scopus 로고    scopus 로고
    • Hedgehog signaling in cancer formation and maintenance
    • Pasca di Magliano M., Hebrok M. Hedgehog signaling in cancer formation and maintenance. Nat Rev Cancer 2003, 3:903-911.
    • (2003) Nat Rev Cancer , vol.3 , pp. 903-911
    • Pasca di Magliano, M.1    Hebrok, M.2
  • 9
    • 70349237014 scopus 로고    scopus 로고
    • Following the hedgehog to new cancer therapies
    • Dlugosz A.A., Talpaz M. Following the hedgehog to new cancer therapies. N Engl J Med 2009, 361:1202-1205.
    • (2009) N Engl J Med , vol.361 , pp. 1202-1205
    • Dlugosz, A.A.1    Talpaz, M.2
  • 10
    • 33745634379 scopus 로고    scopus 로고
    • Activation of the hedgehog pathway in human hepatocellular carcinomas
    • Huang S., He J., Zhang X., et al. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis 2006, 27:1334-1340.
    • (2006) Carcinogenesis , vol.27 , pp. 1334-1340
    • Huang, S.1    He, J.2    Zhang, X.3
  • 11
    • 33645371509 scopus 로고    scopus 로고
    • Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis
    • Sicklick J.K., Li Y.X., Jayaraman A., et al. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis 2006, 27:748-757.
    • (2006) Carcinogenesis , vol.27 , pp. 748-757
    • Sicklick, J.K.1    Li, Y.X.2    Jayaraman, A.3
  • 12
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • Watkins D.N., Berman D.M., Burkholder S.G., et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003, 422:313-317.
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3
  • 13
    • 0037200078 scopus 로고    scopus 로고
    • Medulloblastoma growth inhibition by hedgehog pathway blockade
    • Berman D.M., Karhadkar S.S., Hallahan A.R., et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 2002, 297:1559-1561.
    • (2002) Science , vol.297 , pp. 1559-1561
    • Berman, D.M.1    Karhadkar, S.S.2    Hallahan, A.R.3
  • 14
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman D.M., Karhadkar S.S., Maitra A., et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003, 425:846-851.
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 15
    • 6044243650 scopus 로고    scopus 로고
    • Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    • Karhadkar S.S., Bova G.S., Abdallah N., et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004, 431:707-712.
    • (2004) Nature , vol.431 , pp. 707-712
    • Karhadkar, S.S.1    Bova, G.S.2    Abdallah, N.3
  • 16
    • 0242270878 scopus 로고    scopus 로고
    • Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    • Thayer S.P., di Magliano M.P., Heiser P.W., et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003, 425:851-856.
    • (2003) Nature , vol.425 , pp. 851-856
    • Thayer, S.P.1    di Magliano, M.P.2    Heiser, P.W.3
  • 17
    • 29744463531 scopus 로고    scopus 로고
    • Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development
    • Tostar U., Malm C.J., Meis-Kindblom J.M., et al. Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol 2006, 208:17-25.
    • (2006) J Pathol , vol.208 , pp. 17-25
    • Tostar, U.1    Malm, C.J.2    Meis-Kindblom, J.M.3
  • 18
    • 4344659678 scopus 로고    scopus 로고
    • Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
    • 12561-1256
    • Sanchez P., Hernández A.M., Stecca B., et al. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci USA 2004, 101. 12561-1256.
    • (2004) Proc Natl Acad Sci USA , vol.101
    • Sanchez, P.1    Hernández, A.M.2    Stecca, B.3
  • 19
    • 0034738979 scopus 로고    scopus 로고
    • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
    • Taipale J., Chen J.K., Cooper M.K., et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 2000, 406:1005-1009.
    • (2000) Nature , vol.406 , pp. 1005-1009
    • Taipale, J.1    Chen, J.K.2    Cooper, M.K.3
  • 20
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
    • Chen J.K., Taipale J., Cooper M.K., et al. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 2002, 16:2743-2748.
    • (2002) Genes Dev , vol.16 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3
  • 21
    • 33745764824 scopus 로고    scopus 로고
    • Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer
    • Mukherjee S., Frolova N., Sadlonova A., et al. Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer. Cancer Biol Ther 2006, 5:674-683.
    • (2006) Cancer Biol Ther , vol.5 , pp. 674-683
    • Mukherjee, S.1    Frolova, N.2    Sadlonova, A.3
  • 22
    • 20644431776 scopus 로고    scopus 로고
    • Sonic hedgehog signaling in basal cell carcinomas
    • Daya-Grosjean L., Couve-Privat S. Sonic hedgehog signaling in basal cell carcinomas. Cancer Lett 2005, 225:181-192.
    • (2005) Cancer Lett , vol.225 , pp. 181-192
    • Daya-Grosjean, L.1    Couve-Privat, S.2
  • 23
    • 34347226348 scopus 로고    scopus 로고
    • Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
    • Stecca B., Mas C., Clement V., et al. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci USA 2007, 104:5895-5900.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5895-5900
    • Stecca, B.1    Mas, C.2    Clement, V.3
  • 24
    • 0026655474 scopus 로고
    • Bcl-2 initiates a new category of oncogenes: regulators of cell death
    • Korsmeyer S.J. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992, 80:879-886.
    • (1992) Blood , vol.80 , pp. 879-886
    • Korsmeyer, S.J.1
  • 25
    • 0346463039 scopus 로고    scopus 로고
    • Transcriptional regulation of bcl-2 mediated by the Sonic hedgehog signaling pathway through Gli-1
    • Bigelow R.L., Chari N.S., Unden A.B., et al. Transcriptional regulation of bcl-2 mediated by the Sonic hedgehog signaling pathway through Gli-1. J Biol Chem 2004, 279:1197-1205.
    • (2004) J Biol Chem , vol.279 , pp. 1197-1205
    • Bigelow, R.L.1    Chari, N.S.2    Unden, A.B.3
  • 26
    • 77956608762 scopus 로고    scopus 로고
    • Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells
    • Xu X.F., Guo C.Y., Liu J., et al. Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells. J Carcinog 2009, 8:13.
    • (2009) J Carcinog , vol.8 , pp. 13
    • Xu, X.F.1    Guo, C.Y.2    Liu, J.3
  • 27
    • 77949883895 scopus 로고    scopus 로고
    • FAK is involved in invasion and metastasis of hepatocellular carcinoma
    • Chen J.S., Huang X.H., Wang Q., et al. FAK is involved in invasion and metastasis of hepatocellular carcinoma. Clin Exp Metastasis 2010, 27:71-82.
    • (2010) Clin Exp Metastasis , vol.27 , pp. 71-82
    • Chen, J.S.1    Huang, X.H.2    Wang, Q.3
  • 28
    • 58949100355 scopus 로고    scopus 로고
    • Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation
    • Liao X., Siu M.K., Au C.W., et al. Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 2009, 30:131-140.
    • (2009) Carcinogenesis , vol.30 , pp. 131-140
    • Liao, X.1    Siu, M.K.2    Au, C.W.3
  • 29
    • 33646420651 scopus 로고    scopus 로고
    • Redox control of manumycin A-induced apoptosis in anaplastic thyroid cancer cells: involvement of the xenobiotic apoptotic pathway
    • She M., Yang H., Sun L., Yeung S.C. Redox control of manumycin A-induced apoptosis in anaplastic thyroid cancer cells: involvement of the xenobiotic apoptotic pathway. Cancer Biol Ther 2006, 5:275-280.
    • (2006) Cancer Biol Ther , vol.5 , pp. 275-280
    • She, M.1    Yang, H.2    Sun, L.3    Yeung, S.C.4
  • 30
    • 34249339801 scopus 로고    scopus 로고
    • Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells
    • Cao L.Q., Chen X.L., Wang Q., et al. Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells. Acta Pharmacol Sin 2007, 28:879-887.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 879-887
    • Cao, L.Q.1    Chen, X.L.2    Wang, Q.3
  • 31
    • 40049101451 scopus 로고    scopus 로고
    • Gli-1 siRNA induced apoptosis in Huh7 cells
    • Chen X.L., Cao L.Q., She M.R., et al. Gli-1 siRNA induced apoptosis in Huh7 cells. World J Gastroenterol 2008, 14:582-589.
    • (2008) World J Gastroenterol , vol.14 , pp. 582-589
    • Chen, X.L.1    Cao, L.Q.2    She, M.R.3
  • 32
    • 0018696805 scopus 로고
    • Hepatitis B surface antigen produced by a human hepatoma cell line
    • Skelly J., Copeland J.A., Howard C.R., et al. Hepatitis B surface antigen produced by a human hepatoma cell line. Nature 1979, 282:617-618.
    • (1979) Nature , vol.282 , pp. 617-618
    • Skelly, J.1    Copeland, J.A.2    Howard, C.R.3
  • 33
    • 0033107657 scopus 로고    scopus 로고
    • The apoptosome: heart and soul of the cell death machine
    • Chinnaiyan A.M. The apoptosome: heart and soul of the cell death machine. Neoplasia 1999, 1:5-15.
    • (1999) Neoplasia , vol.1 , pp. 5-15
    • Chinnaiyan, A.M.1
  • 34
    • 31544458968 scopus 로고    scopus 로고
    • Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells
    • Mimeault M., Moore E., Moniaux N., et al. Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells. Int J Cancer 2006, 118:1022-1031.
    • (2006) Int J Cancer , vol.118 , pp. 1022-1031
    • Mimeault, M.1    Moore, E.2    Moniaux, N.3
  • 35
    • 34547597687 scopus 로고    scopus 로고
    • Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells
    • Hu W.G., Liu T., Xiong J.X., et al. Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of EGFR inhibitor in pancreatic cancer cells. Acta Pharmacol Sin 2007, 28:1224-1230.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1224-1230
    • Hu, W.G.1    Liu, T.2    Xiong, J.X.3
  • 36
    • 33751337806 scopus 로고    scopus 로고
    • Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis
    • Chen X., Horiuchi A., Kikuchi N., et al. Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it's inhibition leads to growth suppression and apoptosis. Cancer Sci 2007, 98:68-76.
    • (2007) Cancer Sci , vol.98 , pp. 68-76
    • Chen, X.1    Horiuchi, A.2    Kikuchi, N.3
  • 37
    • 1442303112 scopus 로고    scopus 로고
    • The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells
    • Regl G., Kasper M., Schnidar H., et al. The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells. Oncogene 2004, 23:1263-1274.
    • (2004) Oncogene , vol.23 , pp. 1263-1274
    • Regl, G.1    Kasper, M.2    Schnidar, H.3
  • 38
    • 32644473650 scopus 로고    scopus 로고
    • How the Bcl-2 family of proteins interact to regulate apoptosis
    • van Delft M.F., Huang D.C. How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res 2006, 16:203-213.
    • (2006) Cell Res , vol.16 , pp. 203-213
    • van Delft, M.F.1    Huang, D.C.2
  • 40
    • 34247646461 scopus 로고    scopus 로고
    • Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
    • Morton J.P., Mongeau M.E., Klimstra D.S., et al. Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci USA 2007, 104:5103-5108.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5103-5108
    • Morton, J.P.1    Mongeau, M.E.2    Klimstra, D.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.