-
2
-
-
3342997700
-
Epidemiology and prevention of pancreatic cancer
-
Lowenfels AB, Maisonneuve P. Epidemiology and prevention of pancreatic cancer. Jpn J Clin Oncol 2004;34:238-44.
-
(2004)
Jpn J Clin Oncol
, vol.34
, pp. 238-244
-
-
Lowenfels, A.B.1
Maisonneuve, P.2
-
5
-
-
17144371524
-
Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer
-
Sanchez P, Clement V, Ruiz i Altaba A. Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer. Cancer Res 2005;65:2990-2.
-
(2005)
Cancer Res
, vol.65
, pp. 2990-2992
-
-
Sanchez, P.1
Clement, V.2
Ruiz Altaba, I.A.3
-
6
-
-
34247597260
-
Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development
-
Mfopou JK, De Groote V, Xu X, Heimberg H, Bouwens L. Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development. Stem Cells 2007;25:1156-65.
-
(2007)
Stem Cells
, vol.25
, pp. 1156-1165
-
-
Mfopou, J.K.1
De Groote, V.2
Xu, X.3
Heimberg, H.4
Bouwens, L.5
-
7
-
-
34548241874
-
Shh signaling and pancreatic cancer: Implications for therapy?
-
Morton JP, Lewis BC. Shh signaling and pancreatic cancer: implications for therapy? Cell Cycle 2007;6:1553-7.
-
(2007)
Cell Cycle
, vol.6
, pp. 1553-1557
-
-
Morton, J.P.1
Lewis, B.C.2
-
8
-
-
54049115162
-
An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
-
Feldmann G, Fendrich V, McGovern K, Bedja D, Bisht S, Alvarez H, et al. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer. Mol Cancer Ther 2008;7:2725-35.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2725-2735
-
-
Feldmann, G.1
Fendrich, V.2
McGovern, K.3
Bedja, D.4
Bisht, S.5
Alvarez, H.6
-
9
-
-
52649169761
-
Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer
-
Feldmann G, Habbe N, Dhara S, Bisht S, Alvarez H, Fendrich V, et al. Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer. Gut 2008;57:1420-30.
-
(2008)
Gut
, vol.57
, pp. 1420-1430
-
-
Feldmann, G.1
Habbe, N.2
Dhara, S.3
Bisht, S.4
Alvarez, H.5
Fendrich, V.6
-
10
-
-
34247646461
-
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
-
Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y, et al. Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A 2007;104:5103-8.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 5103-5108
-
-
Morton, J.P.1
Mongeau, M.E.2
Klimstra, D.S.3
Morris, J.P.4
Lee, Y.C.5
Kawaguchi, Y.6
-
11
-
-
51949085076
-
Hedgehog: Functions and mechanisms
-
Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev 2008;22:2454-72.
-
(2008)
Genes Dev
, vol.22
, pp. 2454-2472
-
-
Varjosalo, M.1
Taipale, J.2
-
12
-
-
27744583597
-
Hedgehog signaling pathway and gastric cancer
-
Katoh Y, Katoh M. Hedgehog signaling pathway and gastric cancer. Cancer Biol Ther 2005;4:1050-4.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 1050-1054
-
-
Katoh, Y.1
Katoh, M.2
-
13
-
-
43549101763
-
Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells
-
Yamazaki M, Nakamura K, Mizukami Y, Ii M, Sasajima J, Sugiyama Y, Nishikawa T, et al. Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells. Cancer Sci 2008;99:1131-8.
-
(2008)
Cancer Sci
, vol.99
, pp. 1131-1138
-
-
Yamazaki, M.1
Nakamura, K.2
Mizukami, Y.3
Ii, M.4
Sasajima, J.5
Sugiyama, Y.6
Nishikawa, T.7
-
14
-
-
33751337806
-
Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It′s inhibition leads to growth suppression and apoptosis
-
Chen X, Horiuchi A, Kikuchi N, Osada R, Yoshida J, Shiozawa T, et al. Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: it′s inhibition leads to growth suppression and apoptosis. Cancer Sci 2007;98:68-76.
-
(2007)
Cancer Sci
, vol.98
, pp. 68-76
-
-
Chen, X.1
Horiuchi, A.2
Kikuchi, N.3
Osada, R.4
Yoshida, J.5
Shiozawa, T.6
-
15
-
-
0034724219
-
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
-
Nilsson M, Undn AB, Krause D, Malmqwist U, Raza K, Zaphiropoulos PG, et al. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci U S A 2000;97:3438-43.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 3438-3443
-
-
Nilsson, M.1
Undn, A.B.2
Krause, D.3
Malmqwist, U.4
Raza, K.5
Zaphiropoulos, P.G.6
-
16
-
-
32644473650
-
How the Bcl-2 family of proteins interact to regulate apoptosis
-
van Delft MF, Huang DC. How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res 2006;16:203-13.
-
(2006)
Cell Res
, vol.16
, pp. 203-213
-
-
Van Delft, M.F.1
Huang, D.C.2
-
17
-
-
4143153900
-
Effects of diet consistency on the expression of insulin-like growth factors (IGFs), IGF receptors and IGF binding proteins during the development of rat masseter muscle soon after weaning
-
Saito T, Fukui K, Akutsu S, Nakagawa Y, Ishibashi K, Nagata J, et al. Effects of diet consistency on the expression of insulin-like growth factors (IGFs), IGF receptors and IGF binding proteins during the development of rat masseter muscle soon after weaning. Arch Oral Biol 2004;49:777-82.
-
(2004)
Arch Oral Biol
, vol.49
, pp. 777-782
-
-
Saito, T.1
Fukui, K.2
Akutsu, S.3
Nakagawa, Y.4
Ishibashi, K.5
Nagata, J.6
-
18
-
-
27644547419
-
Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators
-
Hearnes JM, Mays DJ, Schavolt KL, Tang L, Jiang X, Pietenpol JA. Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators. Mol Cell Biol 2005;25:10148-58.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10148-10158
-
-
Hearnes, J.M.1
Mays, D.J.2
Schavolt, K.L.3
Tang, L.4
Jiang, X.5
Pietenpol, J.A.6
-
19
-
-
33746482059
-
Histone modifications and transcription factor binding on chromatin ChIP-PCR assays
-
Won J, Kim TK. Histone modifications and transcription factor binding on chromatin ChIP-PCR assays. Methods Mol Biol 2006; 325: 273-83.
-
(2006)
Methods Mol Biol
, vol.325
, pp. 273-283
-
-
Won, J.1
Kim, T.K.2
-
20
-
-
0023748892
-
Adaptation of the rapid automated tetrazolium dye based (MTT) assay for chemosensitivity testing in childhood leukemia
-
Pieters R, Huismans DR, Leyva A, Veerman AJ. Adaptation of the rapid automated tetrazolium dye based (MTT) assay for chemosensitivity testing in childhood leukemia. Cancer Lett 1988;41:323-32.
-
(1988)
Cancer Lett
, vol.41
, pp. 323-332
-
-
Pieters, R.1
Huismans, D.R.2
Leyva, A.3
Veerman, A.J.4
-
21
-
-
34548555781
-
Expression of interleukin-13 receptor alpha2 in glioblastoma multiforme: Implications for targeted therapies
-
Jarboe JS, Johnson KR, Choi Y, Lonser RR, Park JK. Expression of interleukin-13 receptor alpha2 in glioblastoma multiforme: implications for targeted therapies. Cancer Res 2007;67:7983-6.
-
(2007)
Cancer Res
, vol.67
, pp. 7983-7986
-
-
Jarboe, J.S.1
Johnson, K.R.2
Choi, Y.3
Lonser, R.R.4
Park, J.K.5
-
22
-
-
42649129698
-
Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brain
-
Barrett AL, Krueger S, Datta S. Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brain. Dev Biol 2008;317:234-45.
-
(2008)
Dev Biol
, vol.317
, pp. 234-245
-
-
Barrett, A.L.1
Krueger, S.2
Datta, S.3
-
23
-
-
50649088457
-
Pattern formation in the vertebrate neural tube sonic hedgehog morphogen-regulated transcriptional network
-
Dessaud E, McMahon AP, Briscoe J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 2008;135:2489-503.
-
(2008)
Development
, vol.135
, pp. 2489-2503
-
-
Dessaud, E.1
McMahon, A.P.2
Briscoe, J.3
-
24
-
-
34547687822
-
Differential gene induction by genetic and ligand-mediated activation of the Sonic hedgehog pathway in neural stem cells
-
Galvin KE, Ye H, Wetmore C. Differential gene induction by genetic and ligand-mediated activation of the Sonic hedgehog pathway in neural stem cells. Dev Biol 2007;308:331-42.
-
(2007)
Dev Biol
, vol.308
, pp. 331-342
-
-
Galvin, K.E.1
Ye, H.2
Wetmore, C.3
-
25
-
-
34848818790
-
Regulation of skeletogenic differentiation in cranial dermal bone
-
Abzhanov A, Rodda SJ, McMahon AP, Tabin CJ. Regulation of skeletogenic differentiation in cranial dermal bone. Development 2007;134:3133-44.
-
(2007)
Development
, vol.134
, pp. 3133-3144
-
-
Abzhanov, A.1
Rodda, S.J.2
McMahon, A.P.3
Tabin, C.J.4
-
26
-
-
19944429892
-
Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: Conditional skin tumorigenesis recapitulates the hair growth cycle
-
Hutchin ME, Kariapper MS, Grachtchouk M, Wang A, Wei L, Cummings D, et al. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev 2005;19:214-23.
-
(2005)
Genes Dev
, vol.19
, pp. 214-223
-
-
Hutchin, M.E.1
Kariapper, M.S.2
Grachtchouk, M.3
Wang, A.4
Wei, L.5
Cummings, D.6
-
27
-
-
0025156778
-
The GLI gene encodes a nuclear protein which binds specific sequences in the human genome
-
Kinzler KW, Vogelstein B. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome. Mol Cell Biol 1990;10:634-42.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 634-642
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
28
-
-
0025172883
-
GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity
-
Ruppert JM, Vogelstein B, Arheden K, Kinzler KW. GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol Cell Biol 1990;10:5408-15.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 5408-5415
-
-
Ruppert, J.M.1
Vogelstein, B.2
Arheden, K.3
Kinzler, K.W.4
-
29
-
-
58149397354
-
Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes
-
Yoon JW, Gilbertson R, Iannaccone S, Iannaccone P, Walterhouse D. Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes. Int J Cancer 2008;124:109-19.
-
(2008)
Int J Cancer
, vol.124
, pp. 109-119
-
-
Yoon, J.W.1
Gilbertson, R.2
Iannaccone, S.3
Iannaccone, P.4
Walterhouse, D.5
-
30
-
-
4344659678
-
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
-
Sanchez P, Hernndez AM, Stecca B, Kahler AJ, DeGueme AM, Barrett A, et al. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci U S A 2004;101:12561-6.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 12561-12566
-
-
Sanchez, P.1
Hernndez, A.M.2
Stecca, B.3
Kahler, A.J.4
Degueme, A.M.5
Barrett, A.6
-
31
-
-
33846237601
-
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
-
Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 2007;17:165-72.
-
(2007)
Curr Biol
, vol.17
, pp. 165-172
-
-
Clement, V.1
Sanchez, P.2
De Tribolet, N.3
Radovanovic, I.4
Ruiz Altaba, I.A.5
-
32
-
-
33645211374
-
Purmorphamine activates the Hedgehog pathway by targeting Smoothened
-
Sinha S, Chen JK. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol 2006;2:29-30.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 29-30
-
-
Sinha, S.1
Chen, J.K.2
-
33
-
-
33646231995
-
Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies
-
Sasai K, Romer JT, Lee Y, Finkelstein D, Fuller C, McKinnon PJ, et al. Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res 2006;66:4215-22.
-
(2006)
Cancer Res
, vol.66
, pp. 4215-4222
-
-
Sasai, K.1
Romer, J.T.2
Lee, Y.3
Finkelstein, D.4
Fuller, C.5
McKinnon, P.J.6
-
35
-
-
30344439849
-
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity
-
Hallikas O, Palin K, Sinjushina N, Rautiainen R, Partanen J, Ukkonen E, et al. Genome-wide Prediction of Mammalian Enhancers Based on Analysis of Transcription-Factor Binding Affinity. Cell 2006;124:47-59.
-
(2006)
Cell
, vol.124
, pp. 47-59
-
-
Hallikas, O.1
Palin, K.2
Sinjushina, N.3
Rautiainen, R.4
Partanen, J.5
Ukkonen, E.6
-
36
-
-
0346463039
-
Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1
-
Bigelow RL, Chari NS, Unden AB, Spurgers KB, Lee S, Roop DR, et al. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem 2004;279:1197-205.
-
(2004)
J Biol Chem
, vol.279
, pp. 1197-1205
-
-
Bigelow, R.L.1
Chari, N.S.2
Unden, A.B.3
Spurgers, K.B.4
Lee, S.5
Roop, D.R.6
-
37
-
-
0037085379
-
Gene expression profiling leads to identification of gli1-binding elements in target genes and a role for multiple downstream pathways in gli1-induced cell transformation
-
Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega MA, et al. Gene Expression Profiling Leads to Identification of GLI1-binding Elements in Target Genes and a Role for Multiple Downstream Pathways in GLI1-induced Cell Transformation. J Biol Chem 2002;277:5548-55.
-
(2002)
J Biol Chem
, vol.277
, pp. 5548-5555
-
-
Yoon, J.W.1
Kita, Y.2
Frank, D.J.3
Majewski, R.R.4
Konicek, B.A.5
Nobrega, M.A.6
-
38
-
-
33645850420
-
Insulin-like growth factor-binding protein (IGFBP)-1, -2, -3, -4, -5, and -6 and IGFBP-related protein 1 during rainbow trout postvitellogenesis and oocyte maturation: Molecular characterization, expression profiles, and hormonal regulation
-
Kamangar BB, Gabillard JC, Bobe J. Insulin-like growth factor-binding protein (IGFBP)-1, -2, -3, -4, -5, and -6 and IGFBP-related protein 1 during rainbow trout postvitellogenesis and oocyte maturation: molecular characterization, expression profiles, and hormonal regulation. Endocrinology 2006;147:2399-410.
-
(2006)
Endocrinology
, vol.147
, pp. 2399-2410
-
-
Kamangar, B.B.1
Gabillard, J.C.2
Bobe, J.3
-
39
-
-
29144437760
-
Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy
-
Velzquez-Fernndez D, Laurell C, Geli J, Hg A, Odeberg J, Kjellman M, et al. Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy. Surgery 2005;138:1087-94.
-
(2005)
Surgery
, vol.138
, pp. 1087-1094
-
-
Velzquez-Fernndez, D.1
Laurell, C.2
Geli, J.3
Hg, A.4
Odeberg, J.5
Kjellman, M.6
-
40
-
-
33748092018
-
Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia
-
Fukuda I, Hizuka N, Ishikawa Y, Yasumoto K, Murakami Y, Sata A, et al. Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia. Growth Horm IGF Res 2006;16:211-6.
-
(2006)
Growth Horm IGF Res
, vol.16
, pp. 211-216
-
-
Fukuda, I.1
Hizuka, N.2
Ishikawa, Y.3
Yasumoto, K.4
Murakami, Y.5
Sata, A.6
-
41
-
-
43149125186
-
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
-
Keller MP, Choi Y, Wang P, Davis DB, Rabaglia ME, Oler AT, et al. A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res 2008;18:706-16.
-
(2008)
Genome Res
, vol.18
, pp. 706-716
-
-
Keller, M.P.1
Choi, Y.2
Wang, P.3
Davis, D.B.4
Rabaglia, M.E.5
Oler, A.T.6
-
42
-
-
34147182308
-
Role of Bcl-2 family members in anoxia induced cell death
-
Shroff EH, Snyder C, Chandel NS. Role of Bcl-2 family members in anoxia induced cell death. Cell Cycle 2007;6:807-9.
-
(2007)
Cell Cycle
, vol.6
, pp. 807-809
-
-
Shroff, E.H.1
Snyder, C.2
Chandel, N.S.3
|