Optical imaging of in vivo gene expression: A critical assessment of the methodology and associated technologies

Gene Therapy

Volumn 11, Issue , 2004, Pages S85-S91

  Golzio, M ^a   Rols, M P ^a   Gabriel, B ^a   Teissie J ^a  

^a INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Fluorescence; Gene expression; In vivo optical imaging; Luminescence

Indexed keywords

FLUORESCENT DYE; GREEN FLUORESCENT PROTEIN; LUCIFERASE; RED FLUORESCENT PROTEIN;

ACCURACY; CALCULATION; ENZYME ASSAY; ENZYME SUBSTRATE; FILTER; FLUORESCENCE ANALYSIS; GENE EXPRESSION; GENE TARGETING; GENE TECHNOLOGY; HUMAN; IMAGING SYSTEM; IN VIVO STUDY; LIGHT ABSORPTION; LIGHT REFRACTION; LIGHT SCATTERING; METHODOLOGY; MICROSCOPY; MONITORING; MULTIPHOTON MICROSCOPY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OPTICAL INSTRUMENTATION; OPTICALLY STIMULATED LUMINESCENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; SIGNAL TRANSDUCTION; SPECTROSCOPY; TIME; TOMOGRAPHY; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; FLUORESCENT DYES; GENE EXPRESSION; GENE THERAPY; GENES, REPORTER; HUMANS; LUMINESCENT AGENTS; MODELS, ANIMAL; SPECTRUM ANALYSIS; TOMOGRAPHY;

ANIMALIA;

EID: 5444250992     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302374     Document Type: Review

References (33)

1. Min JJ, Gambhir SS. Gene therapy progress and prospects: noninvasive imaging of gene therapy in living subjects. Gene Therapy 2004; 11: 115-125.
2. Richard JC et al. Repetitive imaging of reporter gene expression in the lung. Mol Imaging 2003; 2: 342-349.
3. Miyawaki A, Sawano A, Kogure T. Lighting up cells: labelling proteins with fluorophores. Nat Cell Biol 2003 (Suppl S): 1-7.
4. Tung CH et al. In vivo imaging of beta-galactosidase activity using far red fluorescent switch. Cancer Res 2004; 64: 1579-1583.
5. Mahmood U, Weissleder R. Near-infrared optical imaging of proteases in cancer. Mol Cancer Ther 2003; 2: 489-496.
6. West JL, Halas NJ. Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics. Annu Rev Biomed Eng 2003; 5: 285-292.
7. Weissleder R, Ntziachristos V. Shedding light onto live molecular targets. Technol Trends Nat Med 2003; 9: 123-128.
8. Zhang J, Campbell RE, Ting AY, Tsien RY. Creating new fluorescent probes for cell biology. Nat Rev Mol Cell Biol 2002; 3: 906-918.
9. Tsien RY. The green fluorescent protein. Annu Rev Biochem 1998; 67: 509-544.
10. Baird GS, Zacharias DA, Tsien RY. Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci USA 2000; 97: 11984-11989.
11. Gurskaya NG et al. GFP-like chromoproteins as a source of far- red fluorescent proteins. FEBS Lett 2001; 507: 16-20.
12. Nickell S et al. Anisotropy of light propagation in human skin. Phys Med Biol 2000; 45: 2873-2886.
13. Yang M et al. Whole-body and intravital optical imaging of angiogenesis in orthotopically implanted tumors. Proc Natl Acad Sci USA 2001; 98: 2616-2621.
14. Natasha S et al. Noninvasive functional optical spectroscopy of human breast tissue. Proc Natl Acad Sci USA 2001; 98: 4420-4425.
15. Dmochowski IJ et al. Quantitative imaging of cis-regulatory reporters in living embryos. Proc Natl Acad Sci USA 2002; 99: 12895-12900.
16. Brown EB et al. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med 2001; 7: 864-868.
17. Wack S et al. Feasibility, sensitivity, and reliability of laser- induced fluorescence imaging of green fluorescent proteinexpressing tumors in vivo. Mol Ther 2003; 7: 765-773.
18. Williams RM, Zipfel WR, Webb WW. Multiphoton microscopy in biological research. Curr Opin Chem Biol 2001; 5: 603-608.
19. Oheim M et al. Two-photon microscopy in brain tissue: parameters influencing the imaging depth. J Neurosci Methods 2001; 111: 29-37.
20. Ntziachristos V, Tung CH, Bremer C, Weissleder R. Fluorescence molecular tomography resolves protease activity in vivo. Nat Med 2002; 8: 757-760.
21. Graves EE, Ripoll J, Weissleder R, Ntziachristos V. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Phys 2003; 30: 901-911.
22. McCaffrey A, Kay MA, Contag CH. Advancing molecular therapies through in vivo bioluminescent imaging. Mol Imaging 2003; 2: 75-86.
23. Contag CH, Bachmann MH. Advances in in vivo bioluminescence imaging of gene expression. Annu Rev Biomed Eng 2002; 4: 235-260.
24. Bhaumik S, Gambhir SS. Optical imaging of Renilla luciferase reporter gene expression in living mice. Proc Natl Acad Sci USA 2002; 99: 377-382.
25. Lipshutz GS et al. In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer produces long-term expression. Mol Ther 2001; 3: 284-292
26. Wu JC, Sundaresan G, Iyer M, Gambhir SS. Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice. Mol Ther 2001; 4: 297-306.
27. Honigman A et al. Imaging transgene expression in live animals. Mol Ther 2001; 4: 239-249.
28. De A, Lewis XZ, Gambhir SS. Noninvasive imaging of lentiviralmediated reporter gene expression in living mice. Mol Ther 2003; (Part 1): 681-691.
29. Honigman A et al. Imaging transgene expression in live animals. Mol Ther 2001; 4: 239-249.
30. Hoffman RM. Watching real-time metastasis in vivo. Trends Mol Med 2002; 8: 354-355.
31. Pfeifer A et al. Transduction of liver cells by lentiviral vectors: analysis in living animals by fluorescence imaging. Mol Ther 2001; 3: 319-322.
32. Ntziachristos V, Tung CH, Bremer C, Weissleder R. Fluorescence molecular tomography resolves protease activity in vivo. Nat Med 2002; 8: 757-760.
33. Tung CH. In vivo imaging of beta-galactosidase activity using far red fluorescent switch. Cancer Res 2004; 64: 1579-1583.