Increased levels of osteopontin in sputum supernatant in severe refractory asthma

Thorax

Volumn 65, Issue 9, 2010, Pages 782-786

  Delimpoura, Vasiliki ^a   Bakakos, Petros ^a   Tseliou, Eleni ^a   Bessa, Vasiliki ^a   Hillas, Georgios ^b   Simoes, Davina C M ^c   Papiris, Spyros ^a   Loukides, Stelios ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b SOTIRIA GENERAL HOSPITAL   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; BIOLOGICAL MARKER; GLUCOCORTICOID; OSTEOPONTIN;

ADULT; AGED; AIRWAY REMODELING; ASTHMA; CHEMISTRY; COHORT ANALYSIS; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; SPUTUM; VITAL CAPACITY;

ADULT; AGED; AIRWAY REMODELING; ASTHMA; BIOLOGICAL MARKERS; COHORT STUDIES; FEMALE; FORCED EXPIRATORY VOLUME; GLUCOCORTICOIDS; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; OSTEOPONTIN; SPUTUM; VITAL CAPACITY;

EID: 77956818233     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2010.138552     Document Type: Article

References (37)

1. Broide DH. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol 2008;121:560-70;quiz 571-62.
2. Hackett TL, Warner SM, Stefanowicz D, et al. Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med 2009;180:122-33.
3. Simcock DE, Kanabar V, Clarke GW, et al. Induction of angiogenesis by airway smooth muscle from patients with asthma. Am J Respir Crit Care Med 2008;178:460-8.
4. Wenzel S. Severe asthma in adults. Am J Respir Crit Care Med 2005;172:149-60.
5. Chanez P, Wenzel SE, Anderson GP, et al. Severe asthma in adults: what are the important questions? J Allergy Clin Immunol 2007;119:1337-48.
6. Kohan M, Bader R, Puxeddu I, et al. Enhanced osteopontin expression in a murine model of allergen-induced airway remodelling. Clin Exp Allergy 2007;37:1444-54.
7. Chaulet H, Desgranges C, Renault MA, et al. Extracellular nucleotides induce arterial smooth muscle cell migration via osteopontin. Circ Res 2001;89:772-8.
8. Ogata T, Ueyama T, Nomura T, et al. Osteopontin is a myosphere-derived secretory molecule that promotes angiogenic progenitor cell proliferation through the phosphoinositide 3-kinase/Akt pathway. Biochem Biophys Res Commun 2007;359:341-7.
9. Ashkar S, Weber GF, Panoutsakopoulou V, et al. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science 2000;287:860-4.
10. Wai PY, Kuo PC. The role of osteopontin in tumor metastasis. J Surg Res 2004;121:228-41.
11. Brown LF, Berse B, Van de Water L, et al. Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces. Mol Biol Cell 1992;3:1169-80.
12. O'Regan AW, Chupp GL, Lowry JA, et al. Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro. J Immunol 1999;162:1024-31.
13. Serlin DM, Kuang PP, Subramanian M, et al. Interleukin-1beta induces osteopontin expression in pulmonary fibroblasts. J Cell Biochem 2006;97:519-29.
14. Takahashi A, Kurokawa M, Konno S, et al. Osteopontin is involved in migration of eosinophils in asthma. Clin Exp Allergy 2009;39:1152-9.
15. Xanthou G, Alissafi T, Semitekolou M, et al. Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nat Med 2007;13:570-8.
16. Simoes DC, Xanthou G, Petrochilou K, et al. Osteopontin deficiency protects against airway remodeling and hyperresponsiveness in chronic asthma. Am J Respir Crit Care Med 2009;179:894-902.
17. Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143-78.
18. American Thoracic Society (ATS). Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000;162:2341-51.
19. Kips JC, Fahy JV, Hargreave FE, et al. Methods for sputum induction and analysis of induced sputum: a method for assessing airway inflammation in asthma. Eur Respir J Suppl 1998;26:9-12S.
20. Grootendorst DC, van den Bos JW, Romeijn JJ, et al. Induced sputum in adolescents with severe stable asthma. Safety and the relationship of cell counts and eosinophil cationic protein to clinical severity. Eur Respir J 1999;13:647-53.
21. Efthimiadis A, Spanevello A, Hamid Q, et al. Methods of sputum processing for cell counts, immunocytochemistry and in situ hybridisation. Eur Respir J Suppl 2002;37:19-23s.
22. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995;152:1107-36.
23. Crapo RO, Casaburi R, Coates AL, et al. Guidelines for methacholine and exercise challenge testing, 1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161:309-29.
24. Menzies D, Nair A, Lipworth BJ. Portable exhaled nitric oxide measurement: comparison with the "gold standard" technique. Chest 2007;131:410-14.
25. Puxeddu I, Berkman N, Ribatti D, et al. Osteopontin is expressed and functional in human eosinophils. Allergy 2010;65:168-74.
26. Nagasaka A, Matsue H, Matsushima H, et al. Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells. Eur J Immunol 2008;38:489-99.
27. Kazanecki CC, Uzwiak DJ, Denhardt DT. Control of osteopontin signaling and function by post-translational phosphorylation and protein folding. J Cell Biochem 2007;102:912-24.
28. Schneider DJ, Lindsay JC, Zhou Y, et al. Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease. FASEB J 2010;24:70-80.
29. Singh K, Balligand JL, Fischer TA, et al. Glucocorticoids increase osteopontin expression in cardiac myocytes and microvascular endothelial cells. Role in regulation of inducible nitric oxide synthase. J Biol Chem 1995;270:28471-8.
30. Wang D, Yamamoto S, Hijiya N, et al. Transcriptional regulation of the human osteopontin promoter: functional analysis and DNA-protein interactions. Oncogene 2000;19:5801-9.
31. Kurokawa M, Konno S, Matsukura S, et al. Effects of corticosteroids on osteopontin expression in a murine model of allergic asthma. Int Arch Allergy Immunol 2009;149(Suppl 1):7-13.
32. Ohno I, Nitta Y, Yamauchi K, et al. Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. Am J Respir Cell Mol Biol 1996;15:404-9.
33. Kohan M, Breuer R, Berkman N. Osteopontin induces airway remodeling and lung fibroblast activation in a murine model of asthma. Am J Respir Cell Mol Biol 2009;41:290-6.
34. Denhardt DT, Noda M, O'Regan AW, et al. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 2001;107:1055-61.
35. Saha SK, Berry MA, Parker D, et al. Increased sputum and bronchial biopsy IL-13 expression in severe asthma. J Allergy Clin Immunol 2008;121:685-91.
36. Kasaian MT, Miller DK. IL-13 as a therapeutic target for respiratory disease. Biochem Pharmacol 2008;76:147-55.
37. Kaminska M, Foley S, Maghni K, et al. Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction. J Allergy Clin Immunol 2009;124:45-51, e1-4.