Suppression of TRIF-dependent signaling pathway of Toll-like receptors by oak wood vinegar in RAW264.7 macrophages

Molecular and Cellular Toxicology

Volumn 6, Issue 1, 2010, Pages 73-78

  Park, Se Jeong ^a   Lee, A Neum ^a   Back, Seong Kyung ^b   Youn, Hyung Sun ^a  

^a Soonchunhyang University   (South Korea)

^b Hong Ik University   (South Korea)

Author keywords

Lipopolysaccharide; Polyinosinic polycytidylic acid; Toll like receptors; TRIF; Wood vinegar

Indexed keywords

EID: 77956765390     PISSN: 1738642X     EISSN: 20928467     Source Type: Journal    
DOI: 10.1007/s13273-010-0010-9     Document Type: Article

References (29)

1. Chandy, T. & Sharma, C.P.Activated charcoal microcapsules and their applications.J Biomater Appl 13: 128-157 (1998).
2. Drucker, M.M., Goldhar, J., Ogra, P.L. & Neter, E.The effect of attapulgite and charcoal on enterotoxicity of Vibrio cholerae and Escherichia coli enterotoxins in rabbits.Infection 5:211-213 (1977).
3. Du, X.N., Niu, Z., Zhou, G.Z. & Li, Z.M.Effect of activated charcoal on endotoxin adsorption.Part I.An in vitro study.Biomater Artif Cells Artif Organs 15: 229-235 (1987).
4. Kim, Y.H., Kim, S.K., Kim, K.S. & Yun, Y.H.Composition of constituents of commercial wood vinegar liquor in Korea.J Korean Soc Agric Chem Biotechnol 44:262-268 (2001).
5. Nakai, S.A. & Siebert, K.J.Validation of bacterial growth inhibition models based on molecular properties of organic acids.Int J Food Microbiol 86:249-255 (2003).
6. Jung, I.S., Kim, Y.J., Gal, S.W. & Choi, Y.J.Antimicrobial and antioxidant activities and inhibition of nitric oxide synthesis of oak wood vinegar.J Life Science 17:105-109 (2007).
7. Jeong, C.H. & Shim, K.H.Nitrite-scavenging and antioxidant activities of wood vinegar.Korean J Food Preserv 9:351-355 (2002).
8. Jung, I.S., Kim, Y.J., Gal, S.W. & Choi, Y.J.Antimicrobial and antitoxidant activities and inhibition of nitric oxide synthesis of oak wood vinegar.J Life Science 17:105-109 (2007).
9. Medzhitov, R., Preston-Hurlburt, P. & Janeway, C.A.Jr.A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.Nature 388:394-397 (1997).
10. Bjorkbacka, H.et al.The induction of macrophage gene expression by LPS predominantly utilizes Myd88- independent signaling cascades.Physiol Genomics 19:319-330 (2004).
11. Takeda, K. & Akira, S.Toll-like receptors in innate immunity.Int Immunol 17:1-14 (2005).
12. Akira, S., Uematsu, S. & Takeuchi, O.Pathogen recognition and innate immunity.Cell 124:783-801 (2006).
13. Kawai, T.et al.Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes.J Immunol 167:5887-5894 (2001).
14. Gao, J.J.et al.Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene.J Immunol 161:4803-4810 (1998).
15. Fitzgerald, K.A.et al.IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.Nat Immunol 4:491-496 (2003).
16. Cook, D.N., Pisetsky, D.S. & Schwartz, D.A.Tolllike receptors in the pathogenesis of human disease.Nat Immunol 5:975-979 (2004).
17. Michelsen, K.S.et al.Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.Proc Natl Acad Sci USA 101:10679-10684 (2004).
18. Bjorkbacka, H.et al.Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.Nat Med 10:416-421 (2004).
19. Lin, R., Heylbroeck, C., Pitha, P.M. & Hiscott, J.Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.Mol Cell Biol 18:2986-2996 (1998).
20. Navarro, L. & David, M.p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide.J Biol Chem 274:35535-35538 (1999).
21. Lin, R., Heylbroeck, C., Genin, P., Pitha, P.M. & Hiscott, J.Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.Mol Cell Biol 19:959-966 (1999).
22. Schafer, S.L., Lin, R., Moore, P.A., Hiscott, J. & Pitha, P.M.Regulation of type I interferon gene expression by interferon regulatory factor-3.J Biol Chem 273:2714-2720 (1998).
23. Stetson, D.B. & Medzhitov, R.Type I interferons in host defense.Immunity 25:373-381 (2006).
24. Honda, K. & Taniguchi, T.IRFs: master regulators of signalling by Toll-like receptors and cytosolic patternrecognition receptors.Nat Rev Immunol 6:644-658 (2006).
25. McWhirter, S.M.et al.IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.Proc Natl Acad Sci USA 101:233-238 (2004).
26. Bjorkbacka, H.et al.The induction of macrophage gene expression by LPS predominantly utilizes Myd88- independent signaling cascades.Physiol Genomics 19:319-330 (2004).
27. Youn, H.S., Ahn, S.I. & Lee, B.Y.Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists.Int immunopharmacol 9:108-112 (2009).
28. Ahn, S.I., Lee, J.K. & Youn, H.S.Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol.Mol Cells 27:211-215 (2009).
29. Youn, H.S., Saitoh, S.I., Miyake, K. & Hwang, D.H.Inhibition of homodimerization of Toll-like receptor 4 by curcumin.Biochem Pharmacol 72:62-69 (2006)