In vivo fluorescence imaging is well-suited for the monitoring of adenovirus directed transgene expression in living organisms

Molecular Imaging and Biology

Volumn 12, Issue 3, 2010, Pages 278-285

  Kahraman, Sevim ^a   Dirice, Ercument ^a   Sanlioglu, Ahter Dilsad ^a   Yoldas, Burcak ^a   Bagci, Huseyin ^a   Erkilic, Metin ^a   Griffith, Thomas S ^b   Sanlioglu, Salih ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Adenoviral vector; CCD camera; EGFP; Gene therapy; In vivo imaging

Indexed keywords

ADENOVIRUS VECTOR; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN;

ADENOVIRUS; ANIMAL EXPERIMENT; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; FLUORESCENCE IMAGING; GENE EXPRESSION; GENE VECTOR; IMAGE ANALYSIS; IN VIVO STUDY; MALE; MOLECULAR IMAGING; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; TISSUE DISTRIBUTION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT; WHOLE BODY IMAGING; ABDOMEN; ANIMAL; ANTIBODY SPECIFICITY; CELL LINE; FLUORESCENCE; GENETICS; HUMAN; LIVER; METABOLISM; METHODOLOGY;

ADENOVIRIDAE; MUS;

ABDOMEN; ADENOVIRIDAE; ANIMALS; CELL LINE; FLUORESCENCE; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LIVER; MALE; MICE; MICE, INBRED BALB C; ORGAN SPECIFICITY; TISSUE DISTRIBUTION; TRANSGENES; WHOLE BODY IMAGING;

EID: 77956671615     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-009-0260-x     Document Type: Article

References (35)

1. Min JJ, Gambhir SS (2004) Gene therapy progress and prospects: noninvasive imaging of gene therapy in living subjects. Gene Ther 11:115-125
2. Sadikot RT, Blackwell TS (2005) Bioluminescence imaging. Proc Am Thorac Soc 2(537-540):511-532
3. Golzio M, Rols MP, Gabriel B, Teissie J (2004) Optical imaging of in vivo gene expression: a critical assessment of the methodology and associated technologies. Gene Ther 11(Suppl 1):S85-S91
4. Muller-Taubenberger A, Anderson KI (2007) Recent advances using green and red fluorescent protein variants. Appl Microbiol Biotechnol 77:1-12
5. Contag CH, Contag PR, Mullins JI et al (1995) Photonic detection of bacterial pathogens in living hosts. Mol Microbiol 18:593-603
6. Rice BW, Cable MD, Nelson MB (2001) In vivo imaging of lightemitting probes. J Biomed Opt 6:432-440
7. Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC (1994) Green fluorescent protein as a marker for gene expression. Science 263:802-805
8. Raty JK, Liimatainen T, Wirth T et al (2006) Magnetic resonance imaging of viral particle biodistribution in vivo. Gene Ther 13:1440-1446
9. Pfeifer A, Kessler T, Yang M et al (2001) Transduction of liver cells by lentiviral vectors: analysis in living animals by fluorescence imaging. Mol Ther 3:319-322
10. Zhao M, Yang M, Baranov E et al (2001) Spatial-temporal imaging of bacterial infection and antibiotic response in intact animals. Proc Natl Acad Sci U S A 98:9814-9818
11. Wack S, Hajri A, Heisel F et al (2003) Feasibility, sensitivity, and reliability of laser-induced fluorescence imaging of green fluorescent protein-expressing tumors in vivo. Mol Ther 7:765-773
12. Sanlioglu S, Luleci G, Thomas KW (2001) Simultaneous inhibition of Rac1 and IKK pathways sensitizes lung cancer cells to TNFalphamediated apoptosis. Cancer Gene Ther 8:897-905
13. Sanlioglu AD, Koksal IT, Karacay B et al (2006) Adenovirus-mediated IKKbetaKA expression sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. Cancer Gene Ther 13:21-31
14. Aydin C, Sanlioglu AD, Karacay B et al (2007) Decoy receptor-2 small interfering RNA (siRNA) strategy employing three different siRNA constructs in combination defeats adenovirus-transferred tumor necrosis factor-related apoptosis-inducing ligand resistance in lung cancer cells. Hum Gene Ther 18:39-50
15. Yang J, Marden JJ, Fan C et al (2003) Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Mol Ther 7:341-353
16. Sanlioglu AD, Karacay B, Koksal IT, Griffith TS, Sanlioglu S (2007) DcR2 (TRAIL-R4) siRNA and adenovirus delivery of TRAIL (Ad5h-TRAIL) break down in vitro tumorigenic potential of prostate carcinoma cells. Cancer Gene Ther 14:976-984
17. Vorburger SA, Hunt KK (2002) Adenoviral gene therapy. Oncologist 7:46-59
18. Sanlioglu AD, Koksal T, Baykara M et al (2003) Current progress in adenovirus mediated gene therapy for patients with prostate carcinoma. Gene Ther Mol Biol 7:113-133
19. Edelstein ML, Abedi MR, Wixon J (2007) Gene therapy clinical trials worldwide to 2007-an update. J Gene Med 9:833-842
20. Honigman A, Zeira E, Ohana P et al (2001) Imaging transgene expression in live animals. Mol Ther 4:239-249
21. Hofherr SE, Shashkova EV, Weaver EA, Khare R, Barry MA (2008) Modification of adenoviral vectors with polyethylene glycol modulates in vivo tissue tropism and gene expression. Mol Ther 16:1276-1282
22. Contag CH, Bachmann MH (2002) Advances in in vivo bioluminescence imaging of gene expression. Annu Rev Biomed Eng 4:235-260
23. Doerschug K, Sanlioglu S, Flaherty DM et al (2002) First-generation adenovirus vectors shorten survival time in a murine model of sepsis. J Immunol 169:6539-6545
24. Dajani R, Sanlioglu S, Zhang Y et al (2007) Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS. Am J Physiol Gastrointest Liver Physiol 292:G242-G252
25. Crettaz J, Berraondo P, Mauleon I et al (2006) Intrahepatic injection of adenovirus reduces inflammation and increases gene transfer and therapeutic effect in mice. Hepatology 44:623-632
26. Wu JC, Sundaresan G, Iyer M, Gambhir SS (2001) Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice. Mol Ther 4:297-306
27. Varnavski AN, Calcedo R, Bove M, Gao G, Wilson JM (2005) Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naive and pre-immunized mice. Gene Ther 12:427-436
28. Raper SE, Chirmule N, Lee FS et al (2003) Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol Genet Metab 80:148-158
29. Sanlioglu AD, Aydin C, Bozcuk H, Terzioglu E, Sanlioglu S (2004) Fundamental principals of tumor necrosis factor-alpha gene therapy approach and implications for patients with lung carcinoma. Lung Cancer 44:199-211
30. Wilson JM (1996) Adenoviruses as gene-delivery vehicles. N Engl J Med 334:1185-1187
31. Lefesvre P, Attema J, Lemckert A, Havenga M, van Bekkum D (2003) Genetic heterogeneity in response to adenovirus gene therapy. BMC Mol Biol 4:4
32. Fechner H, Haack A, Wang H et al (1999) Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. Gene Ther 6:1520-1535
33. Caceres G, Zhu XY, Jiao JA et al (2003) Imaging of luciferase and GFP-transfected human tumours in nude mice. Luminescence 18:218-223
34. Bouchard MB, MacLaurin SA, Dwyer PJ et al (2007) Technical considerations in longitudinal multispectral small animal molecular imaging. J Biomed Opt 12:051601
35. Kaijzel EL, van der Pluijm G, Lowik CW (2007) Whole-body optical imaging in animal models to assess cancer development and progression. Clin Cancer Res 13:3490-3497